{"id":"https://openalex.org/W4390054957","doi":"https://doi.org/10.1038/s41598-023-44662-x","title":"Discovery of 1-(5-bromopyrazin-2-yl)-1-[3-(trifluoromethyl)benzyl]urea as a promising anticancer drug via synthesis, characterization, biological screening, and computational studies","display_name":"Discovery of 1-(5-bromopyrazin-2-yl)-1-[3-(trifluoromethyl)benzyl]urea as a promising anticancer drug via synthesis, characterization, biological screening, and computational studies","publication_year":2023,"publication_date":"2023-12-20","ids":{"openalex":"https://openalex.org/W4390054957","doi":"https://doi.org/10.1038/s41598-023-44662-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/38129413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10739849"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-44662-x","doi":"https://doi.org/10.1038/s41598-023-44662-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-44662-x","pdf_url":"https://www.nature.com/articles/s41598-023-44662-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-44662-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068821076","display_name":"Yasser Hussein Issa Mohammed","orcid":"https://orcid.org/0000-0003-1086-7292","observed_orcids":["https://orcid.org/0000-0003-1086-7292"]},"institutions":[{"id":"https://openalex.org/I4210146209","display_name":"Al-Razi University","ror":"https://ror.org/04rrnb020","country_code":"YE","type":"education","lineage":["https://openalex.org/I4210146209"]},{"id":"https://openalex.org/I4405254395","display_name":"Hajjah University","ror":"https://ror.org/01rpcwa78","country_code":"YE","type":"education","lineage":["https://openalex.org/I4405254395"]}],"countries":["YE"],"is_corresponding":true,"raw_author_name":"Yasser Hussein Issa Mohammed","raw_affiliation_strings":["Department of Biochemistry, Faculty of Applied Science, University of Hajjah, Hajjah, Yemen. issayasser16@gmail.com","Department of Pharmacy, Faculty of Medicine and Medical Science, University of Al-Razi, Sana'a, Yemen. issayasser16@gmail.com","Department of Biochemistry, Faculty of Applied Science, University of Hajjah, Hajjah, Yemen"],"raw_orcid":"https://orcid.org/0000-0003-1086-7292","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Applied Science, University of Hajjah, Hajjah, Yemen. issayasser16@gmail.com","institution_ids":["https://openalex.org/I4405254395"]},{"raw_affiliation_string":"Department of Pharmacy, Faculty of Medicine and Medical Science, University of Al-Razi, Sana'a, Yemen. issayasser16@gmail.com","institution_ids":["https://openalex.org/I4210146209"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Applied Science, University of Hajjah, Hajjah, Yemen","institution_ids":["https://openalex.org/I4405254395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072705264","display_name":"Israa Mohamed Shamkh","orcid":"https://orcid.org/0000-0002-3260-4162","observed_orcids":["https://orcid.org/0000-0002-3260-4162"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Israa M. Shamkh","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt","Chemo and Bioinformatics Lab, Bio Search Research Institution (BSRI), Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Chemo and Bioinformatics Lab, Bio Search Research Institution (BSRI), Giza, Egypt","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004196989","display_name":"Nahed Sail Alharthi","orcid":"https://orcid.org/0000-0001-5597-5882","observed_orcids":["https://orcid.org/0000-0001-5597-5882","https://orcid.org/0009-0008-6602-8715"]},"institutions":[{"id":"https://openalex.org/I142608572","display_name":"Prince Sattam Bin Abdulaziz University","ror":"https://ror.org/04jt46d36","country_code":"SA","type":"education","lineage":["https://openalex.org/I142608572"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nahed S. Alharthi","raw_affiliation_strings":["Department of Medical Laboratory Sciences, College of Applied Medical Sciences in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia","institution_ids":["https://openalex.org/I142608572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058413977","display_name":"Mohammed Adel Shanawaz","orcid":"https://orcid.org/0000-0001-5253-5910","observed_orcids":["https://orcid.org/0000-0001-5253-5910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed A. Shanawaz","raw_affiliation_strings":["Department of Public Health, Faculty of Applied Medical Sciences, Albaha University, Albaha, 65431, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, Faculty of Applied Medical Sciences, Albaha University, Albaha, 65431, Saudi Arabia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034503408","display_name":"Hind Ali Alzahrani","orcid":"https://orcid.org/0009-0008-9974-5665","observed_orcids":["https://orcid.org/0009-0008-9974-5665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hind A. Alzahrani","raw_affiliation_strings":["Department