{"id":"https://openalex.org/W4390277828","doi":"https://doi.org/10.1016/j.jmb.2023.168421","title":"Drebrin Protects Assembled Actin from INF2-FFC-mediated Severing and Stabilizes Cell Protrusions","display_name":"Drebrin Protects Assembled Actin from INF2-FFC-mediated Severing and Stabilizes Cell Protrusions","publication_year":2023,"publication_date":"2023-12-27","ids":{"openalex":"https://openalex.org/W4390277828","doi":"https://doi.org/10.1016/j.jmb.2023.168421","pmid":"https://pubmed.ncbi.nlm.nih.gov/38158176"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmb.2023.168421","doi":"https://doi.org/10.1016/j.jmb.2023.168421","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmb.2023.168421","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jmb.2023.168421","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082686788","display_name":"Sudeepa Rajan","orcid":"https://orcid.org/0000-0002-1455-2426","observed_orcids":["https://orcid.org/0000-0002-1455-2426"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudeepa Rajan","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA","Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, California, 90095, USA"],"raw_orcid":"https://orcid.org/0000-0002-1455-2426","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, California, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093036620","display_name":"Roman Aguirre","orcid":"https://orcid.org/0009-0007-2339-8268","observed_orcids":["https://orcid.org/0009-0007-2339-8268"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman Aguirre","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA 90095, USA","Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, California, 90095, USA","Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California, 90095, USA"],"raw_orcid":"https://orcid.org/0009-0007-2339-8268","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, California, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045810897","display_name":"Z. Hong Zhou","orcid":"https://orcid.org/0000-0002-8373-4717","observed_orcids":["https://orcid.org/0000-0002-8373-4717","https://orcid.org/0000-0002-1396-2909"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Hong Zhou","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA 90095, USA","Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Hauser","orcid":"https://orcid.org/0000-0003-1168-034X","observed_orcids":["https://orcid.org/0000-0003-1168-034X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210145304","display_name":"VA Sepulveda Ambulatory Care Center","ror":"https://ror.org/04zdeh149","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210145304","https://openalex.org/I4210156876"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Hauser","raw_affiliation_strings":["Medical and Research Services, Greater Los Angeles Veterans Affairs Healthcare System at Sepulveda, North Hills, CA 91344, USA; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA","Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, 90095, USA","Medical and Research Services, Greater Los Angeles Veterans Affairs Healthcare System at Sepulveda, North Hills, California, 91344, USA"],"raw_orcid":"https://orcid.org/0000-0003-1168-034X","affiliations":[{"raw_affiliation_string":"Medical and Research Services, Greater Los Angeles Veterans Affairs Healthcare System at Sepulveda, North Hills, CA 91344, USA; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210145304","https://openalex.org/I4210156876"]},{"raw_affiliation_string":"Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Medical and Research Services, Greater Los Angeles Veterans Affairs Healthcare System at Sepulveda, North Hills, California, 91344, USA","institution_ids":["https://openalex.org/I4210145304","https://openalex.org/I4210156876"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038398169","display_name":"Emil Reisler","orcid":"https://orcid.org/0000-0001-7705-7791","observed_orcids":["https://orcid.org/0000-0001-7705-7791"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emil Reisler","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address: reisler@mbi.ucla.edu","Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, California, 90095, USA","Molecular Biology Institute, UCLA, Los Angeles, California, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address: reisler@mbi.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, California, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, UCLA, Los Angeles, California, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038398169"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":{"value":3970,"currency":"USD","value_usd":3970},"fwci":0.3939,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.4496757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"436","issue":"4","first_page":"168421","last_page":"168421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drebrin","display_name":"drebrin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/inverted-formin-2","display_name":"INF2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/actin-severing","display_name":"actin filament severing","score":0.9480000138282776},{"id":"https://openalex.org/keywords/actin-stabilization","display_name":"actin filament stabilization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-protrusions","display_name":"cell protrusions","score":0.878000020980835},{"id":"https://openalex.org/keywords/actin-binding-proteins","display_name":"actin-binding proteins","score":0.6869999766349792},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neuronal-morphology","display_name":"neuronal morphology","score":0.4359999895095825},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C53195969","wikidata":"https://www.wikidata.org/wiki/Q5470213","display_name":"Formins","level":5,"score":0.9200899600982666},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7484023571014404},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.7076557278633118},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.678683876991272},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.6586073040962219},{"id":"https://openalex.org/C59999672","wikidata":"https://www.wikidata.org/wiki/Q21497084","display_name":"MDia1","level":5,"score":0.6454331874847412},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.6228973865509033},{"id":"https://openalex.org/C14228908","wikidata":"https://www.wikidata.org/wiki/Q2920483","display_name":"Protein filament","level":2,"score":0.554567277431488},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.4640369415283203},{"id":"https://openalex.org/C151000934","wikidata":"https://www.wikidata.org/wiki/Q4676834","display_name":"Actin