{"id":"https://openalex.org/W4390192159","doi":"https://doi.org/10.1002/alz.074119","title":"The relation of loneliness and social resources with neuropathology, and cognitive resilience to neuropathology","display_name":"The relation of loneliness and social resources with neuropathology, and cognitive resilience to neuropathology","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390192159","doi":"https://doi.org/10.1002/alz.074119"},"language":"en","primary_location":{"id":"doi:10.1002/alz.074119","doi":"https://doi.org/10.1002/alz.074119","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.074119","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074119","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074119","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083662555","display_name":"Maude Wagner","orcid":"https://orcid.org/0000-0002-1834-3218","observed_orcids":["https://orcid.org/0000-0002-1834-3218"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Maude Wagner","raw_affiliation_strings":["Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL USA","University of Bordeaux, Bordeaux  France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"University of Bordeaux, Bordeaux  France","institution_ids":["https://openalex.org/I15057530"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert S. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Wilson","raw_affiliation_strings":["Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043507147","display_name":"Patricia A. Boyle","orcid":"https://orcid.org/0000-0002-3245-3456","observed_orcids":["https://orcid.org/0000-0002-3245-3456"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia A Boyle","raw_affiliation_strings":["Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070294274","display_name":"Sue E. Leurgans","orcid":"https://orcid.org/0000-0003-2536-1665","observed_orcids":["https://orcid.org/0000-0003-2536-1665"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue E. Leurgans","raw_affiliation_strings":["Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752","observed_orcids":["https://orcid.org/0000-0002-9482-1752"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A Schneider","raw_affiliation_strings":["Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. A Bennett","raw_affiliation_strings":["Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088908376","display_name":"Francine Grodstein","orcid":"https://orcid.org/0000-0002-2699-7051","observed_orcids":["https://orcid.org/0000-0002-2699-7051"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francine Grodstein","raw_affiliation_strings":["Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014401788","display_name":"Ana Werneck Capuano","orcid":"https://orcid.org/0000-0002-3505-344X","observed_orcids":["https://orcid.org/0000-0002-3505-344X","https://orcid.org/0000-0002-8233-8616"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana W. Capuano","raw_affiliation_strings":["Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083662555"],"corresponding_institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I15057530"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24247528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S22","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loneliness","display_name":"loneliness","score":0.9980000257492065},{"id":"https://openalex.org/keywords/social-resources","display_name":"social resources","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.9444791078567505},{"id":"https://openalex.org/C2779998236","wikidata":"https://www.wikidata.org/wiki/Q223270","display_name":"Loneliness","level":2,"score":0.9108760356903076},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.8386029601097107},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5891677737236023},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5510721802711487},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.5376167893409729},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.536298930644989},{"id":"https://openalex.org/C2778087770","wikidata":"https://www.wikidata.org/wiki/Q2297111","display_name":"Social support","level":2,"score":0.45754051208496094},{"id":"https://openalex.org/C137176749","wikidata":"https://www.wikidata.org/wiki/Q4105337","display_name":"Psychological resilience","level":2,"score":0.42775267362594604},{"id":"https://openalex.org/C2778079588","wikidata":"https://www.wikidata.org/wiki/Q5141258","display_name":"Cognitive