{"id":"https://openalex.org/W4390534692","doi":"https://doi.org/10.1038/s41598-023-50984-7","title":"Machine learning-based radiomics strategy for prediction of acquired EGFR T790M mutation following treatment with EGFR-TKI in NSCLC","display_name":"Machine learning-based radiomics strategy for prediction of acquired EGFR T790M mutation following treatment with EGFR-TKI in NSCLC","publication_year":2024,"publication_date":"2024-01-03","ids":{"openalex":"https://openalex.org/W4390534692","doi":"https://doi.org/10.1038/s41598-023-50984-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/38172228","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10764785"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-50984-7","doi":"https://doi.org/10.1038/s41598-023-50984-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-50984-7","pdf_url":"https://www.nature.com/articles/s41598-023-50984-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-50984-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041329689","display_name":"Jiameng Lu","orcid":"https://orcid.org/0000-0002-8767-5371","observed_orcids":["https://orcid.org/0000-0002-8767-5371"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiameng Lu","raw_affiliation_strings":["Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Institute of Anesthesia and Respiratory Critical Medicine, 16766 Jingshilu, Lixia, Jinan, 250014, Shandong, People's Republic of China","School of Microelectronics, Shandong University, Jinan, 250100, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Institute of Anesthesia and Respiratory Critical Medicine, 16766 Jingshilu, Lixia, Jinan, 250014, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"School of Microelectronics, Shandong University, Jinan, 250100, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010407262","display_name":"Xiaoqing Ji","orcid":"https://orcid.org/0000-0002-0683-7667","observed_orcids":["https://orcid.org/0000-0002-0683-7667"]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqing Ji","raw_affiliation_strings":["Department of Nursing, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395659","display_name":"Xinyi Liu","orcid":"https://orcid.org/0009-0007-1893-4417","observed_orcids":["https://orcid.org/0009-0007-1893-4417","https://orcid.org/0000-0002-2332-0897"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Liu","raw_affiliation_strings":["Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065263878","display_name":"Yunxiu Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunxiu Jiang","raw_affiliation_strings":["Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438653","display_name":"Gang Li","orcid":"https://orcid.org/0000-0001-9585-1382","observed_orcids":["https://orcid.org/0000-0001-9585-1382"]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Li","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Shandong Lung Cancer Institute, Shandong Institute of Neuroimmunology, Jinan, 250000, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Shandong Lung Cancer Institute, Shandong Institute of Neuroimmunology, Jinan, 250000, Shandong, China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Fang","raw_affiliation_strings":["Department of Blood Transfusion, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Jinan, 250014, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Transfusion, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Jinan, 250014, Shandong, China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318113","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-1074-9213","observed_orcids":["https://orcid.org/0000-0002-1074-9213","https://orcid.org/0000-0001-7753-9408"]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Shandong Lung Cancer Institute, Shandong Institute of Neuroimmunology, Jinan, 250000, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Shandong Lung Cancer Institute, Shandong Institute of Neuroimmunology, Jinan, 250000, Shandong, China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052358042","display_name":"Anli Zuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anli Zuo","raw_affiliation_strings":["Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044056988","display_name":"Zihan Guo","orcid":"https://orcid.org/0000-0001-6193-1341","observed_orcids":["https://orcid.org/0000-0001-6193-1341","https://orcid.org/0009-0003-7915-4941"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihan