{"id":"https://openalex.org/W4390192894","doi":"https://doi.org/10.1002/alz.079113","title":"Modulation of inflammatory regulation by plasma exchange with albumin replacement revealed by deep plasma and CSF proteomic profiling of the AMBAR study","display_name":"Modulation of inflammatory regulation by plasma exchange with albumin replacement revealed by deep plasma and CSF proteomic profiling of the AMBAR study","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390192894","doi":"https://doi.org/10.1002/alz.079113"},"language":"en","primary_location":{"id":"doi:10.1002/alz.079113","doi":"https://doi.org/10.1002/alz.079113","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.079113","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.079113","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.079113","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040870336","display_name":"Chun-Miao Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267265","display_name":"Alkahest, Inc. (United States)","ror":"https://ror.org/01y7mep45","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chunmiao Feng","raw_affiliation_strings":["Alkahest Inc, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alkahest Inc, San Carlos, CA, USA","institution_ids":["https://openalex.org/I4405267265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086103599","display_name":"Ricardo Gonzalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ricardo Gonzalo","raw_affiliation_strings":["Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066739386","display_name":"Carla Minguet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carla Minguet","raw_affiliation_strings":["Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103723083","display_name":"Ana Mar\u00eda Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Maria Ortiz","raw_affiliation_strings":["Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Isabel Bravo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel Bravo","raw_affiliation_strings":["Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070804975","display_name":"Scott Lohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267265","display_name":"Alkahest, Inc. (United States)","ror":"https://ror.org/01y7mep45","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Lohr","raw_affiliation_strings":["Alkahest Inc, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alkahest Inc, San Carlos, CA, USA","institution_ids":["https://openalex.org/I4405267265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050897246","display_name":"Mer\u00e7\u00e9 Boada","orcid":"https://orcid.org/0000-0003-2617-3009","observed_orcids":["https://orcid.org/0000-0003-2617-3009"]},"institutions":[{"id":"https://openalex.org/I4210124683","display_name":"Fundaci\u00f3 ACE","ror":"https://ror.org/02z2bdj68","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210124683"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Merc\u00e8 Boada","raw_affiliation_strings":["Barcelona Alzheimer Treatment and Research Center Memory Clinic, Fundaci\u00f3 ACE, Barcelona  Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barcelona Alzheimer Treatment and Research Center Memory Clinic, Fundaci\u00f3 ACE, Barcelona  Spain","institution_ids":["https://openalex.org/I4210124683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619838","display_name":"Oscar L. L\u00f3pez","orcid":"https://orcid.org/0000-0002-8546-8256","observed_orcids":["https://orcid.org/0000-0002-8546-8256"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar L. Lopez","raw_affiliation_strings":["University of Pittsburgh Alzheimer\u2019s Disease Research Center, Pittsburgh, PA  USA","University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Alzheimer\u2019s Disease Research Center, Pittsburgh, PA  USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060103925","display_name":"Antonio P\u00e1ez","orcid":"https://orcid.org/0000-0003-1756-4534","observed_orcids":["https://orcid.org/0000-0003-1756-4534"]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio P\u00e1ez","raw_affiliation_strings":["Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037456393","display_name":"Steven P. Braithwaite","orcid":"https://orcid.org/0000-0003-0520-8823","observed_orcids":["https://orcid.org/0000-0003-0520-8823"]},"institutions":[{"id":"https://openalex.org/I4405267265","display_name":"Alkahest, Inc. (United States)","ror":"https://ror.org/01y7mep45","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven P Braithwaite","raw_affiliation_strings":["Alkahest Inc, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alkahest Inc, San Carlos, CA, USA","institution_ids":["https://openalex.org/I4405267265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104219589","display_name":"Montserrat Costa","orcid":"https://orcid.org/0009-0008-8197-6350","observed_orcids":["https://orcid.org/0009-0008-8197-6350"]},"institutions":[{"id":"https://openalex.org/I4210126725","display_name":"Grifols (Spain)","ror":"https://ror.org/02ed64f32","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210126725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Montserrat Costa","raw_affiliation_strings":["Grifols, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grifols, Barcelona, Spain","institution_ids":["https://openalex.org/I4210126725"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078423862","display_name":"Benoit Lehallier","orcid":"https://orcid.org/0000-0001-7452-3785","observed_orcids":["https://orcid.org/0000-0001-7452-3785"]},"institutions":[{"id":"https://openalex.org/I4405267265","display_name":"Alkahest, Inc. (United States)","ror":"https://ror.org/01y7mep45","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benoit Lehallier","raw_affiliation_strings":["Alkahest Inc, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alkahest Inc, San