{"id":"https://openalex.org/W4390192917","doi":"https://doi.org/10.1002/alz.076411","title":"The development of therapeutic nanovaccine that elicits anti\u2010A\u03b2 antibodies and A\u03b2\u2010specific regulatory T cells for the treatment of Alzheimer\u2019s disease.","display_name":"The development of therapeutic nanovaccine that elicits anti\u2010A\u03b2 antibodies and A\u03b2\u2010specific regulatory T cells for the treatment of Alzheimer\u2019s disease.","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390192917","doi":"https://doi.org/10.1002/alz.076411"},"language":"en","primary_location":{"id":"doi:10.1002/alz.076411","doi":"https://doi.org/10.1002/alz.076411","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.076411","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076411","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076411","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079517763","display_name":"Songmin Lee","orcid":"https://orcid.org/0009-0006-3585-1261","observed_orcids":["https://orcid.org/0009-0006-3585-1261"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Songmin Lee","raw_affiliation_strings":["Yonsei University, Incheon, Korea, Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yonsei University, Incheon, Korea, Republic of (South)","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041548362","display_name":"Mungyo Jung","orcid":"https://orcid.org/0000-0001-9366-9026","observed_orcids":["https://orcid.org/0000-0001-9366-9026"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mungyo Jung","raw_affiliation_strings":["Seoul National University, Seoul, Korea, Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University, Seoul, Korea, Republic of (South)","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642851","display_name":"Byung\u2010Soo Kim","orcid":"https://orcid.org/0000-0001-5210-7430","observed_orcids":["https://orcid.org/0000-0001-5210-7430"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung\u2010Soo Kim","raw_affiliation_strings":["Seoul National University, Seoul, Korea, Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University, Seoul, Korea, Republic of (South)","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100713154","display_name":"Young Soo Kim","orcid":"https://orcid.org/0000-0001-5029-7082","observed_orcids":["https://orcid.org/0000-0001-5029-7082"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YoungSoo Kim","raw_affiliation_strings":["Yonsei University, Incheon, Korea, Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yonsei University, Incheon, Korea, Republic of (South)","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079517763"],"corresponding_institution_ids":["https://openalex.org/I193775966"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0956,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31492346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"19","issue":"S21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nanovaccines","display_name":"nanovaccines","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8645159006118774},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6113473176956177},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5507253408432007},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5355883240699768},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5035132765769958},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4952830374240875},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.44387561082839966},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4256700575351715},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.42554157972335815},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.38838717341423035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3750039339065552},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3616645932197571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34693533182144165},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33236777782440186},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.22476139664649963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07373708486557007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07052639126777649}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.076411","doi":"https://doi.org/10.1002/alz.076411","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.076411","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076411","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.076411","doi":"https://doi.org/10.1002/alz.076411","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.076411","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076411","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390192917.pdf","grobid_xml":"https://content.openalex.org/works/W4390192917.