{"id":"https://openalex.org/W4389960907","doi":"https://doi.org/10.2139/ssrn.4669219","title":"Next-generation DNA sequencing identifies mutated FANCD2 Gene as a novel Biomarker for monitoring early disease progression and timely therapeutic interventions in advanced phase Chronic Myeloid Leukemia patients","display_name":"Next-generation DNA sequencing identifies mutated FANCD2 Gene as a novel Biomarker for monitoring early disease progression and timely therapeutic interventions in advanced phase Chronic Myeloid Leukemia patients","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4389960907","doi":"https://doi.org/10.2139/ssrn.4669219"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.4669219","doi":"https://doi.org/10.2139/ssrn.4669219","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4669219","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SSRN Electronic Journal","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.4669219","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093106786","display_name":"Nawaf Alanzazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134149","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/04cjdzt83","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210134149"]},{"id":"https://openalex.org/I4405276535","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/05mvv1442","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210127754","https://openalex.org/I4405269311","https://openalex.org/I4405276535"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nawaf Alanzazi","raw_affiliation_strings":["King Abdulaziz Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdulaziz Hospital","institution_ids":["https://openalex.org/I4210134149","https://openalex.org/I4405276535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019471493","display_name":"Abdulaziz Siyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdulaziz Siyal","raw_affiliation_strings":["King Saud University - Cancer Stem Cell Group","King Saud University - Cancer Stem Cell Group, Riyadh, Saudi Arabia","Cancer Stem Cell Group, Stem Cell Unit, Department of Anatomy, College of Medicine & King Saud University Medical City, KKUH, King Saud University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud University - Cancer Stem Cell Group","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"King Saud University - Cancer Stem Cell Group, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Cancer Stem Cell Group, Stem Cell Unit, Department of Anatomy, College of Medicine & King Saud University Medical City, KKUH, King Saud University","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051184696","display_name":"Muhammad M. Absar","orcid":"https://orcid.org/0000-0002-1284-2673","observed_orcids":["https://orcid.org/0000-0002-1284-2673"]},"institutions":[{"id":"https://openalex.org/I4210134149","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/04cjdzt83","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210134149"]},{"id":"https://openalex.org/I4405276535","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/05mvv1442","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210127754","https://openalex.org/I4405269311","https://openalex.org/I4405276535"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Muhammad Absar","raw_affiliation_strings":["King Abdulaziz Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdulaziz Hospital","institution_ids":["https://openalex.org/I4210134149","https://openalex.org/I4405276535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masood Shammas","raw_affiliation_strings":["Department of Medical Oncology, Harvard (Dana Farber) Cancer Institute","Department of Medical Oncology, Harvard (Dana Farber) Cancer Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Harvard (Dana Farber) Cancer Institute","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Medical Oncology, Harvard (Dana Farber) Cancer Institute, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074297204","display_name":"Sarah AlMukhaylid","orcid":"https://orcid.org/0009-0000-0646-367X","observed_orcids":["https://orcid.org/0009-0000-0646-367X"]},"institutions":[{"id":"https://openalex.org/I185203018","display_name":"King Saud bin Abdulaziz University for Health Sciences","ror":"https://ror.org/0149jvn88","country_code":"SA","type":"education","lineage":["https://openalex.org/I185203018"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Sarah AlMukhaylid","raw_affiliation_strings":["King Saud Bin Abdulaziz University for Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud Bin Abdulaziz University for Health Sciences","institution_ids":["https://openalex.org/I185203018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003104026","display_name":"Amer Mahmood","orcid":"https://orcid.org/0000-0002-9199-0120","observed_orcids":["https://orcid.org/0000-0002-9199-0120"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Amer Mahmood","raw_affiliation_strings":["King Saud University - Cancer Stem Cell Group","King Saud University - Cancer Stem Cell Group, Riyadh, Saudi Arabia","Cancer Stem Cell Group, Stem Cell Unit, Department of Anatomy, College of Medicine & King Saud University Medical City, KKUH, King Saud University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud University - Cancer Stem Cell Group","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"King Saud University - Cancer Stem Cell Group, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Cancer Stem Cell Group, Stem Cell Unit, Department of Anatomy, College of Medicine & King Saud University Medical City, KKUH, King Saud University","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":null,"display_name":"Zafar Iqbal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I185203018","display_name":"King Saud bin Abdulaziz University for Health Sciences","ror":"https://ror.org/0149jvn88","country_code":"SA","type":"education","lineage":["https://openalex.org/I185203018"]},{"id":"https://openalex.org/I2802517405","display_name":"King