{"id":"https://openalex.org/W4390545487","doi":"https://doi.org/10.1007/s13237-023-00456-0","title":"Genetic variants of vitamin D, estrogen \u03b1, parathyroid and collagen type I alpha receptor gene and its influence on circulating serum osteocalcin in postmenopausal osteoporosis: A cohort study","display_name":"Genetic variants of vitamin D, estrogen \u03b1, parathyroid and collagen type I alpha receptor gene and its influence on circulating serum osteocalcin in postmenopausal osteoporosis: A cohort study","publication_year":2024,"publication_date":"2024-01-03","ids":{"openalex":"https://openalex.org/W4390545487","doi":"https://doi.org/10.1007/s13237-023-00456-0"},"language":"en","primary_location":{"id":"doi:10.1007/s13237-023-00456-0","doi":"https://doi.org/10.1007/s13237-023-00456-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13237-023-00456-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210187714","display_name":"The Nucleus","issn_l":"0029-568X","issn":["0029-568X","0976-7975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Nucleus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2772917/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105792089","display_name":"Chrisanne Freeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13268429","display_name":"Madurai Kamaraj University","ror":"https://ror.org/04c8e9019","country_code":"IN","type":"education","lineage":["https://openalex.org/I13268429"]},{"id":"https://openalex.org/I4405261969","display_name":"Bishop Heber College","ror":"https://ror.org/00kxvc646","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405261969"]},{"id":"https://openalex.org/I4405265954","display_name":"Lady Doak College","ror":"https://ror.org/02ettrd42","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405265954"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chrisanne Freeman","raw_affiliation_strings":["Department of Biotechnology, Bishop Heber College, Tiruchirappalli, Tamil Nadu, 620017, India","Department of Plant Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, 625021, India","Department of Zoology and Research Centre, Lady Doak College, Madurai, Tamil Nadu, 625002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Bishop Heber College, Tiruchirappalli, Tamil Nadu, 620017, India","institution_ids":["https://openalex.org/I4405261969"]},{"raw_affiliation_string":"Department of Plant Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, 625021, India","institution_ids":["https://openalex.org/I13268429"]},{"raw_affiliation_string":"Department of Zoology and Research Centre, Lady Doak College, Madurai, Tamil Nadu, 625002, India","institution_ids":["https://openalex.org/I4405265954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068058676","display_name":"Jebasingh Tennyson","orcid":"https://orcid.org/0000-0001-5771-2189","observed_orcids":["https://orcid.org/0000-0001-5771-2189"]},"institutions":[{"id":"https://openalex.org/I13268429","display_name":"Madurai Kamaraj University","ror":"https://ror.org/04c8e9019","country_code":"IN","type":"education","lineage":["https://openalex.org/I13268429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jebasingh Tennyson","raw_affiliation_strings":["Department of Plant Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, 625021, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, 625021, India","institution_ids":["https://openalex.org/I13268429"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045696793","display_name":"A. S. Priscilla","orcid":"https://orcid.org/0000-0003-0580-8036","observed_orcids":["https://orcid.org/0000-0003-0580-8036"]},"institutions":[{"id":"https://openalex.org/I4405265954","display_name":"Lady Doak College","ror":"https://ror.org/02ettrd42","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405265954"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"A. S. Priscilla","raw_affiliation_strings":["Department of Zoology and Research Centre, Lady Doak College, Madurai, Tamil Nadu, 625002, India"],"raw_orcid":"https://orcid.org/0000-0003-0580-8036","affiliations":[{"raw_affiliation_string":"Department of Zoology and Research Centre, Lady Doak College, Madurai, Tamil Nadu, 625002, India","institution_ids":["https://openalex.org/I4405265954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045696793"],"corresponding_institution_ids":["https://openalex.org/I4405265954"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":null,"fwci":0.3467,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50668906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"68","issue":"1","first_page":"63","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/serum-osteocalcin","display_name":"serum osteocalcin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bone-turnover","display_name":"bone turnover","score":0.6510000228881836},{"id":"https://openalex.org/keywords/vitamin-d-receptor-gene","display_name":"vitamin D receptor gene","score":0.7879999876022339},{"id":"https://openalex.org/keywords/parathyroid-hormone-gene","display_name":"parathyroid hormone gene","score":0.9559999704360962},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7450000047683716},{"id":"https://openalex.org/keywords/apai-polymorphism","display_name":"ApaI polymorphism","score":0.8650000095367432},{"id":"https://openalex.org/keywords/taqi-polymorphism","display_name":"TaqI