{"id":"https://openalex.org/W4390065653","doi":"https://doi.org/10.1093/geroni/igad104.0327","title":"CIRCULATING SASP FACTORS ARE ELEVATED IN PATIENTS WITH POSTOPERATIVE DELIRIUM","display_name":"CIRCULATING SASP FACTORS ARE ELEVATED IN PATIENTS WITH POSTOPERATIVE DELIRIUM","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390065653","doi":"https://doi.org/10.1093/geroni/igad104.0327"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igad104.0327","doi":"https://doi.org/10.1093/geroni/igad104.0327","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.0327","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/101/54737491/igad104.0327.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/101/54737491/igad104.0327.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041091292","display_name":"Allyson K. Palmer","orcid":"https://orcid.org/0000-0001-7505-3455","observed_orcids":["https://orcid.org/0000-0001-7505-3455"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allyson K Palmer","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049778012","display_name":"Thomas A. White","orcid":"https://orcid.org/0000-0001-7372-0306","observed_orcids":["https://orcid.org/0000-0001-7372-0306"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas White","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038589760","display_name":"Elizabeth J. Atkinson","orcid":"https://orcid.org/0000-0002-1191-3775","observed_orcids":["https://orcid.org/0000-0002-1191-3775"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Atkinson","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014342029","display_name":"Nathan K. LeBrasseur","orcid":"https://orcid.org/0000-0002-2002-0418","observed_orcids":["https://orcid.org/0000-0002-2002-0418"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan LeBrasseur","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Supplement_1","first_page":"101","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9459999799728394},{"id":"https://openalex.org/keywords/postoperative-delirium","display_name":"postoperative delirium","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8389999866485596},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6850000023841858},{"id":"https://openalex.org/keywords/transcatheter-aortic-valve-replacement","display_name":"transcatheter aortic valve implantation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/surgical-patients","display_name":"surgical patients","score":0.8569999933242798},{"id":"https://openalex.org/keywords/activin-a","display_name":"activin A","score":0.8880000114440918},{"id":"https://openalex.org/keywords/papp-a","display_name":"PAPP-A","score":0.8460000157356262},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7289999723434448},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2779753318","wikidata":"https://www.wikidata.org/wiki/Q160796","display_name":"Delirium","level":2,"score":0.9137061834335327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6405680179595947},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5387580990791321},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4180225431919098},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3291010856628418},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2268219292163849},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15605464577674866}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igad104.0327","doi":"https://doi.org/10.1093/geroni/igad104.0327","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.0327","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/101/54737491/igad104.0327.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10735600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10735600","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10735600/pdf/igad104.0327.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igad104.0327","doi":"https://doi.org/10.1093/geroni/igad104.0327","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/geroni/igad104.0327","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/101/54737491/igad104.0327.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390065653.pdf","grobid_xml":"https://content.openalex.org/works/W4390065653.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2330417402","https://openalex.org/W1202644717","https://openalex.org/W2389540459","https://openalex.org/W2009989870","https://openalex.org/W6921223693","https://openalex.org/W4283079973","https://openalex.org/W1512720883","https://openalex.org/W7206608211","https://openalex.org/W1732763959","https://openalex.org/W4396218514"],"abstract_inverted_index":{"Abstract":[0],"Aging,":[1],"a":[2,24,124,133],"major":[3],"risk":[4,52,73],"factor":[5],"for":[6,88,174],"delirium,":[7],"is":[8,55,236],"associated":[9,70],"with":[10,71,202,219],"accumulation":[11],"of":[12,18,26,53,74,157,160,169,188,200],"senescent":[13,48,248],"cells":[14,22],"in":[15,65,77,198,217],"many":[16],"tissues":[17],"the":[19,34,100,146,163],"body.":[20],"Senescent":[21],"produce":[23],"host":[25],"proinflammatory":[27],"and":[28,51,95,121,153,193],"tissue":[29],"remodeling":[30],"factors":[31,104,190,226],"collectively":[32],"termed":[33],"senescence-associated":[35],"secretory":[36],"phenotype":[37],"(SASP),":[38],"which":[39],"are":[40,69,243],"secreted":[41],"into":[42],"circulation.":[43],"The":[44],"relationship":[45],"between":[46,232],"increased":[47,72,247],"cell":[49,249],"burden":[50],"delirium":[54,76,178,184,203,220],"not":[56,208,229],"known.":[57],"This":[58],"study":[59,235],"aimed":[60],"to":[61,238,246],"determine":[62,239],"whether":[63,240],"changes":[64,242],"circulating":[66],"SASP":[67,103,189,225],"proteins":[68],"postoperative":[75,166],"cognitively":[78],"intact":[79],"older":[80],"adults.":[81],"Participants":[82],"were":[83,105,139,195,228],"recruited":[84],"among":[85],"patients":[86,161,175,182,201,218],"scheduled":[87],"surgical":[89],"or":[90],"transcatheter":[91],"aortic":[92],"valve":[93],"replacement,":[94],"blood":[96],"was":[97,130,171,214],"obtained":[98],"at":[99],"presurgical":[101],"visit.":[102],"measured":[106,227],"using":[107],"commercially":[108],"available":[109],"multiplex":[110],"magnetic":[111],"bead":[112],"immunoassays":[113],"based":[114],"on":[115,123],"Luminex":[116],"xMAP":[117],"multianalyte":[118],"profiling":[119],"platform":[120],"analyzed":[122],"MAGPIX":[125],"system.":[126],"Activin":[127,191],"A":[128,192],"concentration":[129,213],"determined":[131],"by":[132,141],"Quantikine":[134],"ELISA":[135],"kit.":[136],"Delirium":[137],"cases":[138],"identified":[140],"manual":[142],"chart":[143],"abstraction,":[144],"utilizing":[145],"problem":[147],"list,":[148],"ICD-10":[149],"codes,":[150],"clinical":[151],"notes,":[152],"nursing":[154],"flowsheets.":[155],"Eight":[156],"62":[158],"(12.9%)":[159],"within":[162],"cohort":[164],"developed":[165,177],"delirium.":[167,210,223],"Length":[168],"stay":[170],"significantly":[172,196,215],"longer":[173],"who":[176,206],"(10.6":[179],"days)":[180],"versus":[181],"without":[183,222],"(6":[185],"days).":[186],"Concentrations":[187],"PAPP-A":[194],"higher":[197],"plasma":[199],"vs.":[204],"those":[205],"did":[207],"develop":[209],"IL-1":[211],"alpha":[212],"lower":[216],"vs":[221],"Other":[224],"statistically":[230],"different":[231],"groups.":[233],"More":[234],"needed":[237],"these":[241],"directly":[244],"related":[245],"burden.":[250]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-22T00:00:00"}