{"id":"https://openalex.org/W4390080588","doi":"https://doi.org/10.1093/geroni/igad104.3443","title":"INVESTIGATING THE IMPACTS OF METFORMIN ON AGING AND LIFESPAN IN DIVERSITY OUTBRED MICE","display_name":"INVESTIGATING THE IMPACTS OF METFORMIN ON AGING AND LIFESPAN IN DIVERSITY OUTBRED MICE","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390080588","doi":"https://doi.org/10.1093/geroni/igad104.3443"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igad104.3443","doi":"https://doi.org/10.1093/geroni/igad104.3443","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.3443","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1072/54744144/igad104.3443.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1072/54744144/igad104.3443.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058522873","display_name":"Rong Yuan","orcid":"https://orcid.org/0000-0001-9996-7331","observed_orcids":["https://orcid.org/0000-0001-9996-7331"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Yuan","raw_affiliation_strings":["Southern Illinois University School of Medicine School of Medicine , Springfield, Illinois , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University School of Medicine School of Medicine , Springfield, Illinois , United States","institution_ids":["https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021974651","display_name":"Yun Xia Zhu","orcid":"https://orcid.org/0000-0002-8330-4960","observed_orcids":["https://orcid.org/0000-0002-8330-4960"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Zhu","raw_affiliation_strings":["Southern Illinois University School of Medicine School of Medicine , Springfield, Illinois , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University School of Medicine School of Medicine , Springfield, Illinois , United States","institution_ids":["https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027794643","display_name":"M\u00f3nica Beatriz Frungieri","orcid":"https://orcid.org/0000-0002-3847-6245","observed_orcids":["https://orcid.org/0000-0002-3847-6245"]},"institutions":[{"id":"https://openalex.org/I71650599","display_name":"Experimental Medicine and Biology Institute","ror":"https://ror.org/03hnwy706","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568","https://openalex.org/I71650599"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Monica Frungieri","raw_affiliation_strings":["Instituto de Biolog\u00eda y Medicina Experimental , Buenos Aires, Buenos Aires , Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda y Medicina Experimental , Buenos Aires, Buenos Aires , Argentina","institution_ids":["https://openalex.org/I71650599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085220923","display_name":"Micha\u0142 M. Masternak","orcid":"https://orcid.org/0000-0002-8483-930X","observed_orcids":["https://orcid.org/0000-0002-8483-930X"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michal Masternak","raw_affiliation_strings":["University of Central Florida College of Medicine , Orlando, Florida , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Central Florida College of Medicine , Orlando, Florida , United States","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018886262","display_name":"Andrzej Bartke","orcid":"https://orcid.org/0000-0002-2569-557X","observed_orcids":["https://orcid.org/0000-0002-2569-557X"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrzej Bartke","raw_affiliation_strings":["Southern Illinois University School of Medicine School of Medicine , Springfield, Illinois , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois University School of Medicine School of Medicine , Springfield, Illinois , United States","institution_ids":["https://openalex.org/I196729704"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Supplement_1","first_page":"1072","last_page":"1072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.07320000231266022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.9779999852180481},{"id":"https://openalex.org/keywords/diversity-outbred-mice","display_name":"Diversity Outbred mice","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6890000104904175},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/insulin-tolerance","display_name":"insulin tolerance","score":0.8949999809265137},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7369999885559082},{"id":"https://openalex.org/keywords/genetic-background","display_name":"genetic