{"id":"https://openalex.org/W4390063503","doi":"https://doi.org/10.1016/j.cct.2023.107414","title":"Marginal versus conditional rate estimation for count and recurrent event data with an estimand framework","display_name":"Marginal versus conditional rate estimation for count and recurrent event data with an estimand framework","publication_year":2023,"publication_date":"2023-12-21","ids":{"openalex":"https://openalex.org/W4390063503","doi":"https://doi.org/10.1016/j.cct.2023.107414","pmid":"https://pubmed.ncbi.nlm.nih.gov/38141966"},"language":"en","primary_location":{"id":"doi:10.1016/j.cct.2023.107414","doi":"https://doi.org/10.1016/j.cct.2023.107414","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cct.2023.107414","pdf_url":null,"source":{"id":"https://openalex.org/S63040059","display_name":"Contemporary Clinical Trials","issn_l":"1551-7144","issn":["1551-7144","1559-2030"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary Clinical Trials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011819493","display_name":"Sarah C. Conner","orcid":"https://orcid.org/0000-0002-0929-9948","observed_orcids":["https://orcid.org/0000-0002-0929-9948"]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah C. Conner","raw_affiliation_strings":["Vertex Pharmaceuticals, 50 Northern Ave, Boston, MA 02210, USA. Electronic address: sarah_conner@vrtx.com","Vertex Pharmaceuticals, 50 Northern Ave, Boston, MA 02210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, 50 Northern Ave, Boston, MA 02210, USA. Electronic address: sarah_conner@vrtx.com","institution_ids":["https://openalex.org/I61970326"]},{"raw_affiliation_string":"Vertex Pharmaceuticals, 50 Northern Ave, Boston, MA 02210, USA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000917200","display_name":"Yijie Zhou","orcid":"https://orcid.org/0000-0002-8442-581X","observed_orcids":["https://orcid.org/0000-0002-8442-581X"]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yijie Zhou","raw_affiliation_strings":["Vertex Pharmaceuticals, 50 Northern Ave, Boston, MA 02210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, 50 Northern Ave, Boston, MA 02210, USA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064364791","display_name":"Tu Xu","orcid":"https://orcid.org/0000-0001-6568-6048","observed_orcids":["https://orcid.org/0000-0001-6568-6048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tu Xu","raw_affiliation_strings":["Novo Nordisk Inc., 75 Hayden Avenue, Lexington, MA 02421, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Inc., 75 Hayden Avenue, Lexington, MA 02421, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011819493"],"corresponding_institution_ids":["https://openalex.org/I61970326"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":0.2029,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52636287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"138","issue":null,"first_page":"107414","last_page":"107414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/count-data","display_name":"count data","score":0.9559999704360962},{"id":"https://openalex.org/keywords/estimand-framework","display_name":"estimand framework","score":0.953000009059906},{"id":"https://openalex.org/keywords/pulmonary-exacerbations","display_name":"pulmonary exacerbations","score":0.7929999828338623},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9279999732971191},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/covariate-adjustment","display_name":"covariate adjustment","score":0.8220000267028809},{"id":"https://openalex.org/keywords/rate-ratio","display_name":"rate ratios","score":0.6359999775886536},{"id":"https://openalex.org/keywords/nonlinear-models","display_name":"nonlinear models","score":0.5249999761581421},{"id":"https://openalex.org/keywords/poisson-regression","display_name":"Poisson regression","score":0.7950000166893005},{"id":"https://openalex.org/keywords/negative-binomial-regression","display_name":"negative binomial regression","score":0.9879999756813049},{"id":"https://openalex.org/keywords/subgroup-treatment-effects","display_name":"subgroup treatment effects","score":0.8029999732971191},{"id":"https://openalex.org/keywords/fda-guidance","display_name":"FDA guidance","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.7775087356567383},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6419889330863953},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.6326375007629395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5617438554763794},{"id":"https://openalex.org/C33643355","wikidata":"https://www.wikidata.org/wiki/Q5176731","display_name":"Count data","level":3,"score":0.5140758752822876},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.49962496757507324},{"id":"https://openalex.org/C197656967","wikidata":"https://www.wikidata.org/wiki/Q17058458","display_name":"Marginal model","level":3,"score":0.4632132947444916},{"id":"https://openalex.org/C168743327","wikidata":"https://www.wikidata.org/wiki/Q1826427","display_name":"Random effects model","level":3,"score":0.4547847509384155},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.4342314600944519},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.40533679723739624},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.38845422863960266},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.33281588554382324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28902924060821533},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18603381514549255},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.11303499341011047},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cct.2023.107414","doi":"https://doi.org/10.1016/j.cct.2023.107414","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cct.2023.107414","pdf_url":null,"source":{"id":"https://openalex.org/S63040059","display_name":"Contemporary Clinical Trials","issn_l":"1551-7144","issn":["1551-7144","1559-2030"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary Clinical Trials","raw_type":"journal-article"},{"id":"pmid:38141966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38141966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary clinical trials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1975780287","https://openalex.org/W1975915837","https://openalex.org/W1979102876","https://openalex.org/W1996016456","https://openalex.org/W2006623746","https://openalex.org/W2049316269","https://openalex.org/W2082299845","https://openalex.org/W2155571712","https://openalex.org/W2321081482","https://openalex.org/W2529010631","https://openalex.org/W2802877326","https://openalex.org/W2963435772","https://openalex.org/W2985405196","https://openalex.org/W3102970921","https://openalex.org/W3128316034","https://openalex.org/W3135723810","https://openalex.org/W3168533830","https://openalex.org/W3170095964","https://openalex.org/W4214918165","https://openalex.org/W4281293628","https://openalex.org/W4302768905"],"related_works":["https://openalex.org/W7097893681","https://openalex.org/W1978766891","https://openalex.org/W2064701759","https://openalex.org/W7204231463","https://openalex.org/W7117969163","https://openalex.org/W2055398438","https://openalex.org/W2152448026","https://openalex.org/W4403359979","https://openalex.org/W4417136224","https://openalex.org/W2118482010"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-22T00:00:00"}
