{"id":"https://openalex.org/W4390516632","doi":"https://doi.org/10.24953/turkjped.2023.22","title":"Choice and switch of biologic drugs in juvenile idiopathic arthritis","display_name":"Choice and switch of biologic drugs in juvenile idiopathic arthritis","publication_year":2023,"publication_date":"2023-12-25","ids":{"openalex":"https://openalex.org/W4390516632","doi":"https://doi.org/10.24953/turkjped.2023.22","pmid":"https://pubmed.ncbi.nlm.nih.gov/38204313"},"language":"en","primary_location":{"id":"doi:10.24953/turkjped.2023.22","doi":"https://doi.org/10.24953/turkjped.2023.22","is_oa":true,"landing_page_url":"https://doi.org/10.24953/turkjped.2023.22","pdf_url":"https://www.turkishjournalpediatrics.org/pdf.php?&id=2650","source":{"id":"https://openalex.org/S190468492","display_name":"The Turkish Journal of Pediatrics","issn_l":"0041-4301","issn":["0041-4301","2791-6421"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4323283977","host_organization_name":"Turkish National Pediatric Society","host_organization_lineage":["https://openalex.org/P4323283977"],"host_organization_lineage_names":["Turkish National Pediatric Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.turkishjournalpediatrics.org/pdf.php?&id=2650","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060232116","display_name":"Seher \u015eener","orcid":"https://orcid.org/0000-0003-1564-8996","observed_orcids":["https://orcid.org/0000-0003-1564-8996"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seher \u015eener","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058198905","display_name":"\u00d6zge Ba\u015faran","orcid":"https://orcid.org/0000-0002-8534-0930","observed_orcids":["https://orcid.org/0000-0002-8534-0930"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6zge Ba\u015faran","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091194661","display_name":"Ezgi Deniz Batu","orcid":"https://orcid.org/0000-0003-1065-2363","observed_orcids":["https://orcid.org/0000-0003-1065-2363"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ezgi Deniz Batu","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081194698","display_name":"M\u00fc\u015ferref Kasap C\u00fcceo\u011flu","orcid":"https://orcid.org/0000-0002-9957-8894","observed_orcids":["https://orcid.org/0000-0002-9957-8894"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M\u00fc\u015ferref Kasap C\u00fcceo\u011flu","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077037506","display_name":"Zeynep Bal\u0131k","orcid":"https://orcid.org/0000-0002-7685-7364","observed_orcids":["https://orcid.org/0000-0002-7685-7364"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeynep Bal\u0131k","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034971741","display_name":"Emil Aliyev","orcid":"https://orcid.org/0000-0002-3574-2982","observed_orcids":["https://orcid.org/0000-0002-3574-2982"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Emil Aliyev","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075198226","display_name":"Ya\u011fmur Bay\u0131nd\u0131r","orcid":"https://orcid.org/0000-0001-5274-3285","observed_orcids":["https://orcid.org/0000-0001-5274-3285"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ya\u011fmur Bay\u0131nd\u0131r","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014633647","display_name":"Yelda Bilginer","orcid":"https://orcid.org/0000-0002-6232-0072","observed_orcids":["https://orcid.org/0000-0002-6232-0072"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yelda Bilginer","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103207859","display_name":"Seza \u00d6zen","orcid":"https://orcid.org/0000-0002-2389-7282","observed_orcids":["https://orcid.org/0000-0002-2389-7282"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seza \u00d6zen","raw_affiliation_strings":["Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":null,"apc_paid":null,"fwci":0.7194,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73184639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"65","issue":"6","first_page":"980","last_page":"989"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juvenile-idiopathic-arthritis","display_name":"juvenile idiopathic arthritis","score":1.0},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/biologic-switching","display_name":"biologic