{"id":"https://openalex.org/W4390447136","doi":"https://doi.org/10.1093/ofid/ofad704","title":"A Systematic Review of the Therapeutic Outcome of Mucormycosis","display_name":"A Systematic Review of the Therapeutic Outcome of Mucormycosis","publication_year":2023,"publication_date":"2023-12-29","ids":{"openalex":"https://openalex.org/W4390447136","doi":"https://doi.org/10.1093/ofid/ofad704","pmid":"https://pubmed.ncbi.nlm.nih.gov/38288347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10823420"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofad704","doi":"https://doi.org/10.1093/ofid/ofad704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad704","pdf_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad704/54929094/ofad704.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad704/54929094/ofad704.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062988639","display_name":"L. S. M. Sigera","orcid":"https://orcid.org/0000-0002-5519-7619","observed_orcids":["https://orcid.org/0000-0002-5519-7619"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"L Shamithra M Sigera","raw_affiliation_strings":["Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre , Manchester , UK","Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9NT, UK"],"raw_orcid":"https://orcid.org/0000-0002-5519-7619","affiliations":[{"raw_affiliation_string":"Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre , Manchester , UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9NT, UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083752740","display_name":"David W. Denning","orcid":"https://orcid.org/0000-0001-5626-2251","observed_orcids":["https://orcid.org/0000-0001-5626-2251","https://orcid.org/0000-0002-0955-0151"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David W Denning","raw_affiliation_strings":["Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre , Manchester , UK","Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9NT, UK"],"raw_orcid":"https://orcid.org/0000-0001-5626-2251","affiliations":[{"raw_affiliation_string":"Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre , Manchester , UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Fungal Infection Group, Core Technology Facility, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9NT, UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062988639","https://openalex.org/A5083752740"],"corresponding_institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"],"apc_list":{"value":3676,"currency":"USD","value_usd":3676},"apc_paid":{"value":3676,"currency":"USD","value_usd":3676},"fwci":2.4411,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.91561939,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"ofad704","last_page":"ofad704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13385","display_name":"Infectious Diseases and Mycology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mucormycosis","display_name":"mucormycosis","score":1.0},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.765999972820282},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.921999990940094},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9179999828338623},{"id":"https://openalex.org/keywords/azole-antifungals","display_name":"azole antifungals","score":0.7310000061988831},{"id":"https://openalex.org/keywords/posaconazole","display_name":"posaconazole","score":0.9629999995231628},{"id":"https://openalex.org/keywords/isavuconazole","display_name":"isavuconazole","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-mucormycosis","display_name":"pulmonary mucormycosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8370000123977661},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.8159999847412109},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8859157562255859},{"id":"https://openalex.org/C2777292849","wikidata":"https://www.wikidata.org/wiki/Q6931254","display_name":"Mucormycosis","level":2,"score":0.7276355624198914},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.5189078450202942},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38408949971199036},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2168186902999878},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/ofid/ofad704","doi":"https://doi.org/10.1093/ofid/ofad704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad704","pdf_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad704/54929094/ofad704.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10823420","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10823420","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10823420/pdf/ofad704.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"},{"id":"pmid:38288347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38288347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open forum infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/907c9bdc-5031-4b8b-9e1a-d85f4a9063b8","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/907c9bdc-5031-4b8b-9e1a-d85f4a9063b8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sigera, L S M & Denning, D W 2024, 'A Systematic Review of the Therapeutic Outcome of Mucormycosis', Open Forum Infectious Diseases, vol. 11, no. 1, ofad704. https://doi.org/10.1093/ofid/ofad704","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofad704","doi":"https://doi.org/10.1093/ofid/ofad704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofad704","pdf_url":"https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad704/54929094/ofad704.