{"id":"https://openalex.org/W4390192985","doi":"https://doi.org/10.1002/alz.073878","title":"A Phase 1 Clinical Trial of IL\u20102 in Patients with Alzheimer\u2019s Disease: A Regulatory T Cell Expansion Strategy Targeting Inflammation","display_name":"A Phase 1 Clinical Trial of IL\u20102 in Patients with Alzheimer\u2019s Disease: A Regulatory T Cell Expansion Strategy Targeting Inflammation","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390192985","doi":"https://doi.org/10.1002/alz.073878"},"language":"en","primary_location":{"id":"doi:10.1002/alz.073878","doi":"https://doi.org/10.1002/alz.073878","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.073878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.073878","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.073878","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068514644","display_name":"Alireza Faridar","orcid":"https://orcid.org/0000-0001-8238-3858","observed_orcids":["https://orcid.org/0000-0001-8238-3858"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alireza Faridar","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059393335","display_name":"Abdulmunaim M. Eid","orcid":"https://orcid.org/0000-0001-7194-6141","observed_orcids":["https://orcid.org/0000-0001-7194-6141"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdulmunaim M Eid","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050192609","display_name":"Aaron D. Thome","orcid":"https://orcid.org/0000-0002-1015-7111","observed_orcids":["https://orcid.org/0000-0002-1015-7111"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron D Thome","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694249","display_name":"Weihua Zhao","orcid":"https://orcid.org/0000-0002-5672-7132","observed_orcids":["https://orcid.org/0000-0002-5672-7132"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihua Zhao","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048445973","display_name":"David R. Beers","orcid":"https://orcid.org/0000-0002-8757-3500","observed_orcids":["https://orcid.org/0000-0002-8757-3500"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Beers","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026717714","display_name":"Bel\u00e9n Pascual","orcid":"https://orcid.org/0000-0002-4467-7406","observed_orcids":["https://orcid.org/0000-0002-4467-7406"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Belen Pascual","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090258526","display_name":"Mohammad Obadah Nakawah","orcid":"https://orcid.org/0000-0002-8100-0349","observed_orcids":["https://orcid.org/0000-0002-8100-0349"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad O Nakawah","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102930901","display_name":"Gustavo C. Rom\u00e1n","orcid":"https://orcid.org/0000-0002-5429-445X","observed_orcids":["https://orcid.org/0000-0002-5429-445X"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo C Roman","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111433605","display_name":"Charles S. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768063","display_name":"VMware (United States)","ror":"https://ror.org/01mwmh458","country_code":"US","type":"company","lineage":["https://openalex.org/I4391768063"]},{"id":"https://openalex.org/I4405264758","display_name":"Ohara Inc. (Japan)","ror":"https://ror.org/02wq2ma29","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264758"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Charles S. Davis","raw_affiliation_strings":["CSD Biostatistics, Inc., Oro Valley, AZ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSD Biostatistics, Inc., Oro Valley, AZ USA","institution_ids":["https://openalex.org/I4391768063","https://openalex.org/I4405264758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014646926","display_name":"Michael Grundman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Grundman","raw_affiliation_strings":["Global R&amp;D Partners, San Diego, CA USA","University of California, San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global R&amp;D Partners, San Diego, CA USA","institution_ids":[]},{"raw_affiliation_string":"University of California, San Diego, CA USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028700638","display_name":"Joseph C. Masdeu","orcid":"https://orcid.org/0000-0001-9955-6954","observed_orcids":["https://orcid.org/0000-0001-9955-6954"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Masdeu","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015630437","display_name":"Stanley H. Appel","orcid":"https://orcid.org/0000-0003-2747-6298","observed_orcids":["https://orcid.org/0000-0003-2747-6298"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley H Appel","raw_affiliation_strings":["Houston Methodist Research Institute, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Research Institute, Houston, TX USA","institution_ids":["https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25007006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.14550000429153442,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/interleukin-2-therapy","display_name":"interleukin-2 