background","score":0.38499999046325684},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9513148069381714},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6738104820251465},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.5793792605400085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5037309527397156},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49399334192276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4746825397014618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4679488241672516},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3867010474205017},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3644357919692993},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.17821291089057922}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igad104.3443","doi":"https://doi.org/10.1093/geroni/igad104.3443","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.3443","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1072/54744144/igad104.3443.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10738768","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10738768","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10738768/pdf/igad104.3443.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igad104.3443","doi":"https://doi.org/10.1093/geroni/igad104.3443","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.3443","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/1072/54744144/igad104.3443.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390080588.pdf","grobid_xml":"https://content.openalex.org/works/W4390080588.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098171210","https://openalex.org/W3213321508","https://openalex.org/W4387405670","https://openalex.org/W1979757394","https://openalex.org/W4390910914","https://openalex.org/W1567556960","https://openalex.org/W4307227092","https://openalex.org/W1500247249","https://openalex.org/W2016629288","https://openalex.org/W2992185299"],"abstract_inverted_index":{"Abstract":[0],"Metformin,":[1],"a":[2,110,123,149,229,243],"type":[3],"2":[4,90],"diabetes":[5],"treatment,":[6],"has":[7],"profound":[8],"effects":[9],"on":[10,58,235],"regulating":[11],"development,":[12],"metabolism,":[13],"and":[14,27,44,60,103,106,179,203,238],"aging":[15,29,59],"acting":[16],"via":[17],"the":[18,37,53,65,73,81,134,162,186,201,207,218],"mTOR/autophagy":[19],"pathway.":[20],"Nevertheless,":[21],"its":[22],"potential":[23,230],"to":[24,97],"extend":[25],"lifespan":[26,239],"counteract":[28],"remains":[30],"an":[31],"open":[32],"question.":[33],"Previous":[34],"research":[35],"highlighted":[36],"intricate":[38,82],"interplay":[39],"between":[40],"genetic":[41,83],"background,":[42],"gender,":[43],"treatment":[45,168,202],"commencement":[46],"age":[47,163],"in":[48,86,127,143,154,173,176,198,217,247],"shaping":[49],"outcomes.":[50],"To":[51],"examine":[52],"long-term":[54],"effect":[55,140],"of":[56,75,121,157,164,193,200,233],"metformin":[57,167,234],"lifespan,":[61],"this":[62],"project":[63],"utilizes":[64],"diversity":[66],"outbred":[67],"(DO)":[68],"mice,":[69],"initially":[70],"derived":[71],"from":[72,118,242],"interbreeding":[74],"eight":[76],"inbred":[77],"strains,":[78],"effectively":[79],"emulating":[80],"complexity":[84],"found":[85,142],"humans.":[87],"Initiated":[88],"at":[89,161],"months":[91,120,192],"old,":[92],"DO":[93],"mice":[94],"were":[95],"subjected":[96],"metformin-infused":[98],"food":[99],"[0.1%,":[100],"w/w]":[101],"(n=15":[102],"14,":[104],"females":[105,196],"males":[107],"respectively)":[108],"or":[109],"metformin-free":[111],"counterpart":[112],"(n=10":[113],"for":[114],"both":[115,155],"sexes).":[116],"Starting":[117],"12":[119,165],"age,":[122,194,245],"statistically":[124],"significant":[125,139,183],"increase":[126],"male":[128,209,220,248],"body":[129],"weight":[130],"was":[131,141],"observed":[132],"within":[133],"metformin-treated":[135,158,208],"group,":[136],"while":[137],"no":[138,215],"females.":[144],"Indirect":[145],"calorimetry":[146],"assays":[147],"revealed":[148],"significantly":[150,169],"elevated":[151],"respiratory":[152],"ratio":[153],"sexes":[156],"mice.":[159,249],"Surprisingly,":[160],"months,":[166],"impaired":[170],"glucose":[171],"tolerance":[172,181],"females,":[174],"whereas":[175],"males,":[177],"pyruvate":[178],"insulin":[180],"exhibited":[182],"reductions.":[184],"After":[185],"first":[187],"submission":[188],"deadline,":[189],"by":[190],"16":[191],"two":[195],"died":[197],"each":[199],"control":[204,219],"groups.":[205],"Notably,":[206],"cohort":[210,221],"lost":[211],"four":[212],"individuals,":[213],"but":[214],"mortality":[216],"(P=0.07,":[222],"log-rank":[223],"test).":[224],"These":[225],"preliminary":[226],"findings":[227],"underscore":[228],"deleterious":[231],"impact":[232],"metabolic":[236],"traits":[237],"when":[240],"initiated":[241],"young":[244],"particularly":[246]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-22T00:00:00"}
