{"id":"https://openalex.org/W4390054034","doi":"https://doi.org/10.3390/ijms25010118","title":"ETV6::ABL1-Positive Myeloid Neoplasm: A Case of a Durable Response to Imatinib Mesylate without Additional or Previous Treatment","display_name":"ETV6::ABL1-Positive Myeloid Neoplasm: A Case of a Durable Response to Imatinib Mesylate without Additional or Previous Treatment","publication_year":2023,"publication_date":"2023-12-21","ids":{"openalex":"https://openalex.org/W4390054034","doi":"https://doi.org/10.3390/ijms25010118","pmid":"https://pubmed.ncbi.nlm.nih.gov/38203288","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10779409"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25010118","doi":"https://doi.org/10.3390/ijms25010118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25010118","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms25010118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007779887","display_name":"Maria Teresa Bochicchio","orcid":"https://orcid.org/0000-0001-9299-9189","observed_orcids":["https://orcid.org/0000-0001-9299-9189"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Teresa Bochicchio","raw_affiliation_strings":["Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9299-9189","affiliations":[{"raw_affiliation_string":"Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025719686","display_name":"Giovanni Marconi","orcid":"https://orcid.org/0000-0001-6309-0515","observed_orcids":["https://orcid.org/0000-0001-6309-0515"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Marconi","raw_affiliation_strings":["Hematology Unit, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6309-0515","affiliations":[{"raw_affiliation_string":"Hematology Unit, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074502321","display_name":"Carmen Baldazzi","orcid":"https://orcid.org/0000-0003-3796-6418","observed_orcids":["https://orcid.org/0000-0003-3796-6418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Baldazzi","raw_affiliation_strings":["Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3796-6418","affiliations":[{"raw_affiliation_string":"Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037140934","display_name":"Lorenza Bandini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenza Bandini","raw_affiliation_strings":["Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francesca Ruggieri","orcid":"https://orcid.org/0000-0002-4330-6320","observed_orcids":["https://orcid.org/0000-0002-4330-6320"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Ruggieri","raw_affiliation_strings":["Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40100 Bologna, BO, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4330-6320","affiliations":[{"raw_affiliation_string":"Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]},{"raw_affiliation_string":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40100 Bologna, BO, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071210944","display_name":"Alessandro Lucchesi","orcid":"https://orcid.org/0000-0002-0624-5311","observed_orcids":["https://orcid.org/0000-0002-0624-5311"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Lucchesi","raw_affiliation_strings":["Hematology Unit, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0624-5311","affiliations":[{"raw_affiliation_string":"Hematology Unit, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102850085","display_name":"Claudio Agostinelli","orcid":"https://orcid.org/0000-0002-4945-1422","observed_orcids":["https://orcid.org/0000-0002-4945-1422"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Agostinelli","raw_affiliation_strings":["Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40100 Bologna, BO, Italy","Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40100 Bologna, BO, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060227300","display_name":"Elena Sabattini","orcid":"https://orcid.org/0000-0002-4136-3591","observed_orcids":["https://orcid.org/0000-0002-4136-3591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Sabattini","raw_affiliation_strings":["Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4136-3591","affiliations":[{"raw_affiliation_string":"Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035582011","display_name":"Agnese Orsatti","orcid":"https://orcid.org/0009-0005-8560-1925","observed_orcids":["https://orcid.org/0009-0005-8560-1925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnese Orsatti","raw_affiliation_strings":["Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, BO, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016048586","display_name":"Anna Ferrari","orcid":"https://orcid.org/0000-0002-7022-9906","observed_orcids":["https://orcid.org/0000-0002-7022-9906"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Ferrari","raw_affiliation_strings":["Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7022-9906","affiliations":[{"raw_affiliation_string":"Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092614081","display_name":"Giorgia Capirossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgia Capirossi","raw_affiliation_strings":["Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chiara Servili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Servili","raw_affiliation_strings":["Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019004022","display_name":"Andrea Ghelli Luserna di Ror\u00e0","orcid":"https://orcid.org/0000-0002-9744-0533","observed_orcids":["https://orcid.org/0000-0002-9744-0533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Ghelli Luserna di Ror\u00e0","raw_affiliation_strings":["Fondazione Pisana per la Scienza ONLUS, 56017 San Giuliano Terme, PI, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, 56017 San Giuliano Terme, PI, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073761054","display_name":"Giovanni Martinelli","orcid":"https://orcid.org/0000-0002-1025-4210","observed_orcids":["https://orcid.org/0000-0002-1025-4210"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Martinelli","raw_affiliation_strings":["Scientific Directorate, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1025-4210","affiliations":[{"raw_affiliation_string":"Scientific Directorate, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054016975","display_name":"Giorgia Simonetti","orcid":"https://orcid.org/0000-0001-6954-969X","observed_orcids":["https://orcid.org/0000-0001-6954-969X"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgia Simonetti","raw_affiliation_strings":["Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6954-969X","affiliations":[{"raw_affiliation_string":"Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009003698","display_name":"Gianantonio Rosti","orcid":"https://orcid.org/0000-0002-0310-4206","observed_orcids":["https://orcid.org/0000-0002-0310-4206"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianantonio Rosti","raw_affiliation_strings":["Hematology Unit, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Unit, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) \u201cDino Amadori\u201d, 47014 Meldola, FC, Italy","institution_ids":["https://openalex.org/I4210097834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007779887","https://openalex.org/A5009003698"],"corresponding_institution_ids":["https://openalex.org/I4210097834"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":0.7682,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69729043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"25","issue":"1","first_page":"118","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.3483999967575073,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.9369999766349792},{"id":"https://openalex.org/keywords/imatinib-mesylate","display_name":"imatinib mesylate","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hypereosinophilic-syndrome","display_name":"hypereosinophilic syndrome","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fusion-transcripts","display_name":"fusion transcripts","score":0.6439999938011169},{"id":"https://openalex.org/keywords/complete-hematologic-response","display_name":"complete hematologic response","score":0.7139999866485596},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.609000027179718},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C2780833115","wikidata":"https://www.wikidata.org/wiki/Q14914527","display_name":"ETV6","level":4,"score":0.9168450832366943},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.7839647531509399},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.7129056453704834},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.7128217220306396},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.6341869831085205},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6340550780296326},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5759490728378296},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.563107430934906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5289112329483032},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.45304444432258606},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.44573238492012024},{"id":"https://openalex.org/C2779060813","wikidata":"https://www.wikidata.org/wiki/Q17143415","display_name":"Hematopathology","level":5,"score":0.44551706314086914},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43567007780075073},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4241219758987427},{"id":"https://openalex.org/C2780581156","wikidata":"https://www.wikidata.org/wiki/Q112670","display_name":"Systemic