{"id":"https://openalex.org/W4390109783","doi":"https://doi.org/10.30574/wjarr.2023.20.3.2565","title":"Development and characterization of Tinospora cordifolia extract-loaded SLNs for the treatment of autoimmune hepatitis","display_name":"Development and characterization of Tinospora cordifolia extract-loaded SLNs for the treatment of autoimmune hepatitis","publication_year":2023,"publication_date":"2023-12-22","ids":{"openalex":"https://openalex.org/W4390109783","doi":"https://doi.org/10.30574/wjarr.2023.20.3.2565"},"language":"en","primary_location":{"id":"doi:10.30574/wjarr.2023.20.3.2565","doi":"https://doi.org/10.30574/wjarr.2023.20.3.2565","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30574/wjarr.2023.20.3.2565","pdf_url":"https://wjarr.com/sites/default/files/WJARR-2023-2565.pdf","source":{"id":"https://openalex.org/S4210223820","display_name":"World Journal of Advanced Research and Reviews","issn_l":"2581-9615","issn":["2581-9615"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383735917","host_organization_name":"GSC Online Press","host_organization_lineage":["https://openalex.org/P4383735917"],"host_organization_lineage_names":["GSC Online Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Advanced Research and Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://wjarr.com/sites/default/files/WJARR-2023-2565.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111098884","display_name":"Savisa Yadav","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Savisa Yadav","raw_affiliation_strings":["Department of Pharmacy, BBDIT, Duhai, Ghaziabad Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, BBDIT, Duhai, Ghaziabad Uttar Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065185705","display_name":"Pooja Rani","orcid":"https://orcid.org/0000-0003-4783-7062","observed_orcids":["https://orcid.org/0000-0003-4783-7062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pooja Rani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031030422","display_name":"Kumari Shanno","orcid":"https://orcid.org/0009-0003-7443-0599","observed_orcids":["https://orcid.org/0009-0003-7443-0599"]},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kumari Shanno","raw_affiliation_strings":["Department of Pharmacy, Bansthali Vidyapith, Tonk Road Niwaru -304022, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Bansthali Vidyapith, Tonk Road Niwaru -304022, India","institution_ids":["https://openalex.org/I102117144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101283383","display_name":"Raman Kumari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155284866","display_name":"Maharishi Markandeshwar University, Mullana","ror":"https://ror.org/013qfkw58","country_code":"IN","type":"education","lineage":["https://openalex.org/I155284866"]},{"id":"https://openalex.org/I4405262983","display_name":"IIMT University","ror":"https://ror.org/00zncbw15","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262983"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raman Kumari","raw_affiliation_strings":["Department of Pharmacy, Maharishi Markendeshwar College of Pharmacy, Mullana, Ambala, Haryana, India","IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut, Uttar Pradesh, India -250001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Maharishi Markendeshwar College of Pharmacy, Mullana, Ambala, Haryana, India","institution_ids":["https://openalex.org/I155284866"]},{"raw_affiliation_string":"IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut, Uttar Pradesh, India -250001, India","institution_ids":["https://openalex.org/I4405262983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112572400","display_name":"Shamim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262983","display_name":"IIMT University","ror":"https://ror.org/00zncbw15","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262983"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shamim","raw_affiliation_strings":["IIMT College of Medical Sciences , IIMT University , Ganga Nagar , Meerut , Uttar Pradesh , India - 250001 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIMT College of Medical Sciences , IIMT University , Ganga Nagar , Meerut , Uttar Pradesh , India - 250001 , India","institution_ids":["https://openalex.org/I4405262983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114235561","display_name":"Tarmeen Ali","orcid":"https://orcid.org/0009-0003-1762-0791","observed_orcids":["https://orcid.org/0009-0003-1762-0791"]},"institutions":[{"id":"https://openalex.org/I4405262983","display_name":"IIMT University","ror":"https://ror.org/00zncbw15","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405262983"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tarmeen Ali","raw_affiliation_strings":["IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut, Uttar Pradesh, India -250001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut, Uttar Pradesh, India -250001, India","institution_ids":["https://openalex.org/I4405262983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110300768","display_name":"Nitin Chandrakant Mohire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nitin Chandrakant Mohire","raw_affiliation_strings":["Department of Pharmacy , Shivajirao S Jondhle College of Pharmacy , Asangaon , Thane Maharashtra . 