{"id":"https://openalex.org/W4390034252","doi":"https://doi.org/10.1016/j.jot.2023.09.002","title":"Daily low-intensity pulsed ultrasound stimulation mitigates joint degradation and pain in a post-traumatic osteoarthritis rat model","display_name":"Daily low-intensity pulsed ultrasound stimulation mitigates joint degradation and pain in a post-traumatic osteoarthritis rat model","publication_year":2023,"publication_date":"2023-12-20","ids":{"openalex":"https://openalex.org/W4390034252","doi":"https://doi.org/10.1016/j.jot.2023.09.002","pmid":"https://pubmed.ncbi.nlm.nih.gov/38161708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10753057"},"language":"en","primary_location":{"id":"doi:10.1016/j.jot.2023.09.002","doi":"https://doi.org/10.1016/j.jot.2023.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jot.2023.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S2764689464","display_name":"Journal of Orthopaedic Translation","issn_l":"2214-031X","issn":["2214-031X","2214-0328"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Translation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jot.2023.09.002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057926795","display_name":"Wonsae Lee","orcid":"https://orcid.org/0000-0002-4837-3119","observed_orcids":["https://orcid.org/0000-0002-4837-3119"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wonsae Lee","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4837-3119","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005854953","display_name":"Elias Georgas","orcid":"https://orcid.org/0000-0001-6538-9641","observed_orcids":["https://orcid.org/0000-0001-6538-9641"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Georgas","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045488279","display_name":"David E. Komatsu","orcid":"https://orcid.org/0000-0002-2618-9492","observed_orcids":["https://orcid.org/0000-0002-2618-9492"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Komatsu","raw_affiliation_strings":["Department of Orthopaedics and Rehabilitation, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-2618-9492","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011583661","display_name":"Yi\u2010Xian Qin","orcid":"https://orcid.org/0000-0001-5243-8846","observed_orcids":["https://orcid.org/0000-0001-5243-8846"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yi-Xian Qin","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-5243-8846","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011583661"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":2.7228,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.91177556,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"44","issue":null,"first_page":"9","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-intensity-pulsed-ultrasound","display_name":"low-intensity pulsed ultrasound","score":0.996999979019165},{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/anterior-cruciate-ligament-transection","display_name":"anterior cruciate ligament transection","score":0.9399999976158142},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/joint-pain","display_name":"joint pain","score":0.9179999828338623},{"id":"https://openalex.org/keywords/sensory-innervation","display_name":"sensory innervation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/netrin-1","display_name":"netrin-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2778550726","wikidata":"https://www.wikidata.org/wiki/Q3658544","display_name":"Low-intensity pulsed ultrasound","level":4,"score":0.9573447704315186},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8815239667892456},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.6925570964813232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6383096575737},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6301867365837097},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5217503309249878},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.38253694772720337},{"id":"https://openalex.org/C2779727089","wikidata":"https://www.wikidata.org/wiki/Q564875","display_name":"Therapeutic ultrasound","level":3,"score":0.37860244512557983},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3326549828052521},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2253682017326355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22522467374801636},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10127180814743042},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05478474497795105},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jot.2023.09.002","doi":"https://doi.org/10.1016/j.jot.2023.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jot.2023.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S2764689464","display_name":"Journal of Orthopaedic Translation","issn_l":"2214-031X","issn":["2214-031X","2214-0328"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Translation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10753057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10753057","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10753057/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Orthop Translat","raw_type":"Text"},{"id":"pmid:38161708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38161708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic translation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a4f7c60d7e8348ca83d8a5696173a207","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a4f7c60d7e8348ca83d8a5696173a207","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Orthopaedic Translation, Vol 44, Iss , Pp 9-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jot.2023.09.002","doi":"https://doi.org/10.1016/j.jot.2023.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jot.2023.