switching","score":0.8460000157356262},{"id":"https://openalex.org/keywords/anakinra","display_name":"anakinra","score":0.7310000061988831},{"id":"https://openalex.org/keywords/etanercept","display_name":"etanercept","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":1.0},{"id":"https://openalex.org/keywords/systemic-juvenile-idiopathic-arthritis","display_name":"systemic juvenile idiopathic arthritis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/oligoarticular-juvenile-idiopathic-arthritis","display_name":"oligoarticular juvenile idiopathic arthritis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/polyarticular-juvenile-idiopathic-arthritis","display_name":"polyarticular juvenile idiopathic arthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/enthesitis-related-arthritis","display_name":"enthesitis-related arthritis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.765999972820282},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9620157480239868},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.8279978036880493},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.7750468254089355},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.7509583234786987},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6801848411560059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6031484007835388},{"id":"https://openalex.org/C2780366729","wikidata":"https://www.wikidata.org/wiki/Q3350500","display_name":"Oligoarthritis","level":4,"score":0.4925170838832855},{"id":"https://openalex.org/C2911221801","wikidata":"https://www.wikidata.org/wiki/Q2742406","display_name":"Biologic Agents","level":3,"score":0.45991694927215576},{"id":"https://openalex.org/C2781228260","wikidata":"https://www.wikidata.org/wiki/Q415411","display_name":"Anakinra","level":3,"score":0.44739049673080444},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44282495975494385},{"id":"https://openalex.org/C2780131103","wikidata":"https://www.wikidata.org/wiki/Q3055079","display_name":"Enthesitis","level":4,"score":0.4240127205848694},{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.4223966598510742},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.34118154644966125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2534072995185852},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16165506839752197},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.15203067660331726},{"id":"https://openalex.org/C2778917330","wikidata":"https://www.wikidata.org/wiki/Q1274464","display_name":"Polyarthritis","level":3,"score":0.09735560417175293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.24953/turkjped.2023.22","doi":"https://doi.org/10.24953/turkjped.2023.22","is_oa":true,"landing_page_url":"https://doi.org/10.24953/turkjped.2023.22","pdf_url":"https://www.turkishjournalpediatrics.org/pdf.php?&id=2650","source":{"id":"https://openalex.org/S190468492","display_name":"The Turkish Journal of Pediatrics","issn_l":"0041-4301","issn":["0041-4301","2791-6421"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4323283977","host_organization_name":"Turkish National Pediatric Society","host_organization_lineage":["https://openalex.org/P4323283977"],"host_organization_lineage_names":["Turkish National Pediatric Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:38204313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38204313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish journal of pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:836b6af8fd484f65a595bbca7d9c93bb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/836b6af8fd484f65a595bbca7d9c93bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Turkish Journal of Pediatrics, Vol 65, Iss 6 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.24953/turkjped.2023.22","doi":"https://doi.org/10.24953/turkjped.2023.22","is_oa":true,"landing_page_url":"https://doi.org/10.24953/turkjped.2023.22","pdf_url":"https://www.turkishjournalpediatrics.org/pdf.php?&id=2650","source":{"id":"https://openalex.org/S190468492","display_name":"The Turkish Journal of Pediatrics","issn_l":"0041-4301","issn":["0041-4301","2791-6421"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4323283977","host_organization_name":"Turkish National Pediatric Society","host_organization_lineage":["https://openalex.org/P4323283977"],"host_organization_lineage_names":["Turkish National Pediatric Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish Journal of Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390516632.pdf","grobid_xml":"https://content.openalex.org/works/W4390516632.