{"id":"https://openalex.org/W4390196271","doi":"https://doi.org/10.1002/alz.074291","title":"The AD/ADRD Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer\u2019s Disease and Related Dementias","display_name":"The AD/ADRD Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer\u2019s Disease and Related Dementias","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390196271","doi":"https://doi.org/10.1002/alz.074291"},"language":"en","primary_location":{"id":"doi:10.1002/alz.074291","doi":"https://doi.org/10.1002/alz.074291","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.074291","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074291","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074291","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019084646","display_name":"Rakez Kayed","orcid":"https://orcid.org/0000-0001-6216-8640","observed_orcids":["https://orcid.org/0000-0001-6216-8640","https://orcid.org/0000-0002-9422-4421"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rakez Kayed","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004840529","display_name":"Jeff Kuret","orcid":"https://orcid.org/0000-0002-8083-8406","observed_orcids":["https://orcid.org/0000-0002-8083-8406"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Kuret","raw_affiliation_strings":["The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031692016","display_name":"Christopher Dirk Keene","orcid":"https://orcid.org/0000-0002-5291-1469","observed_orcids":["https://orcid.org/0000-0002-5291-1469"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Dirk Keene","raw_affiliation_strings":["University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080439570","display_name":"David S Eisenberg","orcid":"https://orcid.org/0000-0003-2432-5419","observed_orcids":["https://orcid.org/0000-0003-2432-5419"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Eisenberg","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019084646"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24799771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6669999957084656},{"id":"https://openalex.org/keywords/tau-aggregates","display_name":"tau aggregates","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.948418378829956},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5053198933601379},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45776182413101196},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44847768545150757},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.44631844758987427},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4327761232852936},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4247095286846161},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3882392644882202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3714888393878937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2745242118835449},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.1740998923778534},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1365368366241455}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.074291","doi":"https://doi.org/10.1002/alz.074291","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.074291","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074291","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.074291","doi":"https://doi.org/10.1002/alz.074291","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.074291","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074291","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390196271.pdf","grobid_xml":"https://content.openalex.org/works/W4390196271.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1502779454","https://openalex.org/W4307643247","https://openalex.org/W4308970223","https://openalex.org/W2126892892","https://openalex.org/W2152889673","https://openalex.org/W2806336195","https://openalex.org/W4242313143","https://openalex.org/W2140050496","https://openalex.org/W2312794169","https://openalex.org/W2806489495"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Tauopathies,":[2,121],"including":[3,122],"Alzheimer\u2019s":[4,123],"disease":[5,63,124,182],"(AD),":[6,125],"are":[7,32,67,126,151,186,268],"characterized":[8,127],"by":[9,128],"intracellular":[10,129],"lesions":[11,130],"composed":[12,131],"of":[13,26,40,56,111,132,145,159,175,230,244,280,291,303,313],"aggregated":[14,133],"and":[15,23,65,82,88,101,105,134,142,184,201,207,220,224,246,256,263,278,300,311],"post\u2010translationally":[16,135],"modified":[17,136],"tau":[18,43,80,137,162,199,248,294,317],"proteins.":[19,138],"Methods":[20,139],"for":[21,38,140,157,241,273],"preparation":[22,39,141,158],"biochemical":[24,143],"characterization":[25,144],"stable":[27,146],"filaments":[28,81,147,200],"from":[29,84,148,203],"various":[30,149],"tauopathies":[31,150],"well":[33,152],"established.":[34,70,153,189],"In":[35,95,154,214],"contrast,":[36,155],"methods":[37,156,258],"soluble":[41,160],"oligomeric":[42,161,245],"aggregates":[44,163,249,295],"have":[45,164,250],"not":[46,68,165,187],"been":[47,166,251],"standardized":[48,167],"to":[49,76,91,99,115,168,195,210,218,234,259,275,308],"the":[50,54,92,112,169,173,211,231],"same":[51,170],"degree.":[52,171],"Additionally,":[53,172],"structures":[55,174],"oligomers":[57,83,176,202],"which":[58,177],"associate":[59,178],"most":[60,179],"closely":[61,180],"with":[62,181,254,297],"propagation":[64,183],"toxicity,":[66,185],"fully":[69,188],"The":[71,108,190,227,283],"AD/ADRD":[72,191,284],"Resource":[73,192,265],"Network":[74,193,266,286],"aims":[75,194],"isolate":[77,196],"structurally":[78,197,292],"vetted":[79,198,293],"human":[85,204],"tauopathy":[86,118,205,237],"cases":[87,206],"distribute":[89,102,208,221],"them":[90,209],"research":[93,212,315],"community.":[94,213],"addition,":[96,215],"it":[97,216],"seeks":[98,217],"bank":[100,219],"detection":[103,222],"reagents":[104,223,305],"associated":[106,225],"protocols.":[107,226],"overall":[109,228],"mission":[110,229],"network":[113,232],"is":[114,233,306],"support":[116,235],"impactful":[117,236],"research.":[119,238],"Method":[120],"Result":[239],"Protocols":[240],"simultaneous":[242],"isolation":[243],"filamentous":[247],"developed":[252],"along":[253,296],"analytical":[255,271],"quantitative":[257],"estimate":[260],"sample":[261],"heterogenicity":[262],"stability.":[264],"members":[267],"establishing":[269],"cross\u2010laboratory":[270],"benchmarks":[272],"experiments":[274],"ensure":[276],"rigor":[277,310],"reproducibility":[279,312],"results.":[281],"Conclusion":[282],"Research":[285],"banks":[287],"rigorously":[288],"validated":[289],"preparations":[290],"directed":[298],"protocols":[299],"reagents.":[301],"Dissemination":[302],"these":[304],"expected":[307],"maximize":[309],"basic":[314],"involving":[316],"protein":[318],"aggregates.":[319]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-12-26T00:00:00"}