{"id":"https://openalex.org/W4390618565","doi":"https://doi.org/10.1016/j.jmb.2023.168423","title":"How Dedicated Ribosomes Translate a Leaderless mRNA","display_name":"How Dedicated Ribosomes Translate a Leaderless mRNA","publication_year":2024,"publication_date":"2024-01-05","ids":{"openalex":"https://openalex.org/W4390618565","doi":"https://doi.org/10.1016/j.jmb.2023.168423","pmid":"https://pubmed.ncbi.nlm.nih.gov/38185325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11003707"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmb.2023.168423","doi":"https://doi.org/10.1016/j.jmb.2023.168423","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmb.2023.168423","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jmb.2023.168423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038159655","display_name":"F.J. Acosta-Reyes","orcid":"https://orcid.org/0000-0001-8524-1484","observed_orcids":["https://orcid.org/0000-0001-8524-1484"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco J. Acosta-Reyes","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029511880","display_name":"Sayan Bhattacharjee","orcid":"https://orcid.org/0000-0001-6473-5266","observed_orcids":["https://orcid.org/0000-0001-6473-5266","https://orcid.org/0009-0002-6421-1408"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayan Bhattacharjee","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0001-6473-5266","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030867430","display_name":"Max E. Gottesman","orcid":"https://orcid.org/0000-0003-1740-774X","observed_orcids":["https://orcid.org/0000-0003-1740-774X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Max Gottesman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA","Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA","Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042892654","display_name":"Joachim Frank","orcid":"https://orcid.org/0000-0001-5449-6943","observed_orcids":["https://orcid.org/0000-0001-5449-6943","https://orcid.org/0000-0002-2442-1112"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joachim Frank","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA","Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA","Department of Biological Sciences, Columbia University, New York, NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030867430","https://openalex.org/A5042892654"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":4420,"currency":"USD","value_usd":4420},"apc_paid":null,"fwci":0.6781,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.61003334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"436","issue":"4","first_page":"168423","last_page":"168423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leaderless-mrna","display_name":"leaderless mRNA","score":0.9269999861717224},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.621999979019165},{"id":"https://openalex.org/keywords/ribosome-structure","display_name":"ribosome structure","score":0.5690000057220459},{"id":"https://openalex.org/keywords/anti-shine-dalgarno-sequence","display_name":"anti-Shine-Dalgarno sequence","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ribosome-binding-site","display_name":"ribosome binding site","score":0.5550000071525574},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C114847915","wikidata":"https://www.wikidata.org/wiki/Q16948788","display_name":"Ribosomal binding site","level":5,"score":0.7747058868408203},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6365808248519897},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6237016916275024},{"id":"https://openalex.org/C55334214","wikidata":"https://www.wikidata.org/wiki/Q416807","display_name":"Shine-Dalgarno sequence","level":5,"score":0.6072144508361816},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5788411498069763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48167359828948975},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.47561055421829224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4275699257850647},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.42323383688926697},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.41130945086479187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3903387784957886},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.21674662828445435},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1998712420463562},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1690312623977661}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D010442","descriptor_name":"Peptide Chain Initiation, Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054681","descriptor_name":"Ribosome Subunits, Large, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054681","descriptor_name":"Ribosome Subunits, Large, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jmb.2023.168423","doi":"https://doi.org/10.1016/j.jmb.2023.168423","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmb.2023.168423","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:38185325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38185325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11003707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11003707","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11003707/pdf/nihms-1959192.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Mol Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jmb.2023.168423","doi":"https://doi.org/10.1016/j.jmb.2023.168423","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmb.2023.168423","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1395317031","display_name":"DNA double-strand break repair, chromosome translocations and cancer","funder_award_id":"P01CA174653","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3048760434","display_name":"Structural Analysis of Macromolecular Assemblies","funder_award_id":"R01GM029169","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000865450","display_name":"Structural Studies of Macromolecular Assemblies Using Cryo-EM","funder_award_id":"R35GM139453","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1567302774","https://openalex.org/W1945781696","https://openalex.org/W1954517756","https://openalex.org/W1994926732","https://openalex.org/W2008410413","https://openalex.org/W2025362823","https://openalex.org/W2025595745","https://openalex.org/W2030979694","https://openalex.org/W2036032941","https://openalex.org/W2043074370","https://openalex.org/W2073149987","https://openalex.org/W2096118069","https://openalex.org/W2102916349","https://openalex.org/W2116977469","https://openalex.org/W2120498503","https://openalex.org/W2123934971","https://openalex.org/W2134222580","https://openalex.org/W2145502099","https://openalex.org/W2152425069","https://openalex.org/W2155347381","https://openalex.org/W2155552623","https://openalex.org/W2156389356","https://openalex.org/W2159357098","https://openalex.org/W2167358474","https://openalex.org/W2312648638","https://openalex.org/W2502789821","https://openalex.org/W2521190274","https://openalex.org/W2550234534","https://openalex.org/W2557976574","https://openalex.org/W2761125101","https://openalex.org/W2788335694","https://openalex.org/W2887128430","https://openalex.org/W2944873741","https://openalex.org/W2951611668","https://openalex.org/W2983645929","https://openalex.org/W2991309186","https://openalex.org/W2995107466","https://openalex.org/W3006239421","https://openalex.org/W4211030178","https://openalex.org/W4225730454","https://openalex.org/W4239090871","https://openalex.org/W4386501977"],"related_works":["https://openalex.org/W4386401592","https://openalex.org/W2095598198","https://openalex.org/W7095975147","https://openalex.org/W2169552995","https://openalex.org/W2007039595","https://openalex.org/W7138918174","https://openalex.org/W2030405536","https://openalex.org/W1872598604","https://openalex.org/W4220942833","https://openalex.org/W2036032941"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-01-07T00:00:00"}