{"id":"https://openalex.org/W4390103740","doi":"https://doi.org/10.1002/cam4.6876","title":"Serum CXCL10 levels at the start of the second course of atezolizumab plus bevacizumab therapy predict therapeutic efficacy in patients with advanced BCLC stage C hepatocellular carcinoma: A multicenter analysis","display_name":"Serum CXCL10 levels at the start of the second course of atezolizumab plus bevacizumab therapy predict therapeutic efficacy in patients with advanced BCLC stage C hepatocellular carcinoma: A multicenter analysis","publication_year":2023,"publication_date":"2023-12-22","ids":{"openalex":"https://openalex.org/W4390103740","doi":"https://doi.org/10.1002/cam4.6876","pmid":"https://pubmed.ncbi.nlm.nih.gov/38133557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10807580"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.6876","doi":"https://doi.org/10.1002/cam4.6876","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.6876","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.6876","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.6876","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091721791","display_name":"Takanori Suzuki","orcid":"https://orcid.org/0000-0002-8940-2393","observed_orcids":["https://orcid.org/0000-0002-8940-2393"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Suzuki","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786576","display_name":"Kentaro Matsuura","orcid":"https://orcid.org/0009-0005-0163-3971","observed_orcids":["https://orcid.org/0009-0005-0163-3971"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kentaro Matsuura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0009-0005-0163-3971","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005957474","display_name":"Yuta Suzuki","orcid":"https://orcid.org/0000-0002-9406-4691","observed_orcids":["https://orcid.org/0000-0002-9406-4691"]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Suzuki","raw_affiliation_strings":["Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100861068","display_name":"Fumihiro Okumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihiro Okumura","raw_affiliation_strings":["Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003967732","display_name":"Yoshihito Nagura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103227","display_name":"Kasugai Municipal Hospital","ror":"https://ror.org/019ekef14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103227"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihito Nagura","raw_affiliation_strings":["Department of Gastroenterology, Kasugai Municipal Hospital, Kasugai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Kasugai Municipal Hospital, Kasugai, Japan","institution_ids":["https://openalex.org/I4210103227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112304862","display_name":"Satoshi Sobue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103227","display_name":"Kasugai Municipal Hospital","ror":"https://ror.org/019ekef14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103227"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Sobue","raw_affiliation_strings":["Department of Gastroenterology, Kasugai Municipal Hospital, Kasugai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Kasugai Municipal Hospital, Kasugai, Japan","institution_ids":["https://openalex.org/I4210103227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029431407","display_name":"Sho Matoya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095909","display_name":"Toyokawa City Hospital","ror":"https://ror.org/00rsqd019","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095909"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Matoya","raw_affiliation_strings":["Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan","institution_ids":["https://openalex.org/I4210095909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059425932","display_name":"Tomokatsu Miyaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095909","display_name":"Toyokawa City Hospital","ror":"https://ror.org/00rsqd019","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095909"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomokatsu Miyaki","raw_affiliation_strings":["Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan","institution_ids":["https://openalex.org/I4210095909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007300762","display_name":"Yoshihide Kimura","orcid":"https://orcid.org/0000-0003-4801-8384","observed_orcids":["https://orcid.org/0000-0003-4801-8384"]},"institutions":[{"id":"https://openalex.org/I4405283410","display_name":"Nagoya City University West Medical Center","ror":"https://ror.org/01mjfcx54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283410"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihide Kimura","raw_affiliation_strings":["Department of Gastroenterology, Nagoya City University West Medical Center, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4801-8384","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nagoya City University West Medical Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4405283410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044841384","display_name":"Atsunori Kusakabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153328","display_name":"Japanese Red Cross Nagoya Daini Hospital","ror":"https://ror.org/043pqsk20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210153328"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsunori Kusakabe","raw_affiliation_strings":["Department of Gastroenterology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4210153328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004634738","display_name":"Satoshi