vulnerability","level":4,"score":0.41540849208831787},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.38131386041641235},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3643556237220764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32229745388031006},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17626699805259705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17295193672180176},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.06649944186210632},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.074119","doi":"https://doi.org/10.1002/alz.074119","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.074119","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074119","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.074119","doi":"https://doi.org/10.1002/alz.074119","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.074119","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.074119","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390192159.pdf","grobid_xml":"https://content.openalex.org/works/W4390192159.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405960833","https://openalex.org/W4312104023","https://openalex.org/W4399184581","https://openalex.org/W4312087323","https://openalex.org/W3217444214","https://openalex.org/W4312104906","https://openalex.org/W2912759047","https://openalex.org/W4388968524","https://openalex.org/W2921942227","https://openalex.org/W4408088883"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Although":[2],"numerous":[3],"studies":[4],"report":[5,67],"an":[6,32],"association":[7,33],"between":[8,101,122,171,249,311],"loneliness":[9,35,183,201,253,324],"and":[10,16,36,42,58,90,105,108,126,140,163,175,264,296,317,325],"social":[11,37,76,78,80,213,233,280,312,315,326],"resources":[12,38],"with":[13,39,44,187,217,254,284,335,344],"cognitive":[14,45,88,128,137,141],"decline":[15,142],"dementia":[17,63],"risk,":[18],"the":[19,55,69,99,120,150,336],"underlying":[20],"pathways":[21],"remain":[22],"to":[23,47,346],"be":[24,342],"explored.":[25],"Thus,":[26],"we":[27,97,118,245],"investigated":[28],"two":[29,127],"possible":[30],"pathways:":[31],"of":[34,62,68,73,152,252,338],"(i)":[40],"neuropathology":[41,94],"(ii)":[43],"resilience":[46,129,345],"neuropathology.":[48,153],"Method":[49],"We":[50,167],"examined":[51,98],"792":[52],"decedents":[53],"from":[54,145],"Rush":[56],"Memory":[57],"Aging":[59],"Project,":[60],"free":[61],"at":[64,161],"their":[65],"initial":[66],"psychosocial":[70,103,124,173],"risk":[71],"factors":[72],"interest":[74],"(loneliness,":[75],"activity,":[77],"support,":[79],"network":[81,316],"size);":[82],"all":[83,176],"eligible":[84],"participants":[85],"completed":[86],"\u22652":[87],"evaluations":[89],"had":[91],"a":[92],"postmortem":[93],"evaluation.":[95],"First,":[96],"associations":[100,121,170,248],"each":[102,123,172,197],"factor":[104,125,174],"nine":[106,177],"neurodegenerative":[107],"vascular":[109],"neuropathologies,":[110],"using":[111],"linear":[112],"or":[113,314],"logistic":[114],"regression":[115],"models.":[116],"Second,":[117],"assessed":[119],"(CR)":[130,139],"measures.":[131],"The":[132],"measures":[133],"quantify":[134],"how":[135],"late\u2010life":[136],"levels":[138],"(CRSlope)":[143],"differ":[144],"what":[146],"is":[147],"expected,":[148],"given":[149],"profile":[151],"All":[154],"models":[155],"controlled":[156],"for":[157,180,196],"sex,":[158],"education,":[159],"age":[160],"death,":[162],"medical":[164],"comorbidities.":[165],"Result":[166],"found":[168,246],"few":[169],"individual":[178],"neuropathologies;":[179],"example,":[181],"greater":[182,277],"was":[184,215,282,308],"not":[185,332],"associated":[186,216,283,334,343],"higher":[188,250],"global":[189,219],"AD":[190,220],"pathology":[191,221],"(estimated":[192],"mean":[193],"difference":[194],"[MD]":[195],"one\u2010unit":[198],"increment":[199],"in":[200,279,328],"score":[202],"=":[203,206,209,225,228,231,236,239,242,258,261,267,270,273,288,291,294,299,302,305],"0.002,":[204],"95%CI":[205,227,238,260,269,290,301],"\u20100.07,0.07,":[207],"P":[208,230,241,272,293,304],".9),":[210],"while":[211],"more":[212],"engagement":[214],"less":[218],"(social":[222],"activity:":[223],"MD":[224,235],"\u20100.03,":[226],"\u20100.11,0.05,":[229],".5;":[232],"support:":[234],"0.05,":[237],"\u20100.02,0.11,":[240],".2).":[243],"However,":[244],"strong":[247],"degree":[251],"worse":[255],"CR":[256,286],"(MD":[257,266,287,298],"\u20100.25,":[259],"\u20100.37,\u20100.14,":[262],"P<.0001)":[263],"CRSlope":[265,297],"\u20100.23,":[268],"\u20100.34,\u20100.11,":[271],".0002).":[274],"In":[275],"addition,":[276],"participation":[278],"activities":[281],"better":[285],"0.24,":[289],"0.12,0.36,":[292],".0001)":[295],"0.13,":[300],"0.01,0.25,":[303],".04).":[306],"There":[307],"no":[309],"relationship":[310],"support":[313],"CR.":[318],"Conclusion":[319],"These":[320],"findings":[321],"suggest":[322],"that":[323],"activity":[327],"late":[329],"life":[330],"are":[331],"directly":[333],"accumulation":[337],"neuropathologies":[339],"but":[340],"may":[341],"neuropathologies.":[347]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-26T00:00:00"}