{"id":"https://openalex.org/W4390328302","doi":"https://doi.org/10.1097/upj.0000000000000513","title":"A Cost Savings Analysis of Topical Estrogen Therapy in Urinary Tract Infection Prevention Among Postmenopausal Women","display_name":"A Cost Savings Analysis of Topical Estrogen Therapy in Urinary Tract Infection Prevention Among Postmenopausal Women","publication_year":2023,"publication_date":"2023-12-28","ids":{"openalex":"https://openalex.org/W4390328302","doi":"https://doi.org/10.1097/upj.0000000000000513","pmid":"https://pubmed.ncbi.nlm.nih.gov/38154005"},"language":"en","primary_location":{"id":"doi:10.1097/upj.0000000000000513","doi":"https://doi.org/10.1097/upj.0000000000000513","is_oa":false,"landing_page_url":"https://doi.org/10.1097/upj.0000000000000513","pdf_url":null,"source":{"id":"https://openalex.org/S2764617932","display_name":"Urology Practice","issn_l":"2352-0779","issn":["2352-0779","2352-0787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urology Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079400318","display_name":"Charlotte Goldman Houston","orcid":"https://orcid.org/0000-0002-8068-5382","observed_orcids":["https://orcid.org/0000-0002-8068-5382"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte Goldman Houston","raw_affiliation_strings":["Department of Urology, Georgetown University, Washington, District of Columbia"],"raw_orcid":"https://orcid.org/0000-0002-8068-5382","affiliations":[{"raw_affiliation_string":"Department of Urology, Georgetown University, Washington, District of Columbia","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076357926","display_name":"William S. Azar","orcid":"https://orcid.org/0000-0003-0682-3465","observed_orcids":["https://orcid.org/0000-0003-0682-3465"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S. Azar","raw_affiliation_strings":["Department of Urology, Georgetown University, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Georgetown University, Washington, District of Columbia","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058792186","display_name":"Sean Shenghsiu Huang","orcid":"https://orcid.org/0000-0001-8156-6177","observed_orcids":["https://orcid.org/0000-0001-8156-6177"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Shenghsiu Huang","raw_affiliation_strings":["Department of Health Management and Policy, Georgetown University, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Management and Policy, Georgetown University, Washington, District of Columbia","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060412366","display_name":"Rachel S. Rubin","orcid":"https://orcid.org/0000-0003-3621-824X","observed_orcids":["https://orcid.org/0000-0003-3621-824X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Rubin","raw_affiliation_strings":["Department of Urology, Georgetown University, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Georgetown University, Washington, District of Columbia","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028180581","display_name":"Charles Scott Dorris","orcid":"https://orcid.org/0000-0002-4664-6793","observed_orcids":["https://orcid.org/0000-0002-4664-6793"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Scott Dorris","raw_affiliation_strings":["Dahlgren Medical Library, Georgetown University Medical Center, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dahlgren Medical Library, Georgetown University Medical Center, Washington, District of Columbia","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081185434","display_name":"Rachael D. Sussman","orcid":"https://orcid.org/0000-0003-0719-9465","observed_orcids":["https://orcid.org/0000-0003-0719-9465"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachael D. Sussman","raw_affiliation_strings":["Department of Urology, Georgetown University, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Georgetown University, Washington, District of Columbia","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8035,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.95400514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"2","first_page":"257","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-estrogen","display_name":"topical estrogen","score":0.9399999976158142},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.7549999952316284},{"id":"https://openalex.org/keywords/recurrent-urinary-tract-infection","display_name":"recurrent urinary tract infection","score":0.7720000147819519},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/medicare-spending","display_name":"Medicare