{"id":"https://openalex.org/W4389977421","doi":"https://doi.org/10.33425/2771-9057.1023","title":"Neurological Facets of Hematological Malignancies: A Case Series","display_name":"Neurological Facets of Hematological Malignancies: A Case Series","publication_year":2023,"publication_date":"2023-06-30","ids":{"openalex":"https://openalex.org/W4389977421","doi":"https://doi.org/10.33425/2771-9057.1023"},"language":"en","primary_location":{"id":"doi:10.33425/2771-9057.1023","doi":"https://doi.org/10.33425/2771-9057.1023","is_oa":true,"landing_page_url":"http://doi.org/10.33425/2771-9057.1023","pdf_url":"https://doi.org/10.33425/2771-9057.1023","source":{"id":"https://openalex.org/S4387281648","display_name":"Recent Advances in Clinical Trials","issn_l":"2771-9057","issn":["2771-9057"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Advances in Clinical Trials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.33425/2771-9057.1023","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075826998","display_name":"Ichrak Ghachem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118449","display_name":"H\u00f4pital Charles-Nicolle","ror":"https://ror.org/02f6ghw27","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210118449"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ichrak Ghachem","raw_affiliation_strings":["Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210118449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027366093","display_name":"Saloua Fray","orcid":"https://orcid.org/0000-0002-0848-798X","observed_orcids":["https://orcid.org/0000-0002-0848-798X"]},"institutions":[{"id":"https://openalex.org/I4210118449","display_name":"H\u00f4pital Charles-Nicolle","ror":"https://ror.org/02f6ghw27","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210118449"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Saloua Fray","raw_affiliation_strings":["Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","Research laboratory LR12SP01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210118449"]},{"raw_affiliation_string":"Research laboratory LR12SP01","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076529101","display_name":"H\u00e9la Jamoussi","orcid":"https://orcid.org/0000-0003-4904-8913","observed_orcids":["https://orcid.org/0000-0003-4904-8913"]},"institutions":[{"id":"https://openalex.org/I4210118449","display_name":"H\u00f4pital Charles-Nicolle","ror":"https://ror.org/02f6ghw27","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210118449"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hela Jamoussi","raw_affiliation_strings":["Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia, Address: boulevard du 9-Avril 1938, Bab Saadoun, 1006, Tunis, Tel: +21671578000, +21671578409, +21671578346"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia, Address: boulevard du 9-Avril 1938, Bab Saadoun, 1006, Tunis, Tel: +21671578000, +21671578409, +21671578346","institution_ids":["https://openalex.org/I4210118449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113588874","display_name":"Selim Echebbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118449","display_name":"H\u00f4pital Charles-Nicolle","ror":"https://ror.org/02f6ghw27","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210118449"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Selim Echebbi","raw_affiliation_strings":["Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","Research laboratory LR12SP01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210118449"]},{"raw_affiliation_string":"Research laboratory LR12SP01","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080356619","display_name":"Nadia Ali","orcid":"https://orcid.org/0009-0009-2701-8378","observed_orcids":["https://orcid.org/0009-0009-2701-8378","https://orcid.org/0009-0008-1223-4791"]},"institutions":[{"id":"https://openalex.org/I4210118449","display_name":"H\u00f4pital Charles-Nicolle","ror":"https://ror.org/02f6ghw27","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210118449"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Nadia Ben Ali","raw_affiliation_strings":["Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","Research laboratory LR12SP01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210118449"]},{"raw_affiliation_string":"Research laboratory LR12SP01","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110538509","display_name":"Mohamed Fredj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118449","display_name":"H\u00f4pital Charles-Nicolle","ror":"https://ror.org/02f6ghw27","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210118449"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Mohamed Fredj","raw_affiliation_strings":["Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","Research laboratory LR12SP01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Charles Nicolle Hospital, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210118449"]},{"raw_affiliation_string":"Research laboratory LR12SP01","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210118449"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25935604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.21940000355243683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.21940000355243683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.1835000067949295,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.13680000603199005,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-nervous-system-involvement","display_name":"central nervous system involvement","score":0.8600000143051147},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.781000018119812},{"id":"https://openalex.org/keywords/optic-neuritis","display_name":"optic neuritis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8109999895095825},{"id":"https://openalex.org/keywords/spinal-cord-inflammation","display_name":"myelitis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-induced-peripheral-neuropathy","display_name":"drug-induced