mastocytosis","level":3,"score":0.4126538038253784},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.41105177998542786},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.39246371388435364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3415582776069641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33507606387138367},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.29748231172561646},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.2954188585281372},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2524121105670929},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15527108311653137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1395060122013092},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.11106738448143005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08267253637313843},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003582","descriptor_name":"Cytogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050783","descriptor_name":"Proto-Oncogene Proteins c-ets","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms25010118","doi":"https://doi.org/10.3390/ijms25010118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25010118","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10779409","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10779409","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10779409/pdf/ijms-25-00118.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38203288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38203288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Case Reports"},{"id":"pmh:oai:cris.unibo.it:11585/954656","doi":null,"is_oa":true,"landing_page_url":"https://www.mdpi.com/1422-0067/25/1/118","pdf_url":"https://www.mdpi.com/1422-0067/25/1/118/pdf?version=1703139886","source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms25010118","doi":"https://doi.org/10.3390/ijms25010118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25010118","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G4493568517","display_name":null,"funder_award_id":"Ricerca Finalizzata GR-2018-12365278","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390054034.pdf","grobid_xml":"https://content.openalex.org/works/W4390054034.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W199333423","https://openalex.org/W2010954840","https://openalex.org/W2017021967","https://openalex.org/W2049496060","https://openalex.org/W2145842725","https://openalex.org/W2152987588","https://openalex.org/W2268842808","https://openalex.org/W2397706354","https://openalex.org/W2518143119","https://openalex.org/W2534692183","https://openalex.org/W2555393363","https://openalex.org/W2604279744","https://openalex.org/W2888880184","https://openalex.org/W2902814870","https://openalex.org/W2957832123","https://openalex.org/W3015869041","https://openalex.org/W4206269061","https://openalex.org/W4220702518","https://openalex.org/W4292800952","https://openalex.org/W4384405387","https://openalex.org/W4386996864","https://openalex.org/W6608188212","https://openalex.org/W6728729259"],"related_works":["https://openalex.org/W4400596760","https://openalex.org/W4381660968","https://openalex.org/W4413972242","https://openalex.org/W2152987588","https://openalex.org/W2534692183","https://openalex.org/W7095949390","https://openalex.org/W3136346839","https://openalex.org/W2145842725","https://openalex.org/W3110854351","https://openalex.org/W2518143119"],"abstract_inverted_index":{"ETV6::ABL1":[0,102,121],"rearranged":[1],"neoplasms":[2],"are":[3],"rare":[4],"hematological":[5,146],"diseases.":[6],"To":[7],"date,":[8],"about":[9],"80":[10],"cases":[11],"have":[12,34],"been":[13,35],"reported,":[14],"including":[15],"myeloid":[16],"and":[17,30,90,105,123,144,155,158],"lymphoid":[18],"leukemias.":[19],"The":[20,71,115],"ETV6":[21,39,69],"gene":[22],"codes":[23],"for":[24],"an":[25],"ETS":[26],"family":[27],"transcription":[28],"factor":[29],"several":[31],"fusion":[32,107],"partners":[33],"described.":[36],"When":[37],"translocated,":[38],"causes":[40],"the":[41,45,51,62,68,82,124,138,142,151],"constitutive":[42],"activation":[43],"of":[44,53,61,65,96,153],"partner":[46],"genes.":[47],"Here,":[48],"we":[49],"report":[50],"case":[52,149],"a":[54,58,131],"54-year-old":[55],"woman":[56],"with":[57,76,120],"cryptic":[59],"insertion":[60],"3\u2032":[63],"region":[64],"ABL1":[66],"in":[67],"gene.":[70],"patient":[72,125,139],"was":[73,117],"first":[74],"diagnosed":[75],"idiopathic":[77],"hypereosinophilic":[78],"syndrome,":[79],"according":[80],"to":[81],"clinical":[83],"history,":[84],"conventional":[85],"cytogenetics,":[86],"standard":[87],"molecular":[88,143],"analyses":[89],"pathologist":[91],"description.":[92],"Next":[93],"generation":[94],"sequencing":[95],"diagnosis":[97,116],"samples":[98],"unexpectedly":[99],"detected":[100],"both":[101],"type":[103],"A":[104],"B":[106],"transcripts,":[108],"which":[109],"were":[110],"then":[111],"confirmed":[112],"by":[113],"FISH.":[114],"Myeloid/Lymphoid":[118],"neoplasm":[119],"fusion,":[122],"received":[126],"imatinib":[127],"mesylate":[128],"treatment.":[129,163],"In":[130],"follow-up":[132],"after":[133],"more":[134],"than":[135],"one":[136],"year,":[137],"still":[140],"maintained":[141],"complete":[145],"responses.":[147],"This":[148],"highlights":[150],"importance":[152],"timely":[154],"proper":[156],"diagnostics":[157],"prompt":[159],"tyrosine":[160],"kinase":[161],"inhibitor":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-12-22T00:00:00"}