spending","score":0.6669999957084656},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.5260000228881836},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.39800000190734863},{"id":"https://openalex.org/keywords/economic-burden","display_name":"economic burden","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.947464108467102},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5855564475059509},{"id":"https://openalex.org/C26869875","wikidata":"https://www.wikidata.org/wiki/Q2596417","display_name":"Beneficiary","level":2,"score":0.5186540484428406},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4401808977127075},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4358063340187073},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.43153250217437744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3598403036594391},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0993739664554596},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017046","descriptor_name":"Cost Savings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/upj.0000000000000513","doi":"https://doi.org/10.1097/upj.0000000000000513","is_oa":false,"landing_page_url":"https://doi.org/10.1097/upj.0000000000000513","pdf_url":null,"source":{"id":"https://openalex.org/S2764617932","display_name":"Urology Practice","issn_l":"2352-0779","issn":["2352-0779","2352-0787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urology Practice","raw_type":"journal-article"},{"id":"pmid:38154005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38154005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urology practice","raw_type":"Systematic Review"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390795528","https://openalex.org/W7165658428","https://openalex.org/W2026576204","https://openalex.org/W4390792108","https://openalex.org/W2953619019","https://openalex.org/W4282939458","https://openalex.org/W3117174005","https://openalex.org/W182836311","https://openalex.org/W2409532971","https://openalex.org/W2016378380"],"abstract_inverted_index":{"INTRODUCTION:":[0],"UTIs":[1],"are":[2,26,197,239],"some":[3],"of":[4,48,74,105,143,177,205,215],"the":[5,21,38,46,145,175,178,203,211],"most":[6],"common":[7],"infections":[8,17,31,49,124],"in":[9,44,82,147,171,217],"geriatric":[10],"patients,":[11],"with":[12,29,53,113,210],"many":[13],"women":[14,52,209],"experiencing":[15],"recurrent":[16,30,54,114],"after":[18],"menopause.":[19],"In":[20],"US,":[22],"annual":[23],"UTI-related":[24],"costs":[25],"$2":[27],"billion,":[28],"creating":[32],"a":[33,70,111,138,198],"significant":[34],"economic":[35],"burden.":[36],"Given":[37],"data":[39],"published":[40,94],"on":[41,93,97,102,120,162,168,207],"topical":[42,79,116,163,184],"estrogen":[43,80,117,164,185],"reducing":[45],"number":[47],"for":[50,183,213,232,241],"postmenopausal":[51,83,208,233],"UTI,":[55],"we":[56],"sought":[57],"to":[58,64,78,127,129,189,201,225,236],"evaluate":[59],"how":[60],"this":[61],"would":[62],"translate":[63],"cost":[65,87,140,176,181],"savings.":[66,219],"METHODS:":[67],"We":[68],"performed":[69],"systematic":[71],"literature":[72],"review":[73],"UTI":[75,89,98,142,148,206],"reduction":[76,146],"secondary":[77],"utilization":[81],"female":[84],"patients.":[85,242],"The":[86],"per":[88,99,132,134,141,156,158,192],"was":[90,166],"determined":[91],"based":[92],"Medicare":[95,218],"spending":[96,149,161],"beneficiary,":[100],"weighted":[101],"reported":[103,119],"likelihood":[104],"complicated":[106],"and":[107,154,235],"resistant":[108],"infections.":[109],"For":[110],"patient":[112],"infections,":[115],"therapy":[118],"average":[121,169],"can":[122,150],"reduce":[123],"from":[125],"5":[126],"0.5":[128],"2":[130],"times":[131],"person":[133],"year.":[135,159],"RESULTS:":[136],"At":[137],"calculated":[139],"$1222,":[144],"range":[151],"between":[152],"$3670":[153],"$5499":[155],"beneficiary":[157],"Per-beneficiary":[160],"therapies":[165,186,228],"$1013":[167],"($578-$1445)":[170],"2020.":[172],"After":[173],"including":[174],"therapy,":[179],"overall":[180],"savings":[182],"were":[187],"$1226":[188],"$4888":[190],"annually":[191],"patient.":[193],"CONCLUSIONS:":[194],"Topical":[195],"estrogens":[196],"cost-conscious":[199],"way":[200],"improve":[202],"burden":[204],"potential":[212],"billions":[214],"dollars":[216],"System-wide":[220],"efforts":[221],"should":[222],"be":[223],"made":[224],"have":[226],"these":[227],"available":[229],"as":[230],"prophylaxis":[231],"patients":[234],"ensure":[237],"they":[238],"affordable":[240]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-12-29T00:00:00"}