{"id":"https://openalex.org/W4390707122","doi":"https://doi.org/10.1097/wnp.0000000000001060","title":"Corticothalamic Responsive Neurostimulation for Focal Epilepsy: A Single-Center Experience","display_name":"Corticothalamic Responsive Neurostimulation for Focal Epilepsy: A Single-Center Experience","publication_year":2024,"publication_date":"2024-01-09","ids":{"openalex":"https://openalex.org/W4390707122","doi":"https://doi.org/10.1097/wnp.0000000000001060","pmid":"https://pubmed.ncbi.nlm.nih.gov/38194631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11520339"},"language":"en","primary_location":{"id":"doi:10.1097/wnp.0000000000001060","doi":"https://doi.org/10.1097/wnp.0000000000001060","is_oa":true,"landing_page_url":"https://doi.org/10.1097/wnp.0000000000001060","pdf_url":null,"source":{"id":"https://openalex.org/S116127033","display_name":"Journal of Clinical Neurophysiology","issn_l":"0736-0258","issn":["0736-0258","1537-1603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/wnp.0000000000001060","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019331439","display_name":"David E. Burdette","orcid":"https://orcid.org/0000-0002-6235-2568","observed_orcids":["https://orcid.org/0000-0002-6235-2568"]},"institutions":[{"id":"https://openalex.org/I4392738273","display_name":"Corewell Health","ror":"https://ror.org/02hb5yj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4392738273"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Burdette","raw_affiliation_strings":["Corewell Health and Michigan State University College of Human Medicine, Grand Rapids, Michigan, U.S.A.; and"],"raw_orcid":"https://orcid.org/0000-0002-6235-2568","affiliations":[{"raw_affiliation_string":"Corewell Health and Michigan State University College of Human Medicine, Grand Rapids, Michigan, U.S.A.; and","institution_ids":["https://openalex.org/I4392738273","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044778764","display_name":"Sanjay Patra","orcid":"https://orcid.org/0000-0002-3383-0807","observed_orcids":["https://orcid.org/0000-0002-3383-0807"]},"institutions":[{"id":"https://openalex.org/I4392738273","display_name":"Corewell Health","ror":"https://ror.org/02hb5yj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4392738273"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sanjay Patra","raw_affiliation_strings":["Corewell Health and Michigan State University College of Human Medicine, Grand Rapids, Michigan, U.S.A.; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corewell Health and Michigan State University College of Human Medicine, Grand Rapids, Michigan, U.S.A.; and","institution_ids":["https://openalex.org/I4392738273","https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113115331","display_name":"Lise A. Johnson","orcid":"https://orcid.org/0009-0001-8740-3886","observed_orcids":["https://orcid.org/0009-0001-8740-3886"]},"institutions":[{"id":"https://openalex.org/I4210097963","display_name":"NeuroPace (United States)","ror":"https://ror.org/00znwxq75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lise Johnson","raw_affiliation_strings":["NeuroPace, Inc, Mountain View, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NeuroPace, Inc, Mountain View, CA, U.S.A","institution_ids":["https://openalex.org/I4210097963"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019331439","https://openalex.org/A5044778764"],"corresponding_institution_ids":["https://openalex.org/I4392738273","https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":5.9231,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.97291102,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"41","issue":"7","first_page":"630","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.1704999953508377,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-epilepsy","display_name":"focal epilepsy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thalamic-nuclei","display_name":"thalamic nuclei","score":0.8399999737739563},{"id":"https://openalex.org/keywords/centromedian-nucleus","display_name":"centromedian nucleus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pulvinar","display_name":"pulvinar","score":0.8999999761581421},{"id":"https://openalex.org/keywords/anterior-thalamic-nucleus","display_name":"anterior thalamic nuclei","score":0.8550000190734863},{"id":"https://openalex.org/keywords/intracranial-eeg","display_name":"intracranial EEG","score":0.7250000238418579},{"id":"https://openalex.org/keywords/seizure-frequency-reduction","display_name":"seizure frequency reduction","score":0.824999988079071},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.87044358253479},{"id":"https://openalex.org/C2776443511","wikidata":"https://www.wikidata.org/wiki/Q1724687","display_name":"Neurostimulation","level":3,"score":0.7404515743255615},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6726066470146179},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5960568189620972},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5854337811470032},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5801471471786499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5235069394111633},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.489346444606781},{"id":"https://openalex.org/C2780874087","wikidata":"https://www.wikidata.org/wiki/Q7447057","display_name":"Seizure types","level":3,"score":0.46708178520202637},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.4592047333717346},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.36675938963890076},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32238346338272095},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1252516508102417},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/wnp.0000000000001060","doi":"https://doi.org/10.1097/wnp.0000000000001060","is_oa":true,"landing_page_url":"https://doi.org/10.1097/wnp.0000000000001060","pdf_url":null,"source":{"id":"https://openalex.org/S116127033","display_name":"Journal of Clinical Neurophysiology","issn_l":"0736-0258","issn":["0736-0258","1537-1603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Neurophysiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11520339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11520339","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11520339/pdf/jcnp-41-630.