{"id":"https://openalex.org/W4390597906","doi":"https://doi.org/10.1016/j.sajb.2024.01.002","title":"Embelia ribes Burm.f. fruit extract inhibit quorum sensing-dependent production of virulence factors and biofilm formation: An integrated in vitro and in silico approach","display_name":"Embelia ribes Burm.f. fruit extract inhibit quorum sensing-dependent production of virulence factors and biofilm formation: An integrated in vitro and in silico approach","publication_year":2024,"publication_date":"2024-01-04","ids":{"openalex":"https://openalex.org/W4390597906","doi":"https://doi.org/10.1016/j.sajb.2024.01.002"},"language":"en","primary_location":{"id":"doi:10.1016/j.sajb.2024.01.002","doi":"https://doi.org/10.1016/j.sajb.2024.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sajb.2024.01.002","pdf_url":null,"source":{"id":"https://openalex.org/S31493525","display_name":"South African Journal of Botany","issn_l":"0254-6299","issn":["0254-6299","1727-9321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Journal of Botany","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.sajb.2024.01.002","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072038040","display_name":"Mitesh B. Patel","orcid":"https://orcid.org/0000-0002-9283-2124","observed_orcids":["https://orcid.org/0000-0002-9283-2124"]},"institutions":[{"id":"https://openalex.org/I9694494","display_name":"Parul University","ror":"https://ror.org/024v3fg07","country_code":"IN","type":"education","lineage":["https://openalex.org/I9694494"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mitesh Patel","raw_affiliation_strings":["Research and Development Cell, Department of Biotechnology, Parul Institute of Applied Sciences, Parul University, Vadodara, 391760, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Cell, Department of Biotechnology, Parul Institute of Applied Sciences, Parul University, Vadodara, 391760, India","institution_ids":["https://openalex.org/I9694494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017306874","display_name":"Lina I. Alnajjar","orcid":"https://orcid.org/0000-0002-6751-6488","observed_orcids":["https://orcid.org/0000-0002-6751-6488"]},"institutions":[{"id":"https://openalex.org/I106778892","display_name":"Princess Nourah bint Abdulrahman University","ror":"https://ror.org/05b0cyh02","country_code":"SA","type":"education","lineage":["https://openalex.org/I106778892"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Lina I Alnajjar","raw_affiliation_strings":["Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia","institution_ids":["https://openalex.org/I106778892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074366497","display_name":"Sarah Owdah Alomrani","orcid":"https://orcid.org/0009-0003-9163-2416","observed_orcids":["https://orcid.org/0009-0003-9163-2416"]},"institutions":[{"id":"https://openalex.org/I47164929","display_name":"Najran University","ror":"https://ror.org/05edw4a90","country_code":"SA","type":"education","lineage":["https://openalex.org/I47164929"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Sarah Owdah Alomrani","raw_affiliation_strings":["Department of Biology, College of Science and Arts, Najran University, Najran, 66252, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science and Arts, Najran University, Najran, 66252, Saudi Arabia","institution_ids":["https://openalex.org/I47164929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028688009","display_name":"Nawaf I. Alshammari","orcid":"https://orcid.org/0000-0001-7525-8573","observed_orcids":["https://orcid.org/0000-0001-7525-8573","https://orcid.org/0000-0001-7975-4427"]},"institutions":[{"id":"https://openalex.org/I4210088963","display_name":"University of Ha'il","ror":"https://ror.org/013w98a82","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210088963"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nawaf Alshammari","raw_affiliation_strings":["Department of Biology, College of Science, University of Ha'il, Ha'il, P.O. Box 2440, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, University of Ha'il, Ha'il, P.O. Box 2440, Saudi Arabia","institution_ids":["https://openalex.org/I4210088963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033295885","display_name":"Mohammad