{"id":"https://openalex.org/W4390617795","doi":"https://doi.org/10.1093/nop/npad081","title":"RT-PCR assay to detect FGFR3::TACC3 fusions in formalin-fixed, paraffin-embedded glioblastoma samples","display_name":"RT-PCR assay to detect FGFR3::TACC3 fusions in formalin-fixed, paraffin-embedded glioblastoma samples","publication_year":2024,"publication_date":"2024-01-05","ids":{"openalex":"https://openalex.org/W4390617795","doi":"https://doi.org/10.1093/nop/npad081","pmid":"https://pubmed.ncbi.nlm.nih.gov/38496910","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10940835"},"language":"en","primary_location":{"id":"doi:10.1093/nop/npad081","doi":"https://doi.org/10.1093/nop/npad081","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nop/npad081","pdf_url":"https://academic.oup.com/nop/advance-article-pdf/doi/10.1093/nop/npad081/55105631/npad081.pdf","source":{"id":"https://openalex.org/S2735333031","display_name":"Neuro-Oncology Practice","issn_l":"2054-2577","issn":["2054-2577","2054-2585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/nop/advance-article-pdf/doi/10.1093/nop/npad081/55105631/npad081.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058693014","display_name":"Loudy P. Priesterbach-Ackley","orcid":"https://orcid.org/0000-0002-3480-634X","observed_orcids":["https://orcid.org/0000-0002-3480-634X"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Loudy P Priesterbach-Ackley","raw_affiliation_strings":["Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3480-634X","affiliations":[{"raw_affiliation_string":"Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056834546","display_name":"Joyce van Kuik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joyce van Kuik","raw_affiliation_strings":["Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030825777","display_name":"Bastiaan B.J. Tops","orcid":"https://orcid.org/0000-0002-1699-8210","observed_orcids":["https://orcid.org/0000-0002-1699-8210"]},"institutions":[{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bastiaan B J Tops","raw_affiliation_strings":["Princess M\u00e1xima Center for Pediatric Oncology , Utrecht , The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1699-8210","affiliations":[{"raw_affiliation_string":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht , The Netherlands","institution_ids":["https://openalex.org/I4210127118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053349450","display_name":"Anna Lasorella","orcid":"https://orcid.org/0000-0002-1839-5421","observed_orcids":["https://orcid.org/0000-0002-1839-5421"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Lasorella","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine , Miami, Florida , USA"],"raw_orcid":"https://orcid.org/0000-0002-1839-5421","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine , Miami, Florida , USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078024735","display_name":"Antonio Iavarone","orcid":"https://orcid.org/0000-0002-0683-4634","observed_orcids":["https://orcid.org/0000-0002-0683-4634"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Iavarone","raw_affiliation_strings":["Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine , Miami, Florida , USA"],"raw_orcid":"https://orcid.org/0000-0002-0683-4634","affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine , Miami, Florida , USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069559644","display_name":"Wim Van Hecke","orcid":"https://orcid.org/0000-0003-1529-4219","observed_orcids":["https://orcid.org/0000-0003-1529-4219"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wim van Hecke","raw_affiliation_strings":["Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-1529-4219","affiliations":[{"raw_affiliation_string":"Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013779863","display_name":"Pierre A. J. T. Robe","orcid":"https://orcid.org/0000-0001-7845-6196","observed_orcids":["https://orcid.org/0000-0001-7845-6196"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pierre A Robe","raw_affiliation_strings":["Department of Neurosurgery, University Medical Center Utrecht , Utrecht , The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7845-6196","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Medical Center Utrecht , Utrecht , The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050961926","display_name":"Pieter Wesseling","orcid":"https://orcid.org/0000-0001-5453-5201","observed_orcids":["https://orcid.org/0000-0001-5453-5201"]},"institutions":[{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieter Wesseling","raw_affiliation_strings":["Department of Pathology, Amsterdam University Medical Centers/VUmc & Brain Tumor Center Amsterdam , Amsterdam , The Netherlands","Princess M\u00e1xima Center for Pediatric Oncology , Utrecht , The Netherlands","Department of Pathology, Amsterdam University Medical Centers/VUmc & Brain Tumor Center Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-5453-5201","affiliations":[{"raw_affiliation_string":"Department of Pathology, Amsterdam University Medical Centers/VUmc & Brain Tumor Center Amsterdam , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht , The Netherlands","institution_ids":["https://openalex.org/I4210127118"]},{"raw_affiliation_string":"Department of Pathology, Amsterdam University Medical Centers/VUmc & Brain Tumor Center Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103027268","display_name":"Wendy W.J. de Leng","orcid":"https://orcid.org/0000-0003-2911-6018","observed_orcids":["https://orcid.org/0000-0003-2911-6018"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wendy W J de Leng","raw_affiliation_strings":["Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-2911-6018","affiliations":[{"raw_affiliation_string":"Department of Pathology, University Medical Center Utrecht , Utrecht , The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058693014"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":{"value":5288,"currency":"USD","value_usd":5288},"apc_paid":{"value":5288,"currency":"USD","value_usd":5288},"fwci":1.124,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73566232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":"2","first_page":"142","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr3-tacc3-fusion","display_name":"FGFR3-TACC3 fusion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/rt-pcr-assay","display_name":"RT-PCR testing","score":0.8169999718666077},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fgfr3-overexpression","display_name":"FGFR3 overexpression","score":0.9120000004768372},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.625}],"concepts":[{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.6352140307426453},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5124862194061279},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.49191999435424805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4657279849052429},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4270623028278351},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.4166969656944275},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1975671947002411},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15001508593559265},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06796792149543762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/nop/npad081","doi":"https://doi.org/10.1093/nop/npad081","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nop/npad081","pdf_url":"https://academic.oup.com/nop/advance-article-pdf/doi/10.1093/nop/npad081/55105631/npad081.pdf","source":{"id":"https://openalex.org/S2735333031","display_name":"Neuro-Oncology Practice","issn_l":"2054-2577","issn":["2054-2577","2054-2585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Practice","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10940835","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10940835","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10940835/pdf/npad081.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Pract","raw_type":"Text"},{"id":"pmid:38496910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38496910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology practice","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/fa108aaf-e3d7-4b92-9442-801ac22e1a06","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/fa108aaf-e3d7-4b92-9442-801ac22e1a06","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Priesterbach-Ackley, L P, van Kuik, J, Tops, B B J, Lasorella, A, Iavarone, A, van Hecke, W, Robe, P A, Wesseling, P & de Leng, W W J 2024, 'RT-PCR assay to detect FGFR3 : :TACC3 fusions in formalin-fixed, paraffin-embedded glioblastoma samples', Neuro-Oncology Practice, vol. 11, no. 2, pp. 142-149. https://doi.org/10.1093/nop/npad081","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/451947","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/451947","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/nop/npad081","doi":"https://doi.org/10.1093/nop/npad081","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nop/npad081","pdf_url":"https://academic.oup.com/nop/advance-article-pdf/doi/10.1093/nop/npad081/55105631/npad081.pdf","source":{"id":"https://openalex.org/S2735333031","display_name":"Neuro-Oncology Practice","issn_l":"2054-2577","issn":["2054-2577","2054-2585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390617795.pdf","grobid_xml":"https://content.openalex.org/works/W4390617795.