Narahara","orcid":"https://orcid.org/0000-0001-8647-9486","observed_orcids":["https://orcid.org/0000-0001-8647-9486"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Narahara","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049936220","display_name":"Takayuki Tokunaga","orcid":"https://orcid.org/0000-0002-3631-4525","observed_orcids":["https://orcid.org/0000-0002-3631-4525"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Tokunaga","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3631-4525","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005875682","display_name":"Katsuya Nagaoka","orcid":"https://orcid.org/0000-0002-7152-6101","observed_orcids":["https://orcid.org/0000-0002-7152-6101"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Nagaoka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7152-6101","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060079169","display_name":"Keita Kuroyanagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keita Kuroyanagi","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068438828","display_name":"Hayato Kawamura","orcid":"https://orcid.org/0000-0002-7679-4279","observed_orcids":["https://orcid.org/0000-0002-7679-4279"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hayato Kawamura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089198655","display_name":"Kayoko Kuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayoko Kuno","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033332597","display_name":"Kei Fujiwara","orcid":"https://orcid.org/0000-0003-4531-4444","observed_orcids":["https://orcid.org/0000-0003-4531-4444"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Fujiwara","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020203707","display_name":"Shunsuke Nojiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Nojiri","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047369080","display_name":"Hiromi Kataoka","orcid":"https://orcid.org/0000-0001-9491-0723","observed_orcids":["https://orcid.org/0000-0001-9491-0723"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Kataoka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009887722","display_name":"Yasuhito Tanaka","orcid":"https://orcid.org/0000-0002-2473-6966","observed_orcids":["https://orcid.org/0000-0002-2473-6966","https://orcid.org/0000-0002-7658-3690"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Tanaka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5102786576"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":{"value":4070,"currency":"USD","value_usd":4070},"fwci":0.8902,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73777636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"1","first_page":"e6876","last_page":"e6876"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.9259999990463257},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.8809999823570251},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bclc-stage-c","display_name":"BCLC stage C","score":0.9670000076293945},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7450000047683716},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.8809999823570251},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.734000027179718},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.757727861404419},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.7035178542137146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6787240505218506},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6700885891914368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6386862993240356},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5546968579292297},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5188904404640198},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.5024368762969971},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47622114419937134},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.4548635184764862},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.44802743196487427},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3284780979156494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29580748081207275},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29060956835746765},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.21614158153533936},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.184650719165802},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.14051350951194763},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.08979916572570801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07697799801826477},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.07496234774589539},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054357","descriptor_name":"Chemokine CXCL10","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/cam4.6876","doi":"https://doi.org/10.1002/cam4.6876","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.6876","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.6876","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10807580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10807580","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10807580/pdf/CAM4-13-e6876.