{"id":"https://openalex.org/W4390079199","doi":"https://doi.org/10.1017/s1355617723005969","title":"46 Moderating Impact of Trauma on Brain Regions Underlying Social Cognition in Early Onset Psychosis","display_name":"46 Moderating Impact of Trauma on Brain Regions Underlying Social Cognition in Early Onset Psychosis","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4390079199","doi":"https://doi.org/10.1017/s1355617723005969"},"language":"en","primary_location":{"id":"doi:10.1017/s1355617723005969","doi":"https://doi.org/10.1017/s1355617723005969","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1017/s1355617723005969","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CF23AF0A1314EE1DB0EF7F3137FC9DE2/S1355617723005969a.pdf/div-class-title-46-moderating-impact-of-trauma-on-brain-regions-underlying-social-cognition-in-early-onset-psychosis-div.pdf","source":{"id":"https://openalex.org/S9803440","display_name":"Journal of the International Neuropsychological Society","issn_l":"1355-6177","issn":["1355-6177","1469-7661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Neuropsychological Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CF23AF0A1314EE1DB0EF7F3137FC9DE2/S1355617723005969a.pdf/div-class-title-46-moderating-impact-of-trauma-on-brain-regions-underlying-social-cognition-in-early-onset-psychosis-div.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093555995","display_name":"Deanna M Aghbashian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deanna M Aghbashian","raw_affiliation_strings":["Loma Linda University, Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091581329","display_name":"Rhideeta Jalal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhideeta Jalal","raw_affiliation_strings":["Loma Linda University, Loma Linda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University, Loma Linda, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hector Gutierrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hector Gutierrez","raw_affiliation_strings":["Loma Linda University, Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034490404","display_name":"Niharika Verma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niharika Verma","raw_affiliation_strings":["Loma Linda University, Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036850612","display_name":"Holly E. R. Morrell","orcid":"https://orcid.org/0000-0003-2339-7138","observed_orcids":["https://orcid.org/0000-0003-2339-7138"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly E.R. Morrell","raw_affiliation_strings":["Loma Linda University, Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043748844","display_name":"Aarti Nair","orcid":"https://orcid.org/0000-0002-4058-6857","observed_orcids":["https://orcid.org/0000-0002-4058-6857"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aarti Nair","raw_affiliation_strings":["Loma Linda University, Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5093555995"],"corresponding_institution_ids":["https://openalex.org/I26347476"],"apc_list":{"value":3255,"currency":"USD","value_usd":3255},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23662644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"s1","first_page":"456","last_page":"457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10565","display_name":"Psychopathy, Forensic Psychiatry, Sexual Offending","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-psychosis","display_name":"early-onset psychosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/childhood-trauma","display_name":"childhood trauma","score":0.8519999980926514},{"id":"https://openalex.org/keywords/social-cognition","display_name":"social cognition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/social-responsiveness","display_name":"social responsiveness","score":0.6439999938011169},{"id":"https://openalex.org/keywords/precuneus","display_name":"precuneus","score":0.746999979019165},{"id":"https://openalex.org/keywords/superior-frontal-cortex","display_name":"superior frontal cortex","score":0.9100000262260437},{"id":"https://openalex.org/keywords/rostral-anterior-cingulate-cortex","display_name":"rostral anterior cingulate cortex","score":0.9570000171661377},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cortical-bone-volume","display_name":"cortical volume","score":0.9850000143051147},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.8410000205039978},{"id":"https://openalex.org/keywords/emotion-recognition","display_name":"emotion recognition","score":0.746999979019165},{"id":"https://openalex.org/keywords/emotion-differentiation","display_name":"emotion