of Basic Sciences, Faculty of Applied Medical Sciences, Albaha University, Albaha, 65431, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Faculty of Applied Medical Sciences, Albaha University, Albaha, 65431, Saudi Arabia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039593653","display_name":"Basit Jabbar","orcid":"https://orcid.org/0000-0002-9577-1793","observed_orcids":["https://orcid.org/0000-0002-9577-1793"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Basit Jabbar","raw_affiliation_strings":["Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, 53700, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, 53700, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079919039","display_name":"Saba Beigh","orcid":"https://orcid.org/0000-0003-0217-5595","observed_orcids":["https://orcid.org/0000-0003-0217-5595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saba Beigh","raw_affiliation_strings":["Department of Public Health, Faculty of Applied Medical Sciences, Albaha University, Albaha, 65431, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, Faculty of Applied Medical Sciences, Albaha University, Albaha, 65431, Saudi Arabia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064102297","display_name":"Saad Ali Alghamdi","orcid":"https://orcid.org/0000-0003-4532-9128","observed_orcids":["https://orcid.org/0000-0003-4532-9128"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Saad Alghamdi","raw_affiliation_strings":["Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-4532-9128","affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082249769","display_name":"Nada A. Alsakhen","orcid":"https://orcid.org/0000-0003-4543-4243","observed_orcids":["https://orcid.org/0000-0003-4543-4243"]},"institutions":[{"id":"https://openalex.org/I157392197","display_name":"Hashemite University","ror":"https://ror.org/04a1r5z94","country_code":"JO","type":"education","lineage":["https://openalex.org/I157392197"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Nada Alsakhen","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, The Hashemite University, Zarqa, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, The Hashemite University, Zarqa, Jordan","institution_ids":["https://openalex.org/I157392197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033583860","display_name":"Elshiekh Babiker Adam Khidir","orcid":"https://orcid.org/0000-0001-5956-9849","observed_orcids":["https://orcid.org/0000-0001-5956-9849"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Elshiekh B. Khidir","raw_affiliation_strings":["Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006158698","display_name":"Hayaa M. Alhuthali","orcid":"https://orcid.org/0000-0001-5999-081X","observed_orcids":["https://orcid.org/0000-0001-5999-081X"]},"institutions":[{"id":"https://openalex.org/I179331831","display_name":"Taif University","ror":"https://ror.org/014g1a453","country_code":"SA","type":"education","lineage":["https://openalex.org/I179331831"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hayaa M. Alhuthali","raw_affiliation_strings":["Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia","institution_ids":["https://openalex.org/I179331831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093550885","display_name":"Taqwa Hafiz Elamin Karamalla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Taqwa Hafiz Elamin Karamalla","raw_affiliation_strings":["Faculty of Medicine, Helwan University, Helwan, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Helwan University, Helwan, Cairo, Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027641532","display_name":"Amgad M. Rabie","orcid":"https://orcid.org/0000-0003-3681-114X","observed_orcids":["https://orcid.org/0000-0003-3681-114X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amgad M. Rabie","raw_affiliation_strings":["Head of Drug Discovery and Clinical Research Department, Dikernis General Hospital (DGH), Magliss El-Madina Street, Dikernis City 35744, Dikernis, Dakahlia Governorate, Egypt. amgadpharmacist1@yahoo.com","Head of Drug Discovery and Clinical Research Department, Dikernis General Hospital (DGH), Magliss El-Madina Street, Dikernis City 35744, Dikernis, Dakahlia Governorate, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-3681-114X","affiliations":[{"raw_affiliation_string":"Head of Drug Discovery and Clinical Research Department, Dikernis General Hospital (DGH), Magliss El-Madina Street, Dikernis City 35744, Dikernis, Dakahlia Governorate, Egypt. amgadpharmacist1@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Head of Drug Discovery and Clinical Research Department, Dikernis General Hospital (DGH), Magliss El-Madina Street, Dikernis City 35744, Dikernis, Dakahlia