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4308188368","https://openalex.org/W2002417737","https://openalex.org/W7162295101","https://openalex.org/W7116839017","https://openalex.org/W4313385772","https://openalex.org/W1990997454","https://openalex.org/W4401503223","https://openalex.org/W4390672071","https://openalex.org/W2108906052","https://openalex.org/W4318827964"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Alzheimer\u2019s":[2],"disease":[3],"(AD)":[4],"is":[5],"a":[6,75,111,117,275,316],"multi\u2010factorial":[7],"cognitive":[8,177],"disorder":[9],"with":[10,101],"complex":[11],"pathogenesis":[12],"including":[13],"the":[14,34,44,59,68,86,129,145,162,165,184,198,202,206,215,224,229,241,248,254,283,292,308,329],"accumulation":[15,38,157,232],"of":[16,36,47,88,125,141,158,167,179,191,201,209,243,256,261,279,286,331,333],"beta\u2010amyloid":[17],"(A\u03b2)":[18],"plaque":[19,231],"and":[20,66,83,104,131,153,164,173,217,269,282,289,304,336],"neuroinflammation.":[21],"In":[22],"previous":[23],"studies,":[24],"active":[25],"immunotherapy":[26],"injecting":[27],"A\u03b2":[28,37,79,102,159,203,230,280],"peptide":[29],"as":[30,81,267],"an":[31],"antigen":[32,82],"achieved":[33],"prophylaxis":[35],"by":[39,54,135,149,171,223,327],"generating":[40],"anti\u2010A\u03b2":[41,194,334],"antibodies.":[42],"Otherwise,":[43],"adoptive":[45],"transfer":[46],"regulatory":[48],"T":[49,90],"(Treg)":[50],"cells":[51,91,143,211,221,251],"attenuated":[52,284],"neuroinflammation":[53,168],"secreting":[55,263],"anti\u2010inflammatory":[56,259,264],"cytokines":[57,265],"in":[58,128,144,161,214,274,291,307],"AD":[60,119,320],"brain.":[61,218],"To":[62],"combine":[63],"both":[64],"approaches":[65],"improve":[67],"therapeutic":[69,325],"efficacy":[70,326],"against":[71],"AD,":[72],"we":[73],"developed":[74],"nanovaccine":[76],"that":[77,238,322],"presents":[78],"peptides":[80,103],"simultaneously":[84],"induce":[85],"differentiation":[87,255],"naive":[89],"into":[92,116,258],"A\u03b2\u2010specific":[93,126,244,249,337],"Treg":[94,142,220,235,245,250,338],"cells.":[95,246,339],"Method":[96],"A":[97],"lipid":[98],"nanoparticle":[99],"loaded":[100],"rapamycin":[105],"(LNP\u2010R/A\u03b2)":[106],"was":[107,133,147,181,212],"intradermally":[108],"injected":[109,298],"once":[110],"week":[112],"for":[113],"five":[114],"weeks":[115],"transgenic":[118],"mouse":[120],"model,":[121],"5XFAD.":[122],"The":[123,156,176,219],"generation":[124,242],"antibodies":[127,196,335],"plasma":[130],"brain":[132,163],"measured":[134,148],"indirect":[136],"enzyme\u2010linked":[137],"immunosorbent":[138],"assay.":[139,175],"Induction":[140],"spleen":[146,216],"flow":[150],"cytometric":[151],"analysis":[152],"RT\u2010qPCR":[154],"analysis.":[155],"aggregates":[160],"level":[166,208],"were":[169],"evaluated":[170],"immunohistochemical":[172],"immunoblotting":[174],"function":[178,306],"5XFAD":[180,293,299],"assessed":[182],"through":[183],"Morris":[185,309],"water":[186,310],"maze":[187,311],"test.":[188,312],"Result":[189],"Administration":[190],"LNP\u2010R/A\u03b2":[192,225,239,297,314],"generated":[193],"polyclonal":[195],"detecting":[197],"N\u2010terminus":[199],"(A\u03b21\u20108)":[200],"peptide.":[204],"Also,":[205,247],"increased":[207],"CD4+Foxp3+Treg":[210],"observed":[213],"induced":[222],"more":[226],"efficiently":[227],"reduced":[228],"than":[233],"general":[234],"cells,":[236],"indicating":[237],"promoted":[240],"led":[252],"to":[253,319],"microglia":[257,262,288],"form":[260],"such":[266],"TGF\u2010\u03b21":[268],"IL\u201010.":[270],"These":[271],"changes":[272],"resulted":[273],"significantly":[276],"decreased":[277],"amount":[278],"plaques":[281],"proliferation":[285],"reactive":[287],"astrocyte":[290],"mice":[294,300],"brains.":[295],"Furthermore,":[296],"showed":[301],"improved":[302],"learning":[303],"memory":[305],"Conclusion":[313],"proposes":[315],"novel":[317],"approach":[318],"treatment":[321],"achieves":[323],"synergistic":[324],"combining":[328],"mode":[330],"action":[332]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-26T00:00:00"}
