{"id":"https://openalex.org/W4390081405","doi":"https://doi.org/10.1093/geroni/igad104.3482","title":"MULTI-OMICS INTEGRATION IDENTIFIES GENES INFLUENCING TRAITS ASSOCIATED WITH CARDIOVASCULAR RISKS","display_name":"MULTI-OMICS INTEGRATION IDENTIFIES GENES INFLUENCING TRAITS ASSOCIATED WITH CARDIOVASCULAR RISKS","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390081405","doi":"https://doi.org/10.1093/geroni/igad104.3482"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igad104.3482","doi":"https://doi.org/10.1093/geroni/igad104.3482","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.3482","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1084/54742557/igad104.3482.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1084/54742557/igad104.3482.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102868753","display_name":"Sandeep Acharya","orcid":"https://orcid.org/0000-0001-8046-0688","observed_orcids":["https://orcid.org/0000-0001-8046-0688"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandeep Acharya","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110609462","display_name":"Shu Liao","orcid":"https://orcid.org/0000-0001-7740-8096","observed_orcids":["https://orcid.org/0000-0001-7740-8096"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Liao","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112057398","display_name":"Woo Seok Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Woo Seok Jung","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102595946","display_name":"Edward Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Kang","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090396769","display_name":"Vaha Akbary Moghaddam","orcid":"https://orcid.org/0000-0002-9910-0161","observed_orcids":["https://orcid.org/0000-0002-9910-0161"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaha Akbary Moghaddam","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035488928","display_name":"Mary Furlan Feitosa","orcid":"https://orcid.org/0000-0002-0933-2410","observed_orcids":["https://orcid.org/0000-0002-0933-2410"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Feitosa","raw_affiliation_strings":["Washington University School of Medicine , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004832167","display_name":"Michael A. Province","orcid":"https://orcid.org/0000-0001-6102-774X","observed_orcids":["https://orcid.org/0000-0001-6102-774X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Province","raw_affiliation_strings":["Washington University School of Medicine , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010345611","display_name":"Michael R. Brent","orcid":"https://orcid.org/0000-0002-8689-0299","observed_orcids":["https://orcid.org/0000-0002-8689-0299"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Brent","raw_affiliation_strings":["Washington University in St. Louis , St. Louis, Missouri , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis , St. Louis, Missouri , United States","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Supplement_1","first_page":"1084","last_page":"1084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.17190000414848328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6980000138282776},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.6309999823570251},{"id":"https://openalex.org/keywords/long-life-family-study","display_name":"Long Life Family Study","score":0.8870000243186951},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.9269999861717224},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein","display_name":"cholesteryl ester transfer protein","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nlrc5","display_name":"NLRC5","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tomm40","display_name":"TOMM40","score":1.0}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7540444135665894},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.635353684425354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6311978697776794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.605141818523407},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5828131437301636},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5405430197715759},{"id":"https://openalex.org/C84799019","wikidata":"https://www.wikidata.org/wiki/Q426365","display_name":"Polygene","level":4,"score":0.5370093584060669},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5289632678031921},{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.44643673300743103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4330301284790039},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.21675074100494385},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11388018727302551},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07446259260177612},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igad104.3482","doi":"https://doi.org/10.1093/geroni/igad104.3482","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.3482","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1084/54742557/igad104.3482.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10736728","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10736728","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10736728/pdf/igad104.3482.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igad104.3482","doi":"https://doi.org/10.1093/geroni/igad104.3482","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.3482","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1084/54742557/igad104.3482.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390081405.pdf","grobid_xml":"https://content.openalex.org/works/W4390081405.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392467918","https://openalex.org/W4402538379","https://openalex.org/W6959242228","https://openalex.org/W4403729164","https://openalex.org/W3147556802","https://openalex.org/W4292457729","https://openalex.org/W2950868358","https://openalex.org/W2137702285","https://openalex.org/W2111763386","https://openalex.org/W4408843981"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"Long":[2],"Life":[3],"Family":[4],"Study":[5],"(LLFS)":[6],"enrolled":[7],"4,953":[8],"participants":[9,23],"in":[10,117,167,209],"539":[11],"pedigrees":[12],"displaying":[13],"exceptional":[14],"longevity.":[15],"To":[16],"identify":[17],"genetic":[18],"mechanisms":[19],"that":[20,108,138,157],"protect":[21],"LLFS":[22],"against":[24],"age-related":[25],"cardiovascular":[26,44],"risks,":[27],"we":[28,49],"developed":[29],"a":[30,89,118,135,161],"freely":[31],"available":[32],"multi-omics":[33],"integration":[34],"pipeline":[35],"and":[36,57,82,130,169,203],"applied":[37],"it":[38],"to":[39,173],"11":[40],"traits":[41],"associated":[42,94,149],"with":[43,127,134,150,180,200],"risks.":[45],"Using":[46],"our":[47],"pipeline,":[48],"aggregated":[50],"gene-level":[51],"statistics":[52],"from":[53],"Rare-Variant":[54],"Analysis,":[55],"GWAS,":[56],"gene":[58],"expression-trait":[59],"association":[60],"by":[61,190],"Correlated":[62],"Meta-Analysis":[63],"(CMA).":[64],"Across":[65],"all":[66],"traits,":[67],"CMA":[68,111,183,225],"identified":[69,102,216],"51":[70],"significant":[71],"genes":[72,105,126,159,179,199,207,221],"after":[73,224],"Bonferroni":[74],"correction":[75],"(P":[76],"\u2264":[77,113],"2.8\u00d710-7).":[78],"CETP,":[79],"NLRC5,":[80],"SLC45A3,":[81],"TOMM40":[83],"lie":[84,116],"within":[85],"50":[86],"Kb":[87],"of":[88,97,145,165,195],"known":[90,176],"trait-associated":[91],"variant":[92],"(previously":[93],"genes).":[95],"Analysis":[96],"protein-protein":[98],"interaction":[99],"(PPI)":[100],"networks":[101],"another":[103],"63":[104],"(passing":[106],"genes)":[107],"(1)":[109],"have":[110,160],"p-value":[112],"5\u00d710-3,":[114],"(2)":[115],"PPI":[119],"module":[120,142,214],"(highly":[121],"connected":[122],"subnetwork)":[123],"enriched":[124,140,197,205],"for":[125,198,206],"low":[128,201],"P-values,":[129],"(3)":[131],"are":[132,170],"annotated":[133],"biological":[136,211],"process":[137],"is":[139],"among":[141],"genes,":[143],"ten":[144],"which":[146],"were":[147,227],"previously":[148,175],"the":[151,186,192],"same":[152],"traits.":[153],"Permutation":[154],"analysis":[155,215],"showed":[156],"passing":[158],"false":[162],"positive":[163],"rate":[164],"1":[166],"14876":[168],"more":[171],"likely":[172],"be":[174],"than":[177],"non-passing":[178],"similar":[181],"p-values.":[182],"improved":[184],"on":[185],"3":[187],"input":[188],"analyses":[189],"producing":[191],"largest":[193],"number":[194],"modules":[196],"P-values":[202,223],"highly":[204,217],"participating":[208],"shared":[210],"processes.":[212],"Overall,":[213],"plausible":[218],"candidate":[219],"causal":[220],"whose":[222],"alone":[226],"merely":[228],"suggestive.":[229]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-22T00:00:00"}