Guo","raw_affiliation_strings":["Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023618497","display_name":"Shuran Yang","orcid":"https://orcid.org/0000-0001-9143-0900","observed_orcids":["https://orcid.org/0000-0001-9143-0900","https://orcid.org/0009-0002-6256-0049"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuran Yang","raw_affiliation_strings":["Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Shandong First Medical University, Jinan, 250000, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108243462","display_name":"Yanbo Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanbo Ji","raw_affiliation_strings":["Department of Nursing, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006586471","display_name":"Degan Lu","orcid":"https://orcid.org/0000-0003-3986-1425","observed_orcids":["https://orcid.org/0000-0003-3986-1425"]},"institutions":[{"id":"https://openalex.org/I4210153274","display_name":"Shandong Provincial QianFoShan Hospital","ror":"https://ror.org/03wnrsb51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153274"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Degan Lu","raw_affiliation_strings":["Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Institute of Anesthesia and Respiratory Critical Medicine, 16766 Jingshilu, Lixia, Jinan, 250014, Shandong, People's Republic of China. deganlu@126.com","Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Institute of Anesthesia and Respiratory Critical Medicine, 16766 Jingshilu, Lixia, Jinan, 250014, Shandong, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Institute of Anesthesia and Respiratory Critical Medicine, 16766 Jingshilu, Lixia, Jinan, 250014, Shandong, People's Republic of China. deganlu@126.com","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Institute of Anesthesia and Respiratory Critical Medicine, 16766 Jingshilu, Lixia, Jinan, 250014, Shandong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006586471"],"corresponding_institution_ids":["https://openalex.org/I4210153274","https://openalex.org/I4210163399"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":4.5186,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.95714353,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"446","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-t790m-mutation","display_name":"T790M mutation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/acquired-resistance","display_name":"acquired resistance","score":0.6880000233650208},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/radiomics","display_name":"radiomics","score":0.9660000205039978},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.675000011920929},{"id":"https://openalex.org/keywords/machine-learning-prediction","display_name":"machine learning prediction","score":0.6779999732971191},{"id":"https://openalex.org/keywords/lasso-feature-selection","display_name":"LASSO feature selection","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.8483783006668091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6727122664451599},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.647789478302002},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.6432664394378662},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6348094940185547},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5987411737442017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5363470315933228},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.48902472853660583},{"id":"https://openalex.org/C2779177807","wikidata":"https://www.wikidata.org/wiki/Q3658562","display_name":"non-small cell lung cancer (NSCLC)","level":4,"score":0.48319923877716064},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4577232301235199},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4233975112438202},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2524724006652832},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1887514889240265},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.15559011697769165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10804575681686401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06935065984725952},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000097188","descriptor_name":"Radiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-023-50984-7","doi":"https://doi.org/10.1038/s41598-023-50984-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-50984-7","pdf_url":"https://www.nature.com/articles/s41598-023-50984-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3449456/v1","doi":"https://doi.org/10.21203/rs.3.rs-3449456/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3449456/v1","pdf_url":"https://www.researchsquare.com/article/rs-3449456/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10764785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10764785","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10764785/pdf/41598_2023_Article_50984.