{"id":"https://openalex.org/W4390199375","doi":"https://doi.org/10.1002/alz.077343","title":"Deep trans\u2010omic network fusion for altered functional interactions underlying Alzheimer\u2019s Disease","display_name":"Deep trans\u2010omic network fusion for altered functional interactions underlying Alzheimer\u2019s Disease","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390199375","doi":"https://doi.org/10.1002/alz.077343"},"language":"en","primary_location":{"id":"doi:10.1002/alz.077343","doi":"https://doi.org/10.1002/alz.077343","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.077343","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077343","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077343","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059654671","display_name":"Linhui Xie","orcid":"https://orcid.org/0000-0003-1238-8789","observed_orcids":["https://orcid.org/0000-0003-1238-8789"]},"institutions":[{"id":"https://openalex.org/I4388446363","display_name":"Purdue University in Indianapolis","ror":"https://ror.org/0482ksk80","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219","https://openalex.org/I4388446363"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Linhui Xie","raw_affiliation_strings":["Indiana Alzheimer\u2019s Disease Research Center, Indianapolis, IN  USA","Indiana University School of Medicine, Indianapolis, IN, USA","Purdue School of Engineering and Technology, IUPUI, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Alzheimer\u2019s Disease Research Center, Indianapolis, IN  USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Purdue School of Engineering and Technology, IUPUI, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446363","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015187043","display_name":"Yash Raj","orcid":"https://orcid.org/0009-0005-2862-7192","observed_orcids":["https://orcid.org/0009-0005-2862-7192"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yash Raj","raw_affiliation_strings":["Indiana University School of Informatics and Computing, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Informatics and Computing, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063705349","display_name":"Pradeep Varathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeep Varathan","raw_affiliation_strings":["Indiana University School of Informatics and Computing, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Informatics and Computing, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100654854","display_name":"Bing He","orcid":"https://orcid.org/0000-0003-1719-9290","observed_orcids":["https://orcid.org/0000-0003-1719-9290","https://orcid.org/0000-0002-8797-7919"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing He","raw_affiliation_strings":["Indiana University School of Informatics and Computing, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Informatics and Computing, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087302585","display_name":"Kwangsik T. Nho","orcid":"https://orcid.org/0000-0002-7624-3872","observed_orcids":["https://orcid.org/0000-0002-7624-3872"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwangsik Nho","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","Indiana Alzheimer\u2019s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN  USA","Indiana Alzheimer\u2019s Disease Research Center, Indianapolis, IN USA","Indiana University School of Medicine, Indianapolis, IN  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer\u2019s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN  USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer\u2019s Disease Research Center, Indianapolis, IN USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN  USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026393791","display_name":"Paul Salama","orcid":"https://orcid.org/0000-0002-7643-3879","observed_orcids":["https://orcid.org/0000-0002-7643-3879"]},"institutions":[{"id":"https://openalex.org/I4388446363","display_name":"Purdue University in Indianapolis","ror":"https://ror.org/0482ksk80","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219","https://openalex.org/I4388446363"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Salama","raw_affiliation_strings":["Purdue School of Engineering and Technology, IUPUI, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue School of Engineering and Technology, IUPUI, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446363","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257338","display_name":"Andrew J. Saykin","orcid":"https://orcid.org/0000-0002-1376-8532","observed_orcids":["https://orcid.org/0000-0002-1376-8532"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Saykin","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN USA","Indiana Alzheimer\u2019s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN  USA","Indiana University School of Medicine, Indianapolis, IN  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer\u2019s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN  USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN  USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103218500","display_name":"Jingwen Yan","orcid":"https://orcid.org/0000-0001-9066-4908","observed_orcids":["https://orcid.org/0000-0001-9066-4908"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingwen Yan","raw_affiliation_strings":["Indiana Alzheimer\u2019s Disease Research Center, Indianapolis, IN  USA","Indiana University School of Informatics and Computing, Indianapolis, IN, USA","Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Alzheimer\u2019s Disease Research Center, Indianapolis, IN  USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University School of Informatics and