Saquib Ashraf","orcid":"https://orcid.org/0000-0002-2935-7770","observed_orcids":["https://orcid.org/0000-0002-2935-7770"]},"institutions":[{"id":"https://openalex.org/I4210096041","display_name":"Riyadh Elm University","ror":"https://ror.org/00rz3mr26","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210096041"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohammad Saquib Ashraf","raw_affiliation_strings":["Department of Medical Laboratory Science, College of Pharmacy, Nursing and Medical Sciences, Riyadh ELM University, Riyadh, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-2935-7770","affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, College of Pharmacy, Nursing and Medical Sciences, Riyadh ELM University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I4210096041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070678346","display_name":"Mohd Adnan","orcid":"https://orcid.org/0000-0002-7080-6822","observed_orcids":["https://orcid.org/0000-0002-7080-6822","https://orcid.org/0009-0008-1189-8422","https://orcid.org/0009-0006-3007-2680"]},"institutions":[{"id":"https://openalex.org/I4210088963","display_name":"University of Ha'il","ror":"https://ror.org/013w98a82","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210088963"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Mohd Adnan","raw_affiliation_strings":["Department of Biology, College of Science, University of Ha'il, Ha'il, P.O. Box 2440, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-7080-6822","affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, University of Ha'il, Ha'il, P.O. Box 2440, Saudi Arabia","institution_ids":["https://openalex.org/I4210088963"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070678346"],"corresponding_institution_ids":["https://openalex.org/I4210088963"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":1.6114,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.82963306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"165","issue":null,"first_page":"307","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embelia-ribes","display_name":"Embelia ribes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fruit-extract","display_name":"fruit extract","score":0.8180000185966492},{"id":"https://openalex.org/keywords/quorum-quenching","display_name":"quorum sensing inhibition","score":0.9929999709129333},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.7509999871253967},{"id":"https://openalex.org/keywords/chromobacterium-violaceum","display_name":"Chromobacterium violaceum","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9589999914169312},{"id":"https://openalex.org/keywords/serratia-marcescens","display_name":"Serratia marcescens","score":1.0},{"id":"https://openalex.org/keywords/violacein","display_name":"violacein","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pyocyanin","display_name":"pyocyanin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prodigiosin","display_name":"prodigiosin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/swarming-motility","display_name":"swarming motility","score":0.9079999923706055},{"id":"https://openalex.org/keywords/exopolysaccharide-production","display_name":"exopolysaccharide production","score":0.9279999732971191},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.9700000286102295},{"id":"https://openalex.org/keywords/admet-properties","display_name":"ADMET properties","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pains","display_name":"PAINS","score":0.9380000233650208},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8569999933242798},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.9313119649887085},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8999995589256287},{"id":"https://openalex.org/C186380895","wikidata":"https://www.wikidata.org/wiki/Q2258085","display_name":"Swarming motility","level":5,"score":0.8684134483337402},{"id":"https://openalex.org/C2781427627","wikidata":"https://www.wikidata.org/wiki/Q410503","display_name":"Pyocyanin","level":5,"score":0.8178822994232178},{"id":"https://openalex.org/C2777916119","wikidata":"https://www.wikidata.org/wiki/Q3498295","display_name":"Chromobacterium