{"id":"https://openalex.org/W4390640783","doi":"https://doi.org/10.1089/ars.2023.0390","title":"Bioengineered MSC GFPCxcr2-Mmp13 Transplantation Alleviates Hepatic Fibrosis by Regulating Mammalian Target of Rapamycin Signaling","display_name":"Bioengineered MSC GFPCxcr2-Mmp13 Transplantation Alleviates Hepatic Fibrosis by Regulating Mammalian Target of Rapamycin Signaling","publication_year":2024,"publication_date":"2024-01-06","ids":{"openalex":"https://openalex.org/W4390640783","doi":"https://doi.org/10.1089/ars.2023.0390","pmid":"https://pubmed.ncbi.nlm.nih.gov/38183635"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2023.0390","doi":"https://doi.org/10.1089/ars.2023.0390","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1089/ars.2023.0390","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shilpa Chawla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shilpa Chawla","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India","Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India","institution_ids":["https://openalex.org/I55664587","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011743683","display_name":"Subholakshmi Choudhury","orcid":"https://orcid.org/0000-0002-4665-7185","observed_orcids":["https://orcid.org/0000-0002-4665-7185"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subholakshmi Choudhury","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India","Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India","institution_ids":["https://openalex.org/I55664587","https://openalex.org/I66760702"]}]},{"author_position":"last","author":{"id":null,"display_name":"Amitava Das","orcid":"https://orcid.org/0000-0002-7510-1805","observed_orcids":["https://orcid.org/0000-0002-7510-1805"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Amitava Das","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India","Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India"],"raw_orcid":"https://orcid.org/0000-0002-7510-1805","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India","institution_ids":["https://openalex.org/I55664587","https://openalex.org/I66760702"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55664587","https://openalex.org/I66760702","https://openalex.org/I99364266"],"apc_list":null,"apc_paid":null,"fwci":0.3036,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.4295165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"41","issue":"1-3","first_page":"110","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.7139999866485596},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.777999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hepatocyte-like-cells","display_name":"hepatocyte-like cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.531000018119812},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.5759999752044678},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6382579207420349},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5626627802848816},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.519020676612854},{"id":"https://openalex.org/C2776108821","wikidata":"https://www.wikidata.org/wiki/Q15335612","display_name":"SOD2","level":4,"score":0.48526880145072937},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4793872833251953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33485129475593567},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33373159170150757},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32185620069503784},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3075123429298401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2741609811782837},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.20771899819374084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19002053141593933},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.10165098309516907}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/ars.2023.0390","doi":"https://doi.org/10.1089/ars.2023.0390","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1089/ars.2023.0390","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},{"id":"pmid:38183635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38183635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W167492261","https://openalex.org/W1903046457","https://openalex.org/W1970617924","https://openalex.org/W1978370636","https://openalex.org/W1982377789","https://openalex.org/W2020592839","https://openalex.org/W2039640287","https://openalex.org/W2060590346","https://openalex.org/W2067485136","https://openalex.org/W2068443352","https://openalex.org/W2071433447","https://openalex.org/W2077870572","https://openalex.org/W2099218145","https://openalex.org/W2103951982","https://openalex.org/W2104551096","https://openalex.org/W2106569604","https://openalex.org/W2148913003","https://openalex.org/W2224