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1960850967","https://openalex.org/W2005036868","https://openalex.org/W2008550171","https://openalex.org/W2028835984","https://openalex.org/W2047955471","https://openalex.org/W2081069777","https://openalex.org/W2148977460","https://openalex.org/W2169752008","https://openalex.org/W2285921773","https://openalex.org/W2399920431","https://openalex.org/W2467961502","https://openalex.org/W2554921042","https://openalex.org/W2604632554","https://openalex.org/W2747038468","https://openalex.org/W2763733772","https://openalex.org/W2766564649","https://openalex.org/W2782136376","https://openalex.org/W2947351104","https://openalex.org/W2950111756","https://openalex.org/W2971407998","https://openalex.org/W2980759299","https://openalex.org/W3087018809","https://openalex.org/W3105033030","https://openalex.org/W3124295420","https://openalex.org/W3136965026","https://openalex.org/W4210382194","https://openalex.org/W4234865248","https://openalex.org/W4281476189","https://openalex.org/W4289856874","https://openalex.org/W4310531572","https://openalex.org/W6670976478","https://openalex.org/W6763476110","https://openalex.org/W6789024163","https://openalex.org/W7062032832"],"related_works":["https://openalex.org/W2767295886","https://openalex.org/W3124295420","https://openalex.org/W2767365002","https://openalex.org/W2008550171","https://openalex.org/W2763733772","https://openalex.org/W2560838255","https://openalex.org/W6999800557","https://openalex.org/W4289856874","https://openalex.org/W2891577716","https://openalex.org/W2554921042"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"One":[2],"targeted":[3,33,266],"treatment":[4,267],"option":[5],"for":[6,101,122,218,233,261],"isocitrate":[7],"dehydrogenase":[8],"(IDH)-wild-type":[9],"glioblastoma":[10,87,96],"focuses":[11],"on":[12,61,116,157,197,240],"tumors":[13],"with":[14,93,104,135,164,243],"fibroblast":[15],"growth":[16],"factor":[17],"receptor":[18],"3::transforming":[19],"acidic":[20],"coiled-coil-containing":[21],"protein":[22],"3":[23,176],"(FGFR3::TACC3)":[24],"fusions.":[25],"FGFR3::TACC3":[26,83,114,170,210,223,234],"fusion":[27,128,171,178,192,211,224],"detection":[28,124],"can":[29,51,236],"be":[30,52,238],"challenging,":[31],"as":[32],"RNA":[34,149,200],"next-generation":[35],"sequencing":[36,150],"(NGS)":[37],"is":[38,44,73,273],"not":[39,213],"routinely":[40],"performed,":[41],"and":[42,148,187,248],"immunohistochemistry":[43],"an":[45,78,169,209],"imperfect":[46],"surrogate":[47],"marker.":[48],"Fusion":[49],"status":[50,84],"determined":[53],"using":[54,118],"reverse":[55],"transcription":[56],"polymerase":[57],"chain":[58],"reaction":[59],"(RT-PCR)":[60],"fresh":[62],"frozen":[63],"(FF)":[64],"material,":[65,242],"but":[66],"sometimes":[67],"only":[68,270],"formalin-fixed,":[69],"paraffin-embedded":[70],"(FFPE)":[71],"tissue":[72,91,272],"available.":[74,274],"Aim":[75],"To":[76],"develop":[77],"RT-PCR":[79,115,156,196,217,232],"assay":[80,259],"to":[81,113,207,250],"determine":[82],"in":[85,172,225],"FFPE":[86,158,241],"samples.":[88],"Methods":[89],"Twelve":[90],"microarrays":[92],"353":[94],"historical":[95],"samples":[97,131,163],"were":[98,111,132],"immunohistochemically":[99],"stained":[100],"FGFR3.":[102],"Samples":[103],"overexpression":[105],"of":[106,125,160,182,190,222,246,256,264],"FGFR3":[107,140,165],"(n":[108,137,145,151],"=":[109,138,146,152],"13)":[110],"subjected":[112],"FFPE,":[117],"5":[119,126,181],"primer":[120,252],"sets":[121],"the":[123,161,188,191,262],"common":[127],"variants.":[129,179],"Fusion-negative":[130],"additionally":[133],"analyzed":[134],"NGS":[136],"6),":[139,147],"Fluorescence":[141],"In":[142],"Situ":[143],"Hybridization":[144],"5).":[153],"Results":[154],"Using":[155],"material":[159],"13":[162],"overexpression,":[166],"we":[167],"detected":[168],"7":[173],"samples,":[174],"covering":[175],"different":[177],"For":[180],"these":[183],"FF":[184],"was":[185,193,205,228],"available,":[186],"presence":[189],"confirmed":[194],"through":[195],"FF.":[198],"With":[199],"sequencing,":[201],"1":[202],"additional":[203],"sample":[204],"found":[206],"harbor":[208],"(variant":[212],"covered":[214],"by":[215],"current":[216],"FFPE).":[219],"The":[220],"frequency":[221],"this":[226],"cohort":[227],"9/353":[229],"(2.5%).":[230],"Conclusions":[231],"fusions":[235],"successfully":[237],"performed":[239],"a":[244,254],"specificity":[245],"100%":[247],"(due":[249],"limited":[251],"sets)":[253],"sensitivity":[255],"83.3%.":[257],"This":[258],"allows":[260],"identification":[263],"potential":[265],"options":[268],"when":[269],"formalin-fixed":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-01-07T00:00:00"}