{"id":"https://openalex.org/W4390711190","doi":"https://doi.org/10.37990/medr.1368570","title":"Anti-Leukemic Effect of Malachite Green-Mediated Photodynamic Therapy by Inducing ER Stress in HL-60 Cells","display_name":"Anti-Leukemic Effect of Malachite Green-Mediated Photodynamic Therapy by Inducing ER Stress in HL-60 Cells","publication_year":2024,"publication_date":"2024-01-10","ids":{"openalex":"https://openalex.org/W4390711190","doi":"https://doi.org/10.37990/medr.1368570"},"language":"en","primary_location":{"id":"doi:10.37990/medr.1368570","doi":"https://doi.org/10.37990/medr.1368570","is_oa":true,"landing_page_url":"https://doi.org/10.37990/medr.1368570","pdf_url":"https://dergipark.org.tr/en/download/article-file/3443165","source":{"id":"https://openalex.org/S4210212135","display_name":"Medical Records","issn_l":"2687-4555","issn":["2687-4555"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Records","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/3443165","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044579940","display_name":"Metin \u00c7al\u0131\u015fkan","orcid":"https://orcid.org/0000-0002-9243-4943","observed_orcids":["https://orcid.org/0000-0002-9243-4943"]},"institutions":[{"id":"https://openalex.org/I204585392","display_name":"Usak University","ror":"https://ror.org/05es91y67","country_code":"TR","type":"education","lineage":["https://openalex.org/I204585392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Metin \u00c7ALI\u015eKAN","raw_affiliation_strings":["U\u015eAK \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-9243-4943","affiliations":[{"raw_affiliation_string":"U\u015eAK \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I204585392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032956786","display_name":"G\u00fcl\u015fen Bayrak","orcid":"https://orcid.org/0000-0002-1397-7203","observed_orcids":["https://orcid.org/0000-0002-1397-7203"]},"institutions":[{"id":"https://openalex.org/I204585392","display_name":"Usak University","ror":"https://ror.org/05es91y67","country_code":"TR","type":"education","lineage":["https://openalex.org/I204585392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gulsen BAYRAK","raw_affiliation_strings":["U\u015eAK \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-1397-7203","affiliations":[{"raw_affiliation_string":"U\u015eAK \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I204585392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018332490","display_name":"Ser\u00e7in \u00d6zlem \u00c7al\u0131\u015fkan","orcid":"https://orcid.org/0000-0001-8464-5487","observed_orcids":["https://orcid.org/0000-0001-8464-5487"]},"institutions":[{"id":"https://openalex.org/I204585392","display_name":"Usak University","ror":"https://ror.org/05es91y67","country_code":"TR","type":"education","lineage":["https://openalex.org/I204585392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sercin \u00d6ZLEM \u00c7ALI\u015eKAN","raw_affiliation_strings":["U\u015eAK \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":"https://orcid.org/0000-0001-8464-5487","affiliations":[{"raw_affiliation_string":"U\u015eAK \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I204585392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204585392"],"apc_list":null,"apc_paid":null,"fwci":0.1359,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35577158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"6","issue":"1","first_page":"8","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malachite-green","display_name":"malachite green","score":0.9670000076293945},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9909999966621399},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":1.0},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.9750000238418579},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2780704308","wikidata":"https://www.wikidata.org/wiki/Q408815","display_name":"Malachite green","level":3,"score":0.8626428842544556},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7434424161911011},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.643744945526123},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.609691858291626},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.534896969795227},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5026853084564209},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.5005526542663574},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4859553575515747},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4569062292575836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36454468965530396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3476870059967041},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3414197564125061},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33697742223739624},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3156237006187439},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2997199296951294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25246143341064453},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2385534942150116},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.171735018491745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1574556827545166},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.37990/medr.1368570","doi":"https://doi.org/10.37990/medr.1368570","is_oa":true,"landing_page_url":"https://doi.org/10.37990/medr.1368570","pdf_url":"https://dergipark.org.tr/en/download/article-file/3443165","source":{"id":"https://openalex.org/S4210212135","display_name":"Medical