{"id":"https://openalex.org/W4390067331","doi":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","title":"Effect of multicomponent crystal of piperine-nicotinic acid on antihyperlipidemic activity in rats","display_name":"Effect of multicomponent crystal of piperine-nicotinic acid on antihyperlipidemic activity in rats","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4390067331","doi":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","pmid":"https://pubmed.ncbi.nlm.nih.gov/38124418"},"language":"en","primary_location":{"id":"doi:10.36721/pjps.2023.36.6.reg.1777-1781.1","doi":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004042320","display_name":"Maria Dona Octavia","orcid":"https://orcid.org/0000-0003-4310-6035","observed_orcids":["https://orcid.org/0000-0003-4310-6035"]},"institutions":[{"id":"https://openalex.org/I55892964","display_name":"Andalas University","ror":"https://ror.org/04ded0672","country_code":"ID","type":"education","lineage":["https://openalex.org/I55892964"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Maria D Octavia","raw_affiliation_strings":["Doctoral Program, Graduate School of Biomedical Sciences, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia / Schools of Pharmaceuticals Science (STIFARM), Padang, West Sumatra, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral Program, Graduate School of Biomedical Sciences, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia / Schools of Pharmaceuticals Science (STIFARM), Padang, West Sumatra, Indonesia","institution_ids":["https://openalex.org/I55892964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038904209","display_name":"Hasmiwati Hasmiwati","orcid":"https://orcid.org/0000-0001-8095-9032","observed_orcids":["https://orcid.org/0000-0001-8095-9032"]},"institutions":[{"id":"https://openalex.org/I55892964","display_name":"Andalas University","ror":"https://ror.org/04ded0672","country_code":"ID","type":"education","lineage":["https://openalex.org/I55892964"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Hasmiwati Hasmiwati","raw_affiliation_strings":["Department of Parasitology, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia","institution_ids":["https://openalex.org/I55892964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087045416","display_name":"Gusti Revilla","orcid":"https://orcid.org/0000-0001-9373-772X","observed_orcids":["https://orcid.org/0000-0001-9373-772X"]},"institutions":[{"id":"https://openalex.org/I55892964","display_name":"Andalas University","ror":"https://ror.org/04ded0672","country_code":"ID","type":"education","lineage":["https://openalex.org/I55892964"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Gusti Revilla","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia","institution_ids":["https://openalex.org/I55892964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073390459","display_name":"Erizal Zaini","orcid":"https://orcid.org/0000-0003-0108-4464","observed_orcids":["https://orcid.org/0000-0003-0108-4464"]},"institutions":[{"id":"https://openalex.org/I55892964","display_name":"Andalas University","ror":"https://ror.org/04ded0672","country_code":"ID","type":"education","lineage":["https://openalex.org/I55892964"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Erizal Zaini","raw_affiliation_strings":["Departments of Pharmaceutics, Faculty of Pharmacy, Andalas University, field, West Sumatra, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmaceutics, Faculty of Pharmacy, Andalas University, field, West Sumatra, Indonesia","institution_ids":["https://openalex.org/I55892964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55892964"],"apc_list":null,"apc_paid":null,"fwci":0.3053,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43013544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"36","issue":"6","first_page":"1777","last_page":"1781"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperine","display_name":"piperine","score":1.0},{"id":"https://openalex.org/keywords/niacin","display_name":"nicotinic acid","score":1.0},{"id":"https://openalex.org/keywords/multicomponent-crystals","display_name":"multicomponent crystals","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypolipidemic-activity","display_name":"hypolipidemic activity","score":0.9539999961853027},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8169999718666077},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.652999997138977},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":1.0},{"id":"https://openalex.org/keywords/black-pepper","display_name":"black pepper","score":0.8539999723434448},{"id":"https://openalex.org/keywords/solvent-drop-grinding","display_name":"solvent drop