{"id":"https://openalex.org/W4389977553","doi":"https://doi.org/10.1186/s12943-023-01913-9","title":"Unveiling the hidden AP-1: revealing the crucial role of AP-1 in ccRCC at single-cell resolution","display_name":"Unveiling the hidden AP-1: revealing the crucial role of AP-1 in ccRCC at single-cell resolution","publication_year":2023,"publication_date":"2023-12-19","ids":{"openalex":"https://openalex.org/W4389977553","doi":"https://doi.org/10.1186/s12943-023-01913-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/38114996","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10731896"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-023-01913-9","doi":"https://doi.org/10.1186/s12943-023-01913-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-023-01913-9","pdf_url":null,"source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12943-023-01913-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101281915","display_name":"Jie Zheng","orcid":"https://orcid.org/0009-0006-1838-1587","observed_orcids":["https://orcid.org/0009-0006-1838-1587"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zheng","raw_affiliation_strings":["Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China","Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040329236","display_name":"Fengling Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengling Liu","raw_affiliation_strings":["Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China","Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089005621","display_name":"Cheng Su","orcid":"https://orcid.org/0000-0002-8646-2155","observed_orcids":["https://orcid.org/0000-0002-8646-2155"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Su","raw_affiliation_strings":["Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China. sucheng@stu.gxmu.edu.cn","Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. sucheng@stu.gxmu.edu.cn","Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"],"raw_orcid":"https://orcid.org/0000-0002-8646-2155","affiliations":[{"raw_affiliation_string":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China. sucheng@stu.gxmu.edu.cn","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. sucheng@stu.gxmu.edu.cn","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I4210126060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089005621"],"corresponding_institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210126060"],"apc_list":{"value":4890,"currency":"USD","value_usd":4890},"apc_paid":{"value":4890,"currency":"USD","value_usd":4890},"fwci":0.7219,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67406005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"209","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/activator-protein-1","display_name":"activator protein-1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.7739999890327454},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/transcription-factor-activity","display_name":"transcription factor activity","score":0.48399999737739563},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7329999804496765},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.7480000257492065},{"id":"https://openalex.org/keywords/single-cell-multi-omics","display_name":"single-cell multi-omics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ix","display_name":"carbonic anhydrase IX","score":0.6639999747276306},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.756894052028656},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5296584963798523},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.44458338618278503},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43029651045799255},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40400445461273193},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32498371601104736},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.255465567111969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13326624035835266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08501291275024414},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.08278483152389526}],"mesh":[{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12943-023-01913-9","doi":"https://doi.org/10.1186/s12943-023-01913-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-023-01913-9","pdf_url":null,"source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10731896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10731896","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10731896/pdf/12943_2023_Article_1913.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:38114996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38114996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Letter"},{"id":"pmh:oai:doaj.org/article:aeeefde6391044b7aa0754f419eb1fed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aeeefde6391044b7aa0754f419eb1fed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 22, Iss 1, Pp 1-6 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12943-023-01913-9","doi":"https://doi.org/10.1186/s12943-023-01913-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-023-01913-9","pdf_url":null,"source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1717147060","display_name":null,"funder_award_id":"No.2022GXNSFAA035641","funder_id":"https://openalex.org/F4320322768","funder_display_name":"Natural Science Foundation of Guangxi Province"}],"funders":[{"id":"https://openalex.org/F4320322768","display_name":"Natural Science Foundation of Guangxi Province","ror":null},{"id":"https://openalex.org/F4320327301","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389977553.pdf","grobid_xml":"https://content.openalex.org/works/W4389977553.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2049904360","https://openalex.org/W2072319964","https://openalex.org/W2726542547","https://openalex.org/W2887326710","https://openalex.org/W2938933772","https://openalex.org/W3168048358","https://openalex.org/W4283220315","https://openalex.org/W4285795954","https://openalex.org/W4313650150","https://openalex.org/W4361007156","https://openalex.org/W4366372194"],"related_works":["https://openalex.org/W6939741762","https://openalex.org/W4313650150","https://openalex.org/W4416257144","https://openalex.org/W4392508232","https://openalex.org/W4408039123","https://openalex.org/W7133204259","https://openalex.org/W4391323585","https://openalex.org/W4414863023","https://openalex.org/W3112267697","https://openalex.org/W4285795954"],"abstract_inverted_index":{"Clear":[0],"cell":[1,3],"renal":[2],"carcinoma":[4],"(ccRCC),":[5],"as":[6],"the":[7,27,30,56,60,150,154,164,174,190,207,226],"most":[8],"common":[9],"histological":[10],"subtype":[11],"of":[12,59,72,80,100,114,120,149,163,177,194,206,212,228],"kidney":[13,126],"cancer,":[14],"has":[15],"been":[16],"reported":[17],"to":[18,87,108,134,153],"originate":[19],"primarily":[20],"from":[21,51],"proximal":[22],"tubule":[23],"(PT)":[24],"cells":[25,85,105,181],"in":[26,65,82,103,124,137,166,179,214],"kidney.":[28],"However,":[29],"current":[31],"research":[32,53,224],"on":[33],"its":[34],"associated":[35],"molecular":[36],"mechanisms":[37,211],"remains":[38],"relatively":[39],"limited.":[40],"In":[41,112],"our":[42,91],"study,":[43],"we":[44,159],"analyzed":[45],"multiple":[46],"single-cell":[47,94],"multi-omics":[48],"datasets":[49],"obtained":[50],"various":[52,167],"teams,":[54],"revealing":[55],"significant":[57],"role":[58],"activator":[61],"protein":[62],"1":[63],"(AP-1)":[64],"ccRCC":[66,83,109,128,155],"tumorigenesis.":[67],"The":[68],"motif":[69],"activity":[70],"analysis":[71,143],"transcription":[73],"factors":[74],"(TFs)":[75],"showed":[76],"a":[77,97,145,203,218],"predominant":[78],"activation":[79],"AP-1":[81,101,121,151,165,178,195,213],"cancer":[84,110],"compared":[86,107,152],"PT":[88,104,170,180],"cells.":[89,111],"Furthermore,":[90],"findings":[92,198],"at":[93],"resolution":[95],"revealed":[96],"notable":[98],"absence":[99],"expression":[102,119,147,176],"when":[106],"bulk-RNA":[113,138],"discovery":[115],"cohort,":[116],"no":[117],"differential":[118],"was":[122],"detected":[123],"normal":[125],"and":[127,209,225],"samples,":[129],"which":[130],"may":[131,182],"be":[132,183],"attributed":[133],"confounding":[135],"effects":[136],"sequencing.":[139],"Meanwhile,":[140],"spatial":[141],"transcriptomics":[142],"demonstrated":[144],"broader":[146],"range":[148],"marker":[156],"CA9.":[157],"Moreover,":[158],"observed":[160],"chromatin":[161],"accessibility":[162],"cell-types,":[168],"including":[169],"cells,":[171],"suggesting":[172],"that":[173],"transcriptional":[175,187],"influenced":[184],"by":[185],"subsequent":[186],"modifications,":[188],"reflecting":[189],"complex":[191],"regulatory":[192,210],"mechanism":[193],"transcription.":[196],"These":[197],"provide":[199],"important":[200],"insights":[201],"for":[202,221],"deeper":[204],"understanding":[205],"function":[208],"ccRCC,":[215],"thereby":[216],"establishing":[217],"theoretical":[219],"foundation":[220],"future":[222],"clinical":[223],"development":[227],"treatment":[229],"strategies.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-12-20T00:00:00"}
