{"id":"https://openalex.org/W4390082948","doi":"https://doi.org/10.1021/acsomega.3c00763","title":"Salicylic Acid Conjugate of Telmisartan Inhibits Chikungunya Virus Infection and Inflammation","display_name":"Salicylic Acid Conjugate of Telmisartan Inhibits Chikungunya Virus Infection and Inflammation","publication_year":2023,"publication_date":"2023-12-21","ids":{"openalex":"https://openalex.org/W4390082948","doi":"https://doi.org/10.1021/acsomega.3c00763","pmid":"https://pubmed.ncbi.nlm.nih.gov/38222605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10785651"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.3c00763","doi":"https://doi.org/10.1021/acsomega.3c00763","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c00763","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00763","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00763","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rudra Narayan Dash","orcid":"https://orcid.org/0000-0002-9760-0808","observed_orcids":["https://orcid.org/0000-0002-9760-0808"]},"institutions":[{"id":"https://openalex.org/I193073490","display_name":"Siksha O Anusandhan University","ror":"https://ror.org/056ep7w45","country_code":"IN","type":"education","lineage":["https://openalex.org/I193073490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rudra Narayan Dash","raw_affiliation_strings":["Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India"],"raw_orcid":"https://orcid.org/0000-0002-9760-0808","affiliations":[{"raw_affiliation_string":"Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India","institution_ids":["https://openalex.org/I193073490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088025438","display_name":"Amrita Ray","orcid":"https://orcid.org/0000-0001-5220-9402","observed_orcids":["https://orcid.org/0000-0001-5220-9402"]},"institutions":[{"id":"https://openalex.org/I4210094671","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094671"]},{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amrita Ray","raw_affiliation_strings":["Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","Regional Centre for Biotechnology, 121001 Faridabad, India"],"raw_orcid":"https://orcid.org/0000-0001-5220-9402","affiliations":[{"raw_affiliation_string":"Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","institution_ids":["https://openalex.org/I4210118921"]},{"raw_affiliation_string":"Regional Centre for Biotechnology, 121001 Faridabad, India","institution_ids":["https://openalex.org/I4210094671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042396267","display_name":"Prabhudutta Mamidi","orcid":"https://orcid.org/0000-0002-0187-571X","observed_orcids":["https://orcid.org/0000-0002-0187-571X"]},"institutions":[{"id":"https://openalex.org/I4210117092","display_name":"All India Institute of Medical Sciences Bhubaneswar","ror":"https://ror.org/029mnbn96","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210117092"]},{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prabhudutta Mamidi","raw_affiliation_strings":["Department of Microbiology (VRDL), AIIMS, Sijua, Patrapada, Bhubaneswar 751019,Odisha, India","Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology (VRDL), AIIMS, Sijua, Patrapada, Bhubaneswar 751019,Odisha, India","institution_ids":["https://openalex.org/I4210117092"]},{"raw_affiliation_string":"Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","institution_ids":["https://openalex.org/I4210118921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029052246","display_name":"Saikat De","orcid":"https://orcid.org/0000-0003-2028-0428","observed_orcids":["https://orcid.org/0000-0003-2028-0428"]},"institutions":[{"id":"https://openalex.org/I4210094671","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094671"]},{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saikat De","raw_affiliation_strings":["Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","Regional Centre for Biotechnology, 121001 Faridabad, India"],"raw_orcid":"https://orcid.org/0000-0003-2028-0428","affiliations":[{"raw_affiliation_string":"Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","institution_ids":["https://openalex.org/I4210118921"]},{"raw_affiliation_string":"Regional Centre for Biotechnology, 121001 Faridabad, India","institution_ids":["https://openalex.org/I4210094671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080049350","display_name":"Tapas Kumar Mohapatra","orcid":"https://orcid.org/0000-0003-4754-8973","observed_orcids":["https://orcid.org/0000-0003-4754-8973"]},"institutions":[{"id":"https://openalex.org/I193073490","display_name":"Siksha O Anusandhan University","ror":"https://ror.org/056ep7w45","country_code":"IN","type":"education","lineage":["https://openalex.org/I193073490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tapas K Mohapatra","raw_affiliation_strings":["Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India","Nityananda College of Pharmacy, Seragarh, Balasore, Odisha 756060, India"],"raw_orcid":"https://orcid.org/0000-0003-4754-8973","affiliations":[{"raw_affiliation_string":"Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India","institution_ids":["https://openalex.org/I193073490"]},{"raw_affiliation_string":"Nityananda College of Pharmacy, Seragarh, Balasore, Odisha 756060, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068334409","display_name":"Alok