{"id":"https://openalex.org/W4390081975","doi":"https://doi.org/10.1093/geroni/igad104.1680","title":"DIETARY RESTRICTION AND THE TRANSCRIPTION FACTOR CLOCK DELAY EYE AGING TO EXTEND LIFESPAN IN DROSOPHILA MELANOGASTER","display_name":"DIETARY RESTRICTION AND THE TRANSCRIPTION FACTOR CLOCK DELAY EYE AGING TO EXTEND LIFESPAN IN DROSOPHILA MELANOGASTER","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390081975","doi":"https://doi.org/10.1093/geroni/igad104.1680"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igad104.1680","doi":"https://doi.org/10.1093/geroni/igad104.1680","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.1680","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/511/54740043/igad104.1680.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/511/54740043/igad104.1680.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086548741","display_name":"Pankaj Kapahi","orcid":"https://orcid.org/0000-0002-5629-4947","observed_orcids":["https://orcid.org/0000-0002-5629-4947"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pankaj Kapahi","raw_affiliation_strings":["Buck Institute for Research on Aging , Novato, California , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging , Novato, California , United States","institution_ids":["https://openalex.org/I1337826666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086548741"],"corresponding_institution_ids":["https://openalex.org/I1337826666"],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14258002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Supplement_1","first_page":"511","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":1.0},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.7839999794960022},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ocular-aging","display_name":"ocular aging","score":0.7789999842643738},{"id":"https://openalex.org/keywords/photoreceptors","display_name":"photoreceptors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"rhodopsin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antagonistic-pleiotropy","display_name":"antagonistic pleiotropy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.5580000281333923},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.609000027179718},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.8169272541999817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7952714562416077},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7781176567077637},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7435331344604492},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5973211526870728},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5146639943122864},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.4967082142829895},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49264007806777954},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.4425899088382721},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.4199608564376831},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40762606263160706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33490610122680664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19019201397895813}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igad104.1680","doi":"https://doi.org/10.1093/geroni/igad104.1680","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.1680","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/511/54740043/igad104.1680.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10738173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10738173","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10738173/pdf/igad104.1680.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igad104.1680","doi":"https://doi.org/10.1093/geroni/igad104.1680","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.1680","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/511/54740043/igad104.1680.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390081975.pdf","grobid_xml":"https://content.openalex.org/works/W4390081975.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4246202983","https://openalex.org/W2946661310","https://openalex.org/W4253586198","https://openalex.org/W2337036462","https://openalex.org/W2526852929","https://openalex.org/W2559663714","https://openalex.org/W4383295271","https://openalex.org/W2901717206","https://openalex.org/W7216427584","https://openalex.org/W39695230"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"vital":[2],"processes":[3,73],"in":[4,66,132],"the":[5,29,50,76,85,116,137,149],"eye":[6,21,150],"are":[7,113],"under":[8],"circadian":[9,12,36,53,71],"regulation,":[10],"and":[11,34,81,105,157],"dysfunction":[13],"has":[14],"emerged":[15],"as":[16,151],"a":[17,101,143,152],"potential":[18],"driver":[19],"of":[20,28,52,119,139,155],"aging.":[22,170],"Dietary":[23],"restriction":[24,63,112],"(DR)":[25],"is":[26,161],"one":[27],"most":[30],"robust":[31],"lifespan-extending":[32],"therapies":[33],"amplifies":[35],"rhythms":[37],"with":[38],"age.":[39],"We":[40],"have":[41],"previously":[42],"shown":[43],"that":[44,61,74,159,166],"lifespan":[45,65,138,156],"extension":[46],"upon":[47],"DR":[48],"requires":[49],"presence":[51],"clocks":[54],"for":[55],"maximal":[56],"benefits.":[57],"Herein,":[58],"we":[59],"demonstrate":[60],"dietary":[62,111],"extends":[64,136],"Drosophila":[67],"melanogaster":[68],"by":[69],"promoting":[70],"homeostatic":[72],"protect":[75],"visual":[77,98],"system":[78],"from":[79,115],"age-":[80],"light-associated":[82],"damage.":[83],"Altering":[84],"positive":[86],"limb":[87],"core":[88],"molecular":[89],"clock":[90],"transcription":[91],"factor,":[92],"CLOCK,":[93],"or":[94,129],"CLOCK-output":[95],"genes,":[96],"accelerates":[97],"senescence,":[99],"induces":[100],"systemic":[102],"immune":[103],"response,":[104],"shortens":[106],"lifespan.":[107],"Flies":[108],"subjected":[109],"to":[110,168],"protected":[114],"lifespan-shortening":[117],"effects":[118],"photoreceptor":[120,123],"activation.":[121],"Inversely,":[122],"inactivation,":[124],"achieved":[125],"via":[126],"mutating":[127],"rhodopsin":[128],"housing":[130],"flies":[131,140],"constant":[133],"darkness,":[134],"primarily":[135],"reared":[141],"on":[142],"high-nutrient":[144],"diet.":[145],"Our":[146],"findings":[147],"establish":[148],"diet-sensitive":[153],"modulator":[154],"indicates":[158],"vision":[160],"an":[162],"antagonistically":[163],"pleiotropic":[164],"process":[165],"contributes":[167],"organismal":[169]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-22T00:00:00"}
