{"id":"https://openalex.org/W4390052990","doi":"https://doi.org/10.1038/s41467-023-43940-6","title":"The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival","display_name":"The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival","publication_year":2023,"publication_date":"2023-12-21","ids":{"openalex":"https://openalex.org/W4390052990","doi":"https://doi.org/10.1038/s41467-023-43940-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/38129415","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10739865"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-43940-6","doi":"https://doi.org/10.1038/s41467-023-43940-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-43940-6","pdf_url":"https://www.nature.com/articles/s41467-023-43940-6.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-43940-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007144903","display_name":"Prakruti R. Singh","orcid":"https://orcid.org/0000-0003-4853-846X","observed_orcids":["https://orcid.org/0000-0003-4853-846X"]},"institutions":[{"id":"https://openalex.org/I147481903","display_name":"Jawaharlal Nehru Centre for Advanced Scientific Research","ror":"https://ror.org/0538gdx71","country_code":"IN","type":"facility","lineage":["https://openalex.org/I147481903","https://openalex.org/I2799351866","https://openalex.org/I4210098748","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prakruti R. Singh","raw_affiliation_strings":["Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India","Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0003-4853-846X","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, India","institution_ids":["https://openalex.org/I147481903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010037115","display_name":"Venkatareddy Dadireddy","orcid":"https://orcid.org/0000-0002-0271-941X","observed_orcids":["https://orcid.org/0000-0002-0271-941X"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Venkatareddy Dadireddy","raw_affiliation_strings":["Department of Physics, Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0002-0271-941X","affiliations":[{"raw_affiliation_string":"Department of Physics, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013097513","display_name":"Shubha Udupa","orcid":"https://orcid.org/0000-0002-9876-8178","observed_orcids":["https://orcid.org/0000-0002-9876-8178"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubha Udupa","raw_affiliation_strings":["Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066142704","display_name":"Shashwath Malli Kalladi","orcid":"https://orcid.org/0000-0002-0191-3632","observed_orcids":["https://orcid.org/0000-0002-0191-3632"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shashwath Malli Kalladi","raw_affiliation_strings":["Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034208958","display_name":"Somnath Shee","orcid":"https://orcid.org/0000-0001-9313-8559","observed_orcids":["https://orcid.org/0000-0001-9313-8559"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Somnath Shee","raw_affiliation_strings":["Centre for Infectious Disease Research (CIDR), Department of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Infectious Disease Research (CIDR), Department of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103050407","display_name":"Sanjeev Khosla","orcid":"https://orcid.org/0000-0002-7780-1813","observed_orcids":["https://orcid.org/0000-0002-7780-1813"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjeev Khosla","raw_affiliation_strings":["Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh (CSIR -IMTech), Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Council of Scientific and Industrial Research-Institute of Microbial Technology, Chandigarh (CSIR -IMTech), Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113069374","display_name":"Raju S Rajmani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raju S. Rajmani","raw_affiliation_strings":["Centre for Infectious Disease Research (CIDR), Department of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Infectious Disease Research (CIDR), Department of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067909461","display_name":"Amit Singh","orcid":"https://orcid.org/0000-0001-6761-1664","observed_orcids":["https://orcid.org/0000-0001-6761-1664","https://orcid.org/0000-0001-7028-1803"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amit Singh","raw_affiliation_strings":["Centre for Infectious Disease Research (CIDR), Department of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0001-6761-1664","affiliations":[{"raw_affiliation_string":"Centre for Infectious Disease Research (CIDR), Department of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024930481","display_name":"Suryanarayanarao Ramakumar","orcid":"https://orcid.org/0000-0003-0823-359X","observed_orcids":["https://orcid.org/0000-0003-0823-359X"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suryanarayanarao Ramakumar","raw_affiliation_strings":["Department of Physics, Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0003-0823-359X","affiliations":[{"raw_affiliation_string":"Department of Physics, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006030743","display_name":"Valakunja Nagaraja","orcid":"https://orcid.org/0000-0002-3298-8741","observed_orcids":["https://orcid.org/0000-0002-3298-8741","https://orcid.org/0000-0002-9711-5933"]},"institutions":[{"id":"https://openalex.org/I147481903","display_name":"Jawaharlal Nehru Centre for Advanced Scientific