421601 , India","milestone Golbhag Chauraha Noorpur Road Bijnor (U. P) 246701 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy , Shivajirao S Jondhle College of Pharmacy , Asangaon , Thane Maharashtra . 421601 , India","institution_ids":[]},{"raw_affiliation_string":"milestone Golbhag Chauraha Noorpur Road Bijnor (U. P) 246701 , India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093561597","display_name":"Gita Nitin Mohire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gita Nitin Mohire","raw_affiliation_strings":["Department of Pharmacy , Navsahyadri Institute of Pharmacy , Naigaon , Nasarapur , Pune , Maharashtra 412213 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy , Navsahyadri Institute of Pharmacy , Naigaon , Nasarapur , Pune , Maharashtra 412213 , India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029694308","display_name":"Ravindra Bhimraj Laware","orcid":"https://orcid.org/0000-0002-4370-1582","observed_orcids":["https://orcid.org/0000-0002-4370-1582"]},"institutions":[{"id":"https://openalex.org/I3130684616","display_name":"Pravara Institute of Medical Sciences","ror":"https://ror.org/02y0wc381","country_code":"IN","type":"education","lineage":["https://openalex.org/I3130684616"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravindra Bhimraj Laware","raw_affiliation_strings":["College of Pharmaceutical Sciences , PIMS (DU) , Loni (Bk) Tal Rahata , Dist. Ahmednagar , Maharashtra , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences , PIMS (DU) , Loni (Bk) Tal Rahata , Dist. Ahmednagar , Maharashtra , India","institution_ids":["https://openalex.org/I3130684616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111098884"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12641947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"1102","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tinospora-cordifolia","display_name":"Tinospora cordifolia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.9940000176429749},{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.5450000166893005},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.6589999794960022},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.734000027179718},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.5590000152587891},{"id":"https://openalex.org/keywords/immunomodulatory-activity","display_name":"immunomodulatory activity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nanoparticle-stability","display_name":"nanoparticle stability","score":0.7459999918937683},{"id":"https://openalex.org/keywords/drug-excipient-compatibility","display_name":"drug-excipient compatibility","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.780894935131073},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.7387570738792419},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6847391128540039},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5345045328140259},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5250059366226196},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.49732711911201477},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46574437618255615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4627096652984619},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.452023983001709},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.4219900071620941},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37309369444847107},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.36200150847435},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.2712979018688202},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2673489451408386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18063026666641235},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0995376706123352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05706113576889038},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.30574/wjarr.2023.20.3.2565","doi":"https://doi.org/10.30574/wjarr.2023.20.3.2565","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30574/wjarr.2023.20.3.2565","pdf_url":"https://wjarr.com/sites/default/files/WJARR-2023-2565.pdf","source":{"id":"https://openalex.org/S4210223820","display_name":"World Journal of Advanced Research and Reviews","issn_l":"2581-9615","issn":["2581-9615"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383735917","host_organization_name":"GSC Online Press","host_organization_lineage":["https://openalex.org/P4383735917"],"host_organization_lineage_names":["GSC Online Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Advanced Research and Reviews","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.30574/wjarr.2023.20.3.2565","doi":"https://doi.org/10.30574/wjarr.2023.20.3.2565","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30574/wjarr.2023.20.3.2565","pdf_url":"https://wjarr.com/sites/default/files/WJARR-2023-2565.pdf","source":{"id":"https://openalex.org/S4210223820","display_name":"World Journal of Advanced Research and Reviews","issn_l":"2581-9615","issn":["2581-9615"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383735917","host_organization_name":"GSC Online Press","host_organization_lineage":["https://openalex.org/P4383735917"],"host_organization_lineage_names":["GSC Online Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Advanced Research and Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390109783.pdf","grobid_xml":"https://content.openalex.org/works/W4390109783.