{"id":"https://openalex.org/W4390198993","doi":"https://doi.org/10.1002/alz.076725","title":"Assessing patterns of network degeneration in familial frontotemporal lobar degeneration using FDG\u2010PET and unsupervised machine learning","display_name":"Assessing patterns of network degeneration in familial frontotemporal lobar degeneration using FDG\u2010PET and unsupervised machine learning","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390198993","doi":"https://doi.org/10.1002/alz.076725"},"language":"en","primary_location":{"id":"doi:10.1002/alz.076725","doi":"https://doi.org/10.1002/alz.076725","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.076725","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076725","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076725","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021123996","display_name":"Nick Corriveau\u2010Lecavalier","orcid":"https://orcid.org/0000-0002-6561-9870","observed_orcids":["https://orcid.org/0000-0002-6561-9870"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nick Corriveau\u2010Lecavalier","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069272448","display_name":"Leland R Barnard","orcid":"https://orcid.org/0000-0003-1569-9312","observed_orcids":["https://orcid.org/0000-0003-1569-9312"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leland R Barnard","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026250910","display_name":"Scott A. Przybelski","orcid":"https://orcid.org/0009-0009-3437-3773","observed_orcids":["https://orcid.org/0009-0009-3437-3773"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Przybelski","raw_affiliation_strings":["Mayo Clinic, Quantitative Health Sciences, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Quantitative Health Sciences, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111098744","display_name":"Venkatsampath Gogineni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkatsampath Gogineni","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046855704","display_name":"Hugo Botha","orcid":"https://orcid.org/0000-0003-4390-685X","observed_orcids":["https://orcid.org/0000-0003-4390-685X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugo Botha","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110294368","display_name":"Jonathan Graff Radford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Graff Radford","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028946052","display_name":"Vijay K. Ramanan","orcid":"https://orcid.org/0000-0001-6591-8734","observed_orcids":["https://orcid.org/0000-0001-6591-8734"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay K Ramanan","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075932767","display_name":"Leah K. Forsberg","orcid":"https://orcid.org/0000-0003-4086-9598","observed_orcids":["https://orcid.org/0000-0003-4086-9598"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah K. Forsberg","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462803","display_name":"Julie A. Fields","orcid":"https://orcid.org/0000-0002-1282-9866","observed_orcids":["https://orcid.org/0000-0002-1282-9866"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Fields","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048408999","display_name":"Rosa Rademakers","orcid":"https://orcid.org/0000-0002-4049-0863","observed_orcids":["https://orcid.org/0000-0002-4049-0863"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]},{"id":"https://openalex.org/I4210132484","display_name":"VIB-UAntwerp Center for Molecular Neurology","ror":"https://ror.org/041x7eh14","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149213910","https://openalex.org/I2802017950","https://openalex.org/I4210132484"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rosa Rademakers","raw_affiliation_strings":["VIB-UAntwerp Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VIB-UAntwerp Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910","https://openalex.org/I4210132484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087352076","display_name":"Ralitza H. Gavrilova","orcid":"https://orcid.org/0000-0002-4942-6358","observed_orcids":["https://orcid.org/0000-0002-4942-6358"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralitza H. Gavrilova","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035419441","display_name":"Maria I. Lapid","orcid":"https://orcid.org/0000-0002-1163-5584","observed_orcids":["https://orcid.org/0000-0002-1163-5584"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria I. Lapid","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066352714","display_name":"Bradley F. Boeve","orcid":"https://orcid.org/0000-0002-4153-8187","observed_orcids":["https://orcid.org/0000-0002-4153-8187"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad F. Boeve","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027860","display_name":"David S. Knopman","orcid":"https://orcid.org/0000-0002-6544-066X","observed_orcids":["https://orcid.org/0000-0002-6544-066X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Knopman","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001313680","display_name":"Val J. Lowe","orcid":"https://orcid.org/0000-0002-5612-1667","observed_orcids":["https://orcid.org/0000-0002-5612-1667"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val J. Lowe","raw_affiliation_strings":["Mayo Clinic, Radiology, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Radiology, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110342810","display_name":"Ronald Carl Petersen","orcid":"https://orcid.org/0000-0002-8178-6601","observed_orcids":["https://orcid.org/0000-0002-8178-6601"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C. Petersen","raw_affiliation_strings":["Department of Neurology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford R. Jack","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077933873","display_name":"Kejal Kantarci","orcid":"https://orcid.org/0000-0002-8001-2081","observed_orcids":["https://orcid.org/0000-0002-8001-2081"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kejal Kantarci","raw_affiliation_strings":["Mayo Clinic, Radiology, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Radiology, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063489595","display_name":"David Thomas Jones","orcid":"https://orcid.org/0000-0002-4807-9833","observed_orcids":["https://orcid.org/0000-0002-4807-9833"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Jones","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021123996"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27245679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.1331000030040741,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-frontotemporal-lobar-degeneration","display_name":"familial