{"id":"https://openalex.org/W4390200213","doi":"https://doi.org/10.1002/alz.076181","title":"The eye as a window to the brain: hyperspectral retinal imaging as a biomarker for Alzheimer\u2019s disease","display_name":"The eye as a window to the brain: hyperspectral retinal imaging as a biomarker for Alzheimer\u2019s disease","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390200213","doi":"https://doi.org/10.1002/alz.076181"},"language":"en","primary_location":{"id":"doi:10.1002/alz.076181","doi":"https://doi.org/10.1002/alz.076181","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.076181","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076181","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076181","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070344391","display_name":"Yasmin Dahdouh-Guebas","orcid":"https://orcid.org/0000-0002-6578-4462","observed_orcids":["https://orcid.org/0000-0002-6578-4462"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Yasmin Dahdouh\u2010Guebas","raw_affiliation_strings":["Cellular Communication and Neurodegeneration Research Group, Leuven Brain Institute, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Communication and Neurodegeneration Research Group, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053531361","display_name":"Hana Kulenovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hana Kulenovic","raw_affiliation_strings":["Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085537488","display_name":"Eirini Christinaki","orcid":"https://orcid.org/0000-0001-5785-1509","observed_orcids":["https://orcid.org/0000-0001-5785-1509"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eirini Christinaki","raw_affiliation_strings":["Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082359115","display_name":"Jan Van Eijgen","orcid":"https://orcid.org/0000-0001-7243-9280","observed_orcids":["https://orcid.org/0000-0001-7243-9280"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Van Eijgen","raw_affiliation_strings":["Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030189828","display_name":"Sophie Lemmens","orcid":"https://orcid.org/0000-0002-6842-1747","observed_orcids":["https://orcid.org/0000-0002-6842-1747"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sophie Lemmens","raw_affiliation_strings":["Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016458045","display_name":"Jenny Ceccarini","orcid":"https://orcid.org/0000-0003-2774-9516","observed_orcids":["https://orcid.org/0000-0003-2774-9516"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jenny Ceccarini","raw_affiliation_strings":["Mission Lucidity, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Lucidity, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008256216","display_name":"Fr\u00e9d\u00e9ric Rousseau","orcid":"https://orcid.org/0000-0002-9189-7399","observed_orcids":["https://orcid.org/0000-0002-9189-7399"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frederic Rousseau","raw_affiliation_strings":["Switch Laboratory, Leuven Brain Institute, KU Leuven, Leuven, Belgium","VIB \u2010 KU Leuven Center for Brain & Disease Research, Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Switch Laboratory, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB \u2010 KU Leuven Center for Brain & Disease Research, Leuven Belgium","institution_ids":["https://openalex.org/I4210153928","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031589452","display_name":"Joost W. H. Schymkowitz","orcid":"https://orcid.org/0000-0003-2020-0168","observed_orcids":["https://orcid.org/0000-0003-2020-0168"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Joost Schymkowitz","raw_affiliation_strings":["Switch Laboratory, Leuven Brain Institute, KU Leuven, Leuven, Belgium","VIB \u2010 KU Leuven Center for Brain & Disease Research, Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Switch Laboratory, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB \u2010 KU Leuven Center for Brain & Disease Research, Leuven Belgium","institution_ids":["https://openalex.org/I4210153928","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073952660","display_name":"Mathieu Vandenbulcke","orcid":"https://orcid.org/0000-0001-9765-1499","observed_orcids":["https://orcid.org/0000-0001-9765-1499"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mathieu Vandenbulcke","raw_affiliation_strings":["Neuropsychiatry unit, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropsychiatry unit, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067308891","display_name":"Wim Vandenberghe","orcid":"https://orcid.org/0000-0002-9758-5062","observed_orcids":["https://orcid.org/0000-0002-9758-5062"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Wim Vandenberghe","raw_affiliation_strings":["Laboratory for Parkinson