Kumar Moharana","orcid":"https://orcid.org/0000-0002-6169-6000","observed_orcids":["https://orcid.org/0000-0002-6169-6000"]},"institutions":[{"id":"https://openalex.org/I193073490","display_name":"Siksha O Anusandhan University","ror":"https://ror.org/056ep7w45","country_code":"IN","type":"education","lineage":["https://openalex.org/I193073490"]},{"id":"https://openalex.org/I4404532891","display_name":"Arka Jain University","ror":"https://ror.org/02fgksf31","country_code":"IN","type":"education","lineage":["https://openalex.org/I4404532891"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Alok K Moharana","raw_affiliation_strings":["Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India","School of Pharmacy, Arka Jain University, Mohanpur, Jharkhand 832108, India"],"raw_orcid":"https://orcid.org/0000-0002-6169-6000","affiliations":[{"raw_affiliation_string":"Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India","institution_ids":["https://openalex.org/I193073490"]},{"raw_affiliation_string":"School of Pharmacy, Arka Jain University, Mohanpur, Jharkhand 832108, India","institution_ids":["https://openalex.org/I4404532891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057529999","display_name":"Tathagata Mukherjee","orcid":"https://orcid.org/0000-0001-7504-5957","observed_orcids":["https://orcid.org/0000-0001-7504-5957"]},"institutions":[{"id":"https://openalex.org/I163389970","display_name":"National Institute of Science Education and Research","ror":"https://ror.org/02r2k1c68","country_code":"IN","type":"education","lineage":["https://openalex.org/I163389970","https://openalex.org/I200207707"]},{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tathagata Mukherjee","raw_affiliation_strings":["School of Biological Sciences, National Institute of Science Education and Research, HBNI, 752050 Bhubaneswar, India"],"raw_orcid":"https://orcid.org/0000-0001-7504-5957","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, National Institute of Science Education and Research, HBNI, 752050 Bhubaneswar, India","institution_ids":["https://openalex.org/I163389970","https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062801055","display_name":"Soumyajit Ghosh","orcid":"https://orcid.org/0000-0003-3991-3010","observed_orcids":["https://orcid.org/0000-0003-3991-3010"]},"institutions":[{"id":"https://openalex.org/I4210094671","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210094671"]},{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Soumyajit Ghosh","raw_affiliation_strings":["Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","Regional Centre for Biotechnology, 121001 Faridabad, India"],"raw_orcid":"https://orcid.org/0000-0003-3991-3010","affiliations":[{"raw_affiliation_string":"Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","institution_ids":["https://openalex.org/I4210118921"]},{"raw_affiliation_string":"Regional Centre for Biotechnology, 121001 Faridabad, India","institution_ids":["https://openalex.org/I4210094671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101974125","display_name":"Subhasis Chattopadhyay","orcid":"https://orcid.org/0000-0002-2596-8451","observed_orcids":["https://orcid.org/0000-0002-2596-8451"]},"institutions":[{"id":"https://openalex.org/I163389970","display_name":"National Institute of Science Education and Research","ror":"https://ror.org/02r2k1c68","country_code":"IN","type":"education","lineage":["https://openalex.org/I163389970","https://openalex.org/I200207707"]},{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]},{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhasis Chattopadhyay","raw_affiliation_strings":["Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","School of Biological Sciences, National Institute of Science Education and Research, HBNI, 752050 Bhubaneswar, India"],"raw_orcid":"https://orcid.org/0000-0002-2596-8451","affiliations":[{"raw_affiliation_string":"Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","institution_ids":["https://openalex.org/I4210118921"]},{"raw_affiliation_string":"School of Biological Sciences, National Institute of Science Education and Research, HBNI, 752050 Bhubaneswar, India","institution_ids":["https://openalex.org/I163389970","https://openalex.org/I200207707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036119385","display_name":"Bharat Bhusan Subudhi","orcid":"https://orcid.org/0000-0002-2411-7292","observed_orcids":["https://orcid.org/0000-0002-2411-7292"]},"institutions":[{"id":"https://openalex.org/I193073490","display_name":"Siksha O Anusandhan University","ror":"https://ror.org/056ep7w45","country_code":"IN","type":"education","lineage":["https://openalex.org/I193073490"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Bharat B Subudhi","raw_affiliation_strings":["Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India"],"raw_orcid":"https://orcid.org/0000-0002-2411-7292","affiliations":[{"raw_affiliation_string":"Drug Development and Analysis Lab, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar 751003, Odisha, India","institution_ids":["https://openalex.org/I193073490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043216339","display_name":"Soma Chattopadhyay","orcid":"https://orcid.org/0000-0001-8378-1014","observed_orcids":["https://orcid.org/0000-0001-8378-1014"]},"institutions":[{"id":"https://openalex.org/I163389970","display_name":"National