Records","issn_l":"2687-4555","issn":["2687-4555"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Records","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1368570","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/medr/issue/82670/1368570","pdf_url":"https://dergipark.org.tr/tr/pub/medr/issue/82670/1368570","source":{"id":"https://openalex.org/S4210212135","display_name":"Medical Records","issn_l":"2687-4555","issn":["2687-4555"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Records","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.37990/medr.1368570","doi":"https://doi.org/10.37990/medr.1368570","is_oa":true,"landing_page_url":"https://doi.org/10.37990/medr.1368570","pdf_url":"https://dergipark.org.tr/en/download/article-file/3443165","source":{"id":"https://openalex.org/S4210212135","display_name":"Medical Records","issn_l":"2687-4555","issn":["2687-4555"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Records","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390711190.pdf","grobid_xml":"https://content.openalex.org/works/W4390711190.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W204403019","https://openalex.org/W1905347400","https://openalex.org/W1941666480","https://openalex.org/W1965872874","https://openalex.org/W1976943917","https://openalex.org/W2009881719","https://openalex.org/W2046949873","https://openalex.org/W2050050256","https://openalex.org/W2060420887","https://openalex.org/W2062273647","https://openalex.org/W2063043992","https://openalex.org/W2080710543","https://openalex.org/W2085933321","https://openalex.org/W2087200546","https://openalex.org/W2087907678","https://openalex.org/W2089198803","https://openalex.org/W2099429838","https://openalex.org/W2151734986","https://openalex.org/W2162272199","https://openalex.org/W2170801813","https://openalex.org/W2531231403","https://openalex.org/W2577508976","https://openalex.org/W2605018081","https://openalex.org/W2622552908","https://openalex.org/W2790245884","https://openalex.org/W2883022040","https://openalex.org/W2885627142","https://openalex.org/W2915478882","https://openalex.org/W3198007492","https://openalex.org/W4210818981","https://openalex.org/W4248400444","https://openalex.org/W4328046310","https://openalex.org/W4386738945"],"related_works":["https://openalex.org/W4328046310","https://openalex.org/W2095287428","https://openalex.org/W4386738945","https://openalex.org/W4247870988","https://openalex.org/W2978700457","https://openalex.org/W4362597223","https://openalex.org/W2411085607","https://openalex.org/W1955048550","https://openalex.org/W1990670438","https://openalex.org/W2138730271"],"abstract_inverted_index":{"Aim:":[0],"Our":[1,171],"objective":[2],"is":[3],"to":[4,60,76,95,104,141,179],"explore":[5],"the":[6,9,19,38,84,106,128,142,163,180,200,214],"relationship":[7],"between":[8],"anti-leukemic":[10],"impact":[11],"of":[12,21,53,88,108,127,132],"malachite":[13,54,89,133,143,188],"green-mediated":[14,189],"photodynamic":[15],"therapy":[16],"(PDT)":[17],"and":[18,33,56,64,81,99,118,135,147,157],"induction":[20],"endoplasmic":[22],"reticulum":[23],"(ER)":[24],"stress":[25,110,176,205],"in":[26,83,162,183,196,219],"acute":[27],"promyelocytic":[28],"leukemia":[29],"cells":[30,39,73,186],"(HL-60).":[31],"Material":[32],"Method:":[34],"For":[35],"one":[36],"hour":[37],"were":[40,58,74,159],"incubated":[41],"with":[42,78,167],"different":[43],"concentrations":[44],"(3.125,":[45],"1.56,":[46],"0.78,":[47],"0.39,":[48],"0.195,":[49],"0.0975,":[50],"0.04875":[51],"\u03bcM)":[52],"green":[55,134],"then":[57],"exposed":[59,75],"0.47":[61],"mW/cm2":[62],"irradiance":[63],"0.84":[65],"J/cm2":[66],"fluence":[67],"for":[68,216],"30":[69],"minutes.":[70],"Also,":[71],"HL-60":[72,184],"PDT":[77],"light":[79,148,198],"only":[80],"both":[82],"presence":[85],"or":[86],"absence":[87],"green.":[90],"MTT":[91],"assay":[92],"was":[93,102,137],"used":[94,103],"determine":[96],"cell":[97,125],"viability,":[98],"immunocytochemical":[100,151],"staining":[101,152],"detect":[105],"expression":[107],"ER":[109,115,175,204],"markers":[111],"Protein":[112],"Kinase":[113,116],"R-like":[114],"(PERK)":[117],"Glucose-regulated":[119],"protein":[120],"78":[121],"(GRP78).":[122],"Results:":[123],"The":[124],"viability":[126],"treatment":[129,164],"group":[130,165],"(combination":[131],"light)":[136],"significantly":[138,160],"decreased":[139],"compared":[140,166],"green,":[144],"control":[145],"group,":[146],"control.":[149],"Moreover,":[150],"scores":[153],"showed":[154],"that":[155,174,206],"PERK":[156],"GRP78":[158],"upregulated":[161],"other":[168],"groups.":[169],"Conclusion:":[170],"results":[172],"indicate":[173],"may":[177,207],"contribute":[178],"cytotoxicity":[181],"occurring":[182],"cancer":[185],"after":[187,209],"PDT.":[190,210],"Future":[191],"studies":[192],"will":[193],"be":[194],"crucial":[195],"shedding":[197],"on":[199],"molecular":[201],"mechanisms":[202],"underlying":[203],"occur":[208],"These":[211],"findings":[212],"lay":[213],"foundation":[215],"further":[217],"investigations":[218],"this":[220],"area.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-01-13T00:00:00"}
