{"id":"https://openalex.org/W4390191880","doi":"https://doi.org/10.1002/alz.082406","title":"Does FOXO3 longevity genotype explain the conflicting data on late\u2010life hypertension and risk of Alzheimer\u2019s disease?","display_name":"Does FOXO3 longevity genotype explain the conflicting data on late\u2010life hypertension and risk of Alzheimer\u2019s disease?","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390191880","doi":"https://doi.org/10.1002/alz.082406"},"language":"en","primary_location":{"id":"doi:10.1002/alz.082406","doi":"https://doi.org/10.1002/alz.082406","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.082406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082406","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082406","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080086834","display_name":"Randi Chen","orcid":"https://orcid.org/0000-0003-3747-7964","observed_orcids":["https://orcid.org/0000-0003-3747-7964"]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randi Chen","raw_affiliation_strings":["Centers of Biomedical Research Excellence (COBRE), Kuakini Center for Translational Research on Aging, Honolulu, HI, USA","Department of Research, Kuakini Medical Center, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers of Biomedical Research Excellence (COBRE), Kuakini Center for Translational Research on Aging, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]},{"raw_affiliation_string":"Department of Research, Kuakini Medical Center, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022264359","display_name":"Brian J. Morris","orcid":"https://orcid.org/0000-0003-2468-3566","observed_orcids":["https://orcid.org/0000-0003-2468-3566"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Brian J Morris","raw_affiliation_strings":["Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","Department of Research, Kuakini Medical Center, Honolulu, HI, USA","School of Medical Sciences, University of Sydney, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Department of Research, Kuakini Medical Center, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]},{"raw_affiliation_string":"School of Medical Sciences, University of Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071896879","display_name":"Timothy A. Donlon","orcid":"https://orcid.org/0000-0001-6545-6533","observed_orcids":["https://orcid.org/0000-0001-6545-6533"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A Donlon","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","Department of Research, Kuakini Medical Center, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Department of Research, Kuakini Medical Center, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009648410","display_name":"George Webster Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210111178","display_name":"VA Pacific Islands Health Care System","ror":"https://ror.org/028zspe92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111178","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210150257","display_name":"Pacific Health Research and Education Institute","ror":"https://ror.org/05sshfw48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150257"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Webster Ross","raw_affiliation_strings":["Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","Pacific Health Research and Education Institute, Honolulu, HI, USA","Veterans Affairs Pacific Islands Health Care Systems, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Pacific Health Research and Education Institute, Honolulu, HI, USA","institution_ids":["https://openalex.org/I4210150257"]},{"raw_affiliation_string":"Veterans Affairs Pacific Islands Health Care Systems, Honolulu, HI, USA","institution_ids":["https://openalex.org/I4210111178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068589340","display_name":"Kalpana J. Kallianpur","orcid":"https://orcid.org/0000-0002-9978-097X","observed_orcids":["https://orcid.org/0000-0002-9978-097X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalpana J Kallianpur","raw_affiliation_strings":["Centers of Biomedical Research Excellence (COBRE), Kuakini Center for Translational Research on Aging, Honolulu, HI, USA","Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii, HONOLULU, HI, USA","Institute for Biogenesis Research, University of Hawaii, Honolulu, HI, USA, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers of Biomedical Research Excellence (COBRE), Kuakini Center for Translational Research on Aging, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]},{"raw_affiliation_string":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii, HONOLULU, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Institute for Biogenesis Research, University of Hawaii, Honolulu, HI, USA, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036308409","display_name":"Bradley J. Willcox","orcid":"https://orcid.org/0000-0001-9890-3520","observed_orcids":["https://orcid.org/0000-0001-9890-3520"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley J Willcox","raw_affiliation_strings":["Department of Research, Kuakini Medical Center, Honolulu, HI, USA","John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Kuakini Medical Center, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]},{"raw_affiliation_string":"John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111802321","display_name":"Richard Allsopp","orcid":"https://orcid.org/0000-0001-7565-5325","observed_orcids":["https://orcid.org/0000-0001-7565-5325"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard C Allsopp","raw_affiliation_strings":["Institute for Biogenesis Research, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biogenesis Research, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109327526","display_name":"Kazuma Nakagawa","orcid":"https://orcid.org/0000-0002-8744-8531","observed_orcids":["https://orcid.org/0000-0002-8744-8531"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuma Nakagawa","raw_affiliation_strings":["Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","Department of Research, Kuakini Medical Center, Honolulu, HI, USA","Neuroscience Institute, The Queen\u2019s Medical Center, Honolulu, HI  USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Department of Research, Kuakini Medical Center, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]},{"raw_affiliation_string":"Neuroscience Institute, The Queen\u2019s Medical Center, Honolulu, HI  