{"id":"https://openalex.org/W4390191590","doi":"https://doi.org/10.1002/alz.082983","title":"Association of Polygenic Risk Score of Alzheimer\u2019s disease with A/T/N Biomarkers and Cognitive Decline","display_name":"Association of Polygenic Risk Score of Alzheimer\u2019s disease with A/T/N Biomarkers and Cognitive Decline","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390191590","doi":"https://doi.org/10.1002/alz.082983"},"language":"en","primary_location":{"id":"doi:10.1002/alz.082983","doi":"https://doi.org/10.1002/alz.082983","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.082983","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082983","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082983","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048279710","display_name":"Joon Hyung Jung","orcid":"https://orcid.org/0000-0003-1669-6113","observed_orcids":["https://orcid.org/0000-0003-1669-6113"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210161026","display_name":"Chungbuk National University Hospital","ror":"https://ror.org/05529q263","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I163753206","https://openalex.org/I4210161026"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Joon Hyung Jung","raw_affiliation_strings":["Chungbuk National University Hospital, Cheongju, Korea Republic of (South)","Seoul National University College of Medicine, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chungbuk National University Hospital, Cheongju, Korea Republic of (South)","institution_ids":["https://openalex.org/I4210161026"]},{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041808460","display_name":"Min Soo Byun","orcid":"https://orcid.org/0000-0003-3159-4510","observed_orcids":["https://orcid.org/0000-0003-3159-4510"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Soo Byun","raw_affiliation_strings":["Seoul National University College of Medicine, Seoul, Korea Republic of (South)","Seoul National University Hospital, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076078712","display_name":"Dahyun Yi","orcid":"https://orcid.org/0000-0002-0860-0946","observed_orcids":["https://orcid.org/0000-0002-0860-0946"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dahyun Yi","raw_affiliation_strings":["Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005571250","display_name":"Gijung Jung","orcid":"https://orcid.org/0000-0001-5952-3373","observed_orcids":["https://orcid.org/0000-0001-5952-3373"]},"institutions":[{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gijung Jung","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018170929","display_name":"Hye\u2010Jin Ahn","orcid":"https://orcid.org/0000-0002-0085-9566","observed_orcids":["https://orcid.org/0000-0002-0085-9566"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyejin Ahn","raw_affiliation_strings":["Interdisciplinary program of cognitive science, Seoul National University College of Humanities, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary program of cognitive science, Seoul National University College of Humanities, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415818","display_name":"Shiwei Liu","orcid":"https://orcid.org/0000-0003-4711-5959","observed_orcids":["https://orcid.org/0000-0003-4711-5959"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiwei Liu","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103570805","display_name":"Yen-Ning Huang","orcid":"https://orcid.org/0000-0003-1371-8209","observed_orcids":["https://orcid.org/0000-0003-1371-8209"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yen\u2010Ning Huang","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089163662","display_name":"Anthony J. Griswold","orcid":"https://orcid.org/0000-0003-1925-7810","observed_orcids":["https://orcid.org/0000-0003-1925-7810"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. Griswold","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069324665","display_name":"Margaret Ann Pericak\u2010Vance","orcid":"https://orcid.org/0000-0001-7283-8804","observed_orcids":["https://orcid.org/0000-0001-7283-8804","https://orcid.org/0000-0002-3309-1303"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. A Pericak\u2010Vance","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005017390","display_name":"Yu Kyeong Kim","orcid":"https://orcid.org/0000-0002-3282-822X","observed_orcids":["https://orcid.org/0000-0002-3282-822X"]},"institutions":[{"id":"https://openalex.org/I4210100437","display_name":"SNUH SMG-SNU Boramae Medical Center","ror":"https://ror.org/014xqzt56","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210100437"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu Kyeong Kim","raw_affiliation_strings":["SMG-SNU Boramae Medical Center, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMG-SNU Boramae Medical Center, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I4210100437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055814730","display_name":"Yun\u2010Sang