{"id":"https://openalex.org/W4390064929","doi":"https://doi.org/10.1093/geroni/igad104.0546","title":"MUSCLE STRENGTH AND INCIDENT DEMENTIA IN THE NATIONAL HEALTH AND AGING TRENDS STUDY (NHATS)","display_name":"MUSCLE STRENGTH AND INCIDENT DEMENTIA IN THE NATIONAL HEALTH AND AGING TRENDS STUDY (NHATS)","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4390064929","doi":"https://doi.org/10.1093/geroni/igad104.0546"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igad104.0546","doi":"https://doi.org/10.1093/geroni/igad104.0546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igad104.0546","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/167/54738644/igad104.0546.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/167/54738644/igad104.0546.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022687499","display_name":"Amal Asiri Wanigatunga","orcid":"https://orcid.org/0000-0002-5763-5184","observed_orcids":["https://orcid.org/0000-0002-5763-5184"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amal Wanigatunga","raw_affiliation_strings":["Johns Hopkins School of Public Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins School of Public Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101752311","display_name":"Yidan Lu","orcid":"https://orcid.org/0000-0002-0353-4687","observed_orcids":["https://orcid.org/0000-0002-0353-4687"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yidan Lu","raw_affiliation_strings":["Johns Hopkins School of Public Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins School of Public Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005435027","display_name":"Francesca Marino","orcid":"https://orcid.org/0000-0001-9641-052X","observed_orcids":["https://orcid.org/0000-0001-9641-052X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Marino","raw_affiliation_strings":["Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058579794","display_name":"Anis Davoudi","orcid":"https://orcid.org/0000-0002-3383-9481","observed_orcids":["https://orcid.org/0000-0002-3383-9481"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anis Davoudi","raw_affiliation_strings":["Johns Hopkins University , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102715506","display_name":"Ryan James Dougherty","orcid":"https://orcid.org/0000-0002-8640-9549","observed_orcids":["https://orcid.org/0000-0002-8640-9549"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Dougherty","raw_affiliation_strings":["Johns Hopkins University , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077774721","display_name":"Jennifer A. Schrack","orcid":"https://orcid.org/0000-0001-9244-9267","observed_orcids":["https://orcid.org/0000-0001-9244-9267"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Schrack","raw_affiliation_strings":["Johns Hopkins University , Baltimore, Maryland , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University , Baltimore, Maryland , United States","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3615,"currency":"USD","value_usd":3615},"apc_paid":{"value":3615,"currency":"USD","value_usd":3615},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Supplement_1","first_page":"167","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.5329999923706055},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.7950000166893005},{"id":"https://openalex.org/keywords/chair-stand-time","display_name":"chair stand time","score":0.6150000095367432},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.9589999914169312},{"id":"https://openalex.org/keywords/incident-dementia","display_name":"incident dementia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hand-muscle-strength","display_name":"hand muscle strength","score":0.7289999723434448},{"id":"https://openalex.org/keywords/lower-limb-muscle-strength","display_name":"lower limb muscle strength","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neuromuscular-mechanisms","display_name":"neuromuscular mechanisms","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8814465999603271},{"id":"https://openalex.org/C2777433710","wikidata":"https://www.wikidata.org/wiki/Q5609571","display_name":"Grip strength","level":2,"score":0.8201538324356079},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6349886059761047},{"id":"https://openalex.org/C2988918651","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle strength","level":2,"score":0.6301805377006531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6282163262367249},{"id":"https://openalex.org/C70770792","wikidata":"https://www.wikidata.org/wiki/Q7239848","display_name":"Preferred walking