polymorphism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7080000042915344},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.8596760034561157},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8079965114593506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7933510541915894},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.682483434677124},{"id":"https://openalex.org/C2779105492","wikidata":"https://www.wikidata.org/wiki/Q4385680","display_name":"TaqI","level":5,"score":0.6429506540298462},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.611397385597229},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.5932638645172119},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5009078979492188},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.49174192547798157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39163723587989807},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.38020259141921997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3746546506881714},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.36985257267951965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13634079694747925},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12423235177993774},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.10749012231826782},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.09469658136367798},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s13237-023-00456-0","doi":"https://doi.org/10.1007/s13237-023-00456-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13237-023-00456-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210187714","display_name":"The Nucleus","issn_l":"0029-568X","issn":["0029-568X","0976-7975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Nucleus","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2772917/v1","doi":"https://doi.org/10.21203/rs.3.rs-2772917/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2772917/v1","pdf_url":"https://www.researchsquare.com/article/rs-2772917/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2772917/v1","doi":"https://doi.org/10.21203/rs.3.rs-2772917/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2772917/v1","pdf_url":"https://www.researchsquare.com/article/rs-2772917/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8285758350","display_name":null,"funder_award_id":"[NO3/1/2/6/SRF/ORTHO/2018-NCD-I].","funder_id":"https://openalex.org/F4320320720","funder_display_name":"Indian Council of Medical Research"}],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390545487.pdf","grobid_xml":"https://content.openalex.org/works/W4390545487.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W11101350","https://openalex.org/W1508172213","https://openalex.org/W1537346126","https://openalex.org/W1948302122","https://openalex.org/W1964431381","https://openalex.org/W1989389375","https://openalex.org/W2001284366","https://openalex.org/W2001331076","https://openalex.org/W2040645421","https://openalex.org/W2042108905","https://openalex.org/W2045531047","https://openalex.org/W2050834533","https://openalex.org/W2055682847","https://openalex.org/W2061573904","https://openalex.org/W2063518962","https://openalex.org/W2066693823","https://openalex.org/W2067027353","https://openalex.org/W2072266486","https://openalex.org/W2073019665","https://openalex.org/W2073151133","https://openalex.org/W2078948301","https://openalex.org/W2081140214","https://openalex.org/W2089080975","https://openalex.org/W2091233777","https://openalex.org/W2101230854","https://openalex.org/W2102891551","https://openalex.org/W2103062902","https://openalex.org/W2140731548","https://openalex.org/W2145454794","https://openalex.org/W2146114310","https://openalex.org/W2547887911","https://openalex.org/W2947762576","https://openalex.org/W3110381924","https://openalex.org/W4200042088","https://openalex.org/W4213233075","https://openalex.org/W4249195289"],"related_works":["https://openalex.org/W4401222779","https://openalex.org/W2914247028","https://openalex.org/W2074466959","https://openalex.org/W2563234156","https://openalex.org/W2057870444","https://openalex.org/W4411703981","https://openalex.org/W2067027353","https://openalex.org/W2003112481","https://openalex.org/W2374941354","https://openalex.org/W2947578698"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Osteocalcin":[2],"is":[3],"an":[4],"abundant,":[5],"highly":[6],"conserved":[7],"bone":[8,25,48,81,199,241],"specific":[9],"protein":[10],"and":[11,41,70,77,94,121,161,228],"the":[12,38,52,62,108,112,144,155,162,169,202,212,219,224,229,233,244],"serum":[13,57,85,140,176,191],"levels":[14,36,132,142],"of":[15,24,30,64,168,190,198,208,214,218,232,240],"OC":[16,58],"have":[17],"been":[18],"used":[19,105],"as":[20],"a":[21,173,186,195,215,237],"biochemical":[22],"marker":[23],"turnover.":[26,49],"The":[27,96,139,180,206],"genetic":[28],"variation":[29,55],"certain":[31],"candidate":[32],"genes":[33,53,76],"impacts":[34],"osteocalcin":[35,86,131,141,177],"in":[37,56,87,123,151,154,183,201,243],"postmenopausal":[39,88,125,246],"period":[40],"may":[42],"predispose":[43],"some":[44],"women":[45,89,126],"to":[46,106],"high":[47],"To":[50],"identify":[51],"influencing":[54],"levels,":[59],"we":[60],"investigated":[61],"polymorphisms":[63,109,147],"Vitamin":[65],"D,":[66],"Estrogen":[67],"\u03b1,":[68],"Parathyroid":[69],"Collagen":[71],"Type":[72],"I":[73,146],"alpha":[74],"Receptor":[75],"its":[78],"association":[79],"with":[80,158,165],"turnover":[82,200,242],"evaluated":[83],"by":[84,135],"from":[90,127],"south":[91],"India.":[92,129],"Materials":[93],"Methods:":[95],"polymerase":[97],"chain":[98],"reaction-restriction":[99],"fragment":[100],"length":[101],"polymorphism":[102,171,235],"strategy":[103],"was":[104],"detect":[107],"at":[110],"all":[111],"four":[113],"gene":[114],"receptors":[115],"(i.e.,":[116],"for":[117,143],"VDR,":[118],"ER\u03b1,":[119],"PTH":[120],"COLIA1)":[122],"300":[124],"South":[128],"Serum":[130],"were":[133],"measured":[134],"immunoassay":[136],"(ELISA).":[137],"Results:":[138],"Apa":[145],"showed":[148],"varied":[149],"results,":[150],"which,":[152],"subjects":[153],"control":[156],"group":[157,164,182],"\u201cGG\u201d":[159],"genotype":[160,167,227,231],"osteopenic":[163],"\u201cTT\u201d":[166],"ApaI":[170,221],"had":[172,185],"significantly":[174,187],"higher":[175,188,196,238],"concentration":[178],"(p<0.05).":[179],"PTH-AA":[181],"controls":[184],"level":[189],"osteocalcin,":[192],"this":[193,209],"suggests":[194],"state":[197],"AA":[203],"genotype.":[204],"Conclusion:":[205],"outcome":[207],"study":[210],"proposes":[211],"probability":[213],"small":[216],"impact":[217],"VDR-":[220],"(GG)":[222],"genotype,":[223],"VDR-TaqI":[225],"(TT)":[226],"(AA)":[230],"PTH-BstBI":[234],"indicating":[236],"rate":[239],"healthy":[245],"women.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-01-04T00:00:00"}