Computing, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059654671"],"corresponding_institution_ids":["https://openalex.org/I4388446363","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13520782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.065700002014637,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5813443660736084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5500902533531189},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5275580286979675},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.46004676818847656},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.4555377662181854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4495689272880554},{"id":"https://openalex.org/C2780186347","wikidata":"https://www.wikidata.org/wiki/Q11414","display_name":"Subnetwork","level":2,"score":0.44506263732910156},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3305216431617737},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3221968412399292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31514063477516174},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20571815967559814},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20484456419944763},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.16722595691680908},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.08412826061248779},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.077343","doi":"https://doi.org/10.1002/alz.077343","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.077343","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077343","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.077343","doi":"https://doi.org/10.1002/alz.077343","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.077343","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077343","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390199375.pdf","grobid_xml":"https://content.openalex.org/works/W4390199375.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225416287","https://openalex.org/W4396792959","https://openalex.org/W6908033484","https://openalex.org/W4380883362","https://openalex.org/W3163309874","https://openalex.org/W4413276642","https://openalex.org/W4205730889","https://openalex.org/W4214519652","https://openalex.org/W3112837772","https://openalex.org/W2962052403"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Multi\u2010omic":[2],"data":[3,36,65,90,190],"like":[4],"genotype,":[5,58],"gene":[6,60,172],"expression":[7,10,64,252,293],"and":[8,22,42,47,62,75,143,173,211,248,259,306,311,333],"protein":[9,63],"have":[11],"been":[12],"increasingly":[13],"explored":[14],"in":[15,95,160,245,274,300,314,331,342],"post\u2010GWAS":[16],"era":[17],"to":[18,23,111,127,171,203,242,262,286,309,338],"interpret":[19],"GWAS":[20,57],"findings":[21,271],"gain":[24],"more":[25,257],"insight":[26],"of":[27,69,78,117,131,141,158,208,224,231,236,269,294,318],"the":[28,114,156,166,221,225,326,343],"Alzheimer\u2019s":[29],"disease":[30],"(AD)":[31],"mechanism.":[32],"However,":[33],"each":[34],"\u2010omics":[35],"type":[37],"is":[38],"usually":[39],"examined":[40],"individually":[41],"identified":[43,238,281,320],"genetic":[44],"variations,":[45],"genes":[46,258],"proteins":[48,260],"are":[49,138,240,283],"not":[50],"necessarily":[51],"functionally":[52],"related.":[53],"Method":[54],"We":[55,98],"used":[56],"RNA\u2010Seq":[59],"expression,":[61],"from":[66,108,134,169,191],"133":[67],"subjects":[68,77],"ROS/MAP":[70,121,192],"Project":[71],"for":[72,84],"original":[73],"study":[74],"121":[76],"Mount":[79],"Sinai":[80],"Brain":[81],"Bank":[82],"(MSBB)":[83],"replication":[85],"(Fig.":[86,123,215,265],"1a).":[87],"The":[88,176],"multi\u2010omic":[89,146,189,200],"pre\u2010processing":[91],"steps":[92],"were":[93,272],"shown":[94],"Fig.":[96],"1b.":[97],"proposed":[99,177],"a":[100,129,161],"new":[101],"interpretable":[102],"deep":[103],"neural":[104],"network":[105,152],"MoFNet,":[106],"extended":[107],"Varmole":[109],"[1],":[110],"jointly":[112],"model":[113,178],"prior":[115,135,149],"knowledge":[116,136],"functional":[118,132,150,263],"interactions":[119,133],"using":[120,188],"cohort":[122,193,277],"1c).":[124],"It":[125,196],"aimed":[126],"identify":[128],"subnetwork":[130,218],"that":[137,163],"both":[139],"predictive":[140],"AD":[142,340],"evidenced":[144],"by":[145],"data.":[147],"Particularly,":[148],"interaction":[151],"was":[153],"embedded":[154],"into":[155],"architecture":[157],"MoFNet":[159,179,255],"way":[162],"it":[164],"resembles":[165],"information":[167],"flow":[168],"DNA":[170],"protein.":[174],"Result":[175],"significantly":[180],"outperformed":[181],"all":[182,220],"other":[183],"state\u2010of\u2010art":[184],"classifiers":[185],"when":[186],"evaluated":[187],"(Table":[194],"1).":[195],"yielded":[197],"three":[198],"major":[199,222],"sub\u2010networks":[201],"related":[202,241,285],"innate":[204],"immune":[205],"system,":[206],"clearance":[207],"mis\u2010folded":[209],"proteins,":[210],"neurotransmitter":[212],"release":[213],"respectively":[214],"2a).":[216],"One":[217],"includes":[219],"members":[223],"SNARE":[226],"complex,":[227],"an":[228],"essential":[229],"mediator":[230],"synaptic":[232,243,287,329],"vesicle":[233,288],"fusion.":[234],"Majority":[235],"our":[237],"genes/proteins":[239,296,321],"activities":[244],"neuronal,":[246],"astrocyte":[247],"microglial":[249],"cells.":[250],"Differential":[251],"analysis":[253],"show":[254],"returned":[256],"due":[261],"connections":[264],"2b).":[266],"Around":[267],"50%":[268],"these":[270,295,319],"replicated":[273],"another":[275],"independent":[276],"(MSBB).":[278],"Conclusion":[279],"Our":[280],"gene/proteins":[282],"highly":[284],"function.":[289],"Altered":[290],"regulation":[291],"or":[292,302],"could":[297,322],"cause":[298],"disruption":[299],"neuron\u2010neuron":[301],"neuron\u2010glia":[303],"cross":[304],"talk":[305],"further":[307],"lead":[308],"neuronal":[310],"synapse":[312],"loss":[313],"AD.":[315],"Further":[316],"investigation":[317],"possibly":[323],"help":[324],"decipher":[325],"mechanisms":[327],"underlying":[328],"dysfunction":[330],"AD,":[332],"ultimately":[334],"inform":[335],"therapeutic":[336],"strategies":[337],"modify":[339],"progression":[341],"early":[344],"stage.":[345],"[1]":[346],"Nguyen":[347],"et":[348],"al.,":[349],"Bioinformatics,":[350],"2021.":[351]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}