592141","https://openalex.org/W2351437132","https://openalex.org/W2465322459","https://openalex.org/W2582045323","https://openalex.org/W2593456141","https://openalex.org/W2610061835","https://openalex.org/W2730810791","https://openalex.org/W2743485416","https://openalex.org/W2748716747","https://openalex.org/W2777389776","https://openalex.org/W2792576922","https://openalex.org/W2792797433","https://openalex.org/W2804162856","https://openalex.org/W2808993218","https://openalex.org/W2884374723","https://openalex.org/W2914448266","https://openalex.org/W2947834998","https://openalex.org/W2971978173","https://openalex.org/W2980211740","https://openalex.org/W2982399323","https://openalex.org/W2988580977","https://openalex.org/W2996167073","https://openalex.org/W3006165123","https://openalex.org/W3014432468","https://openalex.org/W3022610151","https://openalex.org/W3024187932","https://openalex.org/W3047433286","https://openalex.org/W3127069531","https://openalex.org/W3127853020","https://openalex.org/W3156191644","https://openalex.org/W3166373635","https://openalex.org/W3216238012","https://openalex.org/W4205974962","https://openalex.org/W4214941894","https://openalex.org/W4225297438","https://openalex.org/W4287921731","https://openalex.org/W4290613713","https://openalex.org/W4293096925","https://openalex.org/W4295962493","https://openalex.org/W4313584909"],"related_works":["https://openalex.org/W3200137329","https://openalex.org/W2009705743","https://openalex.org/W2388771406","https://openalex.org/W4415642232","https://openalex.org/W1996623301","https://openalex.org/W6902353205","https://openalex.org/W2789907433","https://openalex.org/W2785633494","https://openalex.org/W3022610151","https://openalex.org/W2994722661"],"abstract_inverted_index":{"Aims:Hepatic":[0],"fibrosis":[1,135,235],"is":[2,25],"the":[3,37,65,90,105,111,117,162,167,178,186,204,207,215,224],"pathological":[4],"change":[5,184],"during":[6],"chronic":[7],"liver":[8,29,237],"diseases":[9],"(CLD)":[10],"that":[11,48,103],"turns":[12],"into":[13,99],"cirrhosis":[14],"if":[15],"not":[16],"reversed":[17],"timely.":[18],"Allogenic":[19],"mesenchymal":[20],"stem":[21],"cell":[22],"(MSC)":[23],"therapy":[24,232],"an":[26,229],"alternative":[27],"to":[28,155],"transplantation":[30,129,222],"for":[31,233],"CLD.":[32],"However,":[33],"poor":[34],"engraftment":[35,141,158],"of":[36,57,62,75,92,130,149,161,171,188,197,206,218],"transplanted":[38,189],"MSCs":[39,44,71,97],"limits":[40],"their":[41,50],"therapeutic":[42,216],"efficacy.":[43],"express":[45],"chemokine":[46],"receptors":[47],"regulate":[49],"physiology.":[51],"We":[52],"observed":[53],"several-fold":[54],"increased":[55,87,156],"expressions":[56],"Cxcl3":[58],"and":[59,79,113,122,142,159,169,174,211],"decreased":[60],"expression":[61,168,176],"Mmp13":[63],"in":[64,136,145,177,185],"fibrotic":[66,208],"liver.":[67,209],"Therefore,":[68],"we":[69],"bioengineered":[70,96],"with":[72,200],"stable":[73],"overexpression":[74],"Cxcr2":[76],"(CXCL3-cognate":[77],"receptor)":[78],"Mmp13,":[80],"collagenase":[81],"(MSCGFPCxcr2-Mmp13).":[82],"Results:The":[83],"CXCL3/CXCR2":[84,150],"axis":[85],"significantly":[86,109],"migration":[88],"through":[89],"activation":[91],"AKT/ERK/mTOR":[93],"signaling.":[94],"These":[95],"transdifferentiated":[98],"hepatocyte-like":[100],"cells":[101],"(MSCGFPCxcr2-Mmp13-HLCs)":[102],"endured":[104],"drug-/hepatotoxicant-induced":[106],"toxicity":[107],"by":[108,138,165,195],"increasing":[110,166],"antioxidants\u2014Nrf2":[112],"Sod2,":[114],"while":[115],"decreasing":[116],"apoptosis\u2014Cyt":[118],"C,":[119],"Casp3,":[120],"Casp9,":[121],"drug-metabolizing":[123],"enzyme\u2014Cyp1A1,":[124],"Cyp1A2,":[125],"Cyp2E1":[126],"markers.":[127],"Therapeutic":[128],"MSCGFPCxcr2-Mmp13":[131,190],"abrogated":[132],"AAP-/CCl4-induced":[133],"hepatic":[134,180,225,234],"mice":[137],"CXCR2-mediated":[139],"targeted":[140,157],"MMP-13-mediated":[143],"reduction":[144],"collagen.":[146],"Mechanistically,":[147],"induction":[148],"axis\u2013activated":[151],"mTOR-p70S6K":[152],"signaling":[153],"led":[154],"modulation":[160],"oxidative":[163,226],"stress":[164,227],"activity":[170],"nuclear":[172],"Nrf2":[173],"SOD2":[175],"regenerated":[179],"tissues.":[181],"A":[182],"marked":[183],"fate":[187],"toward":[191],"hepatocyte":[192],"lineage":[193],"demonstrated":[194],"co-immunostaining":[196],"GFP/HNF4\u03b1":[198],"along":[199],"reduced":[201],"COL1\u03b11":[202],"facilitated":[203],"regeneration":[205],"Innovation":[210],"Conclusions:Our":[212],"study":[213],"suggests":[214],"role":[217],"allogenic":[219],"Cxcr2/Mmp13-bioengineered":[220],"MSC":[221],"decreases":[223],"as":[228],"effective":[230],"translational":[231],"mitigation-mediated":[236],"regeneration.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-08T00:00:00"}
