{"id":"https://openalex.org/W4390192007","doi":"https://doi.org/10.1002/alz.083020","title":"Racial and Ethnic Differences in Plasma Biomarker Eligibility in a Preclinical Alzheimer\u2019s Disease Trial","display_name":"Racial and Ethnic Differences in Plasma Biomarker Eligibility in a Preclinical Alzheimer\u2019s Disease Trial","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390192007","doi":"https://doi.org/10.1002/alz.083020"},"language":"en","primary_location":{"id":"doi:10.1002/alz.083020","doi":"https://doi.org/10.1002/alz.083020","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.083020","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083020","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083020","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079075728","display_name":"Doris P. Molina\u2010Henry","orcid":"https://orcid.org/0000-0002-8105-3571","observed_orcids":["https://orcid.org/0000-0002-8105-3571"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Doris P. Molina\u2010Henry","raw_affiliation_strings":["Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068057129","display_name":"Rema Raman","orcid":"https://orcid.org/0000-0002-4096-6390","observed_orcids":["https://orcid.org/0000-0002-4096-6390"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rema Raman","raw_affiliation_strings":["Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090227807","display_name":"Andy Liu","orcid":"https://orcid.org/0000-0002-8312-6906","observed_orcids":["https://orcid.org/0000-0002-8312-6906"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Liu","raw_affiliation_strings":["Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003352314","display_name":"Oliver Langford","orcid":"https://orcid.org/0009-0006-8951-1326","observed_orcids":["https://orcid.org/0009-0006-8951-1326"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oliver Langford","raw_affiliation_strings":["Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090842068","display_name":"Keith A. Johnson","orcid":"https://orcid.org/0000-0002-5916-6043","observed_orcids":["https://orcid.org/0000-0002-5916-6043","https://orcid.org/0000-0002-3577-8299"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith A. Johnson","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA  USA","Massachusetts General Hospital, Harvard Medical School, Boston, MA  USA","Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA  USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Massachusetts General Hospital, Harvard Medical School, Boston, MA  USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023356954","display_name":"Leona K. Shum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leona K Shum","raw_affiliation_strings":["Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051753404","display_name":"Crystal M. Glover","orcid":"https://orcid.org/0000-0002-1430-7463","observed_orcids":["https://orcid.org/0000-0002-1430-7463"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal M Glover","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical College, Chicago, IL  USA","Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL  USA","Rush Alzheimer\u2019s Disease Center, Chicago, IL  USA","Department of Neurological Sciences, Rush University Medical College, Chicago, IL, USA","Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical College, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer\u2019s Disease Center, Chicago, IL  USA","institution_ids":["https://openalex.org/I49886154"]},{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical College, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034225628","display_name":"Paul S. S Aisen","orcid":"https://orcid.org/0000-0002-2896-5838","observed_orcids":["https://orcid.org/0000-0002-2896-5838"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S. S Aisen","raw_affiliation_strings":["Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Therapeutic Research Institute, University of Southern California, San Diego, CA  USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031104672","display_name":"Shobha Dhadda","orcid":"https://orcid.org/0000-0002-7290-7168","observed_orcids":["https://orcid.org/0000-0002-7290-7168"]},"institutions":[{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shobha Dhadda","raw_affiliation_strings":["Eisai Inc., Nutley, NJ  USA","Eisai Inc., Nutley, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Inc., Nutley, NJ  USA","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Eisai Inc., Nutley, NJ, USA","institution_ids":["https://openalex.org/I4210151718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159919","display_name":"Michael C. Irizarry","orcid":"https://orcid.org/0000-0002-0246-2511","observed_orcids":["https://orcid.org/0000-0002-0246-2511"]},"institutions":[{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Irizarry","raw_affiliation_strings":["Eisai Inc., Nutley, NJ  USA","Eisai Inc., Nutley, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Inc., Nutley, NJ  USA","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Eisai Inc., Nutley, NJ, USA","institution_ids":["https://openalex.org/I4210151718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001795846","display_name":"Reisa Anne Sperling","orcid":"https://orcid.org/0000-0003-1535-6133","observed_orcids":["https://orcid.org/0000-0003-1535-6133"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reisa A. Sperling","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA  USA","Massachusetts General Hospital, Harvard Medical School, Boston, MA  USA","Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA  USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Massachusetts General Hospital, Harvard Medical School, Boston, MA  USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059549486","display_name":"Joshua D. Grill","orcid":"https://orcid.org/0000-0002-4215-7589","observed_orcids":["https://orcid.org/0000-0002-4215-7589"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D. Grill","raw_affiliation_strings":["Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA  USA","Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA  USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5079075728"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.18,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55747563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"S24","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lecanemab","display_name":"lecanemab","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7035772800445557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6548000574111938},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5087071061134338},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.45363882184028625},{"id":"https://openalex.org/C137403100","wikidata":"https://www.wikidata.org/wiki/Q41710","display_name":"Ethnic group","level":2,"score":0.4444119334220886},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.43478119373321533},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4280601441860199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4278016984462738},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4131298065185547},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.21660584211349487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.096009761095047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.083020","doi":"https://doi.org/10.1002/alz.083020","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.083020","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083020","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.083020","doi":"https://doi.org/10.1002/alz.083020","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.083020","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083020","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0},{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.4074000120162964}],"sustainable_development_goals_aurora":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390192007.pdf","grobid_xml":"https://content.openalex.org/works/W4390192007.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2381483116","https://openalex.org/W2348506863","https://openalex.org/W2371917728","https://openalex.org/W2007982614","https://openalex.org/W2113257626","https://openalex.org/W2389579140","https://openalex.org/W2512568326","https://openalex.org/W2808021644","https://openalex.org/W1980355846","https://openalex.org/W2355279474"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"In":[2],"Alzheimer\u2019s":[3,342],"disease":[4],"(AD)":[5],"trials,":[6],"differential":[7],"screen":[8,125,231],"failure":[9,126,200,232],"due":[10,294,326],"to":[11,18,57,62,94,120,168,295,327],"cognitive":[12,298],"and":[13,22,52,82,110,141,194,215,277,324,348],"biomarker":[14,46,78,322],"requirements":[15,299],"may":[16],"contribute":[17],"underrepresentation":[19],"of":[20,40,75,151,230,282,290,316],"racially":[21],"ethnically":[23],"minoritized":[24],"groups.":[25],"The":[26,144],"AHEAD":[27,87],"3\u201045":[28],"Study":[29],"(NCT04468659)":[30],"is":[31,335],"an":[32,131,147],"ongoing":[33],"program":[34],"testing":[35],"lecanemab":[36],"at":[37],"the":[38,73,86,135,288],"stage":[39],"preclinical":[41],"AD":[42],"that":[43,133],"utilizes":[44],"plasma":[45,76,136,176],"prescreening,":[47],"acquired":[48],"before":[49],"cognitive,":[50],"clinical,":[51],"medical":[53],"history":[54],"eligibility":[55,68,79,284],"assessments,":[56],"enrich":[58],"for":[59,204,207,210,213,217,306,321],"participants":[60,91,174,221],"likely":[61],"qualify":[63],"based":[64],"on":[65],"amyloid":[66,77,154,283],"PET":[67],"criteria.":[69],"Methods":[70],"We":[71,89,114,157],"examined":[72],"frequency":[74],"among":[80,233],"racial":[81],"ethnic":[83],"groups":[84,236],"in":[85,124,301,311],"Study.":[88],"assigned":[90],"ages":[92],"55\u201080":[93],"mutually":[95],"exclusive":[96],"groups:":[97],"Hispanic":[98,101],"Black":[99,108],"(HB),":[100],"White":[102,112],"(HW),":[103],"Non\u2010Hispanic":[104,107,111],"Asian":[105],"(NHA),":[106],"(NHB),":[109],"(NHW).":[113],"used":[115],"univariate":[116],"logistic":[117],"regression":[118],"models":[119],"explore":[121],"group":[122,169],"differences":[123,270,310],"rates":[127,201,281],"as":[128,222],"determined":[129],"by":[130,337],"algorithm":[132,145],"includes":[134],"A\u03b2":[137],"42/40":[138],"ratio,":[139],"age,":[140],"APOE":[142,161,274],"status.":[143],"indicates":[146],"adequately":[148],"high":[149],"probability":[150],"elevated":[152,317],"brain":[153],"(>20":[155],"centiloids).":[156],"further":[158],"explored":[159],"whether":[160],"\u03b54":[162,275],"status":[163],"(carrier":[164],"vs":[165],"non\u2010carrier)":[166],"contributed":[167],"differences.":[170],"Results":[171],"Among":[172],"4274":[173],"undergoing":[175],"screening,":[177],"59":[178],"(1.4%)":[179],"were":[180,184,188,192,197,202,271,285],"HB,":[181,205],"622":[182],"(14.6%)":[183],"HW,":[185],"74":[186],"(1.73%)":[187],"NHA,":[189],"329":[190],"(7.7%)":[191],"NHB,":[193,214],"3190":[195],"(74.6%)":[196],"NHW.":[198,218],"Screen":[199],"86%":[203],"76%":[206],"HW;":[208],"80%":[209],"NHA;":[211],"77%":[212],"62%":[216],"Using":[219],"NHW":[220],"a":[223,338],"reference":[224],"group,":[225],"we":[226],"observed":[227,286,300],"increased":[228],"odds":[229],"all":[234],"other":[235,330],"(HB":[237],"OR":[238,246,254,262],"=":[239,247,255,263],"4.0":[240],"95%":[241,249,257,265],"CI":[242,250,258,266],"2.0,":[243],"9.1;":[244],"HW":[245],"2.0":[248],"1.6,":[251,267],"2.4;":[252],"NHA":[253],"2.5":[256],"1.4,":[259],"4.5;":[260],"NHB":[261],"2.1,":[264],"2.7).":[268],"Observed":[269],"consistent":[272],"across":[273],"carriers":[276],"non\u2010carriers.":[278],"Conclusion":[279],"Differential":[280],"despite":[287],"lack":[289],"systematic":[291],"sample":[292],"bias":[293],"clinical":[296,312],"or":[297,329],"previous":[302],"studies.":[303],"Potential":[304],"explanations":[305],"these":[307],"observations":[308],"include":[309],"trial":[313],"access,":[314],"incidences":[315],"amyloid,":[318],"needed":[319],"cutoffs":[320],"assays,":[323],"confounding":[325],"comorbidities":[328],"unmeasured":[331],"covariates.":[332],"This":[333],"work":[334],"supported":[336],"public\u2010private":[339],"partnership":[340],"between":[341],"Clinical":[343],"Trial":[344],"Consortium":[345],"(U24":[346],"AG057437)":[347],"Eisai.":[349]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}