{"id":"https://openalex.org/W4390057539","doi":"https://doi.org/10.57220/jatpb.v2i3.132","title":"Investigation of the phytochemical composition and anti-inflammatory properties of Afzelia africana leaves","display_name":"Investigation of the phytochemical composition and anti-inflammatory properties of Afzelia africana leaves","publication_year":2023,"publication_date":"2023-12-20","ids":{"openalex":"https://openalex.org/W4390057539","doi":"https://doi.org/10.57220/jatpb.v2i3.132"},"language":"en","primary_location":{"id":"doi:10.57220/jatpb.v2i3.132","doi":"https://doi.org/10.57220/jatpb.v2i3.132","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57220/jatpb.v2i3.132","pdf_url":null,"source":{"id":"https://openalex.org/S4387284353","display_name":"Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB)","issn_l":"2756-7362","issn":["2756-7362"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://dx.doi.org/10.57220/jatpb.v2i3.132","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093551645","display_name":"L\u00e9a Kengne Kamkui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lea Kengne Kamkui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093551646","display_name":"Romuald Tebue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romuald Tebue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093551647","display_name":"Mathilde Audrey Pondy Bias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mathilde Audrey Pondy Bias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048289051","display_name":"Foutse Yimta","orcid":"https://orcid.org/0009-0004-7297-6659","observed_orcids":["https://orcid.org/0009-0004-7297-6659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yimta Foutse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051741572","display_name":"Ernest Djoko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernest Djoko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068609836","display_name":"Wona Jean Pierre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Pierre Wona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019992583","display_name":"Th\u00e9ophile Dimo","orcid":"https://orcid.org/0000-0002-8565-1181","observed_orcids":["https://orcid.org/0000-0002-8565-1181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theophile Dimo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010780802","display_name":"Denis Wouessidjewe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denis Wouessidjewe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.09769999980926514,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10431","display_name":"Ethnobotanical and Medicinal Plants Studies","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/afzelia-africana","display_name":"Afzelia africana","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.7839999794960022},{"id":"https://openalex.org/keywords/phytochemical-profile","display_name":"phytochemical composition","score":0.871999979019165},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.824999988079071},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hydroalcoholic-extract","display_name":"hydroalcoholic extract","score":0.7789999842643738},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.8619999885559082},{"id":"https://openalex.org/keywords/topical-hydrogel","display_name":"topical hydrogel","score":0.6000000238418579},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.7889999747276306},{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tannins","display_name":"tannins","score":0.6899999976158142},{"id":"https://openalex.org/keywords/coumaric-acid","display_name":"coumaric acid","score":0.593999981880188},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.5529999732971191},{"id":"https://openalex.org/keywords/diclofenac-comparison","display_name":"diclofenac comparison","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7819315791130066},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7040951251983643},{"id":"https://openalex.org/C133446333","wikidata":"https://www.wikidata.org/wiki/Q38681","display_name":"Bark (sound)","level":2,"score":0.616511344909668},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.6106822490692139},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.6018314957618713},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.6000615358352661},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.5186578631401062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.462630957365036},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.46254321932792664},{"id":"https://openalex.org/C2780751074","wikidata":"https://www.wikidata.org/wiki/Q7189797","display_name":"Phytomedicine","level":2,"score":0.4419773519039154},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39741986989974976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36366918683052063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22714072465896606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17567875981330872},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.13724276423454285},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.57220/jatpb.v2i3.132","doi":"https://doi.org/10.57220/jatpb.v2i3.132","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57220/jatpb.v2i3.132","pdf_url":null,"source":{"id":"https://openalex.org/S4387284353","display_name":"Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB)","issn_l":"2756-7362","issn":["2756-7362"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB)","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5b0eabe5960d43e289aaab7eee85bce3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5b0eabe5960d43e289aaab7eee85bce3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Africain de Technologie Pharmaceutique et Biopharmacie, Vol 2, Iss 3 