peripheral neuropathy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.886542022228241},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5330715775489807},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.48280441761016846},{"id":"https://openalex.org/C2776572573","wikidata":"https://www.wikidata.org/wiki/Q972514","display_name":"Optic neuritis","level":3,"score":0.47839462757110596},{"id":"https://openalex.org/C2777704947","wikidata":"https://www.wikidata.org/wiki/Q551085","display_name":"Myelitis","level":3,"score":0.4756759703159332},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.41042324900627136},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.3627862334251404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3370797038078308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2697013318538666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21762219071388245},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.10015103220939636},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33425/2771-9057.1023","doi":"https://doi.org/10.33425/2771-9057.1023","is_oa":true,"landing_page_url":"http://doi.org/10.33425/2771-9057.1023","pdf_url":"https://doi.org/10.33425/2771-9057.1023","source":{"id":"https://openalex.org/S4387281648","display_name":"Recent Advances in Clinical Trials","issn_l":"2771-9057","issn":["2771-9057"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Advances in Clinical Trials","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33425/2771-9057.1023","doi":"https://doi.org/10.33425/2771-9057.1023","is_oa":true,"landing_page_url":"http://doi.org/10.33425/2771-9057.1023","pdf_url":"https://doi.org/10.33425/2771-9057.1023","source":{"id":"https://openalex.org/S4387281648","display_name":"Recent Advances in Clinical Trials","issn_l":"2771-9057","issn":["2771-9057"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Advances in Clinical Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389977421.pdf","grobid_xml":"https://content.openalex.org/works/W4389977421.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W131836238","https://openalex.org/W1516016724","https://openalex.org/W1974754812","https://openalex.org/W2017007459","https://openalex.org/W2028898086","https://openalex.org/W2032403775","https://openalex.org/W2042400442","https://openalex.org/W2056972419","https://openalex.org/W2064116854","https://openalex.org/W2071897702","https://openalex.org/W2110184403","https://openalex.org/W2117804341","https://openalex.org/W2149112471","https://openalex.org/W2296620396","https://openalex.org/W2487685184","https://openalex.org/W2560980055","https://openalex.org/W2620927386","https://openalex.org/W2750084680","https://openalex.org/W2793678400","https://openalex.org/W2981823371"],"related_works":["https://openalex.org/W7213865202","https://openalex.org/W2750897037","https://openalex.org/W2923155250","https://openalex.org/W4400982758","https://openalex.org/W1988679099","https://openalex.org/W7220123176","https://openalex.org/W2409161858","https://openalex.org/W4360982179","https://openalex.org/W2120722607","https://openalex.org/W4255451094"],"abstract_inverted_index":{"Background:":[0],"Central":[1],"nerve":[2,151],"involvement":[3],"is":[4],"a":[5,78,159],"serious":[6],"complication":[7],"in":[8,158],"hemopathies.":[9],"Clinical":[10],"presentations":[11],"are":[12,29],"heterogeneous;":[13],"it":[14],"can":[15],"affect":[16],"the":[17,24,34,42,50,58,62,71,201],"central":[18,43],"nervous":[19,46],"system":[20],"as":[21,23],"well":[22],"peripheral.":[25],"The":[26,137,163,180],"pathophysiological":[27,51],"mechanisms":[28,52],"multiple.":[30],"Aims:":[31],"To":[32,69],"illustrate":[33,70],"diversity":[35],"of":[36,65,80,83,210,213],"these":[37],"neurological":[38,66,95,125,164,211],"manifestations":[39,126,165],"affecting":[40],"both":[41],"and":[44,53,61,73,90,132,143,149,173,188,207],"peripheral":[45,171],"systems.":[47],"We":[48,56,98,195],"study":[49],"diagnostic":[54],"strategies.":[55],"discuss":[57,196],"therapeutic":[59],"alternatives":[60],"prognostic":[63,208],"value":[64],"damage.":[67],"Methods:":[68],"clinical":[72,81],"etiological":[74,138],"polymorphism,":[75],"we":[76],"report":[77],"series":[79,200],"cases":[82],"seven":[84,100],"patients":[85,101],"followed":[86,102],"for":[87,93,103,123],"malignant":[88,104],"hemopathies":[89],"who":[91],"consulted":[92],"different":[94,124,141,202],"manifestations.":[96],"Results:":[97],"have":[99],"hemopathies:":[105],"Acute":[106,110,154],"lymphoblastic":[107],"Leukemia":[108,112,119],"(ALL),":[109],"myeloblastic":[111],"(AML),":[113],"Myelodysplasic":[114],"syndrome":[115,175],"(MDS),":[116],"Chronic":[117],"myeloid":[118],"(CML).":[120],"Patients":[121],"consult":[122],"(optic":[127,152],"neuritis,":[128],"neuropathic":[129],"pain,":[130],"sensory":[131],"motor":[133],"deficit,":[134],"myopathic":[135,174],"syndrome.":[136,179],"assessment":[139],"identified":[140],"causes":[142],"mechanisms:":[144],"leukemic":[145],"medullary":[146],"infiltration":[147,187],"(myelitis)":[148],"optic":[150],"neuritis).":[153],"post":[155],"infectious":[156],"polyradiculoneuritis":[157],"patient":[160],"undergoing":[161],"chemotherapy.":[162],"related":[166],"to":[167,177],"drugs":[168],"were":[169],"painful":[170],"neuropathy":[172],"secondary":[176],"cytarabine":[178],"fatal":[181],"outcome":[182],"was":[183],"associated":[184],"with":[185],"extensive":[186],"fulminant":[189],"neurovascularitis":[190],"induced":[191],"by":[192],"MDS.":[193],"Conclusion:":[194],"here":[197],"through":[198],"our":[199],"epidemiological,":[203],"physiopathological,":[204],"clinical,":[205],"evolutionary":[206],"aspects":[209],"complications":[212],"hematological":[214],"malignancies.":[215]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-20T00:00:00"}