Research, Leuven Brain Institute, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Parkinson Research, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071341444","display_name":"Rik R. Vandenberghe","orcid":"https://orcid.org/0000-0001-6237-2502","observed_orcids":["https://orcid.org/0000-0001-6237-2502"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rik Vandenberghe","raw_affiliation_strings":["Laboratory for Parkinson Research, Leuven Brain Institute, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Parkinson Research, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021772353","display_name":"Bart De Strooper","orcid":"https://orcid.org/0000-0001-5455-5819","observed_orcids":["https://orcid.org/0000-0001-5455-5819"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bart De Strooper","raw_affiliation_strings":["Laboratory for the Research of Neurodegenerative Diseases, Leuven Brain Institute, KU Leuven, Leuven, Belgium","VIB \u2010 KU Leuven Center for Brain & Disease Research, Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for the Research of Neurodegenerative Diseases, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB \u2010 KU Leuven Center for Brain & Disease Research, Leuven Belgium","institution_ids":["https://openalex.org/I4210153928","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048548400","display_name":"Murali Jayapala","orcid":"https://orcid.org/0000-0001-7917-0149","observed_orcids":["https://orcid.org/0000-0001-7917-0149"]},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Murali Jayapala","raw_affiliation_strings":["Interuniversity Microelectronics Center, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interuniversity Microelectronics Center, Leuven, Belgium","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077783791","display_name":"Matthew B. Blaschko","orcid":"https://orcid.org/0000-0002-2640-181X","observed_orcids":["https://orcid.org/0000-0002-2640-181X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Matthew Blaschko","raw_affiliation_strings":["Center for Processing Speech & Images, KU Leuven, Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Processing Speech & Images, KU Leuven, Leuven Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088679649","display_name":"Lieve Moons","orcid":"https://orcid.org/0000-0003-0186-1411","observed_orcids":["https://orcid.org/0000-0003-0186-1411"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lieve Moons","raw_affiliation_strings":["Research Group Neural Circuit Development and Regeneration, Leuven Brain Institute, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Neural Circuit Development and Regeneration, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043917421","display_name":"Ingeborg Stalmans","orcid":"https://orcid.org/0000-0001-7507-4512","observed_orcids":["https://orcid.org/0000-0001-7507-4512"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ingeborg Stalmans","raw_affiliation_strings":["Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","University Hospital Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Ophthalmology, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University Hospital Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056802160","display_name":"Lies De Groef","orcid":"https://orcid.org/0000-0002-3329-3474","observed_orcids":["https://orcid.org/0000-0002-3329-3474"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lies De Groef","raw_affiliation_strings":["Cellular Communication and Neurodegeneration Research Group, Leuven Brain Institute, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Communication and Neurodegeneration Research Group, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070344391"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27864362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.23010000586509705,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.18029999732971191,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7520835399627686},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6809300184249878},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6532027125358582},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6090051531791687},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5310768485069275},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4960108697414398},{"id":"https://openalex.org/C159078339","wikidata":"https://www.wikidata.org/wiki/Q959005","display_name":"Hyperspectral