Abdulaziz Medical City","ror":"https://ror.org/009djsq06","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2802517405"]},{"id":"https://openalex.org/I3130965127","display_name":"Qarshi University","ror":"https://ror.org/03hakcq28","country_code":"PK","type":"education","lineage":["https://openalex.org/I3130965127"]},{"id":"https://openalex.org/I4210095597","display_name":"King Abdullah International Medical Research Center","ror":"https://ror.org/009p8zv69","country_code":"SA","type":"facility","lineage":["https://openalex.org/I4210095597"]},{"id":"https://openalex.org/I4517696","display_name":"National Guard Health Affairs","ror":"https://ror.org/02pecpe58","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4517696"]}],"countries":["PK","SA"],"is_corresponding":true,"raw_author_name":"Zafar Iqbal","raw_affiliation_strings":["H.O.P.E.S Research Group & DNA Core Facility, Centre for Applied Molecular Biology, University of the Punjab","H.O.P.E.S. Research Group, Next Generation Medical Biotechnology Division, Department of Biology, Qarshi University, Lahore, Pakistan","Hematology, Oncology and Genetic Engineering Sciences Research Group (H.O.P.E.S), Department of Zoology, University of the Punjab, Lahore, Pakistan","King Abdulaziz Medical City","King Abdullah International Medical Research Centre (KAIMRC)","King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs","Qarshi University","Saudi Society for Blood and Bone Marrow Transplantation (SSBMT), National Guard Health Affairs (NGHA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H.O.P.E.S Research Group & DNA Core Facility, Centre for Applied Molecular Biology, University of the Punjab","institution_ids":["https://openalex.org/I172780181"]},{"raw_affiliation_string":"H.O.P.E.S. Research Group, Next Generation Medical Biotechnology Division, Department of Biology, Qarshi University, Lahore, Pakistan","institution_ids":["https://openalex.org/I3130965127"]},{"raw_affiliation_string":"Hematology, Oncology and Genetic Engineering Sciences Research Group (H.O.P.E.S), Department of Zoology, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181"]},{"raw_affiliation_string":"King Abdulaziz Medical City","institution_ids":["https://openalex.org/I2802517405"]},{"raw_affiliation_string":"King Abdullah International Medical Research Centre (KAIMRC)","institution_ids":["https://openalex.org/I4210095597"]},{"raw_affiliation_string":"King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs","institution_ids":["https://openalex.org/I185203018","https://openalex.org/I2802517405","https://openalex.org/I4517696"]},{"raw_affiliation_string":"Qarshi University","institution_ids":["https://openalex.org/I3130965127"]},{"raw_affiliation_string":"Saudi Society for Blood and Bone Marrow Transplantation (SSBMT), National Guard Health Affairs (NGHA","institution_ids":["https://openalex.org/I4517696"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I172780181","https://openalex.org/I185203018","https://openalex.org/I2802517405","https://openalex.org/I3130965127","https://openalex.org/I4210095597","https://openalex.org/I4517696"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.7229999899864197},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7680000066757202},{"id":"https://openalex.org/keywords/accelerated-phase","display_name":"accelerated phase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/blast-crisis","display_name":"blast crisis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fanconi-anemia-pathway","display_name":"Fanconi anemia pathway","score":0.953000009059906},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8140000104904175},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8130000233650208},{"id":"https://openalex.org/keywords/splice-site-variant","display_name":"splice site mutation","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7017900943756104},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5886339545249939},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.500300407409668},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4959772527217865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49519625306129456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46881723403930664},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.4298713207244873},{"id":"https://openalex.org/C2776653068","wikidata":"https://www.wikidata.org/wiki/Q17927069","display_name":"FANCD2","level":5,"score":0.4200842082500458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3525232672691345},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35000014305114746},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33850300312042236},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3137763738632202},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30370983481407166},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.20461848378181458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2013280689716339},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.18268480896949768},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.4669219","doi":"https://doi.org/10.2139/ssrn.4669219","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4669219","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SSRN Electronic Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4669219","doi":"https://doi.org/10.2139/ssrn.4669219","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4669219","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SSRN Electronic Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389981824","https://openalex.org/W4400442899","https://openalex.org/W4252114969","https://openalex.org/W4389230027","https://openalex.org/W4391518197","https://openalex.org/W4390400284","https://openalex.org/W3211616212","https://openalex.org/W4392861991","https://openalex.org/W2015365103","https://openalex.org/W2149322936"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-12-20T00:00:00"}