Governorate, Egypt","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5027641532","https://openalex.org/A5068821076"],"corresponding_institution_ids":["https://openalex.org/I4210146209","https://openalex.org/I4405254395"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":2.6274,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.90836988,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"22824","last_page":"22824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazine-derivatives","display_name":"pyrazine derivatives","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8309999704360962},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sub-g1-phase","display_name":"sub-G1 phase","score":0.7919999957084656},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chick-chorioallantoic-membrane-assay","display_name":"chick chorioallantoic membrane assay","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.878000020980835},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mmp-2-inhibition","display_name":"MMP-2 inhibition","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mmp-9-inhibition","display_name":"MMP-9 inhibition","score":0.9909999966621399},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8820000290870667},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.8800848722457886},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5750539302825928},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5287095308303833},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5248979330062866},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5219768285751343},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5060133337974548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45547154545783997},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4346129298210144},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4322552978992462},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4313986897468567},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.42574697732925415},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4200791120529175},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4190119206905365},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.41659659147262573},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3785250782966614},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3619603216648102},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33827927708625793},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3328292965888977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31338223814964294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2618310749530792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20393890142440796},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.19492140412330627},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.1561584174633026},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13222253322601318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07725119590759277},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-023-44662-x","doi":"https://doi.org/10.1038/s41598-023-44662-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-44662-x","pdf_url":"https://www.nature.com/articles/s41598-023-44662-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10739849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10739849","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10739849/pdf/41598_2023_Article_44662.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38129413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38129413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:07a6f877a2444e2dad96c9bb8bc9e27b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/07a6f877a2444e2dad96c9bb8bc9e27b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)","raw_type":"article"},{"id":"doi:10.60692/ck6he-31d30","doi":"https://doi.org/10.60692/ck6he-31d30","is_oa":true,"landing_page_url":"https://doi.org/10.60692/ck6he-31d30","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/ygv7r-8mw58","doi":"https://doi.org/10.60692/ygv7r-8mw58","is_oa":true,"landing_page_url":"https://doi.org/10.60692/ygv7r-8mw58","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-44662-x","doi":"https://doi.org/10.1038/s41598-023-44662-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-44662-x","pdf_url":"https://www.nature.com/articles/s41598-023-44662-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390054957.pdf","grobid_xml":"https://content.openalex.org/works/W4390054957.