{"id":"https://openalex.org/W4390367488","doi":"https://doi.org/10.1016/j.ejps.2023.106686","title":"Cancer sensitizing effect of deazaflavin analogs is associated with increased intracellular drug accumulation","display_name":"Cancer sensitizing effect of deazaflavin analogs is associated with increased intracellular drug accumulation","publication_year":2023,"publication_date":"2023-12-28","ids":{"openalex":"https://openalex.org/W4390367488","doi":"https://doi.org/10.1016/j.ejps.2023.106686","pmid":"https://pubmed.ncbi.nlm.nih.gov/38159687"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejps.2023.106686","doi":"https://doi.org/10.1016/j.ejps.2023.106686","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejps.2023.106686","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ejps.2023.106686","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016955974","display_name":"Zakia Belhadj","orcid":"https://orcid.org/0000-0001-8457-341X","observed_orcids":["https://orcid.org/0000-0001-8457-341X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zakia Belhadj","raw_affiliation_strings":["Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061623877","display_name":"Samuel D. Offei","orcid":"https://orcid.org/0000-0001-6616-0718","observed_orcids":["https://orcid.org/0000-0001-6616-0718"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Offei","raw_affiliation_strings":["Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110505067","display_name":"Blake A. Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake A. Jacobson","raw_affiliation_strings":["Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044996323","display_name":"Daniel Cambron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Cambron","raw_affiliation_strings":["Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008573977","display_name":"Robert Arthur Kratzke","orcid":"https://orcid.org/0000-0002-1599-7494","observed_orcids":["https://orcid.org/0000-0002-1599-7494"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Kratzke","raw_affiliation_strings":["Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102908188","display_name":"Zhengqiang Wang","orcid":"https://orcid.org/0000-0002-1326-5986","observed_orcids":["https://orcid.org/0000-0002-1326-5986"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengqiang Wang","raw_affiliation_strings":["Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091579621","display_name":"Jiashu Xie","orcid":"https://orcid.org/0000-0002-6148-5203","observed_orcids":["https://orcid.org/0000-0002-6148-5203"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiashu Xie","raw_affiliation_strings":["Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: jxie@umn.edu","Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-6148-5203","affiliations":[{"raw_affiliation_string":"Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: jxie@umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091579621"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":0.0887,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34395058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"193","issue":null,"first_page":"106686","last_page":"106686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.22789999842643738,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.8080000281333923},{"id":"https://openalex.org/keywords/topoisomerase-ii-poisons","display_name":"topoisomerase II poisons","score":0.9470000267028809},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/teniposide","display_name":"teniposide","score":0.7689999938011169},{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":0.9990000128746033},{"id":"https://openalex.org/keywords/abc-transporter-inhibitors","display_name":"ABC transporter inhibitors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5759999752044678},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ccrf-cem-cells","display_name":"CCRF-CEM cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/dt40-cells","display_name":"DT40 cells","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6252043843269348},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6118714809417725},{"id":"https://openalex.org/C2778707968","wikidata":"https://www.wikidata.org/wiki/Q417555","display_name":"Teniposide","level":4,"score":0.5988218188285828},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5698592066764832},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5588266849517822},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5524795651435852},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.4838820695877075},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4664287865161896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4419684112071991},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42743802070617676},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41149166226387024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3337758779525757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3196828067302704},