{"id":"https://openalex.org/W4390106142","doi":"https://doi.org/10.1111/bjh.19266","title":"Clinical factors for central nervous system progression and survival in primary vitreoretinal lymphoma","display_name":"Clinical factors for central nervous system progression and survival in primary vitreoretinal lymphoma","publication_year":2023,"publication_date":"2023-12-22","ids":{"openalex":"https://openalex.org/W4390106142","doi":"https://doi.org/10.1111/bjh.19266","pmid":"https://pubmed.ncbi.nlm.nih.gov/38131400"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.19266","doi":"https://doi.org/10.1111/bjh.19266","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjh.19266","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064934193","display_name":"Yotaro Motomura","orcid":"https://orcid.org/0000-0002-1315-4936","observed_orcids":["https://orcid.org/0000-0002-1315-4936"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yotaro Motomura","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082056388","display_name":"Kota Yoshifuji","orcid":"https://orcid.org/0009-0000-9206-3137","observed_orcids":["https://orcid.org/0009-0000-9206-3137"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kota Yoshifuji","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0000-9206-3137","affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034388223","display_name":"Takayoshi Tachibana","orcid":"https://orcid.org/0000-0002-7780-4459","observed_orcids":["https://orcid.org/0000-0002-7780-4459"]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Tachibana","raw_affiliation_strings":["Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4387152949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101976815","display_name":"Hiroshi Takase","orcid":"https://orcid.org/0000-0001-8327-803X","observed_orcids":["https://orcid.org/0000-0001-8327-803X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Takase","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086342547","display_name":"Ayako Arai","orcid":"https://orcid.org/0000-0002-8275-5372","observed_orcids":["https://orcid.org/0000-0002-8275-5372"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayako Arai","raw_affiliation_strings":["Department of Hematology and Biophysical Systems Analysis, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","Department of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8275-5372","affiliations":[{"raw_affiliation_string":"Department of Hematology and Biophysical Systems Analysis, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keisuke Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Tanaka","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074823672","display_name":"Keigo Okada","orcid":"https://orcid.org/0000-0002-5196-3152","observed_orcids":["https://orcid.org/0000-0002-5196-3152"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keigo Okada","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103687414","display_name":"Ayako Nogami","orcid":"https://orcid.org/0009-0002-6374-3138","observed_orcids":["https://orcid.org/0009-0002-6374-3138"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayako Nogami","raw_affiliation_strings":["Department of Laboratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002230786","display_name":"Yoshihiro Umezawa","orcid":"https://orcid.org/0000-0003-1027-1552","observed_orcids":["https://orcid.org/0000-0003-1027-1552"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Umezawa","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024837018","display_name":"Chizuko Sakashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chizuko Sakashita","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087127498","display_name":"Masahide Yamamoto","orcid":"https://orcid.org/0000-0002-3142-8806","observed_orcids":["https://orcid.org/0000-0002-3142-8806"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahide Yamamoto","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takehiko Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiko Mori","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071276592","display_name":"Toshikage Nagao","orcid":"https://orcid.org/0000-0002-1766-3842","observed_orcids":["https://orcid.org/0000-0002-1766-3842"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikage Nagao","raw_affiliation_strings":["Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082056388"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":4940,"currency":"USD","value_usd":4940},"apc_paid":null,"fwci":0.8245,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.7193685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"204","issue":"4","first_page":"1279","last_page":"1287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-vitreoretinal-lymphoma","display_name":"primary vitreoretinal lymphoma","score":1.0},{"id":"https://openalex.org/keywords/central-nervous-system-progression","display_name":"central nervous system progression","score":0.9710000157356262},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6520000100135803},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/intravitreal-methotrexate","display_name":"intravitreal methotrexate","score":0.8870000243186951},{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.8420000076293945},{"id":"https://openalex.org/keywords/bilateral-disease","display_name":"bilateral disease","score":0.6990000009536743},{"id":"https://openalex.org/keywords/b-cell-clonality","display_name":"B-cell clonality","score":0.996999979019165},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8075170516967773},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6829137206077576},{"id":"https://openalex.org/C2781173314","wikidata":"https://www.wikidata.org/wiki/Q3246818","display_name":"Primary