Lee","orcid":"https://orcid.org/0000-0003-1640-2090","observed_orcids":["https://orcid.org/0000-0003-1640-2090"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun\u2010Sang Lee","raw_affiliation_strings":["Seoul National University College of Medicine, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090095126","display_name":"Chul\u2010Ho Sohn","orcid":"https://orcid.org/0000-0003-0039-5746","observed_orcids":["https://orcid.org/0000-0003-0039-5746"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chul\u2010Ho Sohn","raw_affiliation_strings":["Seoul National University College of Medicine, Seoul, Korea Republic of (South)","Seoul National University Hospital, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055524920","display_name":"Koung Mi Kang","orcid":"https://orcid.org/0000-0001-9643-2008","observed_orcids":["https://orcid.org/0000-0001-9643-2008"]},"institutions":[{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Koung Mi Kang","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398173","display_name":"Jun\u2010Young Lee","orcid":"https://orcid.org/0000-0002-5893-3124","observed_orcids":["https://orcid.org/0000-0002-5893-3124","https://orcid.org/0000-0001-6504-3333","https://orcid.org/0000-0002-7752-2697"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210100437","display_name":"SNUH SMG-SNU Boramae Medical Center","ror":"https://ror.org/014xqzt56","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210100437"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun\u2010Young Lee","raw_affiliation_strings":["SMG-SNU Boramae Medical Center, Seoul, Korea Republic of (South)","Seoul National University College of Medicine, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMG-SNU Boramae Medical Center, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I4210100437"]},{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257338","display_name":"Andrew J. Saykin","orcid":"https://orcid.org/0000-0002-1376-8532","observed_orcids":["https://orcid.org/0000-0002-1376-8532"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Saykin","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087302585","display_name":"Kwangsik T. Nho","orcid":"https://orcid.org/0000-0002-7624-3872","observed_orcids":["https://orcid.org/0000-0002-7624-3872"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwangsik Nho","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100436225","display_name":"Dong Young Lee","orcid":"https://orcid.org/0000-0001-8976-8320","observed_orcids":["https://orcid.org/0000-0001-8976-8320"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Young Lee","raw_affiliation_strings":["Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea Republic of (South)","Interdisciplinary program of cognitive science, Seoul National University College of Humanities, Seoul, Korea Republic of (South)","Seoul National University College of Medicine, Seoul, Korea Republic of (South)","Seoul National University Hospital, Seoul, Korea Republic of (South)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary program of cognitive science, Seoul National University College of Humanities, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Korea Republic of (South)","institution_ids":["https://openalex.org/I2802835388"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048279710"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4210161026"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22324197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"S24","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6774996519088745},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6223031282424927},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5551236271858215},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.54966139793396},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5326993465423584},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.527180552482605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.503149688243866},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4995236396789551},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4837927520275116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47275859117507935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4694874882698059},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46915164589881897},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4501743018627167},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4439276456832886},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43551814556121826},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.41162168979644775},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23076194524765015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12189486622810364},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09802296757698059}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/alz.082983","doi":"https://doi.org/10.1002/alz.082983","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.082983","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082983","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/alz.082983","doi":"https://doi.org/10.1002/alz.082983","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.082983","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.082983","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390191590.pdf","grobid_xml":"https://content.openalex.org/works/W4390191590.