{"id":"https://openalex.org/W4390519081","doi":"https://doi.org/10.1186/s13018-023-04464-3","title":"Exploring molecular mechanisms of intra-articular changes in osteonecrosis of femoral head using DIA proteomics and bioinformatics","display_name":"Exploring molecular mechanisms of intra-articular changes in osteonecrosis of femoral head using DIA proteomics and bioinformatics","publication_year":2024,"publication_date":"2024-01-03","ids":{"openalex":"https://openalex.org/W4390519081","doi":"https://doi.org/10.1186/s13018-023-04464-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/38169408"},"language":"en","primary_location":{"id":"doi:10.1186/s13018-023-04464-3","doi":"https://doi.org/10.1186/s13018-023-04464-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13018-023-04464-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13018-023-04464-3.pdf","source":{"id":"https://openalex.org/S160567915","display_name":"Journal of Orthopaedic Surgery and Research","issn_l":"1749-799X","issn":["1749-799X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Surgery and Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13018-023-04464-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014692354","display_name":"Gang Zhao","orcid":"https://orcid.org/0000-0002-5181-9599","observed_orcids":["https://orcid.org/0000-0002-5181-9599"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Zhao","raw_affiliation_strings":["Department of Orthopaedics, Chinese PLA 984 Hospital, Beijing, 100029, China","Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China","Medical school of Chinese PLA, Beijing, 100853, China"],"raw_orcid":"https://orcid.org/0000-0002-5181-9599","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Chinese PLA 984 Hospital, Beijing, 100029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Medical school of Chinese PLA, Beijing, 100853, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454953","display_name":"Yu-jie Liu","orcid":"https://orcid.org/0000-0002-7736-2195","observed_orcids":["https://orcid.org/0000-0002-7736-2195"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Liu","raw_affiliation_strings":["Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101296015","display_name":"Yongjun Zheng","orcid":"https://orcid.org/0009-0001-0942-5318","observed_orcids":["https://orcid.org/0009-0001-0942-5318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongjun Zheng","raw_affiliation_strings":["Department of Orthopaedics, Chinese PLA 984 Hospital, Beijing, 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Chinese PLA 984 Hospital, Beijing, 100029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023294194","display_name":"Mingyang An","orcid":"https://orcid.org/0000-0003-3755-670X","observed_orcids":["https://orcid.org/0000-0003-3755-670X"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyang An","raw_affiliation_strings":["Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101386167","display_name":"Jia Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Zhang","raw_affiliation_strings":["Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113087192","display_name":"Jing Zhang","orcid":"https://orcid.org/0000-0003-2541-4923","observed_orcids":["https://orcid.org/0000-0003-2541-4923"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhang","raw_affiliation_strings":["Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101651165","display_name":"Zhongli Li","orcid":"https://orcid.org/0000-0002-0602-2599","observed_orcids":["https://orcid.org/0000-0002-0602-2599"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongli Li","raw_affiliation_strings":["Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100776188","display_name":"Chunbao Li","orcid":"https://orcid.org/0000-0001-6979-2526","observed_orcids":["https://orcid.org/0000-0001-6979-2526"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Chunbao","raw_affiliation_strings":["Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China. dr_lichunbao@163.com"],"raw_orcid":"https://orcid.org/0000-0001-6979-2526","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, the No.4 Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China. dr_lichunbao@163.com","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":1.6194,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.79497383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"19","issue":"1","first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/avascular-necrosis-of-the-femoral-head","display_name":"osteonecrosis of the femoral head","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intra-articular-lesions","display_name":"intra-articular lesions","score":0.9369999766349792},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5419999957084656},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7129999995231628},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hemopexin","display_name":"hemopexin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ecm-receptor-interaction","display_name":"ECM-receptor interaction","score":0.8050000071525574},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.7009999752044678},{"id":"https://openalex.org/keywords/complement-and-coagulation-pathways","display_name":"complement and coagulation pathways","score":0.7139999866485596},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.8118864297866821},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6329964995384216},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6276664137840271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.519945502281189},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.45966944098472595},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4543650448322296},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3090330958366394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30416518449783325},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2646327614784241},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17699354887008667},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.14778253436088562}],"mesh":[{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005271","descriptor_name":"Femur Head Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010020","descriptor_name":"Osteonecrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010020","descriptor_name":"Osteonecrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010020","descriptor_name":"Osteonecrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010020","descriptor_name":"Osteonecrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13018-023-04464-3","doi":"https://doi.org/10.1186/s13018-023-04464-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13018-023-04464-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13018-023-04464-3.pdf","source":{"id":"https://openalex.org/S160567915","display_name":"Journal of Orthopaedic Surgery and Research","issn_l":"1749-799X","issn":["1749-799X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Surgery and Research","raw_type":"journal-article"},{"id":"pmid:38169408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38169408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic surgery and research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10763026","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10763026","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10763026/pdf/13018_2023_Article_4464.