Institute of Science Education and Research","ror":"https://ror.org/02r2k1c68","country_code":"IN","type":"education","lineage":["https://openalex.org/I163389970","https://openalex.org/I200207707"]},{"id":"https://openalex.org/I200207707","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67","country_code":"IN","type":"education","lineage":["https://openalex.org/I200207707"]},{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Soma Chattopadhyay","raw_affiliation_strings":["Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","School of Biological Sciences, National Institute of Science Education and Research, HBNI, 752050 Bhubaneswar, India"],"raw_orcid":"https://orcid.org/0000-0001-8378-1014","affiliations":[{"raw_affiliation_string":"Infectious Disease Biology, Institute of Life Sciences, NALCO square, Bhubaneswar 751023,Odisha, India","institution_ids":["https://openalex.org/I4210118921"]},{"raw_affiliation_string":"School of Biological Sciences, National Institute of Science Education and Research, HBNI, 752050 Bhubaneswar, India","institution_ids":["https://openalex.org/I163389970","https://openalex.org/I200207707"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5036119385","https://openalex.org/A5043216339"],"corresponding_institution_ids":["https://openalex.org/I163389970","https://openalex.org/I193073490","https://openalex.org/I200207707","https://openalex.org/I4210118921"],"apc_list":{"value":1685,"currency":"USD","value_usd":1685},"apc_paid":{"value":1685,"currency":"USD","value_usd":1685},"fwci":1.5425,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80216168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"146","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chikungunya-virus","display_name":"chikungunya virus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/telmisartan","display_name":"telmisartan","score":0.9610000252723694},{"id":"https://openalex.org/keywords/salicylic-acid","display_name":"salicylic acid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/antiviral-drug-discovery","display_name":"antiviral drug discovery","score":0.7730000019073486},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/viral-infection-inhibition","display_name":"viral infection inhibition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/drug-selectivity-index","display_name":"drug selectivity index","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2781273456","wikidata":"https://www.wikidata.org/wiki/Q243257","display_name":"Chikungunya","level":3,"score":0.7470076084136963},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6771478056907654},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6345125436782837},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5791265964508057},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5495471358299255},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5443945527076721},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5353491902351379},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5108875632286072},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49495571851730347},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.48957476019859314},{"id":"https://openalex.org/C2779716603","wikidata":"https://www.wikidata.org/wiki/Q733186","display_name":"Telmisartan","level":3,"score":0.4738876223564148},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.44245675206184387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43655964732170105},{"id":"https://openalex.org/C2778221352","wikidata":"https://www.wikidata.org/wiki/Q193572","display_name":"Salicylic acid","level":2,"score":0.43467360734939575},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39598286151885986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37153714895248413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3498597741127014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2087133228778839},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1841387152671814},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1785551905632019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08401939272880554},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.3c00763","doi":"https://doi.org/10.1021/acsomega.3c00763","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c00763","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00763","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10785651","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10785651","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10785651/pdf/ao3c00763.