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Neurophysiol","raw_type":"Text"},{"id":"pmid:38194631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38194631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/wnp.0000000000001060","doi":"https://doi.org/10.1097/wnp.0000000000001060","is_oa":true,"landing_page_url":"https://doi.org/10.1097/wnp.0000000000001060","pdf_url":null,"source":{"id":"https://openalex.org/S116127033","display_name":"Journal of Clinical Neurophysiology","issn_l":"0736-0258","issn":["0736-0258","1537-1603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Neurophysiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390707122.pdf","grobid_xml":"https://content.openalex.org/works/W4390707122.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W216846386","https://openalex.org/W2080438790","https://openalex.org/W2128144507","https://openalex.org/W2800962323","https://openalex.org/W2908226157","https://openalex.org/W2910336363","https://openalex.org/W2912187093","https://openalex.org/W2947016468","https://openalex.org/W2949606941","https://openalex.org/W2953009208","https://openalex.org/W2972781749","https://openalex.org/W3006597874","https://openalex.org/W3084260501","https://openalex.org/W3178175089","https://openalex.org/W3208234271","https://openalex.org/W4200266028","https://openalex.org/W4280537537","https://openalex.org/W4285589084","https://openalex.org/W4309174633","https://openalex.org/W4367837568"],"related_works":["https://openalex.org/W7203898435","https://openalex.org/W7164181585","https://openalex.org/W4394787156","https://openalex.org/W4386558706","https://openalex.org/W3084260501","https://openalex.org/W7166639791","https://openalex.org/W4409503758","https://openalex.org/W4392848096","https://openalex.org/W4283808138","https://openalex.org/W4381087487"],"abstract_inverted_index":{"PURPOSE:":[0],"Owing":[1],"to":[2,33,97,206,217,299],"its":[3],"extensive,":[4],"reciprocal":[5],"connectivity":[6],"with":[7,51,89],"the":[8,14,36,39,57,78,94,106,158,164,208,212,235,242,307],"cortex":[9],"and":[10,38,111,119,124,199,215,251,259,277],"other":[11],"subcortical":[12],"structures,":[13],"thalamus":[15,37,209],"is":[16,31,70,77],"considered":[17],"an":[18,142,286],"important":[19],"target":[20,98,109],"for":[21,108,145],"neuromodulation":[22],"in":[23,151,163,189,241,256,265,290,306],"drug-resistant":[24,291],"focal":[25,292,310],"epilepsy.":[26,293,311],"Using":[27],"corticothalamic":[28,49,90,139,280],"stimulation,":[29],"it":[30,69],"possible":[32],"modulate":[34],"both":[35,274],"cortical":[40],"seizure":[41,153,191],"onset":[42],"zone.":[43],"Limited":[44],"published":[45],"clinical":[46,117],"experience":[47,88],"describes":[48],"stimulation":[50],"depth":[52],"leads":[53],"targeting":[54],"one":[55],"of":[56,74,122,147,156,184,303,309],"anterior":[58],"(ANT),":[59],"centromedian":[60,176],"(centromedian":[61],"nucleus),":[62],"or":[63,175],"pulvinar":[64],"(PUL)":[65],"thalamic":[66,101,159,236,304],"nuclei.":[67,102,268],"However,":[68],"not":[71],"clear":[72],"which":[73],"these":[75,99],"nuclei":[76],"\"best\"":[79],"therapeutic":[80],"target.":[81],"METHODS:":[82],"This":[83],"study":[84,133],"comprised":[85],"a":[86,120,187,225,300],"single-center":[87],"responsive":[91,138,281],"neurostimulation":[92,140,282],"using":[93],"RNS":[95],"System":[96],"three":[100,267],"Presented":[103],"here":[104],"are":[105],"methods":[107],"selection":[110],"device":[112],"programming":[113],"as":[114,116],"well":[115],"outcomes":[118],"comparison":[121],"ictal":[123],"nonictal":[125],"electrophysiological":[126],"features.":[127],"RESULTS:":[128],"In":[129,222],"this":[130],"small":[131],"retrospective":[132],"(":[134,166,171,178],"N":[135,167,172,179],"=":[136,168,173,180],"19),":[137],"was":[141,161,231],"effective":[143,287],"therapy":[144,289],"79%":[146],"patients":[148,185],"(\u226550%":[149],"reduction":[150,188],"disabling":[152,190],"frequency),":[154],"regardless":[155],"whether":[157],"lead":[160],"implanted":[162],"ANT":[165],"2),":[169],"PUL":[170],"6),":[174],"nucleus":[177],"11).":[181],"Twenty-six":[182],"percent":[183],"reported":[186],"frequency":[192,196,203,257,276,279],"\u226590%.":[193],"Both":[194],"high":[195,275],"(\u2265100":[197],"Hz)":[198,202],"low":[200,278],"(\u226420":[201],"were":[204,245,261],"used":[205],"stimulate":[207],"depending":[210],"on":[211,234],"patient's":[213],"response":[214],"ability":[216],"tolerate":[218],"higher":[219],"charge":[220],"densities.":[221],"all":[223,266],"patients,":[224,239],"longer":[226],"burst":[227],"duration":[228],"(2000-5000":[229],"ms)":[230],"ultimately":[232],"implemented":[233],"leads.":[237],"Across":[238],"peaks":[240],"intracranial":[243],"EEG":[244],"observed":[246,262],"at":[247],"theta,":[248],"beta,":[249],"gamma,":[250],"sleep":[252],"spindle":[253],"frequencies.":[254],"Changes":[255],"content":[258],"distribution":[260],"over":[263],"time":[264],"CONCLUSIONS:":[269],"These":[270,294],"results":[271],"indicate":[272],"that":[273],"can":[283,296],"potentially":[284],"be":[285],"adjunctive":[288],"data":[295],"also":[297],"contribute":[298],"broader":[301],"understanding":[302],"electrophysiology":[305],"context":[308]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-01-13T00:00:00"}