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1575187886","https://openalex.org/W1769173164","https://openalex.org/W1987202454","https://openalex.org/W1987433127","https://openalex.org/W1993539603","https://openalex.org/W2000468514","https://openalex.org/W2009861810","https://openalex.org/W2038127901","https://openalex.org/W2051101501","https://openalex.org/W2072033756","https://openalex.org/W2074846494","https://openalex.org/W2075578034","https://openalex.org/W2082883035","https://openalex.org/W2107890026","https://openalex.org/W2127678942","https://openalex.org/W2166223383","https://openalex.org/W2176335656","https://openalex.org/W2182760280","https://openalex.org/W2185212125","https://openalex.org/W2228608559","https://openalex.org/W2407666211","https://openalex.org/W2468840815","https://openalex.org/W2481304745","https://openalex.org/W2561679358","https://openalex.org/W2567774772","https://openalex.org/W2575115152","https://openalex.org/W2766120496","https://openalex.org/W2804846127","https://openalex.org/W2895891965","https://openalex.org/W2991186475","https://openalex.org/W3026858038","https://openalex.org/W3091450230","https://openalex.org/W3097754655","https://openalex.org/W3163636327","https://openalex.org/W3209869758","https://openalex.org/W4247121846","https://openalex.org/W4289705087","https://openalex.org/W4289731102","https://openalex.org/W4310182060","https://openalex.org/W4362453094","https://openalex.org/W4366421522","https://openalex.org/W4366773529"],"related_works":["https://openalex.org/W7215153460","https://openalex.org/W2774845879","https://openalex.org/W4403225081","https://openalex.org/W4406233788","https://openalex.org/W7216900031","https://openalex.org/W7212386047","https://openalex.org/W7171302018","https://openalex.org/W4410871029","https://openalex.org/W2998007625","https://openalex.org/W7105189469"],"abstract_inverted_index":{"Solid":[0],"Lipid":[1],"Nanoparticles":[2],"(SLNs)":[3],"have":[4],"emerged":[5],"as":[6,53,219],"promising":[7],"drug":[8,69,72,110,124,132,144,154,169,186,225],"delivery":[9],"systems":[10],"with":[11,104],"the":[12,16,37,54,90,138,157,179,201,213],"potential":[13,139,180],"to":[14,101,117,128,150,173,199],"enhance":[15],"therapeutic":[17,202],"efficacy":[18,189],"of":[19,39,148,181,194,204,215],"bioactive":[20],"compounds.":[21],"In":[22],"this":[23],"study,":[24],"T.":[25,42,205],"Cordifolia":[26,206],"extract-loaded":[27,207],"SLNs":[28,94],"were":[29,59,135],"developed":[30],"and":[31,48,79,130,142,165,224],"characterized":[32],"for":[33,45,62,140,184],"their":[34],"application":[35],"in":[36,86,191],"treatment":[38],"autoimmune":[40,195],"hepatitis.":[41],"Cordifolia,":[43],"known":[44],"its":[46],"immunomodulatory":[47],"anti-inflammatory":[49],"properties,":[50],"was":[51],"chosen":[52],"active":[55],"ingredient.":[56],"The":[57,81,93],"formulations":[58,183],"systematically":[60],"evaluated":[61],"drug-excipient":[63,87],"compatibility,":[64,88],"particle":[65,97,220],"size,":[66,221],"zeta":[67,113,222],"potential,":[68,223],"loading":[70,125,155,226],"efficiency,":[71,76,227],"release":[73,133,160,170],"kinetics,":[74],"encapsulation":[75],"in-vitro":[77],"release,":[78],"stability.":[80,92,122],"results":[82],"indicated":[83,120],"\"No":[84],"Change\"":[85],"ensuring":[89],"formulation's":[91],"exhibited":[95,167],"nanoscale":[96],"sizes":[98],"(159.30":[99],"nm":[100],"172.12":[102],"nm)":[103],"narrow":[105],"size":[106],"distributions,":[107],"facilitating":[108],"consistent":[109],"delivery.":[111,145,187],"Negative":[112],"potentials":[114],"(-28.28":[115],"mV":[116],"-35.44":[118],"mV)":[119],"colloidal":[121],"High":[123],"efficiencies":[126,147],"(up":[127],"32.23%)":[129],"controlled":[131,185],"kinetics":[134],"observed,":[136],"suggesting":[137],"sustained":[141],"targeted":[143],"Encapsulation":[146],"up":[149],"83.41%":[151],"highlighted":[152],"efficient":[153],"within":[156],"SLNs.":[158,208],"In-vitro":[159],"studies":[161,190,211],"revealed":[162],"that":[163],"SLN2":[164],"SLN4":[166],"superior":[168],"profiles":[171],"compared":[172],"other":[174],"formulations.":[175],"These":[176],"findings":[177],"indicate":[178],"these":[182],"In-vivo":[188],"murine":[192],"models":[193],"hepatitis":[196],"are":[197],"recommended":[198],"assess":[200],"benefits":[203],"Additionally,":[209],"stability":[210],"demonstrated":[212],"maintenance":[214],"critical":[216],"parameters,":[217],"such":[218],"under":[228],"different":[229],"storage":[230],"conditions.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-23T00:00:00"}