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:38222605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38222605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b1fe27825b1a4388b48af5d45884389e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b1fe27825b1a4388b48af5d45884389e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 9, Iss 1, Pp 146-156 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.3c00763","doi":"https://doi.org/10.1021/acsomega.3c00763","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c00763","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00763","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1465150736","display_name":null,"funder_award_id":"EMR/2015/002433","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G319135039","display_name":null,"funder_award_id":"16-6(DEC.2018)/2019(NET/CSIR)","funder_id":"https://openalex.org/F4320320767","funder_display_name":"University Grants Commission"}],"funders":[{"id":"https://openalex.org/F4320311004","display_name":"Jain University","ror":"https://ror.org/01cnqpt53"},{"id":"https://openalex.org/F4320317217","display_name":"Regional Centre for Biotechnology","ror":"https://ror.org/00nc5f834"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"},{"id":"https://openalex.org/F4320324337","display_name":"All-India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71"},{"id":"https://openalex.org/F4320327905","display_name":"National Institute of Science Education and Research","ror":"https://ror.org/02r2k1c68"},{"id":"https://openalex.org/F4320329802","display_name":"Homi Bhabha National Institute","ror":"https://ror.org/02bv3zr67"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390082948.pdf","grobid_xml":"https://content.openalex.org/works/W4390082948.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1264349364","https://openalex.org/W1486868167","https://openalex.org/W1858465734","https://openalex.org/W1973678976","https://openalex.org/W1974630175","https://openalex.org/W1982796443","https://openalex.org/W1989406910","https://openalex.org/W2003367073","https://openalex.org/W2008376262","https://openalex.org/W2026949398","https://openalex.org/W2027259512","https://openalex.org/W2033353435","https://openalex.org/W2039140339","https://openalex.org/W2044550637","https://openalex.org/W2053298605","https://openalex.org/W2057148259","https://openalex.org/W2070608209","https://openalex.org/W2132117914","https://openalex.org/W2262538191","https://openalex.org/W2297473358","https://openalex.org/W2396806161","https://openalex.org/W2404410565","https://openalex.org/W2509132643","https://openalex.org/W2510966473","https://openalex.org/W2740184008","https://openalex.org/W2754763221","https://openalex.org/W2778380021","https://openalex.org/W2800580082","https://openalex.org/W2896641402","https://openalex.org/W2904292098","https://openalex.org/W3035933618","https://openalex.org/W3087665038","https://openalex.org/W3094947198","https://openalex.org/W3165562135","https://openalex.org/W3165683179","https://openalex.org/W3197718606","https://openalex.org/W3212140265","https://openalex.org/W4244755155","https://openalex.org/W4283719907"],"related_works":["https://openalex.org/W3212140265","https://openalex.org/W4366679832","https://openalex.org/W2549022637","https://openalex.org/W2584476310","https://openalex.org/W3015734270","https://openalex.org/W4244693688","https://openalex.org/W3035933618","https://openalex.org/W2887189517","https://openalex.org/W3127453153","https://openalex.org/W4385629247"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"There":[7],"is":[8],"no":[9],"approved":[10],"antiviral":[11,23,130],"for":[12],"the":[13,16,91,107,113,129,162,205],"management":[14],"of":[15,38,54,73,93,110,121,154,170],"Chikungunya":[17],"virus":[18],"(CHIKV).":[19],"To":[20],"develop":[21],"an":[22,35,167],"drug":[24,218],"that":[25,156,220],"can":[26],"manage":[27],"both":[28],"CHIKV":[29,75],"and":[30,41,57,87,123,132,175,191,204,210],"arthritis":[31],"induced":[32],"by":[33,80],"it,":[34],"ester":[36],"conjugate":[37,120],"telmisartan":[39],"(TM)":[40],"salicylic":[42],"acid":[43],"(SA)":[44],"was":[45,77,125,176],"synthesized":[46],"(DDABT1).":[47],"It":[48],"showed":[49,166,200],"higher":[50],"potency":[51],"(IC":[52],"50":[53,65,67,169],"14.53":[55],"\u03bcM)":[56],"a":[58,214],"good":[59,216],"selectivity":[60],"index":[61],"[(SI":[62],"=":[63],"CC":[64],"/IC":[66],")":[68],">":[69],"33].":[70],"On":[71],"post-treatment":[72],"DDABT1,":[74],"infection":[76],"inhibited":[78],"significantly":[79],"reducing":[81],"CPE,":[82],"viral":[83,85,88],"titer,":[84],"RNA,":[86],"proteins.":[89],"Further,":[90],"time":[92],"addition":[94],"experiment":[95],"revealed":[96],">95%":[97],"inhibition":[98],"up":[99],"to":[100,127,138,178,207],"4hpi":[101],"indicating":[102],"its":[103],"interference":[104],"predominantly":[105],"in":[106,163,173,194],"early":[108],"stages":[109,115],"infection.":[111],"However,":[112,148],"late":[114],"were":[116],"also":[117],"affected.":[118],"This":[119],"SA":[122],"TM":[124],"found":[126,177],"increase":[128],"efficacy,":[131],"this":[133],"might":[134,150],"be":[135,179],"partly":[136],"attributed":[137],"modulating":[139],"angiotensin":[140],"II":[141],"(Ang":[142],"II)":[143],"receptor":[144],"type":[145],"1":[146],"(AT1).":[147],"DDABT1":[149,199],"have":[151],"other":[152],"modes":[153],"action":[155],"need":[157],"further":[158,222],"investigation.":[159],"In":[160,197],"addition,":[161],"vivo":[164,195],"experiments":[165],"LD":[168],"5000":[171],"mg/kg":[172],"rats":[174],"more":[180],"effective":[181],"than":[182],"TM,":[183],"SA,":[184],"or":[185],"their":[186],"combination":[187],"against":[188],"acute,":[189],"subacute,":[190],"chronic":[192],"inflammation/arthritis":[193],".":[196],"conclusion,":[198],"remarkable":[201],"anti-CHIKV":[202],"properties":[203],"ability":[206],"reduce":[208],"inflammation":[209],"arthritis,":[211],"making":[212],"it":[213],"very":[215],"potential":[217],"candidate":[219],"needs":[221],"experimental":[223],"validation.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-12-22T00:00:00"}