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W33672687","https://openalex.org/W1548479146","https://openalex.org/W1685776505","https://openalex.org/W1968864783","https://openalex.org/W1969936299","https://openalex.org/W1976595236","https://openalex.org/W1989262657","https://openalex.org/W1996629445","https://openalex.org/W1998460115","https://openalex.org/W2021579922","https://openalex.org/W2024714476","https://openalex.org/W2026404803","https://openalex.org/W2031674246","https://openalex.org/W2070021262","https://openalex.org/W2070538141","https://openalex.org/W2087769239","https://openalex.org/W2112675962","https://openalex.org/W2135974703","https://openalex.org/W2312982528","https://openalex.org/W2591102674","https://openalex.org/W2622023924","https://openalex.org/W2737928968","https://openalex.org/W2895111641","https://openalex.org/W2901193972","https://openalex.org/W2923722987","https://openalex.org/W2947200617","https://openalex.org/W2997360929","https://openalex.org/W3010607792","https://openalex.org/W3040833249","https://openalex.org/W3087448180","https://openalex.org/W3087556346","https://openalex.org/W3096842648","https://openalex.org/W3157913364","https://openalex.org/W3183918665","https://openalex.org/W4214882350","https://openalex.org/W4282054108","https://openalex.org/W4283794729","https://openalex.org/W4288400169","https://openalex.org/W4290851550"],"related_works":["https://openalex.org/W2112119728","https://openalex.org/W1966767321","https://openalex.org/W4283707264","https://openalex.org/W4382753583","https://openalex.org/W4200553866","https://openalex.org/W2044255694","https://openalex.org/W4210455900","https://openalex.org/W2330701776","https://openalex.org/W3094347255","https://openalex.org/W2952829302"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,189],"this":[2,190],"study,":[3,191],"we":[4,192],"aimed":[5],"to":[6,21,129,134,145,167,226],"evaluate":[7],"choices":[8],"and":[9,37,66,104,131,198],"changes":[10],"of":[11,153,211],"biologic":[12,32,83,93,115,136,148,195],"drugs":[13],"in":[14,84,95,117,151,158,170,180,201,209],"juvenile":[15],"idiopathic":[16],"arthritis":[17,64,71],"(JIA)":[18],"patients":[19,29,96,120,125,173,183,213],"according":[20],"disease":[22],"subtypes.":[23],"METHODS:":[24],"We":[25],"retrospectively":[26],"analyzed":[27],"JIA":[28,43,106,160,172,203],"who":[30],"received":[31],"treatment":[33],"between":[34],"January":[35],"2004":[36],"July":[38],"2022.":[39],"RESULTS:":[40],"Of":[41],"294":[42],"patients,":[44,161],"80":[45],"(27.2%)":[46],"had":[47,52,57,62,69],"systemic":[48,85,159],"JIA,":[49,54,59],"68":[50],"(23.1%)":[51],"oligoarticular":[53,101],"61":[55],"(20.7%)":[56],"polyarticular":[58,105],"79":[60],"(26.9%)":[61],"enthesitis-associated":[63],"(ERA),":[65],"six":[67],"(2.1%)":[68],"psoriatic":[70],"(PsA).":[72],"Anakinra":[73],"(n=66,":[74],"82.5%)":[75],"was":[76,88,110,149,163],"the":[77,89,139,186,194],"most":[78,90,140,210],"commonly":[79],"preferred":[80],"first":[81,168],"line":[82],"JIA.":[86],"Etanercept":[87],"frequently":[91],"used":[92,111],"drug":[94,116,196],"with":[97,214],"ERA":[98],"(n=69,":[99],"87.3%),":[100],"(n=37,":[102,156],"54.4%)":[103],"(n=43,":[107],"70.5%).":[108],"Adalimumab":[109],"as":[112],"a":[113,146,215],"first-line":[114],"all":[118],"PsA":[119],"(n=6,":[121],"100%).":[122],"One":[123],"hundred-fourteen":[124],"(38.8%)":[126],"were":[127,178,207],"switched":[128],"second-line":[130,147],"29":[132],"(9.9%)":[133],"third-line":[135],"drugs.":[137],"While":[138],"common":[141],"reason":[142],"for":[143],"switching":[144],"difficulty":[150],"usage":[152,197],"daily":[154],"injections":[155],"60.6%)":[157],"it":[162],"an":[164],"inadequate":[165],"response":[166],"biologics":[169],"non-systemic":[171],"(n=42,":[174],"79.2%).":[175],"Side":[176],"effects":[177],"detected":[179],"only":[181],"seven":[182],"(2.4%)":[184],"during":[185],"follow-up.":[187],"CONCLUSION:":[188],"revealed":[193],"switch":[199],"strategies":[200],"our":[202,212],"patients.":[204],"Good":[205],"responses":[206],"obtained":[208],"reliable":[216],"profile.":[217],"However,":[218],"studies":[219],"on":[220],"larger":[221],"patient":[222],"groups":[223],"are":[224],"needed":[225],"clarify":[227],"these":[228],"results.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}