differentiation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/social-inference","display_name":"social inference","score":0.6729999780654907},{"id":"https://openalex.org/keywords/social-awareness","display_name":"social awareness","score":0.38600000739097595},{"id":"https://openalex.org/keywords/psychosis-risk-factors","display_name":"psychosis risk factors","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6719756722450256},{"id":"https://openalex.org/C86658582","wikidata":"https://www.wikidata.org/wiki/Q1432778","display_name":"Social cognition","level":3,"score":0.6054044961929321},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5599793791770935},{"id":"https://openalex.org/C2776141551","wikidata":"https://www.wikidata.org/wiki/Q16000087","display_name":"Emotion perception","level":3,"score":0.5504140853881836},{"id":"https://openalex.org/C2781441883","wikidata":"https://www.wikidata.org/wiki/Q1632835","display_name":"Precuneus","level":3,"score":0.5314732193946838},{"id":"https://openalex.org/C104996578","wikidata":"https://www.wikidata.org/wiki/Q827617","display_name":"Insula","level":2,"score":0.5132496356964111},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.49108219146728516},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.43335655331611633},{"id":"https://openalex.org/C2778733324","wikidata":"https://www.wikidata.org/wiki/Q2998088","display_name":"Posterior cingulate","level":3,"score":0.43116897344589233},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.43107447028160095},{"id":"https://openalex.org/C2779560602","wikidata":"https://www.wikidata.org/wiki/Q639219","display_name":"Theory of mind","level":3,"score":0.4172765910625458},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3595646321773529},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3553217053413391},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3283596932888031},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2870479226112366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24668273329734802},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.1240200400352478}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/s1355617723005969","doi":"https://doi.org/10.1017/s1355617723005969","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1017/s1355617723005969","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CF23AF0A1314EE1DB0EF7F3137FC9DE2/S1355617723005969a.pdf/div-class-title-46-moderating-impact-of-trauma-on-brain-regions-underlying-social-cognition-in-early-onset-psychosis-div.pdf","source":{"id":"https://openalex.org/S9803440","display_name":"Journal of the International Neuropsychological Society","issn_l":"1355-6177","issn":["1355-6177","1469-7661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Neuropsychological Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1017/s1355617723005969","doi":"https://doi.org/10.1017/s1355617723005969","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1017/s1355617723005969","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CF23AF0A1314EE1DB0EF7F3137FC9DE2/S1355617723005969a.pdf/div-class-title-46-moderating-impact-of-trauma-on-brain-regions-underlying-social-cognition-in-early-onset-psychosis-div.pdf","source":{"id":"https://openalex.org/S9803440","display_name":"Journal of the International Neuropsychological Society","issn_l":"1355-6177","issn":["1355-6177","1469-7661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Neuropsychological Society","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390079199.pdf","grobid_xml":"https://content.openalex.org/works/W4390079199.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7172015016","https://openalex.org/W4390223503","https://openalex.org/W7162796537","https://openalex.org/W2756505744","https://openalex.org/W4410806562","https://openalex.org/W4401924216","https://openalex.org/W4387798836","https://openalex.org/W2600454950","https://openalex.org/W1985320799","https://openalex.org/W3133786989"],"abstract_inverted_index":{"Objective:":[0],"Previous":[1],"research":[2],"has":[3],"found":[4],"that":[5,327,410],"trauma":[6,56,233,350,356,372,391,439],"is":[7],"a":[8,82,275,416],"risk":[9],"factor":[10,418],"for":[11,86,468],"developing":[12],"early-onset":[13],"psychosis":[14],"(EOP),":[15],"both":[16,271,352,447],"exhibiting":[17],"widespread":[18],"structural":[19],"abnormalities":[20],"and":[21,48,64,66,72,97,106,137,149,173,208,220,242,282,291,301,311,313,333,338,341,344,381,399,425,431,441,444,449,478],"social":[22,49,67,221,243,428,432,458,485],"cognitive":[23],"dysfunction