remodeling of neurons","level":5,"score":0.45519930124282837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43609312176704407},{"id":"https://openalex.org/C130861313","wikidata":"https://www.wikidata.org/wiki/Q3775363","display_name":"Actin-binding protein","level":5,"score":0.41678574681282043},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40350764989852905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38459837436676025},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21151477098464966},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1460288166999817}],"mesh":[{"descriptor_ui":"D000080865","descriptor_name":"Formins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D022081","descriptor_name":"Cell Surface Extensions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jmb.2023.168421","doi":"https://doi.org/10.1016/j.jmb.2023.168421","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmb.2023.168421","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:38158176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38158176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jmb.2023.168421","doi":"https://doi.org/10.1016/j.jmb.2023.168421","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmb.2023.168421","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6661353499","display_name":"Actin Dynamics, Interactions and Function","funder_award_id":"R01GM077190","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7363748876","display_name":null,"funder_award_id":"GM077190","funder_id":"https://openalex.org/F4320332502","funder_display_name":"University of California, Los Angeles"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1542497408","https://openalex.org/W1559488195","https://openalex.org/W1969774286","https://openalex.org/W1978322069","https://openalex.org/W1987710873","https://openalex.org/W1988051514","https://openalex.org/W1996892694","https://openalex.org/W1998884471","https://openalex.org/W2005203145","https://openalex.org/W2012823616","https://openalex.org/W2024862053","https://openalex.org/W2025018124","https://openalex.org/W2025480988","https://openalex.org/W2030768863","https://openalex.org/W2033887263","https://openalex.org/W2035653093","https://openalex.org/W2048677414","https://openalex.org/W2059946666","https://openalex.org/W2062852486","https://openalex.org/W2063770484","https://openalex.org/W2075898903","https://openalex.org/W2086396348","https://openalex.org/W2088664176","https://openalex.org/W2091346334","https://openalex.org/W2099945578","https://openalex.org/W2105272775","https://openalex.org/W2112973083","https://openalex.org/W2114129553","https://openalex.org/W2124015317","https://openalex.org/W2133268999","https://openalex.org/W2133621860","https://openalex.org/W2145123926","https://openalex.org/W2153083261","https://openalex.org/W2156222798","https://openalex.org/W2162841844","https://openalex.org/W2167279371","https://openalex.org/W2171919785","https://openalex.org/W2200397695","https://openalex.org/W2410054405","https://openalex.org/W2468275850","https://openalex.org/W2537334474","https://openalex.org/W2750962672","https://openalex.org/W2751860292","https://openalex.org/W2752127367","https://openalex.org/W2752216151","https://openalex.org/W2898961399","https://openalex.org/W2910224398","https://openalex.org/W2952567086","https://openalex.org/W2978562320","https://openalex.org/W2997446182","https://openalex.org/W3000331969","https://openalex.org/W3015871332","https://openalex.org/W3043287600","https://openalex.org/W3046164575","https://openalex.org/W3120204066","https://openalex.org/W3139200974","https://openalex.org/W3200335709","https://openalex.org/W4289520791","https://openalex.org/W4304891832","https://openalex.org/W4315927733","https://openalex.org/W4322619695","https://openalex.org/W4386858997"],"related_works":["https://openalex.org/W2124015317","https://openalex.org/W2751913720","https://openalex.org/W2617025629","https://openalex.org/W2081017799","https://openalex.org/W583490793","https://openalex.org/W2225019253","https://openalex.org/W2141471665","https://openalex.org/W1559488195","https://openalex.org/W1542497408","https://openalex.org/W4417116688"],"abstract_inverted_index":{"Highly":[0],"specialized":[1,181],"cells,":[2],"such":[3],"as":[4,167,169],"neurons":[5],"and":[6,18,68,92,105,113,131,174,183],"podocytes,":[7],"have":[8,125],"arborized":[9],"morphologies":[10],"that":[11,64,83,100,140],"serve":[12],"their":[13,33,191,196],"specific":[14],"functions.":[15],"Actin":[16],"cytoskeleton":[17,34],"its":[19,74,151],"associated":[20],"proteins":[21],"are":[22,176,184],"responsible":[23],"for":[24,162,186],"the":[25,55,58,87,109,170,187],"distinctive":[26],"shapes":[27],"of":[28,32,54,57,89,190],"cells.":[29],"The":[30],"mechanism":[31],"regulation":[35,189],"-":[36,42,157,159],"contributing":[37],"to":[38,45,77,86,138],"cell":[39],"shape":[40],"maintenance":[41],"is":[43,60,96,119,160],"yet":[44],"be":[46],"fully":[47],"clarified.":[48],"Inverted":[49],"formin":[50,63],"2":[51],"(INF2),":[52],"one":[53],"modulators":[56],"cytoskeleton,":[59,193],"an":[61],"atypical":[62],"can":[65],"both":[66],"polymerize":[67],"depolymerize":[69],"actin":[70,90,116,143,192],"filaments":[71,91,103,144],"depending":[72],"on":[73,115],"molar":[75],"ratio":[76],"actin.":[78],"Prior":[79],"work":[80],"has":[81],"established":[82],"INF2":[84,114,148,173],"binds":[85,102],"sides":[88],"severs":[93],"them.":[94],"Drebrin":[95],"another":[97],"actin-binding":[98],"protein":[99],"also":[101],"laterally":[104],"stabilizes":[106],"them,":[107],"but":[108],"interplay":[110],"between":[111],"drebrin":[112,141,156,175],"filament":[117],"stabilization":[118],"not":[120,166],"well":[121],"understood.":[122],"Here,":[123],"we":[124],"used":[126],"biochemical":[127],"assays,":[128],"electron":[129],"microscopy,":[130],"total":[132],"internal":[133],"reflection":[134],"fluorescence":[135],"microscopy":[136],"imaging":[137],"show":[139],"protects":[142],"from":[145],"severing":[146],"by":[147],"without":[149],"inhibiting":[150],"polymerization":[152],"activity.":[153],"Notably,":[154],"truncated":[155],"DrbA1-300":[158],"sufficient":[161],"this":[163],"protection,":[164],"though":[165],"effective":[168],"full-length":[171],"protein.":[172],"abundantly":[177],"expressed":[178],"in":[179,198],"highly":[180],"cells":[182],"crucial":[185],"temporal":[188],"consistent":[194],"with":[195],"involvement":[197],"peripheral":[199],"neuropathy.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-12-28T00:00:00"}