{"id":"https://openalex.org/W4390323393","doi":"https://doi.org/10.1016/j.phrs.2023.107049","title":"Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice","display_name":"Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice","publication_year":2023,"publication_date":"2023-12-28","ids":{"openalex":"https://openalex.org/W4390323393","doi":"https://doi.org/10.1016/j.phrs.2023.107049","pmid":"https://pubmed.ncbi.nlm.nih.gov/38159785"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2023.107049","doi":"https://doi.org/10.1016/j.phrs.2023.107049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2023.107049","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.phrs.2023.107049","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hye-Lim Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye-Lim Lee","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006773652","display_name":"Erica Squire","orcid":"https://orcid.org/0000-0003-2833-3379","observed_orcids":["https://orcid.org/0000-0003-2833-3379"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica Squire","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029755139","display_name":"Yannick Fotio","orcid":"https://orcid.org/0000-0001-5193-2009","observed_orcids":["https://orcid.org/0000-0001-5193-2009"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yannick Fotio","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047005581","display_name":"Alex Mabou Tagne","orcid":"https://orcid.org/0000-0003-3986-8344","observed_orcids":["https://orcid.org/0000-0003-3986-8344"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Mabou Tagne","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110899814","display_name":"Jungyeon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jungyeon Lee","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101285315","display_name":"John Jeongwoo Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Jeongwoo Yoon","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101285316","display_name":"Yedam Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yedam Hong","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063005568","display_name":"Laura Hyunseo Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Hyunseo Kim","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079750857","display_name":"Kwang\u2010Mook Jung","orcid":"https://orcid.org/0000-0003-4096-6953","observed_orcids":["https://orcid.org/0000-0003-4096-6953"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwang-Mook Jung","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031213755","display_name":"Daniele Piomelli","orcid":"https://orcid.org/0000-0002-2983-774X","observed_orcids":["https://orcid.org/0000-0002-2983-774X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniele Piomelli","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine, USA; Department of Biological Chemistry, University of California, Irvine, USA; Department of Pharmaceutical Sciences, University of California, Irvine, USA. Electronic address: piomelli@hs.uci.edu","Department of Anatomy and Neurobiology, University of California, Irvine, USA","Department of Biological Chemistry, University of California, Irvine, USA","Department of Pharmaceutical Sciences, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA; Department of Biological Chemistry, University of California, Irvine, USA; Department of Pharmaceutical Sciences, University of California, Irvine, USA. Electronic address: piomelli@hs.uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Biological Chemistry, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031213755"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.1316,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75514526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"199","issue":null,"first_page":"107049","last_page":"107049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydrocannabinol","display_name":"tetrahydrocannabinol","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7289999723434448},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.8629999756813049},{"id":"https://openalex.org/keywords/sickness-behavior","display_name":"sickness behavior","score":0.8579999804496765},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.6930000185966492},{"id":"https://openalex.org/keywords/brain-transcriptome","display_name":"brain transcriptome","score":0.7390000224113464},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.7179999947547913},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.949999988079071},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.6790000200271606},{"id":"https://openalex.org/keywords/early-life-drug-exposure","display_name":"early-life drug exposure","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C105083479","wikidata":"https://www.wikidata.org/wiki/Q181497","display_name":"Sexual dimorphism","level":2,"score":0.6730617880821228},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42457088828086853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3993947505950928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3942469656467438},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.38380369544029236},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37419557571411133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2588646411895752}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.phrs.2023.107049","doi":"https://doi.org/10.1016/j.phrs.2023.107049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2023.107049","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:38159785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38159785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b44824e99be94afba3434cca9b18dab3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b44824e99be94afba3434cca9b18dab3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacological Research, Vol 199, Iss , Pp 107049- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.phrs.2023.107049","doi":"https://doi.org/10.1016/j.phrs.2023.107049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2023.107049","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000919257","display_name":"Impact of Cannabinoid Across the Lifespan (ICAL)","funder_award_id":"P50DA044118","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1542661692","https://openalex.org/W1771974095","https://openalex.org/W1966478716","https://openalex.org/W1966934571","https://openalex.org/W1980789245","https://openalex.org/W1994028751","https://openalex.org/W1998105826","https://openalex.org/W1999502885","https://openalex.org/W2023634700","https://openalex.org/W2028766716","https://openalex.org/W2033617297","https://openalex.org/W2057821563","https://openalex.org/W2076198632","https://openalex.org/W2076361525","https://openalex.org/W2087685632","https://openalex.org/W2116063788","https://openalex.org/W2128702837","https://openalex.org/W2141659272","https://openalex.org/W2148903648","https://openalex.org/W2170457399","https://openalex.org/W2224479862","https://openalex.org/W2302151110","https://openalex.org/W2335996372","https://openalex.org/W2518536270","https://openalex.org/W2546435310","https://openalex.org/W2617723976","https://openalex.org/W2903808414","https://openalex.org/W2911782966","https://openalex.org/W2938019550","https://openalex.org/W2943515137","https://openalex.org/W3020339135","https://openalex.org/W3085571268","https://openalex.org/W3136257562","https://openalex.org/W3141449612","https://openalex.org/W3156066924","https://openalex.org/W3197046603","https://openalex.org/W3197604508","https://openalex.org/W3198331993","https://openalex.org/W3200008724","https://openalex.org/W3203985315","https://openalex.org/W3206804119","https://openalex.org/W3207566007","https://openalex.org/W3207752238","https://openalex.org/W3217806496","https://openalex.org/W4220784902","https://openalex.org/W4221014902","https://openalex.org/W4229446974","https://openalex.org/W4300972351","https://openalex.org/W4309215157","https://openalex.org/W4317436847","https://openalex.org/W4379057608","https://openalex.org/W4381661543","https://openalex.org/W4383955948","https://openalex.org/W4384661130","https://openalex.org/W6854514408"],"related_works":["https://openalex.org/W2093114310","https://openalex.org/W4229446974","https://openalex.org/W4200198390","https://openalex.org/W4396238047","https://openalex.org/W2969528135","https://openalex.org/W7015925485","https://openalex.org/W2004284072","https://openalex.org/W2130659939","https://openalex.org/W4214848027","https://openalex.org/W4292608353"],"abstract_inverted_index":{"-tetrahydrocannabinol":[0],"(THC)":[1],"has":[2],"enduring":[3],"effects":[4],"on":[5,52,72],"energy":[6],"metabolism":[7],"and":[8,33,67,95,103,179,206,227],"immune":[9],"function.":[10],"Prior":[11],"work":[12],"showed":[13,144],"that":[14,145,192],"daily":[15,71],"administration":[16],"of":[17,21,48,151,174,232],"a":[18,148,169],"low-impact":[19],"dose":[20],"THC":[22,50,61,120,129,161,187,211,216],"(5":[23,62],"mg/kg,":[24,63],"intraperitoneal)":[25,64],"during":[26],"adolescence":[27],"alters":[28],"transcription":[29,173],"in":[30,65,112,122,139,154,162,172,177,198,224,240],"adult":[31],"microglia":[32],"disrupts":[34],"their":[35],"response":[36,136,221],"to":[37,56,137,222],"bacterial":[38],"endotoxin":[39],"or":[40],"social":[41],"stress.":[42],"To":[43],"explore":[44],"the":[45,53,78,88,134,155,165,199,218,229,237],"lasting":[46],"impact":[47],"adolescent":[49,186,215],"exposure":[51,121,130],"brain's":[54,219],"reaction":[55],"viral":[57,89,166,238],"infection,":[58],"we":[59,84],"administered":[60],"male":[66,126,241],"female":[68,123,225],"mice":[69,79,226],"once":[70],"postnatal":[73],"day":[74],"(PND)":[75],"30-43.":[76],"When":[77],"reached":[80],"adulthood":[81],"(PND":[82],"70),":[83],"challenged":[85],"them":[86],"with":[87],"mimic,":[90],"polyinosinic":[91],"acid:polycytidylic":[92],"acid":[93],"[Poly(I:C)],":[94],"assessed":[96],"sickness":[97],"behavior":[98],"(motor":[99],"activity,":[100],"body":[101,113],"temperature)":[102],"whole":[104],"brain":[105],"gene":[106],"transcription.":[107],"Poly(I:C)":[108,138,146,193,223],"caused":[109,168,235],"an":[110],"elevation":[111],"temperature":[114],"which":[115,157,182,202],"was":[116,158,183],"lessened":[117],"by":[118,160,185,209,236],"prior":[119],"but":[124],"not":[125,132],"mice.":[127,242],"Adolescent":[128],"did":[131],"affect":[133],"locomotor":[135],"either":[140],"sex.":[141],"Transcriptomic":[142],"analyses":[143],"produced":[147],"substantial":[149],"upregulation":[150],"immune-related":[152],"genes":[153,175,234],"brain,":[156,201],"decreased":[159],"females.":[163],"Additionally,":[164],"mimic":[167,239],"male-selective":[170],"downregulation":[171,231],"involved":[176],"neurodevelopment":[178],"synaptic":[180],"transmission,":[181],"abrogated":[184],"treatment.":[188],"The":[189],"results":[190],"indicate":[191],"produces":[194],"complex":[195],"transcriptional":[196,230],"alterations":[197],"mouse":[200],"are":[203],"sexually":[204],"dimorphic":[205],"differentially":[207],"affected":[208],"early-life":[210],"exposure.":[212],"In":[213],"particular,":[214],"dampens":[217],"antiviral":[220],"prevents":[228],"neuron-related":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-29T00:00:00"}