Research","ror":"https://ror.org/0538gdx71","country_code":"IN","type":"facility","lineage":["https://openalex.org/I147481903","https://openalex.org/I2799351866","https://openalex.org/I4210098748","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Valakunja Nagaraja","raw_affiliation_strings":["Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India. vraj@iisc.ac.in","Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, India. vraj@iisc.ac.in","Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0002-3298-8741","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Cell Biology, Indian Institute of Science (IISc), Bengaluru, India. vraj@iisc.ac.in","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, India. vraj@iisc.ac.in","institution_ids":["https://openalex.org/I147481903"]},{"raw_affiliation_string":"Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, India","institution_ids":["https://openalex.org/I147481903"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006030743"],"corresponding_institution_ids":["https://openalex.org/I147481903","https://openalex.org/I59270414"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":6.2108,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.97753405,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"8497","last_page":"8497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dot1l","display_name":"DOT1L","score":0.9660000205039978},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8610000014305115},{"id":"https://openalex.org/keywords/h3k79-methylation","display_name":"H3K79 methylation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.765999972820282},{"id":"https://openalex.org/keywords/nlrc3","display_name":"NLRC3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.597000002861023},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.47699999809265137},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6970592141151428},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6320710182189941},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6305012106895447},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5991706848144531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5679981708526611},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5653090476989746},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4805586636066437},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4751455783843994},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.45750144124031067},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42959481477737427},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.42407912015914917},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3785463869571686},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3044268488883972},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2820735573768616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25042325258255005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2157571017742157},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41467-023-43940-6","doi":"https://doi.org/10.1038/s41467-023-43940-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-43940-6","pdf_url":"https://www.nature.com/articles/s41467-023-43940-6.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2023.02.24.529973","doi":"https://doi.org/10.1101/2023.02.24.529973","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.02.24.529973","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/02/25/2023.02.24.529973.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10739865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10739865","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10739865/pdf/41467_2023_Article_43940.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38129415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38129415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai::85322","doi":null,"is_oa":false,"landing_page_url":"https://eprints.iisc.ac.in/85322/1/nat_com_14_1_2023_.pdf","pdf_url":"https://eprints.iisc.ac.in/85322/1/nat_com_14_1_2023_.pdf","source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43940-6","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-43940-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a35a85850b474c0099f01869a8023291","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a35a85850b474c0099f01869a8023291","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)","raw_type":"article"},{"id":"doi:10.60692/3mpr8-83e21","doi":"https://doi.org/10.60692/3mpr8-83e21","is_oa":true,"landing_page_url":"https://doi.org/10.60692/3mpr8-83e21","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/rka8g-x1427","doi":"https://doi.org/10.60692/rka8g-x1427","is_oa":true,"landing_page_url":"https://doi.org/10.60692/rka8g-x1427","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-43940-6","doi":"https://doi.org/10.1038/s41467-023-43940-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-43940-6","pdf_url":"https://www.nature.com/articles/s41467-023-43940-6.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2189144943","display_name":null,"funder_award_id":"CRG/2019/000077","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G3894082748","display_name":null,"funder_award_id":"BT/PR13522/COE/34/27/2015","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"},{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320323128","display_name":"Jawaharlal Nehru Centre for Advanced Scientific Research","ror":"https://ror.org/0538gdx71"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390052990.pdf","grobid_xml":"https://content.openalex.org/works/W4390052990.