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1530769727","https://openalex.org/W1715712374","https://openalex.org/W1969133782","https://openalex.org/W1974209438","https://openalex.org/W1978138839","https://openalex.org/W2095624924","https://openalex.org/W2183961304","https://openalex.org/W2340469241","https://openalex.org/W2572916045","https://openalex.org/W2593436234","https://openalex.org/W2786051587","https://openalex.org/W2804479150","https://openalex.org/W2888936354","https://openalex.org/W2910046601","https://openalex.org/W2948888602","https://openalex.org/W2971253053","https://openalex.org/W3000041699","https://openalex.org/W3008383223","https://openalex.org/W3009680369","https://openalex.org/W3138115862","https://openalex.org/W3198894769","https://openalex.org/W3199189658","https://openalex.org/W4205272405","https://openalex.org/W4205619961","https://openalex.org/W4206529647","https://openalex.org/W4210880377","https://openalex.org/W4283076183","https://openalex.org/W4307287180","https://openalex.org/W4307868928","https://openalex.org/W4313334526","https://openalex.org/W4318480715"],"related_works":["https://openalex.org/W4387241597","https://openalex.org/W4283643854","https://openalex.org/W3149911312","https://openalex.org/W1924035215","https://openalex.org/W3028352347","https://openalex.org/W3173487224","https://openalex.org/W3011476616","https://openalex.org/W4406285994","https://openalex.org/W4413812261","https://openalex.org/W2792526387"],"abstract_inverted_index":{"Abstract":[0],"Cancer":[1],"and":[2,27,52,78,213,257,264,269,290,297,318,331],"different":[3],"types":[4],"of":[5,29,31,63,90,155,199,254,321],"tumors":[6],"are":[7],"still":[8],"the":[9,24,75,88,108,121,147,152,158,166,178,196,207,218,231,250,275,302],"most":[10],"resistant":[11],"diseases":[12],"to":[13,37,54,86,116,135,180,230,249,315],"available":[14],"therapeutic":[15],"agents.":[16],"Finding":[17],"a":[18,41,173,183,280],"highly":[19],"effective":[20,103],"anticancer":[21,61,185,282],"drug":[22,32],"is":[23],"first":[25],"target":[26],"concern":[28],"thousands":[30],"designers.":[33],"In":[34,300],"our":[35],"attempts":[36],"address":[38],"this":[39,139],"concern,":[40],"new":[42],"pyrazine":[43],"derivative,":[44],"1-(5-bromopyrazin-2-yl)-1-[3-(trifluoromethyl)benzyl]urea":[45],"(BPU),":[46],"was":[47,114,133],"designed":[48],"via":[49,157],"structural":[50],"optimization":[51],"synthesized":[53],"investigate":[55],"its":[56],"anticancer/antitumor":[57],"potential.":[58],"The":[59,81,237],"in-vitro":[60,296],"properties":[62],"BPU":[64,91,100,156,200,245,277,322],"were":[65,84],"evaluated":[66],"by":[67,309],"MTT":[68],"assay":[69],"using":[70,96],"selected":[71,293],"cell":[72,93,110,123,136,143,288],"lines,":[73],"including":[74],"Jurkat,":[76],"HeLa,":[77],"MCF-7":[79],"cells.":[80],"Jurkat":[82,122],"cells":[83],"chosen":[85],"study":[87],"effect":[89],"on":[92],"cycle":[94,137,144],"analysis":[95,312],"flow":[97],"cytometry":[98],"technique.":[99],"exhibited":[101],"an":[102],"cytotoxic":[104],"ability":[105],"in":[106,146,192],"all":[107],"three":[109],"lines":[111],"assessed.":[112],"It":[113],"found":[115],"be":[117,279,292,306],"more":[118],"prominent":[119],"with":[120,206,217,260,326],"line":[124],"(IC50":[125],"=":[126],"4.64":[127],"\u00b1":[128],"0.08":[129],"\u00b5M).":[130],"When":[131],"it":[132,285],"subjected":[134],"analysis,":[138],"compound":[140,167,179,276],"effectively":[141,247,286],"arrested":[142],"progression":[145],"sub-G1":[148],"phase.":[149],"Upon":[150],"evaluating":[151],"antiangiogenic":[153],"potential":[154],"in-vivo/ex-vivo":[159],"shell-less":[160],"chick":[161],"chorioallantoic":[162],"membrane":[163],"(CAM)":[164],"assays,":[165],"demonstrated":[168],"very":[169],"significant":[170],"findings,":[171],"revealing":[172],"complementary":[174],"supportive":[175],"action":[176],"for":[177,234,294,323],"act":[181],"as":[182,228,314],"potent":[184],"agent":[186,283],"through":[187],"inhibiting":[188],"blood":[189],"vessel":[190],"formation":[191],"tumor":[193],"tissues.":[194],"Moreover,":[195],"docking":[197],"energy":[198],"computationally":[201],"scored":[202],"\u2212":[203,214],"9.0":[204],"kcal/mol":[205,216],"human":[208,219],"matrix":[209,220],"metalloproteinase":[210,221],"2":[211],"(MMP-2)":[212],"7.8":[215],"9":[222],"(MMP-9),":[223],"denoting":[224],"promising":[225,281],"binding":[226,267],"results":[227,304],"compared":[229],"existing":[232],"drugs":[233],"cancer":[235,324],"therapy.":[236],"molecular":[238],"dynamics":[239],"(MD)":[240],"simulation":[241],"outcomes":[242],"showed":[243],"that":[244,274],"could":[246,278],"bind":[248],"previously-proposed":[251],"catalytic":[252],"sites":[253],"both":[255],"MMP-2":[256],"MMP-9":[258],"enzymes":[259],"relatively":[261],"stable":[262],"statuses":[263],"good":[265],"inhibitory":[266],"abilities":[268],"parameters.":[270],"Our":[271],"findings":[272],"suggest":[273],"since":[284],"inhibited":[287],"proliferation":[289],"can":[291,305],"further":[295],"in-vivo":[298],"investigations.":[299],"addition,":[301],"current":[303],"extensively":[307],"validated":[308],"conducting":[310],"wet-lab":[311],"so":[313],"develop":[316],"novel":[317],"better":[319],"derivatives":[320],"therapy":[325],"much":[327],"less":[328],"side":[329],"effects":[330],"higher":[332],"activities.":[333]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-12-22T00:00:00"}