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1833193600177765},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10926169157028198},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10327330231666565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011042","descriptor_name":"Poisons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejps.2023.106686","doi":"https://doi.org/10.1016/j.ejps.2023.106686","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejps.2023.106686","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:38159687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38159687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ejps.2023.106686","doi":"https://doi.org/10.1016/j.ejps.2023.106686","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejps.2023.106686","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1900083602","https://openalex.org/W2016274489","https://openalex.org/W2016367481","https://openalex.org/W2027706305","https://openalex.org/W2031454576","https://openalex.org/W2039049452","https://openalex.org/W2053863124","https://openalex.org/W2073073775","https://openalex.org/W2079762751","https://openalex.org/W2088393598","https://openalex.org/W2097738814","https://openalex.org/W2111834967","https://openalex.org/W2112359216","https://openalex.org/W2119534425","https://openalex.org/W2119836219","https://openalex.org/W2120174582","https://openalex.org/W2122985935","https://openalex.org/W2131487381","https://openalex.org/W2134772502","https://openalex.org/W2135121954","https://openalex.org/W2137145433","https://openalex.org/W2148874251","https://openalex.org/W2150869032","https://openalex.org/W2166082449","https://openalex.org/W2167058094","https://openalex.org/W2196483897","https://openalex.org/W2342699700","https://openalex.org/W2400064982","https://openalex.org/W2939606452","https://openalex.org/W2944816280","https://openalex.org/W2989335854","https://openalex.org/W3043934334","https://openalex.org/W3048792377","https://openalex.org/W6639729300","https://openalex.org/W6677735523","https://openalex.org/W6677745919","https://openalex.org/W6680178678"],"related_works":["https://openalex.org/W2939606452","https://openalex.org/W2944816280","https://openalex.org/W2989335854","https://openalex.org/W4400800421","https://openalex.org/W2342699700","https://openalex.org/W2347135114","https://openalex.org/W2089642610","https://openalex.org/W3091466206","https://openalex.org/W1555002034","https://openalex.org/W2000972011"],"abstract_inverted_index":{"As":[0],"part":[1],"of":[2,41,71,133,152,171,196],"our":[3],"efforts":[4],"geared":[5],"towards":[6],"developing":[7],"mechanism-based":[8],"cancer":[9,74,90,185,209],"sensitizing":[10,39,210],"agents,":[11],"we":[12,77,110],"have":[13],"previously":[14],"synthesized":[15],"and":[16,141,144,157,179,190],"characterized":[17],"novel":[18],"deazaflavin":[19,80,202],"analogs":[20,44],"as":[21],"potent":[22,114],"tyrosyl":[23],"DNA":[24],"phosphodiesterase":[25],"2":[26],"(TDP2)":[27],"inhibitors":[28,82,100,155],"for":[29,83],"combination":[30],"treatments":[31],"with":[32,52],"topoisomerase":[33],"II":[34],"(TOP2)":[35],"poisons.":[36],"Interestingly,":[37],"the":[38,68,103,122,169,174,194],"effect":[40,147],"a":[42,53,180],"few":[43,181],"toward":[45,164],"TOP2":[46,138],"poison":[47,139],"etoposide":[48],"(ETP)":[49],"was":[50],"associated":[51],"significant":[54],"increase":[55],"in":[56,73,89,106,159,173],"intracellular":[57,123],"drug":[58,87],"accumulation,":[59],"which":[60,117,212],"could":[61,205],"be":[62,206],"an":[63,112,146,207],"alternative":[64],"mechanism":[65],"to":[66],"boost":[67],"clinical":[69],"efficacy":[70],"ETP":[72,104,124,172],"chemotherapies.":[75],"Hence,":[76],"evaluated":[78],"more":[79,148],"TDP2":[81,99],"their":[84],"impact":[85],"on":[86],"retention":[88,105],"cells.":[91,108,192],"We":[92],"found":[93],"that":[94,201],"all":[95],"but":[96],"one":[97],"tested":[98],"substantially":[101],"increased":[102,121],"DT40":[107],"Particularly,":[109],"identified":[111],"exceptionally":[113],"analog,":[115],"ZW-1226,":[116],"at":[118],"3":[119],"nM":[120],"by":[125],"13-fold.":[126],"Significantly,":[127],"ZW-1226":[128,167,204],"also":[129],"stimulated":[130],"cellular":[131],"accumulation":[132],"two":[134],"other":[135],"anticancer":[136],"drugs,":[137],"teniposide":[140],"antifolate":[142],"pemetrexed,":[143],"produced":[145],"pronounced":[149],"than":[150],"those":[151],"ABC":[153],"transporter":[154],"verapamil":[156],"elacridar":[158],"human":[160,176],"leukemic":[161],"CCRF-CEM":[162,177],"cells":[163,178],"ETP.":[165],"Lastly,":[166],"potentiated":[168],"action":[170],"sensitive":[175],"resistant":[182],"non-small-cell":[183],"lung":[184],"(NSCLC)":[186],"cells,":[187],"including":[188],"H460":[189],"H838":[191],"Collectively,":[193],"results":[195],"this":[197],"study":[198],"strongly":[199],"suggest":[200],"analog":[203],"effective":[208],"agent":[211],"warrants":[213],"further":[214],"investigation.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-29T00:00:00"}
