{"id":"https://openalex.org/W4390191768","doi":"https://doi.org/10.1002/alz.082666","title":"Locus coeruleus hyperactivity in middle age may be associated with better cognitive performance","display_name":"Locus coeruleus hyperactivity in middle age may be associated with better cognitive performance","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390191768","doi":"https://doi.org/10.1002/alz.082666"},"language":"en","primary_location":{"id":"doi:10.1002/alz.082666","doi":"https://doi.org/10.1002/alz.082666","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.082666","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082666","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082666","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027580413","display_name":"Elizabeth Riley","orcid":"https://orcid.org/0000-0002-6049-9101","observed_orcids":["https://orcid.org/0000-0002-6049-9101"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth Riley","raw_affiliation_strings":["Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055686185","display_name":"Khena Marie Swallow","orcid":"https://orcid.org/0000-0001-7033-9825","observed_orcids":["https://orcid.org/0000-0001-7033-9825"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khena Swallow","raw_affiliation_strings":["Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018443530","display_name":"Adam Keith Anderson","orcid":"https://orcid.org/0000-0002-6492-6350","observed_orcids":["https://orcid.org/0000-0002-6492-6350"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Anderson","raw_affiliation_strings":["Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082009842","display_name":"Eve De Rosa","orcid":"https://orcid.org/0000-0002-6682-4657","observed_orcids":["https://orcid.org/0000-0002-6682-4657"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eve De Rosa","raw_affiliation_strings":["Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027580413"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.2026,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56278927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"19","issue":"S24","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.639197826385498},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.620030403137207},{"id":"https://openalex.org/C2778711042","wikidata":"https://www.wikidata.org/wiki/Q3410891","display_name":"Pupillometry","level":3,"score":0.5705912113189697},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.55854332447052},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48596084117889404},{"id":"https://openalex.org/C2779424989","wikidata":"https://www.wikidata.org/wiki/Q5959131","display_name":"Hypoactivity","level":2,"score":0.4636140465736389},{"id":"https://openalex.org/C2779758577","wikidata":"https://www.wikidata.org/wiki/Q1202615","display_name":"Middle age","level":2,"score":0.4211321473121643},{"id":"https://openalex.org/C149288182","wikidata":"https://www.wikidata.org/wiki/Q7260673","display_name":"Pupillary response","level":3,"score":0.4102008044719696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38506436347961426},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.34678757190704346},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3260955810546875},{"id":"https://openalex.org/C2777394604","wikidata":"https://www.wikidata.org/wiki/Q173318","display_name":"Pupil","level":2,"score":0.12669143080711365},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.082666","doi":"https://doi.org/10.1002/alz.082666","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.082666","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082666","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.082666","doi":"https://doi.org/10.1002/alz.082666","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.082666","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082666","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390191768.pdf","grobid_xml":"https://content.openalex.org/works/W4390191768.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7118091598","https://openalex.org/W4387271857","https://openalex.org/W6903041579","https://openalex.org/W7116961418","https://openalex.org/W4414824418","https://openalex.org/W7043693432","https://openalex.org/W2112885821","https://openalex.org/W7116854803","https://openalex.org/W2538145923","https://openalex.org/W4406902821"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Measuring":[2],"the":[3,6,10,14,57,79,113,163,170,223,312],"health":[4],"of":[5,13,24,184,259,298],"locus":[7],"coeruleus":[8],"(LC),":[9],"brainstem":[11],"site":[12],"first":[15],"cellular":[16],"damage":[17],"in":[18,50,86,112,332,346],"Alzheimer\u2019s":[19],"Disease":[20],"(AD)":[21],"pathogenesis,":[22],"is":[23],"particular":[25],"interest":[26],"for":[27],"early":[28],"diagnosis.":[29],"In":[30],"both":[31],"rodents":[32],"and":[33,59,62,118,131,176,186,208,219,230,251,273,290,308,319,326],"humans":[34],"(Elman":[35],"2017;":[36],"Kelberman":[37,71],"2023;":[38],"Malatt":[39],"2022;":[40,72,74],"Weinshenker":[41],"2008),":[42],"increased":[43],"tonic":[44],"firing":[45],"rates":[46],"have":[47],"been":[48],"noted":[49],"middle":[51,87,333,347],"age.":[52,348],"This":[53],"occurs":[54],"prior":[55],"to":[56,92,161,202,243,283,329],"hypoactivity":[58],"reduced":[60],"functional":[61],"structural":[63],"connectivity":[64],"associated":[65,336],"with":[66,115,124,222,311,337],"cognitive":[67,206,217,225,288,314,339],"aging":[68,97],"(Jacobs":[69],"2015;":[70],"Langley":[73],"Prokopiou":[75],"2022)":[76],".":[77],"Understanding":[78],"mechanism":[80],"or":[81,137],"function":[82],"behind":[83],"LC":[84,245,324,341],"hyperactivity":[85,342],"age":[88,174,185,249,260,334],"may":[89,343],"be":[90,344],"key":[91],"identifying":[93],"individuals":[94],"on":[95],"pathological":[96],"trajectories.":[98],"Method":[99],"Participants":[100],"(29":[101],"younger,":[102],"18":[103],"middle\u2010aged,":[104],"24":[105],"older)":[106],"performed":[107],"a":[108,146,156,181,200,213,238,262,281,303],"dual":[109],"attention":[110],"task":[111],"scanner":[114],"multi\u2010echo":[116],"fMRI":[117],"concurrent":[119],"pupillometry.":[120],"Cognition":[121],"was":[122,180,212,255,294,302],"assessed":[123],"NIH":[125],"Toolbox":[126],"Cognitive":[127],"Battery":[128],"(Fluid":[129],"Composite)":[130],"sorted":[132],"into":[133],"high":[134,224,313],"(>50th":[135],"percentile)":[136],"low":[138],"(<50th)":[139],"categories.":[140],"Age":[141],"groupings":[142],"were":[143],"determined":[144],"by":[145],"pupillary":[147,166,327],"behavior":[148],"data":[149],"analysis.":[150],"Results":[151],"Pupil":[152],"(Fig.":[153,235],"1):":[154],"using":[155,237],"linear":[157,239],"mixed":[158,240],"effects":[159,241],"model":[160,201,242,282],"predict":[162,203,244,284],"dynamic":[164],"range\u2010normalized":[165],"response":[167,247,286],"area":[168],"under":[169],"curve":[171],"(AUC)":[172],"from":[173,205,248,287],"group":[175,226,250,315],"trial":[177,209,220,252,291,309],"type,":[178,210,221,253,292,310],"there":[179,211,254,293,301],"significant":[182,187,214,257,263,296,304],"effect":[183,258,297],"age*trial":[188,264],"type":[189,265],"interactions.":[190],"Middle\u2010aged":[191,267],"adults":[192,268,275],"had":[193,269,276],"larger":[194,228,270,317],"responses":[195,272,328],"than":[196],"other":[197],"groups.":[198],"Using":[199,280],"AUC":[204],"category":[207,218,289,307],"interaction":[215,305],"between":[216,306],"having":[227,316],"target":[229,278,318,330],"distractor":[231,271,320],"responses.":[232,279,321],"Blood\u2010Oxygen\u2010Level\u2010Dependent":[233],"(BOLD)":[234],"2):":[236],"BOLD":[246,285,325],"no":[256,295],"but":[261,300],"interaction.":[266],"older":[274],"smaller":[277],"category,":[299],"Conclusions":[322],"Elevated":[323],"trials":[331],"are":[335],"better":[338],"performance.":[340],"adaptive":[345]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-26T00:00:00"}