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W57244441","https://openalex.org/W1966429292","https://openalex.org/W1967064280","https://openalex.org/W1967596247","https://openalex.org/W1967841171","https://openalex.org/W1973096737","https://openalex.org/W1980853278","https://openalex.org/W1986853519","https://openalex.org/W2005162189","https://openalex.org/W2010156857","https://openalex.org/W2012025493","https://openalex.org/W2019425225","https://openalex.org/W2026576443","https://openalex.org/W2034066489","https://openalex.org/W2038276395","https://openalex.org/W2039940539","https://openalex.org/W2044007120","https://openalex.org/W2064768985","https://openalex.org/W2067263136","https://openalex.org/W2074862238","https://openalex.org/W2075038734","https://openalex.org/W2075553662","https://openalex.org/W2083248748","https://openalex.org/W2085027758","https://openalex.org/W2091208410","https://openalex.org/W2102304447","https://openalex.org/W2104082208","https://openalex.org/W2124026197","https://openalex.org/W2129443010","https://openalex.org/W2129453816","https://openalex.org/W2130020386","https://openalex.org/W2132120580","https://openalex.org/W2132232570","https://openalex.org/W2138807501","https://openalex.org/W2143815085","https://openalex.org/W2147098153","https://openalex.org/W2149200346","https://openalex.org/W2149691569","https://openalex.org/W2154714625","https://openalex.org/W2158217645","https://openalex.org/W2159211495","https://openalex.org/W2159586303","https://openalex.org/W2163341755","https://openalex.org/W2167160669","https://openalex.org/W2190683602","https://openalex.org/W2256083943","https://openalex.org/W2259938310","https://openalex.org/W2264175950","https://openalex.org/W2282994692","https://openalex.org/W2333941380","https://openalex.org/W2462787445","https://openalex.org/W2520336046","https://openalex.org/W2602856434","https://openalex.org/W2607156755","https://openalex.org/W2613944145","https://openalex.org/W2733650234","https://openalex.org/W2754598098","https://openalex.org/W2761172458","https://openalex.org/W2771821798","https://openalex.org/W2782933375","https://openalex.org/W2790057789","https://openalex.org/W2790545058","https://openalex.org/W2792144827","https://openalex.org/W2888461478","https://openalex.org/W2890022950","https://openalex.org/W2893619628","https://openalex.org/W2907769723","https://openalex.org/W2909109320","https://openalex.org/W2913118546","https://openalex.org/W2913126315","https://openalex.org/W2939146474","https://openalex.org/W2971118426","https://openalex.org/W2973163858","https://openalex.org/W2974637121","https://openalex.org/W2977688599","https://openalex.org/W2982849188","https://openalex.org/W3011106749","https://openalex.org/W3040879201","https://openalex.org/W3044323210","https://openalex.org/W3048331980","https://openalex.org/W3112514862","https://openalex.org/W3128419955","https://openalex.org/W3131373892","https://openalex.org/W3131875767","https://openalex.org/W3179031266","https://openalex.org/W3207000359","https://openalex.org/W4247076899","https://openalex.org/W4283399116","https://openalex.org/W4294763252","https://openalex.org/W4299422128","https://openalex.org/W4299912881","https://openalex.org/W4305040584","https://openalex.org/W7101207261"],"related_works":["https://openalex.org/W4321996516","https://openalex.org/W7204885044","https://openalex.org/W1981829354","https://openalex.org/W2264175950","https://openalex.org/W4404838417","https://openalex.org/W4404048542","https://openalex.org/W4381855032","https://openalex.org/W7163371949","https://openalex.org/W3133998574","https://openalex.org/W7156339991"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1,19],"has":[2],"evolved":[3],"several":[4],"mechanisms":[5],"to":[6,24,89,129],"counter":[7],"host":[8,26,48,91,133],"defense":[9],"arsenals":[10],"for":[11,29,101],"its":[12,30],"proliferation.":[13],"Here":[14],"we":[15],"report":[16],"that":[17],"M.":[18],"employs":[20],"a":[21,43],"multi-pronged":[22],"approach":[23],"modify":[25],"epigenetic":[27,134],"machinery":[28],"survival.":[31],"It":[32],"secretes":[33],"methyltransferase":[34],"(MTase)":[35],"Rv2067c":[36,46,77,107,113,128],"into":[37],"macrophages,":[38],"trimethylating":[39],"histone":[40],"H3K79":[41,105,121],"in":[42,72],"non-nucleosomal":[44],"context.":[45],"downregulates":[47],"MTase":[49],"DOT1L,":[50],"decreasing":[51],"DOT1L-mediated":[52],"nucleosomally":[53],"added":[54],"H3K79me3":[55],"mark":[56],"on":[57,120],"pro-inflammatory":[58],"response":[59],"genes.":[60],"Consequent":[61],"inhibition":[62],"of":[63,68,81,104,112],"caspase-8-dependent":[64],"apoptosis":[65],"and":[66,84,93,108,114,124,136],"enhancement":[67],"RIPK3-mediated":[69],"necrosis":[70],"results":[71],"increased":[73],"pathogenesis.":[74],"In":[75],"parallel,":[76],"enhances":[78],"the":[79,87,98,132],"expression":[80],"SESTRIN3,":[82],"NLRC3,":[83],"TMTC1,":[85],"enabling":[86,127],"pathogen":[88],"overcome":[90],"inflammatory":[92],"oxidative":[94],"responses.":[95],"We":[96],"provide":[97],"structural":[99],"basis":[100],"differential":[102],"methylation":[103],"by":[106],"DOT1L.":[109],"The":[110],"structures":[111],"DOT1L":[115],"explain":[116],"how":[117],"their":[118],"action":[119],"is":[122],"spatially":[123],"temporally":[125],"separated,":[126],"effectively":[130],"intercept":[131],"circuit":[135],"downstream":[137],"signaling.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-12-22T00:00:00"}