":[24],"(Hoy":[25],"et":[26,30,34,117,157,170,203],"al.,":[27,31,35,118,158,171,204],"2012;":[28],"Nair":[29],"2020;":[32],"Rotiker":[33],"2018).":[36],"However,":[37],"few":[38],"studies":[39],"have":[40],"investigated":[41],"the":[42,59,111,129,144,189,215,237,279,323,328,420,435,464,469],"association":[43,60],"between":[44,61,217,239,278,330,422,438],"trauma,":[45],"neural":[46],"architecture,":[47],"behaviors.":[50],"The":[51,160],"current":[52],"study":[53],"examines":[54],"whether":[55],"exposure":[57,185,440],"moderates":[58],"cortical":[62,218,240,379],"volume":[63,105,284,304,315,332,362,424,443],"thickness":[65,107,292,337,343,380,398,426,445],"cognition":[68,244,459],"in":[69,250,419,446,488],"EOP.":[70],"Participants":[71,354],"Methods:":[73],"T1-weighted":[74],"whole-brain":[75],"magnetic":[76],"resonance":[77],"data":[78],"were":[79,108,211,253,452],"acquired":[80],"on":[81,121,348,457,475],"3T":[83],"Siemens":[84],"scanner":[85],"23":[87],"adolescents":[88],"with":[89,355,364,376,395,454],"EOP":[90,198,256,448],"aged":[91],"12-21":[92],"years":[93],"(M":[94,101],"=":[95,102,196,200,265,286,289,294,297,306,309,317,320,369,386,404],"16.12),":[96],"20":[98],"age-matched":[99],"controls":[100,263],"17.22).":[103],"Cortical":[104],"calculated":[109],"using":[110,188],"Freesurfer":[112],"software":[113],"suite":[114],"(v5.3;":[115],"Reuter":[116],"2012).":[119,183],"Based":[120],"prior":[122],"research,":[123],"bilateral":[124],"structures":[125],"of":[126,162,390,427,466,471],"interest":[127],"included":[128,143],"rostral":[130],"anterior":[131],"cingulate":[132],"cortex":[133],"(rACC),":[134],"insula,":[135],"precuneus,":[136],"superior":[138,302],"frontal":[139,303],"cortex.":[140],"Social":[141,163,174],"measures":[142],"WebCNP":[145],"Emotion":[146,150],"Recognition":[147],"(KER40)":[148],"Differentiation":[151],"Test":[152,165],"(MED36)":[153],"accuracy":[154],"score":[155,281],"(Gur":[156],"2010),":[159],"Awareness":[161],"Inference":[164],"Total":[166],"Score":[167],"(TASIT;":[168],"McDonald":[169],"2003),":[172],"Responsiveness":[175],"Scale,":[176],"2nd":[177],"Edition":[178],"(SRS-2;":[179],"Constantino":[180],"&":[181],"Gruber,":[182],"Trauma":[184],"was":[186,228,274,373,393],"assessed":[187],"Structured":[190],"Clinical":[191],"Interview":[192],"Diagnostic":[193],"(controls":[194],"n":[195,199],"5;":[197],"9;":[201],"First":[202],"2015).":[205],"Pearson\u2019s":[206],"correlations":[207],"independent":[209],"t-tests":[210],"used":[212,229],"to":[213,230,484],"examine":[214,231],"relationship":[216,238,421],"measurements":[219,241],"cognition.":[222,433],"Additionally,":[223],"PROCESS":[224],"macro":[225],"(Hayes,":[226],"2018)":[227],"if":[232],"history":[234],"statistically":[235],"moderated":[236],"performance.":[245],"Results:":[246],"Significant":[247],"group":[248],"differences":[249],"SRS-2":[251,280,334,366],"scores":[252,346,367,384,402],"observed,":[254],"as":[255],"participants":[257,451],"scored":[258],"24.272":[259],"points":[260],"higher":[261,365,400],"than":[262],"(t":[264],"20.724,":[266],"p":[267,288,296,308,319],"<":[268],".001).":[269],"Across":[270],"groups,":[272],"there":[273],"negative":[276],"correlation":[277],"precuneus":[283,331,336,361,378],"(r":[285,293,305,316],"-.438,":[287],".011)":[290],"-.383,":[295],".028),":[298],"TASIT":[299],"total":[300],"-.349,":[307],".023),":[310],"KER40":[312,345,401],"insular":[314],"-.437,":[318],".20).":[321],"Further,":[322],"moderation":[324],"analysis":[325],"revealed":[326],"relationships":[329],"scores,":[335,340],"MED36":[339,383],"rACC":[342,397],"depended":[347],"experiencing":[349,490],"across":[351,357],"groups.":[353],"groups":[358],"had":[359],"increased":[360,442,455],"associated":[363,375,394,453],"(p":[368,385,403],".0442).":[370],"Experiencing":[371],"also":[374],"lower":[377,382],".0172).":[387],"Conversely,":[388],"lack":[389],"experience":[392],"greater":[396],".0119).":[405],"Conclusions:":[406],"Our":[407],"findings":[408,462],"indicate":[409],"past":[411],"traumatic":[412],"experiences":[413],"may":[414,481],"be":[415,482],"moderating":[417],"atypical":[423],"brain":[429,476],"regions":[430],"Overall,":[434],"significant":[436],"interactions":[437],"control":[450],"impairment":[456],"measures.":[460],"These":[461],"emphasize":[463],"importance":[465],"accounting":[467],"impact":[470],"early":[472],"life":[473],"adversities":[474],"development":[477],"how":[479],"it":[480],"relevant":[483],"impairments,":[486],"especially":[487],"individuals":[489],"psychosis.":[491]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-12-22T00:00:00"}