USA","institution_ids":["https://openalex.org/I4210104115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061871901","display_name":"Kamal Masaki","orcid":"https://orcid.org/0000-0003-1170-3118","observed_orcids":["https://orcid.org/0000-0003-1170-3118"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamal H Masaki","raw_affiliation_strings":["Department of Research, Kuakini Medical Center, Honolulu, HI, USA","John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Kuakini Medical Center, Honolulu, HI, USA","institution_ids":["https://openalex.org/I1312008915"]},{"raw_affiliation_string":"John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5080086834"],"corresponding_institution_ids":["https://openalex.org/I1312008915"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24532445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S24","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.6911617517471313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6815268397331238},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6566122174263},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6556161642074585},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5749276280403137},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.47757914662361145},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47219809889793396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46816298365592957},{"id":"https://openalex.org/C168003608","wikidata":"https://www.wikidata.org/wiki/Q21101484","display_name":"FOXO3","level":4,"score":0.4277162551879883},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4152998924255371},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3668249547481537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0958336591720581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09511539340019226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.082406","doi":"https://doi.org/10.1002/alz.082406","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.082406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082406","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.082406","doi":"https://doi.org/10.1002/alz.082406","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/alz.082406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082406","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390191880.pdf","grobid_xml":"https://content.openalex.org/works/W4390191880.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387517776","https://openalex.org/W4384695236","https://openalex.org/W4312088238","https://openalex.org/W4312102769","https://openalex.org/W4315707227","https://openalex.org/W7222620067","https://openalex.org/W4390083877","https://openalex.org/W4389050326","https://openalex.org/W4391438384","https://openalex.org/W2179965364"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2],"association":[3,22,296],"of":[4,34,64,72,147,152,185,250,268,321,334,354],"late\u2010life":[5,355,366],"hypertension":[6,356,367],"(LHTN)":[7],"with":[8,75,100,104,108,202,225],"Alzheimer\u2019s":[9,85,369],"disease":[10,86],"(AD)":[11],"remains":[12],"controversial.":[13],"We":[14,141],"hypothesize":[15],"that":[16,348],"FOXO3":[17,56,73,148,188,203,226,258,274,322,349],"longevity\u2010associated":[18],"genotype":[19,74,190,206,229,325,350],"modulates":[20,351],"the":[21,47,94,160,248,260,280,304,317,331,352,362],"between":[23,297],"LHTN":[24,59,76,124,186,208,231,251,269,298,335],"and":[25,62,77,84,106,119,157,174,187,299,330,368],"incident":[26,65,78,192,358],"AD.":[27,300],"Method":[28],"Subjects":[29],"were":[30,98,311],"2,688":[31],"American":[32],"men":[33,97,201,224],"Japanese":[35],"ancestry":[36],"(baseline":[37],"age:":[38],"77.0":[39],"\u00b1":[40],"4.1":[41],"years,":[42],"range":[43],"71\u201093":[44],"years)":[45],"from":[46],"Kuakini":[48],"Honolulu":[49],"Heart":[50],"Program.":[51],"Status":[52],"was":[53,87,180],"known":[54],"for":[55,115,170],"rs2802292":[57,204,227,323],"genotype,":[58,150,259],"at":[60,159],"baseline,":[61],"diagnosis":[63],"dementia":[66,82,156],"over":[67],"21":[68],"years":[69],"follow\u2010up.":[70],"Association":[71],"all\u2010cause":[79,101,155],"dementia,":[80,102],"vascular":[81],"(VD)":[83],"assessed":[88],"using":[89],"Cox":[90,112,167],"regression.":[91],"Result":[92],"During":[93],"follow\u2010up,":[95],"725":[96],"diagnosed":[99],"513":[103],"AD":[105,139,158,193,212,253,271,339],"104":[107],"VD.":[109],"A":[110],"multivariable":[111],"model,":[113],"adjusting":[114,169],"age,":[116,171],"education,":[117,172],"APOE\u2010\u03b54":[118,173],"cardiovascular":[120,176],"risk":[121,127,177],"factors,":[122,178],"showed":[123,209],"increased":[125],"VD":[126],"(HR":[128,213,236],"=":[129,132,135,195,198,214,218,221,237,241,244,284,341],"1.71,":[130],"95%CI":[131],"1.08\u20132.71,":[133],"p":[134,197,220,243],"0.022),":[136],"but":[137],"not":[138],"risk.":[140],"found":[142,293,347],"no":[143,233,294],"significant":[144,182,295],"protective":[145,234],"effect":[146,184,235,249,267,333,353],"longevity":[149,189,205,324],"nor":[151],"LHTN,":[153],"on":[154,191,252,270,357,365],"population":[161],"level.":[162],"However,":[163],"in":[164,307,327,336],"a":[165,181,264],"full":[166],"model":[168],"other":[175],"there":[179],"interaction":[183],"(\u00df":[194],"\u20130.52,":[196],"0.0061).":[199],"In":[200,223],"(TG/GG),":[207],"protection":[210],"against":[211,338],"0.72;":[215],"95%":[216,239],"CI":[217,240],"0.55\u20130.95,":[219],"0.021).":[222],"non\u2010longevity":[228],"(TT),":[230],"had":[232],"1.16;":[238],"0.90\u20101.51,":[242],"0.25).":[245],"Discussion":[246],"Since":[247],"incidence":[254],"differed":[255],"according":[256],"to":[257],"overall":[261],"effect,":[262],"namely,":[263],"weighted":[265],"average":[266],"across":[272],"different":[273],"genotypes,":[275],"would":[276,287],"be":[277],"moving":[278],"towards":[279],"null":[281],"(i.e.,":[282],"HR":[283],"1).":[285],"This":[286,344],"explain":[288],"why":[289],"most":[290],"studies":[291],"have":[292,316],"One":[301],"exception":[302],"is":[303],"Ibadan":[305],"study,":[306],"which":[308],"all":[309,328],"participants":[310],"African":[312,314],"American.":[313],"Americans":[315],"highest":[318],"proportion":[319],"(94%)":[320],"(TG/GG)":[326],"races,":[329],"strongest":[332],"protecting":[337],"(RR":[340],"0.33).":[342],"Conclusion":[343],"longitudinal":[345],"study":[346],"AD,":[359],"thus":[360],"explaining":[361],"conflicting":[363],"data":[364],"disease.":[370]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}