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S2764689464","display_name":"Journal of Orthopaedic Translation","issn_l":"2214-031X","issn":["2214-031X","2214-0328"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Translation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G798691235","display_name":"GCR: Programmable Nanorobots Integration with Magnetically-Driven Neuron and Brain Tissue Regeneration","funder_award_id":"2020867","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8062782843","display_name":"Scholars in BioMedical Sciences (SBMS) Training Program","funder_award_id":"T32GM127253","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G836180499","display_name":"Functional Fluid Flow Regulated Bone Regeneration","funder_award_id":"R01AR061821","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1574811776","https://openalex.org/W1972701083","https://openalex.org/W1991938395","https://openalex.org/W1994174812","https://openalex.org/W2004772967","https://openalex.org/W2006433730","https://openalex.org/W2014796138","https://openalex.org/W2045289729","https://openalex.org/W2060646810","https://openalex.org/W2070796291","https://openalex.org/W2075371618","https://openalex.org/W2089845241","https://openalex.org/W2099427592","https://openalex.org/W2103027702","https://openalex.org/W2105204667","https://openalex.org/W2112245605","https://openalex.org/W2119527637","https://openalex.org/W2141219254","https://openalex.org/W2270756512","https://openalex.org/W2335869333","https://openalex.org/W2409667587","https://openalex.org/W2574647359","https://openalex.org/W2578304222","https://openalex.org/W2592758426","https://openalex.org/W2609054180","https://openalex.org/W2611414060","https://openalex.org/W2753084136","https://openalex.org/W2765096927","https://openalex.org/W2777589129","https://openalex.org/W2778795974","https://openalex.org/W2888080003","https://openalex.org/W2893461213","https://openalex.org/W2896365664","https://openalex.org/W2905013468","https://openalex.org/W2969175530","https://openalex.org/W2989973707","https://openalex.org/W3004347334","https://openalex.org/W3030615868","https://openalex.org/W3159659265","https://openalex.org/W3217030925","https://openalex.org/W4225823353","https://openalex.org/W4300861458","https://openalex.org/W4365445778","https://openalex.org/W6651422685"],"related_works":["https://openalex.org/W2893461213","https://openalex.org/W7165002602","https://openalex.org/W4387865837","https://openalex.org/W2765779920","https://openalex.org/W3015872858","https://openalex.org/W3119948191","https://openalex.org/W7166684294","https://openalex.org/W3031883604","https://openalex.org/W4310718106","https://openalex.org/W2003520795"],"abstract_inverted_index":{"Objectives:":[0],".":[1],"Methods:":[2],"Thirty-eight":[3],"male,":[4],"four-month-old":[5],"Sprague":[6],"Dawley":[7],"rats":[8],"were":[9,74,87,92,119],"randomly":[10],"assigned":[11],"to":[12,26,39,108,202,249],"Sham,":[13],"Sham":[14,22,48],"\u200b+":[15,20,49,53],"\u200bUS,":[16],"OA,":[17,172],"and":[18,32,51,78,89,96,123,135,184,240,253],"OA":[19,52,227],"\u200bUS.":[21],"surgery":[23],"was":[24,37,130,147],"performed":[25,75,93],"serve":[27],"as":[28],"a":[29,143,193,219],"negative":[30],"control,":[31],"anterior":[33],"cruciate":[34],"ligament":[35],"transection":[36],"used":[38],"induce":[40],"OA.":[41,209],"Three":[42],"days":[43],"after":[44],"the":[45,61,64,85,110,150,168,203,230,236,241],"surgical":[46],"procedures,":[47],"\u200bUS":[50,54],"animals":[55],"received":[56,66],"daily":[57,189],"LIPUS":[58,115,151,162,190],"treatment,":[59,116],"while":[60],"rest":[62],"of":[63,112,141,170,205,213,232,238,243],"groups":[65],"sham":[67],"ultrasound":[68],"(US)":[69],"signals.":[70],"Behavioral":[71],"pain":[72,178],"tests":[73],"at":[76],"baseline":[77],"every":[79],"week":[80],"thereafter.":[81],"After":[82],"31":[83],"days,":[84],"tissues":[86],"collected,":[88],"histological":[90,133],"analyses":[91,134],"on":[94,196],"knees":[95],"innervated":[97],"dorsal":[98],"root":[99],"ganglia":[100],"(DRG)":[101],"neurons":[102],"traced":[103],"by":[104,114],"retrograde":[105],"labeling.":[106],"Furthermore,":[107,188],"assess":[109],"activation":[111],"osteoclasts":[113,122],"RAW264.7":[117],"\u200bcells":[118],"differentiated":[120],"into":[121],"treated":[124,152],"with":[125],"LIPUS.":[126],"Results:":[127],",":[128],"which":[129,198,234],"confirmed":[131],"via":[132],"mRNA":[136],"expression.":[137],"Finally,":[138],"lower":[139],"expression":[140],"netrin-1,":[142],"sensory":[144,186,206],"innervation-related":[145],"protein,":[146],"found":[148],"in":[149,208,225],"cells.":[153],"Conclusion:":[154],"Our":[155],"findings":[156],"demonstrate":[157],"that":[158],"early":[159,223],"intervention":[160,224,247],"using":[161],"treatment":[163,191],"has":[164,192],"protective":[165],"effects":[166],"from":[167],"progression":[169],"knee":[171],"including":[173],"reduced":[174],"tissue":[175],"degradation,":[176],"mitigated":[177],"characteristics,":[179],"improved":[180],"subchondral":[181],"bone":[182],"microarchitecture,":[183],"less":[185],"innervation.":[187],"suppressive":[194],"effect":[195],"osteoclastogenesis,":[197],"may":[199],"be":[200],"linked":[201],"suppression":[204,237],"innervation":[207],"The":[210],"translational":[211],"potential":[212,221],"this":[214],"article:":[215],"This":[216,246],"study":[217],"presents":[218],"new":[220],"for":[222],"treating":[226],"symptoms":[228],"through":[229],"use":[231],"LIPUS,":[233],"involves":[235],"osteoclastogenesis":[239],"alteration":[242],"DRG":[244],"profiles.":[245],"aims":[248],"delay":[250],"joint":[251],"degradation":[252],"reduce":[254],"pain.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-21T00:00:00"}