{"id":"https://openalex.org/W4390081561","doi":"https://doi.org/10.1093/geroni/igad104.1965","title":"MITOCHONDRIAL DNA COPY NUMBER IS ASSOCIATED WITH PHYSICAL FUNCTION","display_name":"MITOCHONDRIAL DNA COPY NUMBER IS ASSOCIATED WITH PHYSICAL FUNCTION","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390081561","doi":"https://doi.org/10.1093/geroni/igad104.1965"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igad104.1965","doi":"https://doi.org/10.1093/geroni/igad104.1965","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.1965","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/601/54741831/igad104.1965.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/601/54741831/igad104.1965.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062307557","display_name":"Qu Tian","orcid":"https://orcid.org/0000-0003-2706-1439","observed_orcids":["https://orcid.org/0000-0003-2706-1439"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qu Tian","raw_affiliation_strings":["National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033258563","display_name":"David A. Zweibaum","orcid":"https://orcid.org/0009-0006-7413-4038","observed_orcids":["https://orcid.org/0009-0006-7413-4038"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Zweibaum","raw_affiliation_strings":["National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108080230","display_name":"Yong Qian","orcid":"https://orcid.org/0000-0002-6937-2449","observed_orcids":["https://orcid.org/0000-0002-6937-2449"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Qian","raw_affiliation_strings":["National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075457170","display_name":"Richard Oppong","orcid":"https://orcid.org/0000-0002-3244-6694","observed_orcids":["https://orcid.org/0000-0002-3244-6694"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Oppong","raw_affiliation_strings":["National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006474256","display_name":"Jun Ding","orcid":"https://orcid.org/0000-0002-4302-5027","observed_orcids":["https://orcid.org/0000-0002-4302-5027"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Ding","raw_affiliation_strings":["National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048196698","display_name":"Luigi Ferrucci","orcid":"https://orcid.org/0000-0002-6273-1613","observed_orcids":["https://orcid.org/0000-0002-6273-1613"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luigi Ferrucci","raw_affiliation_strings":["National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging, National Institutes of Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Supplement_1","first_page":"601","last_page":"601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":1.0},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.9380000233650208},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.9980000257492065},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mitochondrial-health","display_name":"mitochondrial health","score":0.753000020980835},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6959999799728394},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7099999785423279},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5149999856948853},{"id":"https://openalex.org/keywords/mitochondrial-markers","display_name":"mitochondrial markers","score":0.5130000114440918},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2777433710","wikidata":"https://www.wikidata.org/wiki/Q5609571","display_name":"Grip strength","level":2,"score":0.658090353012085},{"id":"https://openalex.org/C70770792","wikidata":"https://www.wikidata.org/wiki/Q7239848","display_name":"Preferred walking speed","level":2,"score":0.5799971222877502},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.5365680456161499},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.49157699942588806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48281964659690857},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4793761074542999},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.46996375918388367},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3826696276664734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24958762526512146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21938243508338928},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07201135158538818}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igad104.1965","doi":"https://doi.org/10.1093/geroni/igad104.1965","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.1965","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/601/54741831/igad104.1965.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10735787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10735787","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10735787/pdf/igad104.1965.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igad104.1965","doi":"https://doi.org/10.1093/geroni/igad104.1965","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.1965","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/601/54741831/igad104.1965.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390081561.pdf","grobid_xml":"https://content.openalex.org/works/W4390081561.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3114804379","https://openalex.org/W7154230046","https://openalex.org/W2594164805","https://openalex.org/W4401014473","https://openalex.org/W3139292184","https://openalex.org/W7214624292","https://openalex.org/W1913796783","https://openalex.org/W3112492594","https://openalex.org/W2144652882","https://openalex.org/W7127583877"],"abstract_inverted_index":{"Abstract":[0],"Mitochondria":[1],"generate":[2],"the":[3,202],"energy":[4],"required":[5],"by":[6,64],"cells":[7],"to":[8,229,242],"maintain":[9],"functionality":[10],"and":[11,34,71,87,99,127,141,168,235,250],"muscle":[12,26,35],"health.":[13],"They":[14],"may":[15],"play":[16],"a":[17,44,111,161,169,192],"key":[18],"role":[19],"in":[20,74,97,103,124,156,165,209,214,232],"age-related":[21],"physical":[22,53,230,247],"function":[23,28,54,226,231,248],"decline.":[24],"Skeletal":[25],"mitochondrial":[27,38,47,225],"is":[29,43,55,227,240],"associated":[30,136,159],"with":[31,52,68,137,160,204,246],"gait":[32,69,125,139,166,187],"speed":[33,70,91,126,140,167],"strength.":[36,129,198],"Blood-derived":[37],"DNA":[39],"copy":[40],"number":[41],"(mtDNAcn)":[42],"biomarker":[45],"of":[46,61,85,120,173,224],"health,":[48],"but":[49],"its":[50,244],"association":[51,203],"unclear.":[56],"We":[57,114,130],"examined":[58],"cross-sectional":[59],"associations":[60],"mtDNAcn":[62,134,157],"estimated":[63],"whole":[65],"genome":[66],"sequencing":[67],"grip":[72,128,143,197,205],"strength":[73,107,206],"participants":[75],"aged":[76],"50+":[77],"from":[78],"two":[79],"population-based":[80],"studies:":[81],"Baltimore":[82],"Longitudinal":[83],"Study":[84],"Aging(BLSA,n=688)":[86],"UK":[88,104],"Biobank(n=150,448).":[89],"Gait":[90],"was":[92,108,135,158,181,191,207],"measured":[93,109],"using":[94,110],"6-meter":[95],"walk":[96],"BLSA":[98],"self-reported":[100],"walking":[101,176],"pace":[102],"Biobank.":[105],"Handgrip":[106],"hand":[112],"dynamometer.":[113],"additionally":[115],"tested":[116],"sex":[117,122],"differences":[118,123],"because":[119],"known":[121],"found":[131],"that":[132,221],"higher":[133],"faster":[138,164],"greater":[142],"strength,":[144],"after":[145],"adjustment":[146],"for":[147,186,196],"age,sex,race,and":[148],"autosomal":[149],"coverage.":[150],"Specifically,":[151],"each":[152],"standard":[153],"deviation":[154],"increase":[155],"0.05":[162],"m/sec":[163],"19%":[170],"lower":[171],"odds":[172],"reporting":[174],"slow":[175],"pace(both":[177],"p<":[178],"0.0001).":[179],"There":[180,190],"no":[182],"significant":[183,193],"sex-by-mtDNAcn":[184,194],"interaction":[185,195],"(both":[188],"p>0.05).":[189],"In":[199],"sex-stratified":[200],"analysis,":[201],"stronger":[208],"men":[210],"(\u03b2=0.129,p=0.002;\u03b2=0.032,p<":[211],"2e-16,respectively)":[212],"than":[213],"women":[215],"(\u03b2=0.007,p=0.784;\u03b2=0.015,p<":[216],"2e-16,respectively).":[217],"These":[218],"findings":[219],"suggest":[220],"blood-based":[222],"estimate":[223],"related":[228],"community-dwelling":[233],"middle-aged":[234],"older":[236],"adults.":[237],"Further":[238],"research":[239],"needed":[241],"understand":[243],"relationship":[245],"decline":[249],"underlying":[251],"mechanisms.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-22T00:00:00"}