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Orthop Surg Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c8ce7c5d68de4095be11e57c3ce88d96","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c8ce7c5d68de4095be11e57c3ce88d96","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13018-023-04464-3","doi":"https://doi.org/10.1186/s13018-023-04464-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13018-023-04464-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13018-023-04464-3.pdf","source":{"id":"https://openalex.org/S160567915","display_name":"Journal of Orthopaedic Surgery and Research","issn_l":"1749-799X","issn":["1749-799X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Surgery and Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3591063313","display_name":null,"funder_award_id":"7192195","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G4507636175","display_name":null,"funder_award_id":"82072517","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5995029997","display_name":null,"funder_award_id":"2019YFE0126300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null},{"id":"https://openalex.org/F4320325891","display_name":"General Hospital of People\u2019s Liberation Army","ror":"https://ror.org/04gw3ra78"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390519081.pdf","grobid_xml":"https://content.openalex.org/works/W4390519081.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W2408836981","https://openalex.org/W2466888170","https://openalex.org/W2793515649","https://openalex.org/W2804170803","https://openalex.org/W2900569176","https://openalex.org/W2908604263","https://openalex.org/W2918968023","https://openalex.org/W2943246799","https://openalex.org/W2952425682","https://openalex.org/W2954865478","https://openalex.org/W2989576036","https://openalex.org/W2999425408","https://openalex.org/W3008589161","https://openalex.org/W3014516901","https://openalex.org/W3031941728","https://openalex.org/W3083290660","https://openalex.org/W3088940978","https://openalex.org/W3104199058","https://openalex.org/W3104255151","https://openalex.org/W3107527779","https://openalex.org/W3111184200","https://openalex.org/W3123173117","https://openalex.org/W3139224393","https://openalex.org/W3146670806","https://openalex.org/W3154839865","https://openalex.org/W3205235670","https://openalex.org/W4206296357","https://openalex.org/W4210379184","https://openalex.org/W4297964482","https://openalex.org/W4387077566","https://openalex.org/W4387080432","https://openalex.org/W4387337561","https://openalex.org/W4387571809","https://openalex.org/W4387733456","https://openalex.org/W4388670849"],"related_works":["https://openalex.org/W1982829397","https://openalex.org/W2106414650","https://openalex.org/W2347437365","https://openalex.org/W1999412725","https://openalex.org/W2124137418","https://openalex.org/W4390205769","https://openalex.org/W2391458050","https://openalex.org/W2086860678","https://openalex.org/W3022402204","https://openalex.org/W2114732768"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2,218],"is":[3],"aimed":[4],"to":[5],"delve":[6],"into":[7],"the":[8,16,45,49,61,82,92,111,132,220,231,259],"crucial":[9],"proteins":[10,85,113,207,249],"associated":[11],"with":[12,66],"hormonal":[13],"osteonecrosis":[14],"of":[15,48,94,104,223,237,261],"femoral":[17,50,67],"head":[18,51],"(ONFH)":[19],"and":[20,29,41,52,75,80,101,106,109,128,151,155,161,169,179,189,203,214,234,263],"its":[21],"intra-articular":[22,224],"lesions":[23,225],"through":[24,116],"data-independent":[25],"acquisition":[26],"(DIA)":[27],"proteomics":[28,213],"bioinformatics":[30,215],"analysis.":[31],"METHODS:":[32],"We":[33],"randomly":[34],"selected":[35],"samples":[36,43],"from":[37,44,60],"eligible":[38],"ONFH":[39,115,238,262],"patients":[40,65],"collected":[42],"necrotic":[46,232],"area":[47,233],"load-bearing":[53,235],"cartilage.":[54],"The":[55],"control":[56],"group":[57],"comprised":[58],"specimens":[59],"same":[62],"location":[63],"in":[64,114,139,156,177,208,226,230],"neck":[68],"fractures.":[69],"With":[70,211],"DIA":[71,212],"proteomics,":[72],"we":[73,90,193],"quantitatively":[74],"qualitatively":[76],"tested":[77],"both":[78],"groups":[79],"analyzed":[81],"differentially":[83],"expressed":[84],"(DEPs)":[86],"between":[87,131],"groups.":[88,134],"Additionally,":[89],"enriched":[91],"analysis":[93,188],"DEP":[95],"functions":[96],"using":[97],"gene":[98,187],"ontology":[99],"terms":[100],"Kyoto":[102],"Encyclopedia":[103],"Genes":[105],"Genomes":[107],"pathways":[108,157],"verified":[110],"key":[112,206,247],"Western":[117,190],"blot.":[118],"RESULTS:":[119],"Proteomics":[120],"experiment":[121],"uncovered":[122],"937":[123],"common":[124],"DEPs":[125,136],"(422":[126],"upregulated":[127],"515":[129],"downregulated)":[130],"two":[133],"These":[135,252],"mainly":[137],"participate":[138],"biological":[140],"processes":[141],"such":[142,158],"as":[143,159,205,243,245],"hidden":[144],"attributes,":[145],"catalytic":[146],"activity,":[147,154],"molecular":[148,221],"function":[149],"regulators,":[150],"structural":[152],"molecule":[153],"starch":[160],"sucrose":[162],"metabolism,":[163],"ECM-receptor":[164],"interaction,":[165],"PI3K-Akt":[166],"signaling,":[167,173],"complement":[168],"coagulation":[170],"cascades,":[171],"IL-17":[172],"phagosome,":[174],"transcriptional":[175],"misregulation":[176],"cancers,":[178],"focal":[180],"adhesion.":[181],"Through":[182],"protein-protein":[183],"interaction":[184],"network":[185],"target":[186],"blot":[191],"validation,":[192],"identified":[194],"C3,":[195],"MMP9,":[196],"APOE,":[197],"MPO,":[198],"LCN2,":[199],"ELANE,":[200],"HPX,":[201],"LTF,":[202],"THBS1":[204],"ONFH.":[209,227],"CONCLUSIONS:":[210],"analysis,":[216],"this":[217],"reveals":[219],"mechanisms":[222],"A":[228],"correlation":[229],"cartilage":[236],"at":[239],"ARCO":[240],"stages":[241],"IIIB-IV":[242],"well":[244],"potential":[246],"regulatory":[248],"was":[250],"identified.":[251],"findings":[253],"will":[254],"help":[255],"more":[256,270],"deeply":[257],"understand":[258],"pathogenesis":[260],"may":[264],"provide":[265],"important":[266],"clues":[267],"for":[268],"seeking":[269],"effective":[271],"treatment":[272],"strategies.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}