{"id":"https://openalex.org/W4390199285","doi":"https://doi.org/10.1002/alz.080582","title":"Alzheimer\u2019s disease induces pathological changes in the lungs of humans and the AppNL\u2010G\u2010F mouse model","display_name":"Alzheimer\u2019s disease induces pathological changes in the lungs of humans and the AppNL\u2010G\u2010F mouse model","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390199285","doi":"https://doi.org/10.1002/alz.080582"},"language":"en","primary_location":{"id":"doi:10.1002/alz.080582","doi":"https://doi.org/10.1002/alz.080582","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.080582","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.080582","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.080582","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073294913","display_name":"Bijayani Sahu","orcid":"https://orcid.org/0000-0002-3473-4024","observed_orcids":["https://orcid.org/0000-0002-3473-4024"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bijayani Sahu","raw_affiliation_strings":["University of North Dakota, Grand Forks, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Dakota, Grand Forks, ND, USA","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063859243","display_name":"Suba Nookala","orcid":"https://orcid.org/0000-0002-4632-265X","observed_orcids":["https://orcid.org/0000-0002-4632-265X"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suba Nookala","raw_affiliation_strings":["University of North Dakota, Grand Forks, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Dakota, Grand Forks, ND, USA","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043778889","display_name":"Angela Marie Floden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela M Floden","raw_affiliation_strings":["University of North Dakota, Grand Forks, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Dakota, Grand Forks, ND, USA","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005767279","display_name":"Nilesh Sudhakar Ambhore","orcid":"https://orcid.org/0000-0002-9293-6062","observed_orcids":["https://orcid.org/0000-0002-9293-6062"]},"institutions":[{"id":"https://openalex.org/I57328836","display_name":"North Dakota State University","ror":"https://ror.org/05h1bnb22","country_code":"US","type":"education","lineage":["https://openalex.org/I57328836"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilesh Ambhore","raw_affiliation_strings":["North Dakota State University, Fargo, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Dakota State University, Fargo, ND, USA","institution_ids":["https://openalex.org/I57328836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029451309","display_name":"Venkatachalem Sathish","orcid":"https://orcid.org/0000-0001-9770-8299","observed_orcids":["https://orcid.org/0000-0001-9770-8299"]},"institutions":[{"id":"https://openalex.org/I57328836","display_name":"North Dakota State University","ror":"https://ror.org/05h1bnb22","country_code":"US","type":"education","lineage":["https://openalex.org/I57328836"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sathish Venkatachalem","raw_affiliation_strings":["North Dakota State University, Fargo, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Dakota State University, Fargo, ND, USA","institution_ids":["https://openalex.org/I57328836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086869525","display_name":"Colin Kelly Combs","orcid":"https://orcid.org/0000-0001-8671-5880","observed_orcids":["https://orcid.org/0000-0001-8671-5880"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin K Combs","raw_affiliation_strings":["University of North Dakota, Grand Forks, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Dakota, Grand Forks, ND, USA","institution_ids":["https://openalex.org/I24571045"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073294913"],"corresponding_institution_ids":["https://openalex.org/I24571045"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2568486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S13","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pulmonary-dysfunction","display_name":"pulmonary dysfunction","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.6811779737472534},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.674608588218689},{"id":"https://openalex.org/C163031210","wikidata":"https://www.wikidata.org/wiki/Q3325848","display_name":"Masson's trichrome stain","level":3,"score":0.6257081627845764},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5317047238349915},{"id":"https://openalex.org/C59469219","wikidata":"https://www.wikidata.org/wiki/Q7841079","display_name":"Trichrome","level":4,"score":0.5246465802192688},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5152947902679443},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.5086251497268677},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4966796040534973},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.4582916498184204},{"id":"https://openalex.org/C2777802486","wikidata":"https://www.wikidata.org/wiki/Q491741","display_name":"Neutrophilia","level":2,"score":0.43771225214004517},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.42656606435775757},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