violaceum","level":5,"score":0.8148410320281982},{"id":"https://openalex.org/C2779337610","wikidata":"https://www.wikidata.org/wiki/Q415663","display_name":"Prodigiosin","level":5,"score":0.7535877823829651},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7431718111038208},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6982730031013489},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6432316899299622},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5042649507522583},{"id":"https://openalex.org/C2776309202","wikidata":"https://www.wikidata.org/wiki/Q140004","display_name":"Serratia marcescens","level":4,"score":0.503025472164154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48184049129486084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37897858023643494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29186370968818665},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.178043395280838},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.sajb.2024.01.002","doi":"https://doi.org/10.1016/j.sajb.2024.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sajb.2024.01.002","pdf_url":null,"source":{"id":"https://openalex.org/S31493525","display_name":"South African Journal of Botany","issn_l":"0254-6299","issn":["0254-6299","1727-9321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Journal of Botany","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.sajb.2024.01.002","doi":"https://doi.org/10.1016/j.sajb.2024.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sajb.2024.01.002","pdf_url":null,"source":{"id":"https://openalex.org/S31493525","display_name":"South African Journal of Botany","issn_l":"0254-6299","issn":["0254-6299","1727-9321"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Journal of Botany","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6853684154","display_name":null,"funder_award_id":"PNURSP2024R341","funder_id":"https://openalex.org/F4320322484","funder_display_name":"Princess Nourah Bint Abdulrahman University"}],"funders":[{"id":"https://openalex.org/F4320322484","display_name":"Princess Nourah Bint Abdulrahman University","ror":"https://ror.org/05b0cyh02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W25450385","https://openalex.org/W1230696280","https://openalex.org/W1564219524","https://openalex.org/W1586861415","https://openalex.org/W1878373862","https://openalex.org/W1894776803","https://openalex.org/W1927570869","https://openalex.org/W1954672268","https://openalex.org/W1956082477","https://openalex.org/W1967474107","https://openalex.org/W1978792930","https://openalex.org/W1983740472","https://openalex.org/W1984596253","https://openalex.org/W1994749876","https://openalex.org/W1994937222","https://openalex.org/W2000461931","https://openalex.org/W2002083418","https://openalex.org/W2003660731","https://openalex.org/W2007119550","https://openalex.org/W2007758793","https://openalex.org/W2008503425","https://openalex.org/W2011123758","https://openalex.org/W2015026819","https://openalex.org/W2017413302","https://openalex.org/W2022914875","https://openalex.org/W2023281014","https://openalex.org/W2024534479","https://openalex.org/W2032092088","https://openalex.org/W2038404933","https://openalex.org/W2042240800","https://openalex.org/W2043110235","https://openalex.org/W2058965595","https://openalex.org/W2067686851","https://openalex.org/W2070220101","https://openalex.org/W2086607832","https://openalex.org/W2089753998","https://openalex.org/W2096178280","https://openalex.org/W2102072080","https://openalex.org/W2104768590","https://openalex.org/W2109731896","https://openalex.org/W2115012192","https://openalex.org/W2125082350","https://openalex.org/W2134967712","https://openalex.org/W2140203065","https://openalex.org/W2144420520","https://openalex.org/W2155439177","https://openalex.org/W2160968421","https://openalex.org/W2327974216","https://openalex.org/W2398667805","https://openalex.org/W2415695598","https://openalex.org/W2475881350","https://openalex.org/W2593436234","https://openalex.org/W2625061791","https://openalex.org/W2738549171","https://openalex.org/W2789283961","https://openalex.org/W2946552382","https://openalex.org/W2996513170","https://openalex.org/W3019794995","https://openalex.org/W3025713889","https://openalex.org/W3080460032","https://openalex.org/W3129419644","https://openalex.org/W3132375528","https://openalex.org/W3146319028","https://openalex.org/W3165248693","https://openalex.org/W3197848967","https://openalex.org/W3200996902","https://openalex.org/W3214941071","https://openalex.org/W4211163608","https://openalex.org/W4214764905","https://openalex.org/W4253231527","https://openalex.org/W4281560571","https://openalex.org/W4285394135","https://openalex.org/W4378902126","https://openalex.org/W6635312873","https://openalex.org/W6739080154"],"related_works":["https://openalex.org/W4412440459","https://openalex.org/W2608366939","https://openalex.org/W2007575930","https://openalex.org/W4309791562","https://openalex.org/W4399476990","https://openalex.org/W4391213127","https://openalex.org/W7197129841","https://openalex.org/W7213628026","https://openalex.org/W4401598926","https://openalex.org/W2750462090"],"abstract_inverted_index":{"Quorum":[0],"sensing":[1],"(QS)":[2],"is":[3],"a":[4,17,38,216],"cell-to-cell":[5],"signaling":[6],"method":[7],"that":[8],"allows":[9],"bacteria":[10],"to":[11,237],"control":[12,184],"gene":[13],"expression":[14],"and":[15,28,45,74,114,121,136,156,181,195,208,252],"regulate":[16],"variety":[18],"of":[19,25,32,49,61,70,89,99,125,138,142,145,173,204,243],"physiological":[20],"processes,":[21],"particularly":[22],"the":[23,43,47,58,82,87,186,202,224,227,240,249],"synthesis":[24],"virulence":[26,72],"factors":[27,73],"biofilm":[29,75,174],"formation.":[30],"Inhibition":[31],"QS":[33,135],"has":[34],"been":[35,221],"proposed":[36],"as":[37,67],"promising":[39],"strategy":[40],"in":[41,77,134,165,201,247],"attenuating":[42],"pathogenicity":[44,251],"enhancing":[46],"efficacy":[48],"antimicrobial":[50],"drugs":[51],"targeting":[52],"bacterial":[53,250],"infections.":[54,254],"This":[55],"study":[56],"investigated":[57],"potential":[59,127],"utilization":[60],"Embelia":[62],"ribes":[63],"fruit":[64],"extract":[65],"(ERFE)":[66],"an":[68],"inhibitor":[69],"QS-dependent":[71],"development":[76,172],"Gram":[78],"negative":[79],"pathogens.":[80],"Further,":[81],"results":[83],"were":[84,129,212],"correlated":[85],"with":[86,232],"inhibition":[88],"biofilms.":[90],"High":[91],"performance":[92],"thin-layer":[93],"chromatography":[94],"(HPTLC),":[95],"followed":[96],"by":[97,178],"analysis":[98,141],"phytochemicals":[100,128],"using":[101],"gas":[102],"chromatography-mass":[103],"spectrometry":[104],"(GC\u2013MS)":[105],"was":[106,175],"conducted.":[107],"Analyzing":[108],"ADMET":[109],"(absorption,":[110],"distribution,":[111],"metabolism,":[112],"excretion":[113],"toxicity)":[115],"profiles,":[116],"PAINS":[117],"(Pan-assay":[118],"interference":[119,164],"compounds),":[120],"molecular":[122],"docking":[123],"analyses":[124],"selected":[126],"performed":[130],"against":[131,147],"proteins":[132],"participating":[133],"formation":[137,167],"biofilm.":[139],"In-vitro":[140],"anti-QS":[143,228],"activity":[144],"ERFE":[146],"Chromobacterium":[148],"violaceum":[149],"(violacein":[150],"production),":[151],"Pseudomonas":[152],"aeruginosa":[153,194],"(pyocyanin":[154],"production)":[155,160],"Serratia":[157],"marcescens":[158,197],"(prodigiosin":[159],"demonstrated":[161],"significant":[162],"dose-dependent":[163],"pigment":[166],"at":[168,185],"sub-MIC":[169,188],"concentrations.":[170],"The":[171],"significantly":[176],"reduced":[177],"84.10,":[179],"85.52":[180],"70.64%":[182],"over":[183],"highest":[187],"levels":[189],"for":[190],"C.":[191],"violaceum,":[192],"P.":[193],"S.":[196],",":[198],"respectively.":[199],"Furthermore,":[200],"presence":[203],"ERFE,":[205],"swarming":[206],"motility":[207],"exopolysaccharide":[209],"production":[210],"(EPS)":[211],"also":[213],"reduced.":[214],"As":[215],"result,":[217],"further":[218],"insights":[219],"have":[220],"gained":[222],"into":[223],"mechanism":[225],"underlying":[226],"activity.":[229],"Further":[230],"investigations":[231],"in-vivo":[233],"studies":[234],"are":[235],"warranted":[236],"fully":[238],"explore":[239],"therapeutic":[241],"applications":[242],"this":[244],"natural":[245],"compound":[246],"managing":[248],"biofilm-related":[253]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-05T00:00:00"}