{"id":"https://openalex.org/W4390729907","doi":"https://doi.org/10.1158/1538-7445.dnarepair24-a001","title":"Abstract A001: Discovery of imidazo [4,5-c]pyridin-2-ones as selective inhibitors of DNA-dependent protein kinase and effective radiosensitizers","display_name":"Abstract A001: Discovery of imidazo [4,5-c]pyridin-2-ones as selective inhibitors of DNA-dependent protein kinase and effective radiosensitizers","publication_year":2024,"publication_date":"2024-01-09","ids":{"openalex":"https://openalex.org/W4390729907","doi":"https://doi.org/10.1158/1538-7445.dnarepair24-a001"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.dnarepair24-a001","doi":"https://doi.org/10.1158/1538-7445.dnarepair24-a001","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.dnarepair24-a001","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2292/70128","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067234230","display_name":"Michael P. Hay","orcid":"https://orcid.org/0000-0002-7087-9087","observed_orcids":["https://orcid.org/0000-0002-7087-9087"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Michael P. Hay","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017270961","display_name":"Cho Rong Hong","orcid":"https://orcid.org/0000-0002-4304-1764","observed_orcids":["https://orcid.org/0000-0002-4304-1764"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Cho R. Hong","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090643688","display_name":"Lydia P. Liew","orcid":"https://orcid.org/0000-0002-9322-2010","observed_orcids":["https://orcid.org/0000-0002-9322-2010"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Lydia P. Liew","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065301832","display_name":"Benjamin D. Dickson","orcid":"https://orcid.org/0000-0001-6860-903X","observed_orcids":["https://orcid.org/0000-0001-6860-903X"]},"institutions":[{"id":"https://openalex.org/I52179390","display_name":"University of Waikato","ror":"https://ror.org/013fsnh78","country_code":"NZ","type":"education","lineage":["https://openalex.org/I52179390"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Benjamin D. Dickson","raw_affiliation_strings":["2University of Waikato, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Waikato, Hamilton, New Zealand","institution_ids":["https://openalex.org/I52179390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113289545","display_name":"Way Wua Wong","orcid":"https://orcid.org/0000-0002-2300-0930","observed_orcids":["https://orcid.org/0000-0002-2300-0930"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Way W. Wong","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092117853","display_name":"Sophia F. O'Brien-Gortner","orcid":"https://orcid.org/0009-0005-6001-5380","observed_orcids":["https://orcid.org/0009-0005-6001-5380"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Sophia F. O'Brien-Gortner","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093673866","display_name":"Rebecca Airey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Rebecca Airey","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109720872","display_name":"Jagdish Kumar Jaiswal","orcid":"https://orcid.org/0000-0002-0731-2117","observed_orcids":["https://orcid.org/0000-0002-0731-2117"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Jagdish Jaiswal","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087508568","display_name":"William Robert Wilson","orcid":"https://orcid.org/0000-0002-9939-8738","observed_orcids":["https://orcid.org/0000-0002-9939-8738"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"William R. Wilson","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078146193","display_name":"Stephen M. F. Jamieson","orcid":"https://orcid.org/0000-0002-5485-9211","observed_orcids":["https://orcid.org/0000-0002-5485-9211"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Stephen M. Jamieson","raw_affiliation_strings":["1University of Auckland, Auckland, New Zealand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Auckland, Auckland, New Zealand,","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"1_Supplement","first_page":"A001","last_page":"A001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.4399000108242035,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.4399000108242035,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.11540000140666962,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-dependent-protein-kinase","display_name":"DNA-dependent protein kinase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/dna-pk-inhibitor","display_name":"DNA-PK inhibitor","score":0.8209999799728394},{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9110000133514404},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.5410000085830688},{"id":"https://openalex.org/keywords/dactolisib","display_name":"dactolisib","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prkdc","display_name":"PRKDC","score":0.781000018119812},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5070000290870667},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7129999995231628},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.6493226289749146},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.605825662612915},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5468345880508423},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.49677973985671997},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4824667274951935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47128549218177795},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4208661913871765},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.41949376463