41147202253341675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3928059935569763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38867083191871643},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.3757966160774231},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3396686613559723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3187781572341919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17474117875099182},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.144191712141037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.080582","doi":"https://doi.org/10.1002/alz.080582","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.080582","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.080582","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.080582","doi":"https://doi.org/10.1002/alz.080582","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.080582","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.080582","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390199285.pdf","grobid_xml":"https://content.openalex.org/works/W4390199285.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4380880383","https://openalex.org/W4253092337","https://openalex.org/W3108652697","https://openalex.org/W4401074252","https://openalex.org/W4406049984","https://openalex.org/W4406345401","https://openalex.org/W4415274371","https://openalex.org/W3007343519","https://openalex.org/W4312086541","https://openalex.org/W7118001066"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Alzheimer\u2019s":[2],"disease":[3],"(AD)":[4],"is":[5,34],"an":[6],"age\u2010related":[7],"neurodegenerative":[8],"disorder":[9],"characterized":[10],"by":[11,109,182],"brain":[12,38,327],"accumulation":[13],"of":[14,44,241,308,320],"amyloid":[15],"beta":[16],"(A\u03b2)":[17],"plaques,":[18],"neurofibrillary":[19],"tangles,":[20],"neuron":[21],"death,":[22],"robust":[23],"gliosis,":[24],"and":[25,69,79,84,92,97,112,121,124,131,135,139,148,151,155,163,175,177,184,188,209,212,234,256,264,274,281,284,313,323],"neuroinflammation,":[26],"affecting":[27],"around":[28],"35":[29],"million":[30],"individuals":[31],"worldwide.":[32],"It":[33],"well":[35],"known":[36],"that":[37],"immune":[39,48,60,106],"changes":[40,61,292,304,328],"are":[41,72,293],"a":[42,331],"component":[43],"the":[45,75,113,195,306,314],"disease,":[46],"but":[47,199],"dysfunction":[49,68,322],"in":[50,62,215,226,296,305],"secondary":[51],"organs":[52],"has":[53],"also":[54,204,260,294],"been":[55],"reported.":[56],"To":[57],"assess":[58],"peripheral":[59],"AD,":[63],"we":[64],"asked":[65],"whether":[66],"lung":[67,144,268,291,321],"inflammatory":[70],"change":[71],"present":[73,295],"during":[74],"disease.":[76,298,336],"Method":[77],"Male":[78],"female":[80,257,275],"C57BL/6":[81],"wild":[82],"type":[83],"AppNL\u2010G\u2010F":[85,149,202,235,242,258,315],"mice":[86,150,168,203,243,259],"(8\u20109":[87],"months":[88],"old)":[89],"were":[90,99,129,158,223],"sacrificed,":[91],"broncho\u2010alveolar":[93],"lavage":[94],"fluid":[95],"(BALF)":[96],"lungs":[98,237,276,307],"collected.":[100],"BALF":[101,114,217,227,252],"was":[102,116],"used":[103,117],"to":[104,118,194,219,288,326,335],"quantify":[105],"cell":[107,208],"phenotype":[108],"flow":[110],"cytometry,":[111],"supernatant":[115,228,253],"determine":[119],"A\u03b2":[120,162,285],"cytokine":[122],"concentrations":[123],"total":[125,229],"protein":[126,230],"content.":[127],"Lungs":[128],"sectioned":[130],"stained":[132],"with":[133,267],"hematoxylin":[134,183],"eosin,":[136,185],"Alcian":[137,186],"blue":[138,187],"Masson\u2019s":[140,189],"trichrome.":[141],"In":[142],"addition,":[143],"sections":[145],"from":[146,238,254],"wild\u2010type":[147,196,233],"human":[152,297,310],"AD":[153,167,272,311],"patient":[154],"healthy":[156],"controls":[157,289],"immunostained":[159],"for":[160],"APP,":[161],"claudin":[164],"4.":[165],"Result":[166],"showed":[169],"significantly":[170],"increased":[171,282],"pulmonary":[172],"airway":[173],"thickening":[174],"mucus":[176],"collagen":[178],"production":[179],"as":[180],"indicated":[181],"trichrome":[190],"staining,":[191],"respectively,":[192],"compared":[193,218,287],"controls.":[197,220],"Female":[198],"not":[200],"male":[201,255,273],"demonstrated":[205],"reduced":[206,278],"B":[207],"neutrophil":[210],"numbers":[211],"elevated":[213],"IL\u20101\u03b2":[214],"their":[216],"Although":[221],"there":[222],"no":[224],"differences":[225],"content":[231],"between":[232],"mice,":[236],"both":[239,309],"sexes":[240],"had":[244,277],"decreased":[245],"claudin\u20104":[246,279],"immunoreactivity":[247,280],"suggesting":[248],"altered":[249],"epithelial":[250],"permeability.":[251],"contained":[261],"soluble":[262],"A\u03b21\u201040":[263],"A\u03b21\u201042":[265],"correlating":[266],"APP":[269,283],"immunoreactivity.":[270],"Human":[271],"staining":[286],"verifying":[290],"Conclusion":[299],"These":[300],"data":[301],"demonstrate":[302],"disease\u2010associated":[303],"patients":[312],"mouse":[316],"model.":[317],"Further":[318],"characterization":[319],"its":[324],"contribution":[325,334],"may":[329],"define":[330],"novel":[332],"lung\u2010to\u2010brain":[333]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}