grinding","score":0.7450000047683716},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.6129999756813049},{"id":"https://openalex.org/keywords/bcs-class-ii","display_name":"BCS class II","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.9935135841369629},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7636910676956177},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.628518283367157},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5253745317459106},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4811626374721527},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.443342000246048},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.44110560417175293},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.4233192801475525},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3841700553894043},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.35879790782928467},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3030549883842468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29108697175979614},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21293297410011292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1278076469898224},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09725934267044067}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009525","descriptor_name":"Niacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.36721/pjps.2023.36.6.reg.1777-1781.1","doi":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:38124418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38124418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:48d031e72938445aa0ca05d754e15178","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/48d031e72938445aa0ca05d754e15178","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences, Vol 36, Iss 6 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.36721/pjps.2023.36.6.reg.1777-1781.1","doi":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2023.36.6.reg.1777-1781.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7164043066","https://openalex.org/W4200170246","https://openalex.org/W4406342088","https://openalex.org/W1995930136","https://openalex.org/W4386396518","https://openalex.org/W2126762359","https://openalex.org/W3008595228","https://openalex.org/W4401033248","https://openalex.org/W2420291775","https://openalex.org/W1591294562"],"abstract_inverted_index":{"The":[0,79],"alkaloid":[1],"piperine":[2],"is":[3,19],"the":[4,42,60,69,83,105,124,182,186],"main":[5],"bioactive":[6],"compound":[7],"in":[8,34,52,117],"black":[9],"pepper":[10],"(Piper":[11],"nigrum":[12],"L)":[13],"and":[14,99,164,194],"exhibits":[15],"antihyperlipidemic":[16,50,80],"activity.":[17],"Piperine":[18],"a":[20,55,77,111,130],"Biopharmaceutical":[21],"Classification":[22],"System":[23],"(BCS)":[24],"Class":[25],"II":[26],"compound,":[27],"which":[28],"has":[29],"low":[30,35],"water":[31],"solubility,":[32],"resulting":[33],"bioavailability.":[36],"This":[37],"study":[38],"aims":[39],"to":[40,156,162,170,178],"examine":[41],"effects":[43],"of":[44,62,82,132,148],"multicomponent":[45,66,125,146,187],"nicotinic":[46,74],"acid-piperine":[47],"crystals":[48,67,128,147,190],"on":[49],"activity":[51,81],"rats":[53,122],"fed":[54,110],"high-fat":[56,112],"diet.":[57],"To":[58],"increase":[59,116],"effectiveness":[61],"piperine,":[63],"we":[64],"prepared":[65],"by":[68,87],"solvent-drop":[70],"grinding":[71],"method,":[72],"using":[73,104],"acid":[75,127,150,189],"as":[76],"co-former.":[78],"preparation":[84],"was":[85],"estimated":[86],"measuring":[88],"total":[89,92],"cholesterol":[90,97,102],"(TC),":[91],"triglycerides":[93],"(TG),":[94],"low-density":[95],"lipoprotein":[96,101],"(LDLc)":[98],"high-density":[100],"(HDLc),":[103],"enzymatic":[106],"colorimetric":[107],"method.":[108],"Rats":[109],"diet":[113],"exhibited":[114],"an":[115],"plasma":[118,139],"lipid":[119,140],"levels.":[120,141],"However,":[121],"administered":[123],"piperine-nicotinic":[126,149,188],"at":[129],"dose":[131],"40":[133],"mg/kg/BW":[134],"showed":[135],"significantly":[136],"(p<0.050)":[137],"reduced":[138],"Compared":[142],"with":[143],"hyperlipidemic":[144],"rats,":[145],"decreased":[151],"TC":[152],"from":[153,160,167,176],"237.8\u00b18.02":[154],"mg/dL":[155,169],"174.53\u00b17.07mg/dL,":[157],"TG":[158,193],"levels":[159,166,175],"208.33\u00b15.79":[161],"85.95\u00b17.41mg/dL":[163],"LDLc":[165,195],"144.225\u00b115.99":[168],"88.55\u00b110.83mg/dL":[171],"but":[172,196],"increased":[173,197],"HDLc":[174],"51.93\u00b110.92mg/dL":[177],"68.78\u00b12.56":[179],"mg/dL.":[180],"Thus,":[181],"results":[183],"demonstrate":[184],"that":[185],"lowered":[191],"TC,":[192],"HDLc.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-22T00:00:00"}