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Med","raw_type":"Text"},{"id":"pmid:38133557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38133557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:62de0767db2a49edbc37c059b963d6d0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/62de0767db2a49edbc37c059b963d6d0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cam4.6876","doi":"https://doi.org/10.1002/cam4.6876","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.6876","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.6876","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2163449755","display_name":"Elucidation of the resistance mechanism to chemotherapy in biliary tract and pancreatic cancer by focusing on energy-metabolizing coenzymes","funder_award_id":"22K15971","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2661224630","display_name":"Exodomal miRNA\u30fb\u7d30\u83cc\u53e2\u89e3\u6790\u304c\u62d3\u304f\u809d\u764c\u514d\u75ab\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u4e88\u6e2c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u78ba\u7acb","funder_award_id":"23K15076","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4359795407","display_name":"Development of biomarkers to predict the efficacy of cancer immunotherapy for unresectable hepatocellular carcinoma","funder_award_id":"23K07359","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6083085152","display_name":"Analysis of pathogenesis by epsilon structure of hepatitis B virus","funder_award_id":"21K20906","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7472133857","display_name":"Drug discovery research targeting the lysosomal nutrient sensing mechanism for the prevention of NASH-related liver cancer","funder_award_id":"23K27589","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390103740.pdf","grobid_xml":"https://content.openalex.org/works/W4390103740.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1019458012","https://openalex.org/W1971837077","https://openalex.org/W1994003134","https://openalex.org/W2008603652","https://openalex.org/W2019607817","https://openalex.org/W2024411037","https://openalex.org/W2028319026","https://openalex.org/W2081796577","https://openalex.org/W2085852125","https://openalex.org/W2103310685","https://openalex.org/W2119190881","https://openalex.org/W2121960517","https://openalex.org/W2147172608","https://openalex.org/W2560499218","https://openalex.org/W2761031851","https://openalex.org/W2770893462","https://openalex.org/W2787358630","https://openalex.org/W2795334950","https://openalex.org/W2809889937","https://openalex.org/W2891693342","https://openalex.org/W2902530914","https://openalex.org/W2934884265","https://openalex.org/W2945224722","https://openalex.org/W2965854675","https://openalex.org/W2990602950","https://openalex.org/W2990771207","https://openalex.org/W3014830197","https://openalex.org/W3025022288","https://openalex.org/W3047106569","https://openalex.org/W3110414417","https://openalex.org/W3128646645","https://openalex.org/W4200388794","https://openalex.org/W4210963086","https://openalex.org/W4213062169","https://openalex.org/W4213154232","https://openalex.org/W4281695324","https://openalex.org/W4292553490","https://openalex.org/W4294904355","https://openalex.org/W4307886382","https://openalex.org/W4316506182","https://openalex.org/W4317467445","https://openalex.org/W4318754607","https://openalex.org/W4324262440"],"related_works":["https://openalex.org/W4382502741","https://openalex.org/W4400157588","https://openalex.org/W4406179792","https://openalex.org/W4400331892","https://openalex.org/W4318754607","https://openalex.org/W4307886382","https://openalex.org/W4405192996","https://openalex.org/W4402478849","https://openalex.org/W4403604533","https://openalex.org/W3205595708"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"Relationships":[3],"of":[4,38,45,100,104,144,166,215,228,237],"serum":[5,138],"C-C":[6],"motif":[7,14],"chemokine":[8,15],"ligand":[9,16],"5":[10],"(CCL5)":[11],"and":[12,66,85,96,107,161,190,209,218],"C-X-C":[13],"10":[17],"(CXCL10)":[18],"levels":[19,40,87,140,208,234],"with":[20,29,52,59,62,110,121,130,242],"hot":[21],"immune":[22],"features":[23],"have":[24],"been":[25],"reported":[26],"in":[27,50,152,155,157,240],"patients":[28,51,58,129,174,241],"hepatocellular":[30],"carcinoma":[31],"(HCC).":[32],"Therefore,":[33],"we":[34],"examined":[35],"the":[36,43,98,101,122,127,142,158,213],"utility":[37],"their":[39,67,108],"for":[41],"predicting":[42],"efficacy":[44,112,239],"atezolizumab":[46],"plus":[47],"bevacizumab":[48],"(Atez/Bev)":[49],"HCC.":[53,246],"DESIGN:":[54],"In":[55,203],"total,":[56],"98":[57],"HCC":[60],"treated":[61],"Atez/Bev":[63,105,238],"were":[64,70,88,113,224,235],"enrolled,":[65],"initial":[68,123,159],"responses":[69],"evaluated":[71],"at":[72,97,141,212,222],"least":[73],"once":[74],"via":[75],"dynamic":[76],"computed":[77],"tomography":[78],"or":[79],"magnetic":[80],"resonance":[81],"imaging.":[82],"Serum":[83,232],"CCL5":[84],"CXCL10":[86,139,207],"assessed":[89],"by":[90],"enzyme-linked":[91],"immunosorbent":[92],"assay":[93],"before":[94],"treatment":[95,111],"start":[99,214],"second":[102],"course":[103,145,216],"therapy,":[106],"relationships":[109],"determined.":[114],"RESULTS:":[115],"No":[116],"analyzed":[117],"factor":[118],"was":[119],"associated":[120],"therapeutic":[124],"response.":[125],"Among":[126],"56":[128],"Barcelona":[131],"Clinic":[132],"Liver":[133],"Cancer":[134],"(BCLC)":[135],"stage":[136,220,244],"C,":[137],"beginning":[143],"two":[146,217],"(CXCL10-2c)":[147],"tended":[148],"to":[149,172],"be":[150,170],"higher":[151],"responders":[153],"than":[154],"non-responders":[156],"evaluation,":[160],"its":[162],"optimal":[163],"cutoff":[164],"level":[165],"690":[167],"pg/mL":[168],"could":[169],"used":[171],"stratify":[173],"regarding":[175],"overall":[176],"survival":[177,192],"(OS;":[178],"high":[179,206],"vs.":[180,184,194,197],"low:":[181,195],"not":[182],"reached":[183],"17.6":[185],"months,":[186,199],"p":[187,200],"=":[188,201],"0.034)":[189],"progression-free":[191],"(high":[193],"13.6":[196],"5.1":[198],"0.014).":[202],"multivariate":[204],"analysis,":[205],"neutrophil-to-lymphocyte":[210],"ratios":[211],"Child-Pugh":[219],"A":[221],"baseline":[223],"independent":[225],"predictive":[226,236],"factors":[227],"improved":[229],"OS.":[230],"CONCLUSIONS:":[231],"CXCL10-2c":[233],"BCLC":[243],"C":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-12-23T00:00:00"}