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2900370721","https://openalex.org/W3112882294","https://openalex.org/W7204465938","https://openalex.org/W4401743809","https://openalex.org/W6977930468","https://openalex.org/W4390195076","https://openalex.org/W4297448040","https://openalex.org/W4414585181","https://openalex.org/W4391168460","https://openalex.org/W4414524008"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Polygenic":[2],"risk":[3,20],"scores":[4,259],"(PRS)":[5],"quantify":[6],"the":[7,15,23,34,52,88,94,160,168,189,231,237],"combined":[8],"effects":[9],"of":[10,17,21,54,99,122,171,271,286],"genetic":[11],"variants":[12],"to":[13,236,352,355],"enable":[14],"prediction":[16],"an":[18,283],"individual\u2019s":[19],"developing":[22],"disease.":[24],"Alzheimer\u2019s":[25,100],"disease":[26],"(AD)":[27],"is":[28],"a":[29,64,172],"complex":[30],"disorder":[31],"in":[32,47,63,188,230,345],"which":[33,156],"relationship":[35],"among":[36],"PRS,":[37],"neuropathological":[38],"substrates,":[39],"and":[40,60,83,97,105,116,139,151,196,212,220,256,295,334,347],"related":[41],"cognitive":[42,61,80,223,341],"decline":[43],"remain":[44],"especially":[45],"understudied":[46],"Asian":[48],"populations.":[49,358],"We":[50],"investigated":[51],"associations":[53,192],"PRS":[55,164,195,226,241,278,328],"with":[56,209,244,282,309],"AD":[57,85,178,232,272],"neuroimaging":[58,112,215,273],"biomarkers":[59,274],"phenotypes":[62,131,198],"Korean":[65,89],"Cohort.":[66],"Method":[67],"The":[68,181,191],"study":[69,176],"included":[70],"501":[71],"older":[72],"adults":[73],"(264":[74],"cognitively":[75],"normal":[76],"[CN],":[77],"146":[78],"mild":[79],"impairment":[81],"[MCI],":[82],"91":[84],"dementia)":[86],"from":[87],"Brain":[90],"Aging":[91],"Study":[92],"for":[93,146,177,214,222],"Early":[95],"Diagnosis":[96],"Prediction":[98],"Disease":[101],"(KBASE).":[102],"Comprehensive":[103],"clinical":[104],"neuropsychological":[106],"evaluations,":[107],"as":[108,110,337,339],"well":[109,338],"multi\u2010modal":[111],"including":[113,132],"3T":[114],"MRI":[115],"11C\u2010PiB\u2010PET":[117],"were":[118,144,199],"administered.":[119],"A":[120],"subset":[121],"participants":[123],"underwent":[124],"18F\u2010AV\u20101451":[125],"PET":[126],"(n":[127],"=":[128,248,251,254,261,264,267,290,293,299,302,305,314,317,320],"167).":[129],"Imaging":[130],"beta\u2010amyloid":[133],"(A\u03b2)":[134],"positivity,":[135],"global":[136,310],"tau":[137,149,311],"deposition,":[138],"adjusted":[140],"hippocampal":[141],"volume":[142],"(HVa)":[143],"used":[145],"amyloid":[147],"(A),":[148],"(T),":[150],"neurodegeneration":[152],"(N)":[153],"biomarkers,":[154],"respectively.,":[155],"was":[157,165,186,227,242,279],"imputed":[158],"using":[159,167,201],"TOPMed":[161],"reference":[162],"panel.":[163],"calculated":[166],"summary":[169],"statistics":[170],"recent":[173],"large\u2010scale":[174],"GWAS":[175],"by":[179],"PRS\u2010CS.":[180],"Apolipoprotein":[182],"E":[183],"(APOE)":[184],"region":[185],"excluded":[187],"calculation.":[190],"between":[193],"standardized":[194],"imaging/cognitive":[197],"examined":[200],"either":[202],"multiple":[203],"linear":[204],"or":[205],"logistic":[206],"regression":[207],"analysis":[208],"covariates":[210],"(age":[211],"sex":[213,219],"biomarker":[216],"phenotypes;":[217],"age,":[218],"education":[221],"phenotypes).":[224],"Result":[225],"significantly":[228,280],"higher":[229,277,327],"dementia":[233],"group":[234],"compared":[235],"CN":[238],"group.":[239],"Higher":[240],"associated":[243,281],"greater":[245,340],"CDR\u2010sum\u2010of\u2010boxes":[246],"(\u03b2[SE]":[247,260,298,313],"0.233[0.083],":[249],"t":[250,263,301,316],"2.818,":[252],"p":[253,266,304,319],"0.005)":[255],"lower":[257,296],"MMSE":[258],"\u20100.648[0.198],":[262],"\u20103.271,":[265],"0.001).":[268],"In":[269],"terms":[270],"(Figure":[275],"1),":[276],"increased":[284,330],"likelihood":[285],"A\u03b2":[287,332],"positivity":[288],"(OR":[289],"1.233,":[291],"95%CI":[292],"1.024\u20101.491),":[294],"HVa":[297],"\u2010132.79[49.624],":[300],"\u20102.676,":[303],"0.008),":[306],"but":[307],"not":[308],"deposition":[312,333],"0.075[0.048],":[315],"1.573,":[318],"0.118).":[321],"Conclusion":[322],"These":[323],"findings":[324],"suggest":[325],"that":[326],"predicts":[329],"pathological":[331],"accelerated":[335],"neurodegeneration,":[336],"decline.":[342],"Further":[343],"investigation":[344],"larger":[346],"multiethnic":[348],"samples":[349],"are":[350],"needed":[351],"determine":[353],"generalizability":[354],"other":[356],"ethnoracial":[357]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-12-26T00:00:00"}