890076},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3973127603530884},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3663244843482971},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3632713556289673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36263057589530945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31066620349884033},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2889322340488434}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1538-7445.dnarepair24-a001","doi":"https://doi.org/10.1158/1538-7445.dnarepair24-a001","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.dnarepair24-a001","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/70128","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2292/70128","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Item"}],"best_oa_location":{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/70128","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2292/70128","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Item"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400651280","https://openalex.org/W4390761622","https://openalex.org/W3152832865","https://openalex.org/W4403763430","https://openalex.org/W7055362271","https://openalex.org/W7148755119","https://openalex.org/W7222793954","https://openalex.org/W2044680650","https://openalex.org/W2971556441","https://openalex.org/W7160841414"],"abstract_inverted_index":{"Abstract":[0],"Inhibition":[1],"of":[2,5,24,30,46,52,57,89,106,121,145,166,214,227,257,277,288,322,328,338],"the":[3,13,28,44,50,62,72,87,104,107,135,156,286,339],"repair":[4,29],"radiation-induced":[6,31],"DNA":[7,346],"double":[8],"strand":[9],"breaks":[10],"(DSB)":[11],"offers":[12],"potential":[14,282],"to":[15,18,103,352],"sensitize":[16],"tumors":[17],"radiation":[19,241],"therapy.":[20],"The":[21,65],"dominant":[22],"role":[23],"non-homologous":[25],"end-joining":[26],"in":[27,86,125,234,261,343],"DSBs":[32],"indicates":[33],"that":[34],"DNA-dependent":[35,329],"protein":[36,330],"kinase":[37,58,79,123,331],"(DNA-PK)":[38],"is":[39],"an":[40],"excellent":[41,98],"target":[42],"for":[43,132,285],"development":[45,84],"radiosensitizers.":[47],"We":[48],"report":[49],"discovery":[51,105],"a":[53,92,126,196,212,237,271],"new":[54],"chemical":[55],"class":[56,66,276],"inhibitor":[59,81,96],"based":[60],"on":[61],"imidazo[4,5-c]pyridin-2-one":[63],"scaffold.":[64],"was":[67],"developed":[68],"by":[69,244],"scaffold-hopping":[70],"from":[71],"pan":[73],"phosphoinositide":[74],"3-kinsase":[75],"(PI3K)":[76],"and":[77,110,116,137,161,176,181,183,185,191,202,219,230,268,274,332],"PI3K-like":[78],"(PIKK)":[80],"dactolisib.":[82],"Iterative":[83],"culminated":[85],"identification":[88],"SN39536":[90,115,160,201,218,250,267],"as":[91,283,325],"low":[93],"nM":[94],"DNA-PK":[95,122,133,278],"with":[97,129,152,236,263,280],"selectivity.":[99],"Further":[100],"modification":[101],"led":[102],"more":[108,111],"potent":[109],"selective":[112,275,326],"SN40905.":[113],"Both":[114,140,200],"SN40905":[117,162,203,220,269],"were":[118,163],"effective":[119,164,333],"inhibitors":[120,279,327],"activity":[124],"biochemical":[127],"assay":[128],"substantial":[130,253],"selectivity":[131],"across":[134],"PIKK":[136],"PI3K":[138],"families.":[139],"compounds":[141],"selectively":[142],"inhibited":[143],"growth":[144,255],"HAP1":[146],"PRKDC":[147],"wild-type":[148],"cells":[149,193],"when":[150],"combined":[151],"radiation,":[153],"but":[154],"not":[155],"corresponding":[157],"PRKDC-/-":[158],"cells.":[159],"radiosensitizers":[165,284,334],"colorectal":[167],"carcinoma":[168,189],"(HCT116),":[169],"non-small":[170],"cell":[171,188,225],"lung":[172],"cancer":[173],"(H460,":[174],"H1299,":[175],"A549),":[177],"pancreatic":[178],"(BxPC-3,":[179],"PANC-1,":[180],"MiaPaCa-2)":[182],"head":[184],"neck":[186],"squamous":[187],"(FaDu":[190],"UT-SCC-74B)":[192],"determined":[194,243],"using":[195],"clonogenic":[197,247],"survival":[198,248],"endpoint.":[199],"displayed":[204],"high":[205],"oral":[206],"bioavailability.":[207],"When":[208],"administered":[209],"PO":[210],"at":[211],"range":[213],"non-toxic":[215],"doses,":[216],"both":[217],"provided":[221,252],"significant":[222,281],"additional":[223],"tumor":[224,232,254,259],"killing":[226],"HCT116,":[228],"UT-SCC-74B,":[229],"BxPC-3":[231],"xenografts":[233,260],"combination":[235,262],"single":[238],"(13":[239],"Gy)":[240],"treatment":[242,287],"ex":[245],"vivo":[246],"assays.":[249],"also":[251],"inhibition":[256],"HCT116":[258],"RAD":[264],"(10":[265],"Gy).":[266],"represent":[270],"new,":[272],"potent,":[273],"human":[289],"cancers.":[290],"Citation":[291],"Format:":[292],"Michael":[293],"P.":[294,300],"Hay,":[295],"Cho":[296],"R.":[297,316],"Hong,":[298],"Lydia":[299],"Liew,":[301],"Benjamin":[302],"D.":[303],"Dickson,":[304],"Way":[305],"W.":[306],"Wong,":[307],"Sophia":[308],"F.":[309],"O'Brien-Gortner,":[310],"Rebecca":[311],"Airey,":[312],"Jagdish":[313],"Jaiswal,":[314],"William":[315],"Wilson,":[317],"Stephen":[318],"M.":[319],"Jamieson.":[320],"Discovery":[321],"imidazo":[323],"[4,5-c]pyridin-2-ones":[324],"[abstract].":[335],"In:":[336],"Proceedings":[337],"AACR":[340],"Special":[341],"Conference":[342],"Cancer":[344,364],"Research:":[345],"Damage":[347],"Repair:":[348],"From":[349],"Basic":[350],"Science":[351],"Future":[353],"Clinical":[354],"Application;":[355],"2024":[356],"Jan":[357],"9-11;":[358],"Washington,":[359],"DC.":[360],"Philadelphia":[361],"(PA):":[362],"AACR;":[363],"Res":[365],"2024;84(1":[366],"Suppl):Abstract":[367],"nr":[368],"A001.":[369]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-13T00:00:00"}