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.57220/jatpb.v2i3.132","doi":"https://doi.org/10.57220/jatpb.v2i3.132","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57220/jatpb.v2i3.132","pdf_url":null,"source":{"id":"https://openalex.org/S4387284353","display_name":"Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB)","issn_l":"2756-7362","issn":["2756-7362"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3200395225","https://openalex.org/W2037380204","https://openalex.org/W4313550265","https://openalex.org/W4317241193","https://openalex.org/W2463670686","https://openalex.org/W3083038488","https://openalex.org/W2795996672","https://openalex.org/W4200620259","https://openalex.org/W3121005809","https://openalex.org/W2804141826"],"abstract_inverted_index":{"Introduction:":[0],"Afzelia":[1],"africana":[2,115],"is":[3,8,15,511],"a":[4,44,66,235,245,263,333,573,601],"large":[5],"tree":[6],"that":[7,86,143,419],"widespread":[9],"in":[10,17,140,155,168,214,296,302,372,397,513,546],"West":[11],"Africa.":[12],"Its":[13,522],"bark":[14,341,507],"used":[16,233,512],"traditional":[18,103,514,609],"medicine":[19,515],"to":[20,56,85,125,142,150,256,338,401,418,481,516,527,548],"treat":[21,517],"rheumatism,":[22],"edema,":[23],"and":[24,50,69,76,134,148,171,176,184,193,239,271,276,289,349,353,367,433,446,457,463,468,470,495,500,520,532],"pain.":[25,521],"In":[26,222,406],"our":[27],"previous":[28],"researches,":[29],"we":[30,108,553],"studied":[31],"the":[32,36,74,96,111,119,128,132,138,145,169,185,223,283,297,303,317,325,339,388,408,412,421,431,529,536,555,558,567,570,592,599,605],"phytochemical":[33,530,561],"characteristics":[34],"of":[35,39,47,87,93,98,101,113,131,137,144,163,212,247,316,329,360,385,411,420,436,455,483,492,508,535,557,576,591,607],"aqueous":[37,133,170,238,326,352,389,413,432],"extract":[38,61,328,380,415],"trunk":[40,120,146,340,422,506,537,568],"bark,":[41,147,423,569],"which":[42,53,488,581],"showed":[43,323,563],"high":[45,574],"content":[46,410,575],"phenolic":[48],"compounds":[49],"particularly":[51,579],"flavonoids,":[52,346],"are":[54,582],"known":[55,583],"have":[57,80,572],"anti-inflammatory":[58,82,153,533,544,586,589],"properties.":[59],"This":[60],"has":[62,332,595],"been":[63,596],"formulated":[64],"as":[65,189,234,262,565],"topical":[67,210,523],"hydrogel,":[68],"preclinical":[70],"animal":[71,157],"studies":[72],"on":[73,314],"chronic":[75],"acute":[77,204],"inflammation":[78,206],"model":[79,207],"demonstrated":[81,541],"activity":[83,154,199,534,590],"comparable":[84,417,480],"diclofenac":[88],"with":[89,363,392,424,430,452,486],"an":[90,156,203,542],"inhibition":[91,292,453,477,490],"rate":[92,293],"85.31%.":[94],"With":[95],"aim":[97],"industrial":[99],"production":[100],"improved":[102,608],"medicine,":[104],"while":[105],"preserving":[106],"biodiversity,":[107],"investigated":[109,167,554],"whether":[110],"leaves":[112,139,439,571,600],"A.":[114,330,437,509],"could":[116],"advantageously":[117],"replace":[118],"back.":[121],"The":[122,160,174,258,285,291,321,351,377,505,560,588],"objectives":[123],"were":[124,166,179,187,217,228,242,253,267,280,310,479],"first":[126],"study":[127,528,562],"phytochemically":[129],"composition":[130,337,531],"hydroethanolic":[135,172,240,354,378,434],"extracts":[136,241,356,435,594],"comparison":[141],"then":[149,277],"evaluate":[151],"its":[152],"model.":[158],"Methodology:":[159],"main":[161],"families":[162],"secondary":[164,335],"metabolites":[165],"extracts.":[173],"polyphenol":[175],"flavonoid":[177,409],"contents":[178],"determined":[180,201],"by":[181,209,312],"spectrophotometric":[182],"assay,":[183],"results":[186,322],"expressed":[188],"gallic":[190,373],"acid":[191,374],"equivalents":[192,399],"quercetin":[194,398],"equivalents,":[195,375],"respectively.":[196,376,475,503],"Anti-":[197],"inflammatory":[198,518],"was":[200,232,287,294,416],"using":[202],"ear":[205,260,305,442],"induced":[208],"application":[211,309,524],"xylene":[213,308,450],"mice.":[215,257],"Mice":[216],"divided":[218],"into":[219],"four":[220],"groups.":[221,299],"negative":[224],"control":[225],"group,":[226],"mice":[227],"not":[229],"treated;":[230],"betamethasone":[231],"positive":[236],"control;":[237],"administered":[243,254],"at":[244],"dose":[246],"20":[248],"mg":[249],"per":[250],"ear.":[251],"Doses":[252],"topically":[255],"contralateral":[259],"served":[261],"control.":[264],"All":[265],"animals":[266,484],"sacrificed":[268],"0.5,":[269,444,498],"1,":[270,445,499],"4":[272,447,473,501],"hours":[273,448,474],"after":[274,307,449,459,465,472,497],"xylene,":[275],"two":[278],"ears":[279],"cut":[281],"along":[282],"pinna.":[284],"pinna":[286],"harvested":[288],"weighed.":[290],"calculated":[295],"different":[298],"Structural":[300],"changes":[301],"inner":[304],"wall":[306],"evaluated":[311],"histology":[313],"sections":[315],"animals'":[318],"ears.":[319],"Results:":[320],"that,":[324,564],"leaf":[327,355,379,390,414,593],"Africana":[331,438,510],"similar":[334,358],"metabolite":[336],"extract,":[342,391],"containing":[343],"tannins,":[344],"alkaloids,":[345],"steroids,":[347],"coumarins,":[348],"quinones.":[350],"contained":[357,381],"levels":[359,384],"total":[361],"polyphenols,":[362,580],"196.44":[364],"\u00b1":[365,369,394,403,427],"4.22":[366,404],"214.58":[368],"1.78":[370],"mg/g":[371,396,426],"significantly":[382,440],"higher":[383],"flavonoids":[386],"than":[387],"59.16":[393],"0.22":[395],"compared":[400],"32.23":[402],"mg/g.":[405],"addition,":[407],"25.8":[425],"0.26.":[428],"Treatment":[429],"inhibited":[441],"edema":[443],"application,":[451],"percentages":[454,478,491],"44.49%":[456],"12.39%":[458],"0.5":[460],"hour,":[461,467],"80.26%":[462],"80.67%":[464],"1":[466],"63.97%":[469],"49.44%":[471],"These":[476],"those":[482],"treated":[485],"betamethasone,":[487],"had":[489],"56.38%,":[493],"75.30%,":[494],"76.39%":[496],"hours,":[502],"Conclusion:":[504],"diseases":[519],"inspired":[525],"us":[526],"bark.":[538],"Although":[539],"it":[540],"interesting":[543],"potential,":[545],"order":[547],"protect":[549],"this":[550],"precious":[551],"resource,":[552],"potential":[556],"leaves.":[559],"for":[566,584,604],"active":[577],"metabolites,":[578],"their":[585],"potential.":[587],"demonstrated,":[597],"making":[598],"good":[602],"candidate":[603],"development":[606],"medicines.":[610]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-12-22T00:00:00"}