speed","level":2,"score":0.6104609370231628},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.5697306394577026},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.5672063231468201},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5231793522834778},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.4537199139595032},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.436550498008728},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.36508744955062866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3617951571941376},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.19413286447525024},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.060982465744018555},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/geroni/igad104.0546","doi":"https://doi.org/10.1093/geroni/igad104.0546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igad104.0546","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/167/54738644/igad104.0546.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10736584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10736584","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10736584/pdf/igad104.0546.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igad104.0546","doi":"https://doi.org/10.1093/geroni/igad104.0546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igad104.0546","pdf_url":"https://academic.oup.com/innovateage/article-pdf/7/Supplement_1/167/54738644/igad104.0546.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390064929.pdf","grobid_xml":"https://content.openalex.org/works/W4390064929.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414547540","https://openalex.org/W4412493035","https://openalex.org/W4296949128","https://openalex.org/W3212170433","https://openalex.org/W4414347669","https://openalex.org/W4200587143","https://openalex.org/W4283321780","https://openalex.org/W2158237524","https://openalex.org/W4297897089","https://openalex.org/W4400018733"],"abstract_inverted_index":{"Abstract":[0],"Slower":[1],"gait":[2,38,115,156,180,205],"speed":[3,116,157,181],"is":[4,18,31,207],"linked":[5,228],"to":[6,33,90,161,229],"dementia":[7,34,55,73,78,130,146,169,210],"risk,":[8],"but":[9,173],"the":[10,27,215,220],"role":[11],"muscle":[12,23,97,216],"strength":[13,24,59,65,98],"plays":[14],"in":[15,26,136,144],"this":[16],"relationship":[17],"unclear.":[19],"We":[20,40],"examined":[21],"whether":[22],"measured":[25,61],"hands":[28,221],"and":[29,67,76,99,107,110,222,235],"legs":[30,223],"related":[32],"risk":[35],"beyond":[36],"usual":[37,113],"speed.":[39],"included":[41],"3,212":[42],"NHATS":[43,83],"participants":[44],"(mean":[45],"age":[46],"75":[47],"years,":[48,124],"54%":[49],"women)":[50],"followed":[51],"from":[52,194],"2011-2019":[53],"without":[54],"at":[56],"baseline.":[57,195],"Muscle":[58],"was":[60,140,165],"by":[62,80],"maximal":[63],"grip":[64,137,200],"(kg)":[66],"repeated":[68],"chair":[69,163],"stands":[70,164],"(seconds).":[71],"Incident":[72],"combined":[74],"possible":[75],"probable":[77],"defined":[79],"a":[81,141],"validated":[82],"algorithm.":[84],"Cox":[85],"regression":[86],"models":[87],"were":[88,103,126,175],"used":[89],"estimate":[91],"longitudinal":[92],"associations":[93],"between":[94,219],"each":[95],"baseline":[96],"incident":[100,145],"dementia.":[101,230],"Models":[102],"adjusted":[104],"for":[105,112,155,179,204],"demographics":[106],"medical":[108],"conditions,":[109],"additionally":[111],"paced":[114],"(m/s).":[117],"Over":[118],"an":[119],"average":[120],"of":[121,232],"5":[122],"(SD=3)":[123],"there":[125,139],"946":[127],"(30%)":[128],"first-time":[129],"events.":[131],"For":[132],"1":[133,192],"kg":[134],"higher":[135],"strength,":[138,201],"2%":[142],"decrease":[143],"(HR:0.98;":[147],"95%CI:":[148],"0.97-0.99;p<0.001),":[149],"which":[150],"remained":[151,185],"significant":[152],"after":[153,177,187,202],"adjustment":[154],"(p=0.005).":[158],"More":[159],"time":[160],"complete":[162],"positively":[166],"associated":[167,208],"with":[168,209],"incidence":[170],"(HR:1.02;":[171],"95%CI:1.01-1.03;p<0.001)":[172],"results":[174,184,213],"attenuated":[176],"adjusting":[178],"(p>0.10).":[182],"All":[183],"robust":[186],"removing":[188],"events":[189],"that":[190,199],"occurred":[191],"year":[193],"These":[196,212],"findings":[197,234],"suggest":[198,214],"accounting":[203],"speed,":[206],"incidence.":[211],"morphology":[217],"differences":[218],"capture":[224],"different":[225],"neuromuscular":[226],"mechanisms":[227,241],"Replication":[231],"these":[233],"further":[236],"investigation":[237],"into":[238],"potential":[239],"biological":[240],"are":[242],"needed.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-22T00:00:00"}