therapy","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7938959002494812},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7085325121879578},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5788304209709167},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5595065355300903},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5440101623535156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4753448963165283},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4711671769618988},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4636157155036926},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4574545919895172},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.44257038831710815},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.42889249324798584},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.41704750061035156},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37779462337493896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3387371301651001},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.31095731258392334},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13236409425735474},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.073878","doi":"https://doi.org/10.1002/alz.073878","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.073878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.073878","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.073878","doi":"https://doi.org/10.1002/alz.073878","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.073878","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.073878","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390192985.pdf","grobid_xml":"https://content.openalex.org/works/W4390192985.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7117239214","https://openalex.org/W2534117315","https://openalex.org/W4388670202","https://openalex.org/W4406225102","https://openalex.org/W3112015379","https://openalex.org/W2980532262","https://openalex.org/W2257167523","https://openalex.org/W4389466223","https://openalex.org/W4312087500","https://openalex.org/W3045308842"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Regulatory":[2],"T":[3,234],"cells":[4],"(Tregs)":[5],"play":[6],"a":[7,78,328,343],"neuroprotective":[8],"role":[9],"by":[10,95],"suppressing":[11],"inflammation.":[12],"We":[13],"previously":[14],"documented":[15],"that":[16],"Treg":[17,133,229,311],"immunomodulatory":[18],"mechanisms":[19],"are":[20,29],"compromised":[21],"in":[22,62,77,107,182,256,318],"people":[23],"with":[24,31,70],"Alzheimer\u2019s":[25],"disease":[26],"(AD)":[27],"and":[28,36,49,59,124,135,148,163,168,198,221,253,259,264,270,292,313,337],"associated":[30],"activation":[32],"of":[33,38,52,84,89,115,157,180,208,298,323,339],"peripheral":[34,310],"monocytes":[35,258],"upregulation":[37],"inflammatory":[39],"mediators.":[40],"In":[41],"this":[42,324],"original":[43],"study,":[44],"we":[45],"investigated":[46],"the":[47,154,177,202,226,242,282,293,335],"feasibility":[48,82],"potential":[50,344],"impact":[51],"low\u2010dose":[53,193,340],"IL\u20102":[54,85,117,146,194,217,244,248,307,341],"immunotherapy":[55,195,308],"on":[56,232,281],"restoring":[57],"Tregs":[58,210],"modifying":[60],"inflammation":[61],"an":[63,128],"AD":[64,72,319],"clinical":[65,186,330],"setting.":[66],"Method":[67],"Eight":[68],"patients":[69,200],"mild\u2010to\u2010moderate":[71],"dementia":[73],"(MMSE:12\u201025)":[74],"were":[75,125,138,173,279],"enrolled":[76],"phase":[79,246],"1,":[80],"open\u2010label,":[81],"study":[83,325,331],"treatment.":[86],"The":[87,206,321],"presence":[88],"elevated":[90],"brain":[91],"amyloid,":[92],"as":[93,204,342],"demonstrated":[94],"either":[96],"CSF":[97],"or":[98,185],"amyloid":[99],"positron":[100],"emission":[101],"tomography":[102],"(PET)":[103],"scan,":[104],"was":[105,196],"confirmed":[106],"all":[108,199],"participants.":[109],"Enrolled":[110],"individuals":[111],"received":[112,201],"monthly":[113],"five\u2010day\u2010courses":[114],"subcutaneous":[116],"(1":[118],"million":[119],"units/day)":[120],"for":[121,127,346],"four":[122],"months":[123,131],"followed":[126],"additional":[129],"two":[130,212],"post\u2010treatment.":[132],"immunophenotype":[134],"functional":[136],"analysis":[137],"obtained":[139],"serially":[140],"at":[141,165,188],"screening,":[142],"day":[143,149],"1":[144],"(before":[145],"treatment)":[147],"8":[150],"(three":[151],"days":[152],"after":[153,215],"fifth":[155],"dose)":[156],"each":[158,183,189,216],"treatment":[159,203,218,245,249,345],"cycle":[160,219],"during":[161],"therapy,":[162],"then":[164],"weeks":[166],"17":[167],"24.":[169],"Two\u2010sided":[170],"paired":[171],"t\u2010tests":[172],"used":[174],"to":[175,213,223,332],"assess":[176],"statistical":[178],"significance":[179],"changes":[181],"analyte":[184],"outcome":[187],"timepoint.":[190],"Result":[191],"Overall,":[192],"well\u2010tolerated":[197],"planned.":[205],"number":[207],"CD4+CD25highFoxP3+":[209],"increased":[211,240],"three\u2010fold":[214],"(p<0.01)":[220],"returned":[222],"baseline":[224],"before":[225],"next":[227],"cycle.":[228],"suppressive":[230],"function":[231,312],"responder":[233],"cell":[235],"(Tresp)":[236],"proliferation":[237],"also":[238],"progressively":[239],"through":[241],"four\u2010month":[243],"(p<0.01).":[247],"down\u2010regulated":[250],"IL\u20101\u03b2,":[251],"IL\u20106":[252],"TNFa":[254],"transcripts":[255],"circulating":[257],"modulated":[260],"plasma":[261],"pro\u2010inflammatory":[262,316],"chemokines":[263],"cytokines":[265],"(IL\u201015,":[266],"CCL2,":[267],"CCL4,":[268],"CCL11":[269],"FLT3LG;":[271],"p<0.01).":[272],"Clinical":[273,294],"benefits":[274],"(mean":[275],"change":[276],"\u00b1":[277,287,301],"SE)":[278],"observed":[280],"Mini\u2010Mental":[283],"State":[284],"Exam":[285],"(+2.25":[286],"0.59,":[288],"p":[289,303],"=":[290,304],"0.007)":[291],"Dementia":[295],"Rating":[296],"Sum":[297],"Boxes":[299],"(\u20100.56":[300],"0.24;":[302],"0.051).":[305],"Conclusion":[306],"restored":[309],"ameliorated":[314],"systemic":[315],"mediators":[317],"patients.":[320],"results":[322],"warrant":[326],"conducting":[327],"well\u2010controlled":[329],"further":[333],"evaluate":[334],"safety":[336],"efficacy":[338],"AD.":[347]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}