Carlos, CA, USA","institution_ids":["https://openalex.org/I4405267265"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040870336"],"corresponding_institution_ids":["https://openalex.org/I4405267265"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.1763,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52881314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"S21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.8309999704360962},{"id":"https://openalex.org/keywords/albumin-replacement","display_name":"albumin replacement","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6469659209251404},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5412766933441162},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49070799350738525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47146421670913696},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.46123194694519043},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.43295520544052124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4053947329521179},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3598049283027649},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.274636834859848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24235042929649353}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.079113","doi":"https://doi.org/10.1002/alz.079113","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.079113","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.079113","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.079113","doi":"https://doi.org/10.1002/alz.079113","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.079113","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.079113","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390192894.pdf","grobid_xml":"https://content.openalex.org/works/W4390192894.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403921577","https://openalex.org/W4206451305","https://openalex.org/W4390192773","https://openalex.org/W2537234777","https://openalex.org/W2917728658","https://openalex.org/W2532079032","https://openalex.org/W4307499125","https://openalex.org/W3046027807","https://openalex.org/W4377205985","https://openalex.org/W4286447786"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"AMBAR":[2,333],"trial":[3],"(phase":[4],"2b/3":[5],"clinical":[6],"trial)":[7],"evaluates":[8],"plasma":[9,54,83,103,184,307],"exchange":[10],"efficacy":[11],"with":[12,261],"albumin":[13],"replacement":[14],"(PE\u2010Alb)":[15],"in":[16,101,163,222,230,235,254,279,321],"mild\u2010to\u2010moderate":[17],"Alzheimer\u2019s":[18],"Disease":[19],"(AD)":[20],"patients.":[21],"It":[22],"includes":[23],"an":[24],"intensive":[25],"period":[26,41],"(IP)":[27],"comprising":[28],"6\u2010weeks":[29],"of":[30,42,91,132,136,156,215,238,249,269,315,318,332],"conventional":[31],"therapeutic":[32,334],"PE\u2010Alb":[33,45,65,291],"(TPE;":[34],"1":[35,47],"TPE/week)":[36],"followed":[37],"by":[38,64,98,174,193],"12\u2010month":[39],"maintenance":[40],"low":[43],"volume":[44],"(LVPE;":[46],"LVPE/month).":[48],"Our":[49],"previous":[50],"study":[51,137,325],"reporting":[52],"deep":[53],"and":[55,78,84,109,125,165,181,185,210,220,224,242,275,289,295,303,308],"CSF":[56,85,111,186,256,309],"proteomics":[57],"profiling":[58],"identified":[59,159,299],"multiple":[60],"AD\u2010associated":[61],"pathways":[62,74,171,233],"modulated":[63],"(Feng":[66],"et":[67],"al.":[68],"CTAD2022).":[69],"Here":[70],"we":[71],"dissected":[72],"immune":[73,223,232,280,294,310],"changes":[75],"over":[76,246],"time":[77],"reported":[79],"their":[80],"crosstalk":[81,176,305],"between":[82,169,183,306],"to":[86,129,339],"further":[87,326],"understand":[88,328],"molecular":[89,330],"mechanisms":[90],"PE\u2010Alb.":[92],"Method":[93],"7288":[94],"proteins":[95,228,260],"were":[96,142,161,172,191,217,234,243,273,276],"measured":[97],"SomaScan":[99],"technology":[100],"671":[102],"samples":[104,112,198],"(148":[105],"patients,":[106,114],"5":[107],"visits)":[108],"422":[110],"(144":[113],"3":[115,271,300],"visits).":[116],"Acute":[117],"effects":[118,127,292],"(post\u2010TPE/LVPE":[119],"versus":[120,152],"pre\u2010TPE/LVPE":[121],"samples)":[122],"for":[123,139],"plasma,":[124],"lasting":[126,290],"(baseline":[128],"either":[130],"end":[131,135,214],"IP":[133,216],"or":[134],"(EOS))":[138],"both":[140],"matrices":[141],"calculated":[143,192],"through":[144],"a":[145,304],"mixed":[146],"model":[147],"approach":[148,335],"comparing":[149],"PE\u2010Alb\u2010treated":[150],"patients":[151],"placebo.":[153],"Network":[154],"features":[155],"the":[157,213,236,239,255,270,313,316,329],"top":[158],"proteoforms":[160,202],"explored":[162],"STRING":[164],"OmniPath":[166],"databases.":[167],"Relationships":[168],"enriched":[170,221,278],"analyzed":[173],"pathway":[175],"based":[177],"on":[178,293],"Jaccard":[179],"coefficient":[180],"correlations":[182,263],"proteomes":[187],"at":[188,212,265,267],"each":[189],"visit":[190],"spearman":[194,262],"correlation.":[195],"Result":[196],"Plasma":[197],"showed":[199],"that":[200,336],"90":[201],"from":[203,207],"acute":[204,208,288],"TPE,":[205],"16":[206],"LVPE,":[209],"14":[211],"significantly":[218,252,277],"decreased":[219,253],"inflammation\u2010related":[225],"pathways.":[226,297],"Three":[227],"involved":[229],"immunoglobulin\u2010mediated":[231],"core":[237],"interactome":[240],"network":[241],"consistently":[244],"decreasing":[245],"time,":[247],"one":[248,268],"them":[250],"also":[251],"proteome.":[257],"Finally,":[258],"113":[259],">0.5":[264],"least":[266],"visits":[272],"detected":[274],"system":[281],"functions":[282],"(adjusted\u2010pvalue<0.05).":[283],"Conclusion":[284],"This":[285,324],"analysis":[286],"demonstrates":[287],"inflammatory":[296],"We":[298],"potential":[301],"players":[302],"proteomes,":[311],"suggesting":[312],"importance":[314],"modulation":[317],"peripheral":[319],"inflammation":[320],"AD":[322,342],"treatment.":[323],"helps":[327],"basis":[331],"may":[337],"contribute":[338],"slowing":[340],"down":[341],"progression.":[343]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}