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320320291","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27"},{"id":"https://openalex.org/F4320320916","display_name":"European Society of Clinical Microbiology and Infectious Diseases","ror":"https://ror.org/02vkssr45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390447136.pdf","grobid_xml":"https://content.openalex.org/works/W4390447136.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1972001596","https://openalex.org/W1974241692","https://openalex.org/W2029257244","https://openalex.org/W2091101997","https://openalex.org/W2100096120","https://openalex.org/W2100285393","https://openalex.org/W2113690161","https://openalex.org/W2125502424","https://openalex.org/W2171789838","https://openalex.org/W2296337564","https://openalex.org/W2317409360","https://openalex.org/W2527919889","https://openalex.org/W2622783936","https://openalex.org/W2791487059","https://openalex.org/W2793832562","https://openalex.org/W2802096240","https://openalex.org/W2883135211","https://openalex.org/W2910205286","https://openalex.org/W2922047687","https://openalex.org/W2955331470","https://openalex.org/W2967890583","https://openalex.org/W2987248752","https://openalex.org/W2993195785","https://openalex.org/W3014407821","https://openalex.org/W3030784734","https://openalex.org/W3096253920","https://openalex.org/W3119060139","https://openalex.org/W3134134106","https://openalex.org/W3169095010","https://openalex.org/W3176054457","https://openalex.org/W3185631697","https://openalex.org/W3210893320","https://openalex.org/W3213519171","https://openalex.org/W3215485267","https://openalex.org/W4205589739","https://openalex.org/W4213291491","https://openalex.org/W4223434989","https://openalex.org/W4225166128","https://openalex.org/W4292509594","https://openalex.org/W4312219558","https://openalex.org/W4316035745","https://openalex.org/W4321595586","https://openalex.org/W4365145183","https://openalex.org/W4380629452"],"related_works":["https://openalex.org/W2993195785","https://openalex.org/W3216673415","https://openalex.org/W7163255596","https://openalex.org/W4200165457","https://openalex.org/W2278310178","https://openalex.org/W2090291939","https://openalex.org/W2903564317","https://openalex.org/W4414297046","https://openalex.org/W3107257671","https://openalex.org/W4312048335"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Mucormycosis":[2,214],"is":[3,215,225,235],"a":[4],"potentially":[5],"lethal":[6],"mycosis.":[7],"We":[8],"reviewed":[9],"peer-reviewed":[10],"publications":[11],"on":[12],"mucormycosis":[13,34],"to":[14,37,58,228],"assess":[15],"therapeutic":[16,53],"outcomes.":[17],"Methods":[18],"A":[19],"systematic":[20],"literature":[21],"search":[22],"using":[23],"the":[24,47,78],"Ovid":[25],"MEDLINE":[26],"and":[27,42,46,165,177,224],"EMBASE":[28],"databases":[29],"identified":[30],"manuscripts":[31],"describing":[32],"human":[33],"diagnosed":[35],"according":[36],"European":[38],"Organization":[39],"for":[40,238],"Research":[41],"Treatment":[43],"of":[44,179,194,201],"Cancer":[45],"Mycoses":[48],"Study":[49],"Group":[50],"criteria":[51],"with":[52,114,199,233],"outcomes":[54,184],"published":[55],"from":[56,70,185],"2000":[57],"2022.":[59],"Results":[60],"In":[61],"126":[62],"articles,":[63],"10":[64],"335":[65],"patients":[66,89,113,190,204],"were":[67],"described,":[68],"most":[69,79,126],"Asia":[71,220],"(n":[72,83,100,107,120,134,147,157,168],"=":[73,84,101,108,121,135,148,158,169,174,211],"6632,":[74],"66%).":[75],"Diabetes":[76],"was":[77,98,125],"frequent":[80],"underlying":[81,92],"disease":[82],"6188,":[85],"60%);":[86],"222":[87],"(2.1%)":[88],"had":[90],"no":[91],"diseases.":[93],"The":[94],"dominant":[95],"clinical":[96],"form":[97],"rhino-orbitocerebral":[99],"7159,":[102],"69.3%),":[103],"followed":[104,128,144],"by":[105,129,145],"pulmonary":[106],"1062,":[109],"10.3%).":[110],"Of":[111],"5364":[112],"outcome":[115],"data,":[116],"amphotericin":[117,130,142],"B":[118,131,143],"monotherapy":[119],"3749,":[122],"mortality":[123,137,150,160,171],"31.5%)":[124],"frequent,":[127],"+":[132],"azole":[133,146],"843,":[136],"6.6%;":[138],"P":[139,152,162,173],"<":[140,153,163],".0001),":[141,154,164],"357,":[149],"13.7%;":[151],"posaconazole":[155],"only":[156,167],"250,":[159],"17.2%;":[161],"isavuconazole":[166],"65,":[170],"24.6%;":[172],".24).":[175],"Duration":[176],"dose":[178],"antifungals":[180],"varied":[181],"widely.":[182],"Documented":[183],"surgical":[186],"resections":[187],"in":[188,219,222],"149":[189],"found":[191],"that":[192],"47":[193],"125":[195],"died":[196],"(37.6%),":[197],"compared":[198],"16":[200],"24":[202],"(66.7%)":[203],"who":[205],"did":[206],"not":[207],"undergo":[208],"surgery":[209],"(P":[210],".008).":[212],"Conclusions":[213],"more":[216],"frequently":[217,236],"reported":[218],"than":[221],"Europe":[223],"often":[226],"linked":[227],"diabetes.":[229],"Antifungal":[230],"therapy,":[231],"usually":[232],"surgery,":[234],"effective":[237],"mucormycosis.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-31T00:00:00"}