central nervous system lymphoma","level":3,"score":0.6646459698677063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6074166893959045},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5910230875015259},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5799037218093872},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4994668960571289},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.45928075909614563},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4487622082233429},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.37303391098976135},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3430882692337036},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1663971245288849}],"mesh":[{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019572","descriptor_name":"Retinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019572","descriptor_name":"Retinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/bjh.19266","doi":"https://doi.org/10.1111/bjh.19266","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjh.19266","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:38131400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38131400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2905430913","display_name":"Elucidation of the mechanism of central nervous system progression in primary vitreoretinal lymphoma","funder_award_id":"23K15296","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3643969597","display_name":"Therapeutic potential of novel antibody-oligonucleotide conjugate for intractable B-cell lymphomas","funder_award_id":"22K08497","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4336016780","display_name":"Search for novel biomarkers of primary vitreoretinal lymphoma by comprehensive genetic analysis","funder_award_id":"22K20785","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5977162723","display_name":"Association between CD79B gene mutation and prognosis in vitreoretinal lymphoma","funder_award_id":"22K09763","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1983979831","https://openalex.org/W2003105250","https://openalex.org/W2004883460","https://openalex.org/W2018712601","https://openalex.org/W2092367552","https://openalex.org/W2095662635","https://openalex.org/W2121960517","https://openalex.org/W2152162065","https://openalex.org/W2179808839","https://openalex.org/W2231865806","https://openalex.org/W2315924559","https://openalex.org/W2470586266","https://openalex.org/W2735085256","https://openalex.org/W2775539199","https://openalex.org/W2786766048","https://openalex.org/W2898779567","https://openalex.org/W2902013385","https://openalex.org/W3134930493","https://openalex.org/W3153537561","https://openalex.org/W3157344999","https://openalex.org/W3158109059","https://openalex.org/W3163960854","https://openalex.org/W4205489115","https://openalex.org/W4214773008","https://openalex.org/W4283066110","https://openalex.org/W7075738152"],"related_works":["https://openalex.org/W7168465357","https://openalex.org/W7108609360","https://openalex.org/W4283066110","https://openalex.org/W2911285591","https://openalex.org/W4410110295","https://openalex.org/W2095662635","https://openalex.org/W4392509813","https://openalex.org/W7127430172","https://openalex.org/W3163960854","https://openalex.org/W2902013385"],"abstract_inverted_index":{"Primary":[0],"vitreoretinal":[1],"lymphoma":[2,10],"(PVRL)":[3],"is":[4,32],"a":[5,12,44,99,174],"rare":[6],"subtype":[7],"of":[8,16,19,26,38,47,90,101,115,122,145,167,198],"malignant":[9],"with":[11,29,40,51,62,71,87,157,200],"poor":[13],"prognosis":[14,37],"because":[15],"high":[17],"frequency":[18],"central":[20],"nervous":[21],"system":[22],"(CNS)":[23],"progression.":[24,159],"Identification":[25],"factors":[27,60,155,181],"associated":[28,61,156],"CNS":[30,63,123,158,168,183],"progression":[31,64,124,169,184],"essential":[33],"to":[34,58,189,194],"improve":[35,195],"the":[36,77,143,165,190,196],"patients":[39,49,68,84,199],"PVRL.":[41,201],"We":[42],"conducted":[43],"retrospective":[45],"study":[46],"54":[48],"diagnosed":[50],"PVRL":[52],"and":[53,65,125,132,137,142,170],"treated":[54,70,86],"at":[55],"our":[56],"hospital":[57],"identify":[59],"prognosis.":[66],"All":[67],"were":[69,85,130,153],"intravitreal":[72,105],"methotrexate":[73],"(MTX)":[74],"injections":[75],"in":[76],"affected":[78],"eyes":[79],"until":[80],"lesion":[81],"resolution.":[82],"Twenty-four":[83],"systemic":[88,116,161],"administration":[89],"high-dose":[91],"MTX":[92,106],"(systemic":[93],"HD-MTX)":[94],"every":[95],"other":[96],"week":[97],"for":[98,182],"total":[100],"five":[102,113],"cycles":[103,114],"following":[104],"injection.":[107],"Of":[108],"24":[109],"patients,":[110],"20":[111],"completed":[112],"HD-MTX.":[117],"The":[118],"5-year":[119],"cumulative":[120],"incidence":[121],"overall":[126],"survival":[127,197],"(OS)":[128],"rate":[129],"78.0%":[131],"69.0%":[133],"respectively.":[134],"By":[135],"univariate":[136],"multivariate":[138],"analyses,":[139],"bilateral":[140],"disease":[141],"detection":[144],"B-cell":[146],"clonality":[147],"confirmed":[148],"by":[149],"flow":[150],"cytometric":[151],"analysis":[152],"risk":[154,166],"Moreover,":[160],"HD-MTX":[162],"completion":[163],"reduced":[164],"was":[171],"identified":[172,185],"as":[173],"factor":[175],"affecting":[176],"OS.":[177],"In":[178],"this":[179],"study,":[180],"may":[186],"potentially":[187],"contribute":[188],"optimized":[191],"therapeutic":[192],"stratification":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-23T00:00:00"}