imaging","level":2,"score":0.4942333996295929},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.48319995403289795},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4666846692562103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4282693564891815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35271263122558594},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3495752513408661},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22451189160346985},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13972344994544983},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.10387280583381653},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.076181","doi":"https://doi.org/10.1002/alz.076181","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.076181","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076181","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.076181","doi":"https://doi.org/10.1002/alz.076181","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.076181","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076181","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390200213.pdf","grobid_xml":"https://content.openalex.org/works/W4390200213.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2973454555","https://openalex.org/W2979889813","https://openalex.org/W4406595857","https://openalex.org/W4206487743","https://openalex.org/W2897371018","https://openalex.org/W4390194888","https://openalex.org/W4401455065","https://openalex.org/W7221103721","https://openalex.org/W4390192228","https://openalex.org/W4406210962"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Alzheimer\u2019s":[2],"disease":[3],"(AD)":[4],"is":[5,10,304],"a":[6,98,113,165,208,233],"neurodegenerative":[7,186],"disorder":[8],"that":[9,53,116,242],"the":[11,24,35,40,44,49,56,88,127,143,150,198,214,224,288,296],"leading":[12],"cause":[13],"of":[14,39,48,90,126,149,153,175,185,204,227,290,295,301],"dementia,":[15],"affecting":[16],"more":[17],"than":[18],"50":[19],"million":[20],"people":[21],"worldwide.":[22],"In":[23,82,136,207],"search":[25],"for":[26,77,101,306],"new":[27],"biomarkers,":[28],"increasing":[29],"attention":[30],"has":[31],"been":[32],"dedicated":[33],"to":[34,119,130,141,196,247,286],"retina.":[36],"As":[37],"part":[38],"central":[41],"nervous":[42],"system,":[43],"retina":[45],"manifests":[46],"many":[47],"characteristic":[50],"pathological":[51,202],"processes":[52],"occur":[54],"in":[55,91,133,164,251,269],"AD":[57,78,160,252,263,313],"brain.":[58],"Moreover,":[59],"it":[60,73,157],"can":[61,158,229,244],"be":[62,75,230,245],"imaged":[63],"at":[64,68,109],"low\u2010cost":[65],"and":[66,71,80,147,155,168,179,182,188,201,219,221,255,265,298],"non\u2010invasively":[67],"high":[69],"resolution,":[70],"therefore":[72],"may":[74],"used":[76,246],"diagnosis":[79],"monitoring.":[81],"this":[83,106,137],"context,":[84],"emerging":[85],"evidence":[86,294],"suggests":[87],"potential":[89,99],"vivo":[92],"hyperspectral":[93],"retinal":[94,249],"imaging":[95,235,314],"(HSRI)":[96],"as":[97,112,258,260,311],"biomarker":[100,115],"brain":[102],"amyloid\u2010\u03b2":[103],"accumulation.":[104],"Therefore,":[105],"project":[107],"aims":[108],"studying":[110],"HSRI":[111,151,174,205,220,228,243,302],"novel":[114],"could":[117],"lead":[118],"inexpensive":[120],"population":[121],"screening,":[122],"thereby":[123],"removing":[124],"one":[125],"principal":[128],"bottlenecks":[129],"therapeutic":[131],"advances":[132],"AD.":[134,291],"Method":[135],"study,":[138,211],"we":[139,212],"seek":[140],"define":[142],"molecular":[144,193,199,299],"basis,":[145],"sensitivity,":[146],"specificity":[148,297],"signal":[152],"AD,":[154],"whether":[156,223],"distinguish":[159],"from":[161],"other":[162],"dementias":[163],"translational":[166],"pre\u2010clinical":[167],"clinical":[169,210,309],"research":[170,281],"project.":[171],"We":[172],"perform":[173],"synthetic":[176],"protein":[177],"aggregates,":[178],"different":[180],"cell":[181],"mouse":[183],"models":[184,254],"proteinopathies,":[187],"correlate":[189],"these":[190],"data":[191],"with":[192,267],"biology":[194],"assays,":[195],"study":[197,282],"basis":[200,300],"correlates":[203],"signals.":[206],"parallel":[209],"assess":[213],"correlation":[215],"between":[216,262],"amyloid":[217,250],"status":[218],"evaluate":[222],"diagnostic":[225],"power":[226],"increased":[231],"via":[232],"multimodal":[234],"approach.":[236],"Result":[237],"Our":[238],"preliminary":[239],"results":[240],"demonstrate":[241],"quantify":[248],"animal":[253],"post\u2010mortem":[256],"tissues":[257],"well":[259],"discriminate":[261],"patients":[264],"controls,":[266],"improvement":[268],"classification":[270],"accuracy":[271],"by":[272],"including":[273],"optical":[274],"coherence":[275],"tomography":[276],"(OCT)":[277],"data.":[278],"Conclusion":[279],"This":[280],"covers":[283],"out\u2010of\u2010the\u2010box":[284],"thinking":[285],"transform":[287],"detection":[289],"It":[292],"collects":[293],"which":[303],"essential":[305],"its":[307],"rational":[308],"use":[310],"an":[312],"biomarker.":[315]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}