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38172228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38172228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aec74a1a125641de8d72e9923cb57168","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aec74a1a125641de8d72e9923cb57168","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-50984-7","doi":"https://doi.org/10.1038/s41598-023-50984-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-50984-7","pdf_url":"https://www.nature.com/articles/s41598-023-50984-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390534692.pdf","grobid_xml":"https://content.openalex.org/works/W4390534692.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1408981388","https://openalex.org/W2029799473","https://openalex.org/W2081240902","https://openalex.org/W2089588713","https://openalex.org/W2097475056","https://openalex.org/W2111547563","https://openalex.org/W2126301392","https://openalex.org/W2127890285","https://openalex.org/W2133149289","https://openalex.org/W2149199519","https://openalex.org/W2151591509","https://openalex.org/W2153505392","https://openalex.org/W2153733592","https://openalex.org/W2159013299","https://openalex.org/W2166084034","https://openalex.org/W2171139285","https://openalex.org/W2174661749","https://openalex.org/W2327037637","https://openalex.org/W2330406605","https://openalex.org/W2339573327","https://openalex.org/W2468983064","https://openalex.org/W2496214527","https://openalex.org/W2534193912","https://openalex.org/W2535300095","https://openalex.org/W2544979428","https://openalex.org/W2560717039","https://openalex.org/W2566863750","https://openalex.org/W2612451620","https://openalex.org/W2736101782","https://openalex.org/W2736107213","https://openalex.org/W2736731826","https://openalex.org/W2744168758","https://openalex.org/W2744755223","https://openalex.org/W2753391559","https://openalex.org/W2760639821","https://openalex.org/W2767346095","https://openalex.org/W2770828094","https://openalex.org/W2784371446","https://openalex.org/W2790122515","https://openalex.org/W2790958665","https://openalex.org/W2794026637","https://openalex.org/W2806191962","https://openalex.org/W2809785120","https://openalex.org/W2884746788","https://openalex.org/W2906802315","https://openalex.org/W2917364154","https://openalex.org/W2925148107","https://openalex.org/W2954500503","https://openalex.org/W2966768540","https://openalex.org/W2967735100","https://openalex.org/W2976278991","https://openalex.org/W2987190657","https://openalex.org/W2988665311","https://openalex.org/W2990041408","https://openalex.org/W2995595042","https://openalex.org/W2998789541","https://openalex.org/W3003975456","https://openalex.org/W3006104185","https://openalex.org/W3009139184","https://openalex.org/W3019509846","https://openalex.org/W3020873097","https://openalex.org/W3021898219","https://openalex.org/W3042073415","https://openalex.org/W3064574647","https://openalex.org/W3082658746","https://openalex.org/W3092778937","https://openalex.org/W3096690547","https://openalex.org/W3113050690","https://openalex.org/W3128646645","https://openalex.org/W3134678567","https://openalex.org/W3137805818","https://openalex.org/W3141307275","https://openalex.org/W3147464644","https://openalex.org/W3157179041","https://openalex.org/W3185997674","https://openalex.org/W3190850324","https://openalex.org/W3191259318","https://openalex.org/W3204629012","https://openalex.org/W4229332535","https://openalex.org/W4286631900"],"related_works":["https://openalex.org/W4393157754","https://openalex.org/W7211919850","https://openalex.org/W4328049160","https://openalex.org/W4286631900","https://openalex.org/W7167708711","https://openalex.org/W4388157477","https://openalex.org/W4297252652","https://openalex.org/W3096690547","https://openalex.org/W4408460103","https://openalex.org/W4313357446"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Epidermal":[2],"growth":[3],"factor":[4],"receptor":[5],"(EGFR)-tyrosine":[6],"kinase":[7],"inhibitors":[8],"(TKIs)":[9],"are":[10,33,76],"considered":[11],"the":[12,40,47,56,71,188,192,209,215,249,255,288,298,324,331],"standard":[13],"first-line":[14],"therapy":[15],"for":[16,39,166,334,415],"treatment-naive":[17],"patients":[18,69,116,129,374,394,417],"with":[19,85,109,117,130,136,375,380,395],"advanced/metastatic":[20],"non-small":[21],"cell":[22],"lung":[23],"cancer":[24],"(NSCLC)":[25],"who":[26,75],"have":[27],"sensitizing":[28],"EGFR":[29,43,59,120,132,285,336,376,419],"mutations.":[30,121,420],"Currently,":[31],"there":[32],"three":[34],"generations":[35],"of":[36,42,50,58,73,125,146,191,261,283,307,330,360],"EGFR-TKIs":[37],"available":[38],"treatment":[41,84,108,135,379,413],"mutation-positive":[44],"NSCLC.":[45],"However,":[46],"optimal":[48],"sequence":[49],"administering":[51],"these":[52],"drugs":[53],"to":[54,67,78,102,174,186,228,273,278,392],"maximize":[55],"duration":[57],"signaling":[60],"inhibition":[61],"remains":[62],"uncertain.":[63],"It":[64],"is":[65],"crucial":[66],"identify":[68,368],"at":[70,399],"time":[72],"diagnosis":[74,400],"likely":[77],"acquire":[79],"a":[80,86,96,110,381],"Thr790Met":[81],"(T790M)":[82],"after":[83,378],"first-":[87,111,137,382],"or":[88,112,138,383],"second-generation":[89,113,139,384],"EGFR-TKI.":[90],"Purpose:":[91],"To":[92],"develop":[93],"and":[94,134,150,159,195,200,214,222,243,252,267,305,318,328,347,352,406],"validate":[95],"machine":[97],"learning":[98],"(ML)-based":[99],"radiomics":[100,176,216,263,269,292,365],"approach":[101],"predict":[103],"acquired":[104,396],"EGFR-T790M":[105,239,274,369,397],"mutation":[106,133,275,337,370,398],"following":[107],"EGFR-TKI":[114,140],"in":[115,371,411],"NSCLC":[118,128,373,416],"harboring":[119],"Methods:":[122],"A":[123,204,259],"total":[124,260],"274":[126,234],"advanced":[127,372],"sensitive":[131],"were":[141,148,153,172,226,246,265,276,338],"retrospectively":[142],"collected.":[143],"Tumor":[144],"regions":[145],"interest":[147],"segmented":[149],"radiomic":[151,193],"features":[152,199,264,270,293],"extracted.":[154],"The":[155,178,350],"least":[156],"absolute":[157],"shrinkage":[158],"selection":[160],"operator":[161],"(LASSO)":[162],"algorithm":[163],"was":[164,184,206],"used":[165,173,391],"feature":[167],"selection,":[168],"7":[169],"ML":[170],"approaches":[171],"build":[175],"models.":[177,280],"receiver":[179,299],"operating":[180,300],"characteristic":[181,301],"(ROC)":[182],"curve":[183,219,224,354],"established":[185],"evaluate":[187,229],"discriminating":[189,335],"performance":[190],"models":[194],"combined":[196,332],"ones":[197],"(radiomic":[198],"relevant":[201,272],"clinical":[202,212,230,358],"factors).":[203],"nomogram":[205],"constructed":[207],"using":[208],"most":[210,271],"important":[211],"factors":[213],"signatures.":[217],"Decision":[218],"analysis":[220],"(DCA)":[221],"calibration":[223,353],"analyses":[225,355],"applied":[227],"utility.":[231],"Results:":[232],"In":[233,281,322],"patients,":[235],"128":[236],"cases":[237,245],"harbor":[238],"mutation.":[240],"One":[241],"hundred":[242],"ninety-two":[244],"selected":[247,277],"into":[248,254],"training":[250],"cohort":[251],"82":[253],"independent":[256],"validation":[257],"cohort.":[258],"1316":[262],"extracted":[266],"10":[268],"construct":[279],"terms":[282],"predicting":[284],"T790M":[286],"mutation,":[287],"model":[289,333,366],"derived":[290],"from":[291,401],"had":[294],"an":[295],"area":[296],"under":[297],"(AUC),":[302],"sensitivity,":[303,326],"specificity,":[304,327],"accuracy":[306,329],"0.80":[308],"(95%":[309,340],"confidence":[310],"interval":[311],"[CI]:":[312],"0.79\u20130.81),":[313],"0.85":[314],"(0.81\u20130.89),":[315],"0.70":[316],"(0.65\u20130.74),":[317],"0.75":[319],"(0.71\u20130.78),":[320],"respectively.":[321,349],"addition,":[323],"AUC,":[325],"0.86":[339],"CI:":[341],"0.85\u20130.88),":[342],"0.78":[343],"(0.72\u20130.84),":[344],"0.76":[345],"(0.67\u20130.85),":[346],"0.77(0.73\u20130.82),":[348],"DCA":[351],"confirmed":[356],"potential":[357],"usefulness":[359],"our":[361],"nomogram.":[362],"Conclusions:":[363],"ML-based":[364],"can":[367,388],"mutations":[377],"EGFR-":[385],"TKI,":[386],"which":[387],"be":[389],"conveniently":[390],"discriminate":[393],"those":[402],"without.":[403],"This":[404],"convenient":[405],"noninvasive":[407],"method":[408],"may":[409],"aid":[410],"targeted":[412],"planning":[414],"bearing":[418]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-04T00:00:00"}