frontotemporal lobar degeneration","score":0.996999979019165},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.751914918422699},{"id":"https://openalex.org/C2777415128","wikidata":"https://www.wikidata.org/wiki/Q419849","display_name":"Fluorodeoxyglucose","level":3,"score":0.6264873147010803},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5371623039245605},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5212376713752747},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4813183546066284},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.4812728762626648},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4537707269191742},{"id":"https://openalex.org/C2777898937","wikidata":"https://www.wikidata.org/wiki/Q5008447","display_name":"C9orf72","level":5,"score":0.4219890832901001},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3953924775123596},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39088720083236694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36525678634643555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32757484912872314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24881020188331604},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1636735200881958},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.13244956731796265},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.1232312023639679},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08465701341629028}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.076725","doi":"https://doi.org/10.1002/alz.076725","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.076725","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076725","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.076725","doi":"https://doi.org/10.1002/alz.076725","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.076725","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076725","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390198993.pdf","grobid_xml":"https://content.openalex.org/works/W4390198993.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390102297","https://openalex.org/W4312038467","https://openalex.org/W2897967274","https://openalex.org/W2997261605","https://openalex.org/W4291916411","https://openalex.org/W1974801876","https://openalex.org/W3036116009","https://openalex.org/W3030923756","https://openalex.org/W3191164633","https://openalex.org/W98994697"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Genetic":[2],"mutations":[3,49,205],"causative":[4],"of":[5,14,40,44,62,133,136,140,164,181,191,224,263,285,289,315,326,332,351],"familial":[6],"fronto\u2010temporal":[7],"lobar":[8],"degeneration":[9,42,291],"(f\u2010FTLD)":[10],"are":[11],"highly":[12],"predictive":[13],"a":[15,87,93,99,111,120,134,236,282],"specific":[16,46],"proteinopathy,":[17],"but":[18],"there":[19],"exists":[20],"substantial":[21],"inter\u2010individual":[22],"variability":[23],"in":[24,194,227,267,287,353],"their":[25],"system\u2010level":[26,303],"pathophysiology,":[27],"which":[28,178],"can":[29],"be":[30],"assessed":[31],"with":[32,74,86,92,212,235,243,306,318],"18Fluorodeoxyglucose\u2010positron":[33],"emission":[34],"tomography":[35],"(FDG\u2010PET).":[36],"Determining":[37],"data\u2010driven":[38],"patterns":[39,131,288],"network":[41,290],"suggestive":[43],"underlying":[45],"FTLD\u2010related":[47,293,307],"genetic":[48,165,204,257,269,294],"is":[50],"paramount":[51],"to":[52,128,159,301,328,341,345],"guide":[53,329],"complex":[54],"clinical":[55,67,168,213,244,273,316,335],"decision":[56,336],"making":[57,337],"supported":[58],"by":[59],"the":[60,79,146,182,302,313,324,330],"quantification":[61],"FDG\u2010PET.":[63],"Method":[64],"We":[65,118,152],"collected":[66],"and":[68,108,143,167,209,231,249,265,271,310,338,349],"FDG\u2010PET":[69,126,185,327],"data":[70],"from":[71,202,255],"39":[72],"patients":[73],"f\u2010FTLD,":[75],"including":[76],"11":[77],"carrying":[78,98,110],"C9orf72":[80],"hexanucleotide":[81],"expansion":[82],"(1":[83,102],"asymptomatic,":[84,103,115],"9":[85],"predominant":[88,94,272],"behavioral":[89],"phenotype,":[90,274],"1":[91],"language":[95,217],"phenotype),":[96],"12":[97],"GRN":[100,199],"mutation":[101,113,166,200,253],"7":[104],"behavioral,":[105],"4":[106],"language),":[107],"16":[109],"MAPT":[112,252],"(6":[114],"10":[116],"behavioral).":[117],"performed":[119],"spectral":[121,172],"covariance":[122,183,286],"decomposition":[123,173],"analysis":[124,174],"between":[125,184],"images":[127,186],"yield":[129],"latent":[130],"reflective":[132],"distribution":[135],"metabolism":[137],"opposing":[138],"poles":[139],"relative":[141,192,225],"hyper\u2010":[142],"hypo\u2010metabolism":[144],"across":[145,292],"entire":[147],"brain":[148],"(\u201ceigenbrains\u201d":[149],"or":[150],"EBs).":[151],"then":[153],"conducted":[154],"linear":[155],"discriminant":[156],"analyses":[157],"(LDAs)":[158],"perform":[160],"EB\u2010based":[161],"multiclass":[162],"predictions":[163],"phenotype.":[169],"Result":[170],"The":[171,259],"yielded":[175,261],"five":[176],"eigenbrains,":[177],"explained":[179,281],"58.79%":[180],"(Fig.":[187,276],"1).":[188],"Gradients":[189],"indicative":[190,223],"hypometabolism":[193,226],"left":[195],"fronto\u2010temporo\u2010parietal":[196],"areas":[197,229,233],"distinguished":[198,251],"carriers":[201,254],"other":[203,256],"(EB1,":[206,218],"EB2,":[207,219],"EB4)":[208],"were":[210,240],"associated":[211,242,305],"phenotypes":[214,245],"predominantly":[215,246],"involving":[216,247],"EB3).":[220],"Conversely,":[221],"those":[222],"prefrontal":[228],"(EB3)":[230],"temporopolar":[232],"(EB2)":[234],"right":[237],"hemispheric":[238],"predominance":[239],"mostly":[241],"behavior/personality,":[248],"EB2":[250],"mutations.":[258,295],"LDAs":[260],"accuracies":[262],"80%":[264],"75%":[266],"predicting":[268],"status":[270],"respectively":[275],"2).":[277],"Conclusion":[278],"Five":[279],"EBs":[280,297],"high":[283,320],"proportion":[284],"These":[296],"contained":[298],"information":[299],"relevant":[300],"physiology":[304],"pathogenic":[308],"mechanisms":[309],"that":[311],"allowed":[312],"prediction":[314],"phenotype":[317],"relatively":[319],"accuracy.":[321],"This":[322],"supports":[323],"utility":[325],"development":[331],"tools":[333],"supporting":[334],"ongoing":[339],"efforts":[340],"develop":[342],"network\u2010based":[343],"biomarkers":[344],"track":[346],"disease":[347],"progression":[348],"risk":[350],"phenoconversion":[352],"f\u2010FTLD.":[354]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}